{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:15:14Z","timestamp":1789398914256,"version":"build-2803163510"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Cardiogenic shock seriously affects the survival rate of patients. However, few prognostic models are concerned with the score of cardiogenic shock, and few clinical studies have validated it. In order to optimize the diagnosis and treatment of myocardial infarction complicated with cardiogenic shock and facilitate the classification of clinical trials, the prognosis score model is urgently needed.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Cardiogenic shock, severe case, prognosis score, myocardial infarction and external verification were used as the search terms to search PubMed, Embase, Web of Science, Cochrane, EBSCO (Medline), Scopus, BMC, NCBI, Oxford Academy, Science Direct, and other databases for pertinent studies published up until 1 August 2021. There are no restrictions on publication status and start date. Filter headlines and abstracts to find articles that may be relevant. The list of references for major studies was reviewed to obtain more references.<\/jats:p><jats:p><jats:bold>Results and Conclusions:<\/jats:bold> The existing related models are in urgent need of more external clinical verifications. In the meanwhile, with the development of molecular omics and the clinical need for optimal treatment of CS, it is urgent to establish a prognosis model with higher differentiation and coincidence rates.<\/jats:p>","DOI":"10.3389\/fcvm.2021.754303","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T05:33:01Z","timestamp":1639114381000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["A Review of Prognosis Model Associated With Cardiogenic Shock After Acute Myocardial Infarction"],"prefix":"10.3389","volume":"8","author":[{"given":"Jingyue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1007\/s00134-018-5214-9","article-title":"Management of cardiogenic shock complicating myocardial infarction","volume":"44","author":"Mebazaa","year":"2018","journal-title":"Intensive Care Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ijcard.2016.09.019","article-title":"Predictors of in-hospital mortality among cardiogenic shock patients. Prognostic and therapeutic implications","volume":"224","author":"Li","year":"2016","journal-title":"Int J Cardiol"},{"key":"B3","first-page":"7","article-title":"The TIMI risk score for STEMI predicts in-hospital mortality and adverse events in patients without cardiogenic shock undergoing primary angioplasty","volume":"82","author":"Gonz\u00e1lez-Pacheco","year":"2012","journal-title":"Arch Cardiol Mex"},{"key":"B4","doi-asserted-by":"publisher","first-page":"8530539","DOI":"10.1155\/2017\/8530539","article-title":"Prognostic analysis for cardiogenic shock in patients with acute myocardial infarction receiving percutaneous coronary intervention","volume":"2017","author":"Lin","year":"2017","journal-title":"Biomed Res Int"},{"key":"B5","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/ejhf.260","article-title":"CardShock Study Investigators; GREAT network. Clinical picture and risk prediction of short-term mortality in cardiogenic shock","volume":"17","author":"Harjola","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"B6","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1007\/s001340050456","article-title":"The ability of the Simplified Acute Physiology Score (SAPS II) to predict outcome in coronary care patients","volume":"23","author":"Schuster","year":"1997","journal-title":"Intensive Care Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/01.CCM.0000098605.58349.76","article-title":"Complicated acute myocardial infarction requiring mechanical ventilation in the intensive care unit: prognostic factors of clinical outcome in a series of 157 patients","volume":"32","author":"Lesage","year":"2004","journal-title":"Crit Care Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1001\/jama.270.24.2957","article-title":"A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study","volume":"271","author":"Le Gall","year":"1994","journal-title":"JAMA"},{"key":"B10","first-page":"24","article-title":"In-hospital outcome of acute myocardial infarction in correlation with \u2018thrombolysis in myocardial infarction' risk score","volume":"21","author":"Masood","year":"2009","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"B11","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1007\/s00063-013-0234-2","article-title":"Predictive value of outcome scores in patients suffering from cardiogenic shock complicating AMI: APACHE II, APACHE III, Elebute-Stoner, SOFA, and SAPS II","volume":"108","author":"Kellner","year":"2013","journal-title":"Med Klin Intensivmed Notfmed"},{"key":"B12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/SHK.0000000000000170","article-title":"Cardiac power index, mean arterial pressure, and simplified acute physiology score II are strong predictors of survival and response to revascularization in cardiogenic shock","volume":"42","author":"Popovic","year":"2014","journal-title":"Shock"},{"key":"B13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.amjcard.2005.02.040","article-title":"American