{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:52:57Z","timestamp":1786488777549,"version":"build-2736575974"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Primary pericardial mesothelioma is an extremely rare tumor, and early identification and accurate diagnosis may improve its clinical outcome.<\/jats:p><jats:p><jats:bold>Case presentation:<\/jats:bold> In this study, we reported a case of a 70-year-old woman who presented with dyspnea. Conventional transthoracic echocardiography showed massive pericardial effusion. Contrast-enhanced ultrasonography revealed a hyper-enhancing mass in the pericardium. Further imaging methods, including cardiac MRI and positron emission tomography\/computed tomography, showed invasion of the pericardial mass into the adjacent tissues and distant metastases. Pathologic examination of a puncture biopsy specimen finally confirmed the diagnosis of PPM.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Pericardial masses are difficult to detect when a large amount of pericardial effusion is present and the mass is small. The combination of multiple modalities plays a meaningful role in identifying PPM.<\/jats:p>","DOI":"10.3389\/fcvm.2021.758988","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T05:24:52Z","timestamp":1637299492000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Multimodal Diagnostic Workup of Primary Pericardial Mesothelioma: A Case Report"],"prefix":"10.3389","volume":"8","author":[{"given":"Jiahui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1016\/j.cllc.2018.11.008","article-title":"Treatment and outcomes of primary pericardial mesothelioma: a contemporary review of 103 published cases","volume":"20","author":"McGehee","year":"2019","journal-title":"Clin Lung Cancer."},{"key":"B2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/jcu.22673","article-title":"Localized primary malignant pericardial mesothelioma","volume":"47","author":"Song","year":"2019","journal-title":"J Clin Ultrasound."},{"key":"B3","first-page":"257","article-title":"Neoplastic pericarditis","volume":"7","author":"Cohen","year":"1976","journal-title":"Cardiovasc Clin."},{"key":"B4","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/0002-8703(85)90175-9","article-title":"Pericardial mesothelioma: hyaluronic acid in pericardial fluid","volume":"110","author":"Takeda","year":"1985","journal-title":"Am Heart J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12947-018-0125-z","article-title":"Echocardiographic characteristics of primary malignant pericardial mesothelioma and outcomes analysis: a retrospective study","volume":"16","author":"Kong","year":"2018","journal-title":"Cardiovasc Ultrasound."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.jcmg.2009.05.008","article-title":"Ultrasound contrast agent safety: from anecdote to evidence","volume":"2","author":"Main","year":"2009","journal-title":"JACC Cardiovasc Imaging."},{"key":"B7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/echo.14597","article-title":"Clinical diagnostic value of contrast-enhanced ultrasonography in the diagnosis of cardiac masses: a pilot study","volume":"37","author":"Wang","year":"2020","journal-title":"Echocardiography."},{"key":"B8","doi-asserted-by":"publisher","first-page":"L1","DOI":"10.1007\/s00330-002-1789-0","article-title":"Role of magnetic resonance imaging for evaluation of tumors in the cardiac region","volume":"13","author":"Kaminaga","year":"2003","journal-title":"Eur Radiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1136\/hrt.79.6.618","article-title":"Images in cardiology. 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