{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:16:58Z","timestamp":1764260218110,"version":"3.41.2"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Sinus of Valsalva aneurysm (SoVA) is an uncommon clinical entity, which is present in roughly 0. 09% of the general population. The cause can either be acquired or congenital. Clinically the SoVA of unruptured status are rarely captured or even diagnosed due to atypical clinical presentations. Here, we present a rare case of exertional angina pectoris and recurrent syncope due to an extrinsically compressed left coronary artery by a giant SoVA in a 50-year-old female patient. This SoVA was successfully repaired by the surgical exclusion and the patient was still doing well after 2 years of follow-up.<\/jats:p>","DOI":"10.3389\/fcvm.2021.753154","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T06:08:21Z","timestamp":1636956501000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Extrinsic Compression of the Left Main Coronary Artery by a Giant Sinus of Valsalva Aneurysm"],"prefix":"10.3389","volume":"8","author":[{"given":"Feifei","family":"Ning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manyun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"Muhlestein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1148\/rg.301095719","article-title":"Valsalva sinus aneurysms: findings at CT and MR imaging","volume":"30","author":"Bricker","year":"2010","journal-title":"Radiographics."},{"key":"B2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/clc.22359","article-title":"Sinus of valsalva aneurysms: review of the literature and an update on management","volume":"38","author":"Weinreich","year":"2015","journal-title":"Clin Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000092635","article-title":"Aneurysms of the sinuses of Valsalva","volume":"106","author":"Feldman","year":"2006","journal-title":"Cardiology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ijcard.2014.02.003","article-title":"Echocardiographic diagnosis of sinus of Valsalva aneurysm: a 17-year (1995-2012) experience of 212 surgically treated patients from one single medical center in China","volume":"173","author":"Cheng","year":"2014","journal-title":"Int J Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"E577","DOI":"10.1532\/HSF98.20041128","article-title":"The four seasons of ruptured sinus of valsalva aneurysms: case presentations and review","volume":"7","author":"Golzari","year":"2004","journal-title":"Heart Surg Forum."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1590\/S0066-782X2009000600017","article-title":"Right sinus of Valsalva aneurysm causing extrinsic coronary compression","volume":"50","author":"Dias","year":"2009","journal-title":"Arquivos Brasileiros Cardiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"234","DOI":"10.6001\/actamedica.v25i4.3934","article-title":"Angina pectoris and sinus of Valsalva aneurysm: a rare manifestation of an uncommon disease","volume":"25","author":"Simonavi\u010dius","year":"2018","journal-title":"Acta Medica Lituanica."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.753154\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T06:08:24Z","timestamp":1636956504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.753154\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":7,"alternative-id":["10.3389\/fcvm.2021.753154"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2021.753154","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2021,11,15]]},"article-number":"753154"}}