{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:11:17Z","timestamp":1784243477854,"version":"3.55.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is a gaseous signaling molecule and redox factor important for cardiovascular function. Deficiencies in its production or bioavailability are implicated in atherosclerotic disease. However, it is unknown if circulating H\n                    <jats:sub>2<\/jats:sub>\n                    S levels differ between vasculopaths and healthy individuals, and if so, whether H\n                    <jats:sub>2<\/jats:sub>\n                    S measurements can be used to predict surgical outcomes. Here, we examined: (1) Plasma H\n                    <jats:sub>2<\/jats:sub>\n                    S levels in patients undergoing vascular surgery and compared these to healthy controls, and (2) the association between H\n                    <jats:sub>2<\/jats:sub>\n                    S levels and mortality in a cohort of patients undergoing surgical revascularization.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    One hundred and fifteen patients undergoing carotid endarterectomy, open lower extremity revascularization or lower leg amputation were enrolled at a single institution. Peripheral blood was also collected from a matched control cohort of 20 patients without peripheral or coronary artery disease. Plasma H\n                    <jats:sub>2<\/jats:sub>\n                    S production capacity and sulfide concentration were measured using the lead acetate and monobromobimane methods, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Plasma H\n                    <jats:sub>2<\/jats:sub>\n                    S production capacity and plasma sulfide concentrations were reduced in patients with PAD (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.013, respectively). Patients that underwent surgical revascularization were divided into high vs. low H\n                    <jats:sub>2<\/jats:sub>\n                    S production capacity groups by median split. Patients in the low H\n                    <jats:sub>2<\/jats:sub>\n                    S production group had increased probability of mortality (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003). This association was robust to correction for potentially confounding variables using Cox proportional hazard models.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Circulating H\n                    <jats:sub>2<\/jats:sub>\n                    S levels were lower in patients with atherosclerotic disease. Patients undergoing surgical revascularization with lower H\n                    <jats:sub>2<\/jats:sub>\n                    S production capacity, but not sulfide concentrations, had increased probability of mortality within 36 months post-surgery. This work provides insight on the role H\n                    <jats:sub>2<\/jats:sub>\n                    S plays as a diagnostic and potential therapeutic for cardiovascular disease.\n                  <\/jats:p>","DOI":"10.3389\/fcvm.2021.750926","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T11:51:12Z","timestamp":1635162672000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Plasma Hydrogen Sulfide Is Positively Associated With Post-operative Survival in Patients Undergoing Surgical Revascularization"],"prefix":"10.3389","volume":"8","author":[{"given":"Alban","family":"Longchamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"MacArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Trocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Ganahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte G.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Ditr\u00f3i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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