College of Cardiology National Cardiovascular Data Registry. Mortality after emergent percutaneous coronary intervention in cardiogenic shock secondary to acute myocardial infarction and usefulness of a mortality prediction model","volume":"96","author":"Klein","year":"2005","journal-title":"Am J Cardiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ahj.2010.06.024","article-title":"A severity scoring system for risk assessment of patients with cardiogenic shock: a report from the SHOCK trial and registry","volume":"160","author":"Sleeper","year":"2010","journal-title":"Am Heart J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1093\/eurheartj\/ehn602","article-title":"A systematic review and meta-analysis of intra-aortic balloon pump therapy in ST-elevation myocardial infarction: should we change the guidelines?","volume":"30","author":"Sjauw","year":"2009","journal-title":"Eur Heart J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jacc.2005.03.047","article-title":"Sustained benefit 20 years after reperfusion therapy in acute myocardial infarction","volume":"46","author":"van Domburg","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1001\/jama.294.4.448","article-title":"NRMI Investigators. Trends in management and outcomes of patients with acute myocardial infarction complicated by cardiogenic shock","volume":"294","author":"Babaev","year":"2005","journal-title":"JAMA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/j.jacc.2017.02.027","article-title":"Risk Stratification for patients in cardiogenic shock after acute myocardial infarction","volume":"69","author":"P\u00f6ss","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1161\/CIRCULATIONAHA.118.038201","article-title":"Intraaortic balloon pump in cardiogenic shock complicating acute myocardial infarction: long-term 6-year outcome of the randomized IABP-SHOCK II trial","volume":"139","author":"Thiele","year":"2019","journal-title":"Circulation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.amjcard.2008.12.033","article-title":"Early risk stratification of patients with cardiogenic shock complicating acute myocardial infarction who undergo percutaneous coronary intervention","volume":"103","author":"Garcia-Alvarez","year":"2009","journal-title":"Am J Cardiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"R218","DOI":"10.1186\/cc13035","article-title":"Prognostic value of admission blood glucose level in patients with and without diabetes mellitus who sustain ST segment elevation myocardial infarction complicated by cardiogenic shock","volume":"17","author":"Yang","year":"2013","journal-title":"Crit Care"},{"key":"B22","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0140-6736(99)08415-9","article-title":"Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview","volume":"355","author":"Capes","year":"2000","journal-title":"Lancet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ijcard.2015.04.242","article-title":"Prognostic impact of established and novel renal function biomarkers in myocardial infarction with cardiogenic shock: a biomarker substudy of the IABP-SHOCK II-trial","volume":"191","author":"Fuernau","year":"2015","journal-title":"Int J Cardiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/2048872615568966","article-title":"A simple risk chart for initial risk assessment of 30-day mortality in patients with cardiogenic shock from ST-elevation myocardial infarction","volume":"5","author":"Cheng","year":"2016","journal-title":"Eur Heart J. Acute Cardiovasc Care."},{"key":"B25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.resuscitation.2014.11.010","article-title":"Prognostic implication of out-of-hospital cardiac arrest in patients with cardiogenic shock and acute myocardial infarction","volume":"87","author":"Ostenfeld","year":"2015","journal-title":"Resuscitation"},{"key":"B26","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.jcmg.2011.10.007","article-title":"Plaque features associated with increased cerebral infarction after minor stroke and TIA: a prospective, case-control, 3-T carotid artery MR imaging study","volume":"5","author":"Lindsay","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"B27","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1067\/mhj.2003.6","article-title":"OPUS-TIMI 16 Investigators. Prior peripheral arterial disease and cerebrovascular disease are independent predictors of adverse outcome in patients with acute coronary syndromes: are we doing enough? Results from the Orbofiban in Patients with Unstable Coronary Syndromes-Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study","volume":"145","author":"Cotter","year":"2003","journal-title":"Am Heart J"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1002\/ehf2.13224","article-title":"Mortality risk prediction in elderly patients with cardiogenic shock: results from the CardShock study","volume":"8","author":"Hongisto","year":"2021","journal-title":"ESC Heart Fail"},{"key":"B29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jacc.2018.04.051","article-title":"Epinephrine versus norepinephrine