{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:11:17Z","timestamp":1785553877728,"version":"3.56.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis and atherosclerosis have overlapping pathophysiological mechanisms. However, the association between psoriasis and coronary artery calcification (CAC), a hallmark of atherosclerosis and a predictor of poor cardiovascular prognosis, remains to be determined. We performed a systematic review and meta-analysis to comprehensively evaluate the association between these related inflammatory conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational studies evaluating the relationship between psoriasis and CAC were retrieved by searching PubMed, Cochrane\u2019s Library, and Embase databases. Presence of CAC was confirmed according to an Agatston\u2019s Score &amp;gt;0 upon computed tomography examination. A random-effect model incorporating between-study heterogeneity was used to pool the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen studies involving 3,039 patients with psoriasis and 46,191 controls without psoriasis were included in the meta-analysis. All participants were without previously known cardiovascular diseases. Pooled results showed that psoriasis was associated with overall CAC [odds ratio (OR): 1.54, 95% confidence interval: 1.23\u20131.91, <jats:italic>p &amp;lt;<\/jats:italic> 0.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 57%], after matching or adjusting the conventional cardiovascular risk factors. Subgroup analyses showed that study country, comorbidity of psoriatic arthritis, baseline Psoriasis Area and Severity Index, and duration of psoriasis (<jats:italic>p<\/jats:italic> for subgroup difference all &amp;gt;0.05) did not significantly affect the association of psoriasis and CAC. However, a stronger association was observed in younger patients (mean age &amp;lt;50 years, OR: 2.63, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) compared to older patients (\u226550 years, OR: 1.24, <jats:italic>p<\/jats:italic> = 0.02; <jats:italic>p<\/jats:italic> for subgroup difference &amp;lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Psoriasis is associated with CAC, and the association may be stronger in younger patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.1044117","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T05:29:13Z","timestamp":1669354153000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between psoriasis and coronary artery calcification: A systematic review and 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