{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:59:26Z","timestamp":1783706366622,"version":"3.55.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> Large ventricular aneurysm secondary to myocardial infarction (MI) results in severe heart failure (HF) and limits the effectiveness of regeneration therapy, which can be improved by surgical ventricular reconstruction (SVR). However, the conventional SVR procedures do not yield optimal long-term outcome in post-MI rodents. We hypothesized that a modified SVR procedure without aggressive purse string suture would persistently alleviate HF and improve cardiac regeneration in post-MI mice.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Adult male C57 mice were subjected to MI or sham surgery. Four weeks later, mice with MI underwent SVR or 2nd open-chest operation alone. SVR was performed by plicating the aneurysm with a single diagonal linear suture from the upper left ventricle (LV) to the right side of the apex. Cardiac remodeling, heart function and myocardial regeneration were evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Three weeks after SVR, the scar area, LV volume, and heart weight\/body weight ratio were significantly smaller, while LV ejection fraction, the maximum rising and descending rates of LV pressure, LV contractility and global myocardial strain were significantly higher in SVR group than in SVR-control group. The inhibitory effects of SVR on LV remodeling and HF persisted for at least eight-week. SVR group exhibited improved cardiac regeneration, as reflected by more Ki67-, Aurora B- and PH3-positive cardiomyocytes and a higher vessel density around the plication area of the infarcted LV.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> SVR with a single linear suture results in a significant and sustained reduction in LV volume and improvement in both LV systolic and diastolic function as well as cardiac regeneration.<\/jats:p>","DOI":"10.3389\/fcvm.2021.789493","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T09:41:08Z","timestamp":1640338868000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration"],"prefix":"10.3389","volume":"8","author":[{"given":"Siyuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangjun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Bin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairuo","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jchf.2017.09.015","article-title":"Post-myocardial infarction heart failure","volume":"6","author":"Bahit","year":"2018","journal-title":"JACC Heart Fail."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1161\/01.CIR.0000036014.90197.FA","article-title":"Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications","volume":"106","author":"Bolognese","year":"2002","journal-title":"Circulation."},{"key":"B3","doi-asserted-by":"publisher","first-page":"326","DOI":"10.14503\/THIJ-16-6068","article-title":"Left ventricular reconstruction for postinfarction left ventricular aneurysm: review of surgical techniques","volume":"44","author":"Ruzza","year":"2017","journal-title":"Tex Heart Inst J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1093\/eurjhf\/hfq020","article-title":"End-systolic volume following surgical ventricular reconstruction impacts survival in patients with ischaemic dilated cardiomyopathy","volume":"12","author":"Di Donato","year":"2010","journal-title":"Eur J Heart Fail."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.jacc.2004.07.017","article-title":"Surgical ventricular restoration in the treatment of congestive heart failure due to post-infarction ventricular dilation","volume":"44","author":"Athanasuleas","year":"2004","journal-title":"J Am Coll Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/157340310790231626","article-title":"Surgical ventricular restoration to reverse left ventricular remodeling","volume":"6","author":"Castelvecchio","year":"2010","journal-title":"Curr Cardiol Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1056\/NEJMoa0900559","article-title":"Coronary bypass surgery with or without surgical ventricular reconstruction","volume":"360","author":"Jones","year":"2009","journal-title":"N Engl J Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1541","DOI":"10.4244\/EIJ-D-19-00225","article-title":"A transcatheter procedure for direct modification of the aneurysmatic left ventricle","volume":"16","author":"Wang","year":"2021","journal-title":"EuroIntervention."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1002\/ejhf.1669","article-title":"Less invasive ventricular reconstruction for ischaemic heart failure","volume":"21","author":"Klein","year":"2019","journal-title":"Eur J Heart Fail."