for cardiogenic shock after acute myocardial infarction","volume":"72","author":"Levy","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1177\/0885066619878125","article-title":"Comparative prognostic accuracy of risk prediction models for cardiogenic shock","volume":"35","author":"Miller","year":"2020","journal-title":"J Intensive Care Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1177\/2048872619895230","article-title":"External validation and comparison of the CardShock and IABP-SHOCK II risk scores in real-world cardiogenic shock patients","volume":"10","author":"Rivas-Lasarte","year":"2021","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"B32","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1097\/00003246-198411000-00012","article-title":"A simplified acute physiology score for ICU patients","volume":"12","author":"Le Gall","year":"1984","journal-title":"Crit Care Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.amjcard.2003.11.036","article-title":"Predicting mortality in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention (PAMI risk score)","volume":"93","author":"Addala","year":"2004","journal-title":"Am J Cardiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1161\/01.CIR.0000131765.73959.87","article-title":"Prognostic assessment of patients with acute myocardial infarction treated with primary angioplasty: implications for early discharge","volume":"109","author":"De Luca","year":"2004","journal-title":"Circulation"},{"key":"B35","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.hlc.2020.08.026","article-title":"Utility of Zwolle risk score in guiding low-risk STEMI discharge","volume":"30","author":"Lim","year":"2021","journal-title":"Heart Lung Circ"},{"key":"B36","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/MCA.0000000000001002","article-title":"Portuguese Registry on Acute Coronary Syndromes (ProACS) investigators. Creatinine variation improves Zwolle score in selecting low-risk patients after ST-segment elevation myocardial infarction","volume":"32","author":"Rodrigues Br\u00e1s","year":"2021","journal-title":"Coron Artery Dis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ijcard.2016.04.148","article-title":"GREAT Network. Natriuretic peptides in addition to Zwolle score to enhance safe and early discharge after acute myocardial infarction: a prospective observational cohort study","volume":"215","author":"Ganovska","year":"2016","journal-title":"Int J Cardiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ancard.2004.07.003","article-title":"Facteurs pronostiques de mortalit\u00e9 chez les patients en etat de choc cardiog\u00e9nique primaire trait\u00e9s par angioplastie en phase aigu\u00eb d'infarctus [Mortality prognostic factors of cardiogenic shock complicating an acute myocardial infarction and treated by percutaneous coronary intervention]","volume":"54","author":"Chodek","year":"2005","journal-title":"Ann Cardiol Angeiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1001\/jama.295.21.2511","article-title":"SHOCK Investigators. Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction","volume":"295","author":"Hochman","year":"2006","journal-title":"JAMA"},{"key":"B40","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1093\/eurheartj\/ehi729","article-title":"SHOCK Investigators. Emergency revascularization in patients with cardiogenic shock on admission: a report from the SHOCK trial and registry","volume":"27","author":"Jeger","year":"2006","journal-title":"Eur Heart J"},{"key":"B41","first-page":"II65","article-title":"Prognosis and management of anterolateral myocardial infarction in patients with severe left main disease and cardiogenic shock. The left main shock syndrome","volume":"88","author":"Quigley","year":"1993","journal-title":"Circulation"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/S0735-1097(03)01050-7","article-title":"SHOCK Investigators. Percutaneous coronary intervention for cardiogenic shock in the SHOCK trial","volume":"42","author":"Webb","year":"2003","journal-title":"J Am Coll Cardiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/j.jacc.2007.04.101","article-title":"Long-term outcome and its predictors among patients with ST-segment elevation myocardial infarction complicated by shock: insights from the GUSTO-I trial","volume":"50","author":"Singh","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1093\/eurheartj\/ehv194","article-title":"Predicting survival after ECMO for refractory cardiogenic shock: the survival after veno-arterial-ECMO (SAVE)-score","volume":"36","author":"Schmidt","year":"2015","journal-title":"Eur Heart J"},{"key":"B45","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s00134-016-4223-9","article-title":"The ENCOURAGE mortality risk score and analysis of long-term outcomes after VA-ECMO for acute myocardial infarction with cardiogenic shock","volume":"42","author":"Muller","year":"2016","journal-title":"Intensive Care Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1093\/eurheartj\/ehz294","article-title":"Protein-based cardiogenic shock patient classifier","volume":"40","author":"Rueda","year":"2019","journal-title":"Eur