{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:14:13Z","timestamp":1790813653797,"version":"4.1.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the feasibility of drainage from the superior vena cava (SVC) to improve upper body oxygenation in patients with cardiogenic shock undergoing femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen adult patients receiving peripheral femoral VA ECMO for circulatory support were enrolled. The femoral drainage cannula was shifted three times (from the inferior vena cava (IVC) level to the SVC level and then the IVC level again), all under ultrasound guidance, at an interval of 15 minutes. The blood gas levels of the right radial artery (RA) and SVC and cerebral oxygen saturation (ScO<jats:sub>2<\/jats:sub>) were measured and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients (88.2%) were successfully weaned from ECMO, and 12 patients (70.6%) survived to discharge. The oxygen saturation (SO<jats:sub>2<\/jats:sub>) and oxygen partial pressure (PO<jats:sub>2<\/jats:sub>) of the RA (97.0 \u00b1 3.5% to 98.3 \u00b1 1.5%, <jats:italic>P<\/jats:italic> &amp;lt; 0.05, SO<jats:sub>2<\/jats:sub>; 127.4 \u00b1 58.2 mmHg to 153.1 \u00b1 67.8 mmHg, <jats:italic>P<\/jats:italic> &amp;lt; 0.05, PO<jats:sub>2<\/jats:sub>) and SVC (69.5 \u00b1 9.0% to 75.7 \u00b1 8.5%, <jats:italic>P<\/jats:italic> &amp;lt; 0.05, SO<jats:sub>2<\/jats:sub>; 38.5 \u00b1 5.6 mmHg to 43.6 \u00b1 6.4 mmHg, <jats:italic>P<\/jats:italic> &amp;lt; 0.05, PO<jats:sub>2<\/jats:sub>) were increased; ScO<jats:sub>2<\/jats:sub> was also increased on both sides (left: 50.6 \u00b1 8.6% to 55.0 \u00b1 9.0%, <jats:italic>P<\/jats:italic> &amp;lt; 0.05; right: 48.7 \u00b1 9.2% to 52.3 \u00b1 9.8%, <jats:italic>P<\/jats:italic> &amp;lt; 0.05) when the femoral drainage cannula was shifted from the IVC level to the SVC level. When the femoral drainage cannula was shifted from SVC level to the IVC level again, the SO<jats:sub>2<\/jats:sub> and PO<jats:sub>2<\/jats:sub> of RA (98.3 \u00b1 1.5% to 96.9 \u00b1 3.2%, <jats:italic>P<\/jats:italic> &amp;lt;0.05, SO<jats:sub>2<\/jats:sub>; 153.1 \u00b1 67.8 mmHg to 125.8 \u00b1 63.3 mmHg, <jats:italic>P<\/jats:italic> &amp;lt;0.05, PO<jats:sub>2<\/jats:sub>) and SVC (75.7 \u00b1 38.5% to 70.4 \u00b1 7.6%, <jats:italic>P<\/jats:italic> &amp;lt;0.05, SO<jats:sub>2<\/jats:sub>; 43.6 \u00b1 6.4 mmHg to 38.9 \u00b1 4.5 mmHg, <jats:italic>P<\/jats:italic> &amp;lt;0.05, PO<jats:sub>2<\/jats:sub>) were decreased; ScO<jats:sub>2<\/jats:sub> was also reduced on both sides (left: 55.0 \u00b1 9.0% to 50.7 \u00b1 8.2%, <jats:italic>P<\/jats:italic> &amp;lt; 0.05; right: 52.3 \u00b1 9.8% to 48.7 \u00b1 9.3%, <jats:italic>P<\/jats:italic> &amp;lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Drainage from the SVC by shifting the cannula upward could improve upper body oxygenation in patients with cardiogenic shock undergoing femoral VA ECMO. This cannulation strategy provides an alternative solution for differential hypoxia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2021.807663","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T09:19:46Z","timestamp":1644916786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation"],"prefix":"10.3389","volume":"8","author":[{"given":"Tong","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1164\/rccm.201710-2130CP","article-title":"The extracorporeal life support organization maastricht treaty for nomenclature in extracorporeal life support. 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