},{"key":"B10","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jtcvs.2016.09.038","article-title":"Right ventricular dysfunction affects survival after surgical left ventricular restoration","volume":"153","author":"Couperus","year":"2017","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1177\/0218492313501165","article-title":"Clinical impact of diastolic function after surgical ventricular restoration","volume":"22","author":"Shimamoto","year":"2014","journal-title":"Asian Cardiovasc Thorac Ann."},{"key":"B12","doi-asserted-by":"publisher","first-page":"I115","DOI":"10.1161\/01.cir.0000032887.55215.5c","article-title":"Angiotensin-converting enzyme inhibitor helps prevent late remodeling after left ventricular aneurysm repair in rats","volume":"106","author":"Nomoto","year":"2002","journal-title":"Circulation."},{"key":"B13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.hjc.2016.11.036","article-title":"A combined cellular and surgical ventricular reconstruction therapeutic approach produces attenuation of remodeling in infarcted rats","volume":"58","author":"Bonios","year":"2017","journal-title":"Hellenic J Cardiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11748-019-01187-3","article-title":"Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model","volume":"68","author":"Nagasawa","year":"2020","journal-title":"Gen Thorac Cardiovasc Surg."},{"key":"B15","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.jtcvs.2008.09.038","article-title":"Surgical ventricular reconstruction in mice: elucidating potential targets for combined molecular\/surgical intervention","volume":"137","author":"Yeh","year":"2009","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.bbrc.2015.06.117","article-title":"Ablation of C\/EBP homologous protein increases the acute phase mortality and doesn't attenuate cardiac remodeling in mice with myocardial infarction","volume":"464","author":"Luo","year":"2015","journal-title":"Biochem Biophys Res Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"13585","DOI":"10.18632\/aging.202879","article-title":"Characterizing a long-term chronic heart failure model by transcriptomic alterations and monitoring of cardiac remodeling","volume":"13","author":"Zhu","year":"2021","journal-title":"Aging."},{"key":"B18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cardiores.2006.01.021","article-title":"Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice","volume":"70","author":"Liao","year":"2006","journal-title":"Cardiovasc Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.1111\/bph.12736","article-title":"Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53","volume":"171","author":"Chen","year":"2014","journal-title":"Br J Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e59431","DOI":"10.3791\/59431","article-title":"Induction of right ventricular failure by pulmonary artery constriction and evaluation of right ventricular function in mice","volume":"147","author":"Wang","year":"2019","journal-title":"J Vis Exp."},{"key":"B21","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-1-60761-247-6_8","article-title":"Echocardiographic examination in rats and mice","volume":"573","author":"Liu","year":"2009","journal-title":"Methods Mol Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.18632\/aging.202385","article-title":"RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome","volume":"13","author":"Chen","year":"2021","journal-title":"Aging."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1016\/j.ultrasmedbio.2017.07.020","article-title":"Echocardiographic strain analysis for the early detection of myocardial structural abnormality and initiation of drug therapy in a mouse model of dilated cardiomyopathy","volume":"43","author":"Zheng","year":"2017","journal-title":"Ultrasound Med Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"21972","DOI":"10.1038\/srep21972","article-title":"Loss of CEACAM1, a tumor-associated factor, attenuates post-infarction cardiac remodeling by inhibiting apoptosis","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1093\/cvr\/cvx001","article-title":"Ablation of periostin inhibits post-infarction myocardial regeneration in neonatal mice mediated by the phosphatidylinositol 3 kinase\/glycogen synthase kinase 3beta\/cyclin D1 signalling pathway","volume":"113","author":"Chen","year":"2017","journal-title":"Cardiovasc Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1540-8191.2002.tb01191.x","article-title":"A rat model of ischemic cardiomyopathy for investigating left ventricular volume reduction surgery","volume":"17","author":"Nishina","year":"2002","journal-title":"J Card Surg."