{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:17:58Z","timestamp":1783023478358,"version":"3.54.6"},"reference-count":144,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods. Modern cryopreservation prolongs the preservation time of homograft valved conduit, which makes it become the most important treatment at present, and is widely used in Ross and other operations. However, homograft valved conduit has limited biocompatibility and durability and lacks any additional growth capacity. Therefore, decellularized valved conduit has been proposed as an effective improved method, which can reduce immune response and calcification, and has potential growth ability. In addition, as a possible substitute, commercial xenograft valved conduit has certain advantages in clinical application, and tissue engineering artificial valved conduit needs to be further studied.<\/jats:p>","DOI":"10.3389\/fcvm.2021.740871","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:32:44Z","timestamp":1634146364000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Application of Homograft Valved Conduit in Cardiac Surgery"],"prefix":"10.3389","volume":"8","author":[{"given":"Yige","family":"Huyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/s0140-6736(66)90600-3","article-title":"Correction of pulmonary atresia with a homograft aortic valve","volume":"2","author":"Ross","year":"1966","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-5223(19)42568-3","article-title":"Anatomic correction of transposition of the great arteries with ventricular septal defect and subpulmonary stenosis","volume":"58","author":"Rastelli","year":"1969","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/s0003-4975(10)65826-2","article-title":"Reoperation after insertion of aortic homograft as a right ventricular outflow tract","volume":"16","author":"Merin","year":"1973","journal-title":"Ann Thorac Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"S371","DOI":"10.1016\/s0003-4975(01)02547-4","article-title":"Repair of truncus arteriosus in early infancy with antibiotic sterilized aortic homografts","volume":"71","author":"Alexiou","year":"2001","journal-title":"Ann Thorac Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1055\/s-2007-1022045","article-title":"Right ventricular outflow reconstruction with aortic homograft conduit: analysis of the long-term results","volume":"28","author":"Shabbo","year":"1980","journal-title":"Thorac Cardiovasc Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0033-0620(69)90054-1","article-title":"Homograft replacement of the aortic valve. 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