Heart J"},{"key":"B47","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.amjcard.2016.10.034","article-title":"A new risk score to predict long-term cardiac mortality in patients with acute myocardial infarction complicated by cardiogenic shock and treated with primary percutaneous intervention","volume":"119","author":"Vergara","year":"2017","journal-title":"Am J Cardiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/ccd.28329","article-title":"SCAI clinical expert consensus statement on the classification of cardiogenic shock: This document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019","volume":"94","author":"Baran","year":"2019","journal-title":"Catheter Cardiovasc Interv"},{"key":"B49","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/MCC.0000000000000739","article-title":"An outlook on biomarkers in cardiogenic shock","volume":"26","author":"Iborra-Egea","year":"2020","journal-title":"Curr Opin Crit Care"},{"key":"B50","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/MCC.0000000000000746","article-title":"Kidney and liver dysfunction in cardiogenic shock","volume":"26","author":"Lassus","year":"2020","journal-title":"Curr Opin Crit Care"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0217006","DOI":"10.1371\/journal.pone.0217006","article-title":"CardShock investigators. Hypoalbuminemia is a frequent marker of increased mortality in cardiogenic shock","volume":"14","author":"J\u00e4ntti","year":"2019","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1136\/hrt.2010.195511","article-title":"GRACE Investigators. Quantitative troponin and death, cardiogenic shock, cardiac arrest and new heart failure in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS): insights from the Global Registry of Acute Coronary Events","volume":"97","author":"Jolly","year":"2011","journal-title":"Heart"},{"key":"B53","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1056\/NEJMoa0907118","article-title":"SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock","volume":"362","author":"De Backer","year":"2010","journal-title":"N Engl J Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/ejhf.1494","article-title":"Heart Failure Association of the European Society of Cardiology. Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations","volume":"21","author":"Mueller","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"B55","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/CCM.0b013e3181b78671","article-title":"Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome","volume":"38","author":"Prondzinsky","year":"2010","journal-title":"Crit Care Med"},{"key":"B56","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1016\/j.cardfail.2005.04.016","article-title":"N-terminal pro-brain natriuretic peptide as an indicator of right ventricular dysfunction","volume":"11","author":"Pruszczyk","year":"2005","journal-title":"J Card Fail"},{"key":"B57","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1399-6576.2006.00963.x","article-title":"B-type natriuretic peptide (BNP) and N-terminal-proBNP for heart failure diagnosis in shock or acute respiratory distress","volume":"50","author":"Bal","year":"2006","journal-title":"Acta Anaesthesiol Scand"},{"key":"B58","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1186\/cc4839","article-title":"Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study","volume":"10","author":"Januzzi","year":"2006","journal-title":"Crit Care"},{"key":"B59","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1160\/TH11-12-0901","article-title":"NT-pro-BNP levels in patients with acute pulmonary embolism are correlated to right but not left ventricular volume and function","volume":"108","author":"Pasha","year":"2012","journal-title":"Thromb Haemost"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1097\/CCM.0b013e31819fe896","article-title":"Early assessment of outcome in cardiogenic shock: relevance of plasma N-terminal pro-B-type natriuretic peptide and interleukin-6 levels","volume":"37","author":"Jarai","year":"2009","journal-title":"Crit Care Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e18029","DOI":"10.1097\/MD.0000000000018029","article-title":"Neutrophil to lymphocyte ratio (NLR) as a prognostic marker for in-hospital mortality of patients with sepsis: a secondary analysis based on a single-center, retrospective, cohort study","volume":"98","author":"Ni","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e922167","DOI":"10.12659\/MSM.922167","article-title":"Prognostic value of neutrophil-lymphocyte ratio in cardiogenic shock: a cohort study","volume":"26","author":"Peng","year":"2020","journal-title":"Med Sci Monit"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.754303\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T05:33:06Z","timestamp":1639114386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.754303\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,10]]},"references-count":62,"alternative-id":["10.3389\/fcvm.2021.754303"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2021.754303","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,10]]},"article-number":"754303"}}