},{"key":"B27","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.jtcvs.2004.06.006","article-title":"Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep","volume":"129","author":"Walker","year":"2005","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B28","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jtcvs.2013.08.030","article-title":"Off-pump epicardial ventricular reconstruction restores left ventricular twist and reverses remodeling in an ovine anteroapical aneurysm model","volume":"148","author":"Cheng","year":"2014","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B29","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.rvsc.2021.03.023","article-title":"Surgical ventricular restoration for rabbit dilated cardiomyopathy model: preliminary study","volume":"136","author":"Isaka","year":"2021","journal-title":"Res Vet Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"E786","DOI":"10.1532\/HSF98.20061035","article-title":"An experimental rabbit model for off-pump left ventricular reconstruction following left ventricular aneurysm","volume":"9","author":"Ootaki","year":"2006","journal-title":"Heart Surg Forum."},{"key":"B31","doi-asserted-by":"publisher","first-page":"I241","DOI":"10.1161\/hc37t1.094522","article-title":"Initial effects of the left ventricular repair by plication may not last long in a rat ischemic cardiomyopathy model","volume":"104","author":"Nishina","year":"2001","journal-title":"Circulation."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.04.167.","article-title":"Outcomes after surgical ventricular restoration for ischemic cardiomyopathy","author":"Stefanelli","year":"2020","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B33","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1001\/jama.1958.02990220027008","article-title":"Ventricular aneurysm after myocardial infarction; surgical excision with use of temporary cardiopulmonary bypass","volume":"167","author":"Cooley","year":"1958","journal-title":"J Am Med Assoc."},{"key":"B34","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.ahj.2012.02.013","article-title":"Percutaneous left ventricular partitioning in patients with chronic heart failure and a prior anterior myocardial infarction: results of the percutaneous ventricular restoration in chronic heart failUre PaTiEnts trial","volume":"163","author":"Mazzaferri","year":"2012","journal-title":"Am Heart J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/j.athoracsur.2008.08.010","article-title":"Impact of surgical ventricular restoration on diastolic function: implications of shape and residual ventricular size","volume":"86","author":"Castelvecchio","year":"2008","journal-title":"Ann Thorac Surg."},{"key":"B36","first-page":"1101","volume":"75","author":"Ledain","year":"1982","journal-title":"Arch Mal Coeur Vaiss."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1093\/ejcts\/ezx201","article-title":"Right ventricular dysfunction after surgical left ventricular restoration: prevalence, risk factors and clinical implications","volume":"52","author":"Couperus","year":"2017","journal-title":"Eur J Cardiothorac Surg."},{"key":"B38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.biomaterials.2013.09.066","article-title":"Augmentation of integrin-mediated mechanotransduction by hyaluronic acid","volume":"35","author":"Chopra","year":"2014","journal-title":"Biomaterials."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.jacc.2011.06.038","article-title":"Echocardiographic assessment of myocardial strain","volume":"58","author":"Gorcsan","year":"2011","journal-title":"J Am Coll Cardiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1089\/scd.2017.0271","article-title":"Lower senescence of adipose-derived stem cells than donor-matched bone marrow stem cells for surgical ventricular restoration","volume":"27","author":"Wu","year":"2018","journal-title":"Stem Cells Dev."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.08.097.","article-title":"Ventricular reshaping with a beating heart implant improves pump function in experimental heart failure","author":"Onohara","year":"2020","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B42","doi-asserted-by":"publisher","first-page":"i49","DOI":"10.1093\/ejcts\/ezy367","article-title":"Myocardial reconstruction in ischaemic cardiomyopathy","volume":"55","author":"Castelvecchio","year":"2019","journal-title":"Eur J Cardiothorac Surg."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.athoracsur.2018.11.054","article-title":"Long-term survival and echocardiographic findings after surgical ventricular restoration","volume":"107","author":"Hobbs","year":"2019","journal-title":"Ann Thorac Surg."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.jtcvs.2005.06.045","article-title":"Residual high incidence of ventricular arrhythmias after left ventricular reconstructive surgery","volume":"130","author":"O'Neill","year":"2005","journal-title":"J Thorac Cardiovasc Surg."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.789493\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T09:41:11Z","timestamp":1640338871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.789493\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,24]]},"references-count":44,"alternative-id":["10.3389\/fcvm.2021.789493"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2021.789493","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,24]]},"article-number":"789493"}}