{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:36:45Z","timestamp":1782754605403,"version":"3.54.5"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The upper physiological threshold for tricuspid regurgitation velocity (TRV) of 2.8 m\/s proposed by the Pulmonary Hypertension (PH) guidelines had been questioned. The aim of this study was to evaluate the prognostic significance of preoperative PH in patients with aortic stenosis, long-term after valve replacement, using two different TRV thresholds (2.55 and 2.8 m\/s).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Four hundred and forty four patients were included (mean age 73 \u00b1 9 years; 55% male), with a median follow-up of 5.8 years (98% completed). Patients were divided into three PH probability groups according to guidelines (low, intermediate and high) for both thresholds (TRV \u2264 2.8 m\/s and TRV \u2264 2.55 m\/s), using right atrial area&amp;gt;18 cm<jats:sup>2<\/jats:sup> and right ventricle\/left ventricle ratio&amp;gt;1 as additional echocardiographic variables.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In patients with measurable TRV (<jats:italic>n<\/jats:italic> = 304), the low group mortality rate was 25% and 30%, respectively for 2.55 and 2.8 m\/s TRV thresholds. The intermediate group with TRV &amp;gt; 2.55 m\/s was an independent mortality risk factor (HR 2.04; 95% CI: 1.91 to 3.48, <jats:italic>p<\/jats:italic> = 0.01), in contrast to the intermediate group with TRV&amp;gt;2.8 m\/s (HR 1.44; 95% CI: 0.89 to 2.32, <jats:italic>p<\/jats:italic> = 0.14). Both high probability groups were associated with an increased mortality risk, as compared to their respective low groups. When including all patients (with measurable and non-measurable TRV), both intermediate groups remained independently associated with an increased mortality risk: HR 1.62 (95% CI 1.11 to 2.35 <jats:italic>p<\/jats:italic> = 0.01) for the new cut-off point; and HR 1.43 (95% CI: 0.96 to 2.13, <jats:italic>p<\/jats:italic> = 0.07) for guidelines threshold.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> A TRV threshold of 2.55 m\/s, together with right cavities measures, allowed a better risk assessment of patients with PH secondary to severe aortic stenosis, with or without tricuspid regurgitation.<\/jats:p>","DOI":"10.3389\/fcvm.2021.720643","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T11:31:08Z","timestamp":1636543868000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Importance of Tricuspid Regurgitation Velocity Threshold in Risk Assessment of Pulmonary Hypertension-Long-Term Outcome of Patients Submitted to Aortic Valve Replacement"],"prefix":"10.3389","volume":"8","author":[{"given":"Cora","family":"Garcia-Ribas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirea","family":"Ble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Mas-Stachurska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Farr\u00e9-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Cladellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 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