{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:07:35Z","timestamp":1768982855957,"version":"3.49.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients suffering cardiac arrest resulting from ST-segment-elevation myocardial infarction (STEMI) are at very high risk of death. In addition to reperfusion strategies, therapeutic hypothermia is recommended for cardiac arrest patients who remain unconscious after resuscitation. However, data analysis of the impact of therapeutic hypothermia on survival showed inconsistent results. We aimed to investigate the benefits of therapeutic hypothermia in STEMI patients after cardiopulmonary resuscitation (CPR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with STEMI who received CPR were identified after nationwide German inpatient data (2005\u20132019) were screened. These patients were stratified for therapeutic hypothermia. The impact of hypothermia on mortality and adverse in-hospital outcomes was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 133,070 inpatients with STEMI and CPR (53.3% aged \u226570 years; 34% females) were recorded in Germany between 2005 and 2019, of which 12.3% (16,386 patients) underwent therapeutic hypothermia. Females (23.8 vs. 35.4%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) and patients aged \u226570 years (34.9 vs. 55.9%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) were less frequently treated with therapeutic hypothermia. The in-hospital case fatality rate was lower for STEMI with CPR and subsequent therapeutic hypothermia than for treatment without therapeutic hypothermia (53.5 vs. 66.7%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). Therapeutic hypothermia was independently associated with a reduced in-hospital case fatality rate {OR 0.83 [95% confidence interval (CI) 0.80\u20130.86], <jats:italic>p<\/jats:italic> &amp;lt; 0.001}. In addition, therapeutic hypothermia was associated with an increased risk for stroke (OR 1.37 [95% CI 1.25\u20131.49], <jats:italic>p<\/jats:italic> &amp;lt; 0.001), pneumonia (OR 1.75 [95% CI 1.68\u20131.82], <jats:italic>p<\/jats:italic> &amp;lt; 0.001), and acute kidney injury (OR 2.21 [95% CI 2.07\u20132.35], <jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therapeutic hypothermia is associated with a survival benefit for STEMI patients after cardiac arrest.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.1051978","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T08:27:42Z","timestamp":1669710462000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypothermia and its role in patients with ST-segment-elevation myocardial infarction and cardiac arrest"],"prefix":"10.3389","volume":"9","author":[{"given":"Karsten","family":"Keller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Sagoschen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker H.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Gori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the european society of cardiology (ESC)","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","author":"Hypothermia","year":"2002","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","article-title":"ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"33","author":"Steg","year":"2012","journal-title":"Eur Heart J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.resuscitation.2015.07.028","article-title":"European resuscitation council guidelines for resuscitation 2015: section 1","volume":"95","author":"Monsieurs","year":"2015","journal-title":"Exec Summ Resusc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.resuscitation.2021.02.009","article-title":"European resuscitation council guidelines 2021: executive summary","volume":"161","author":"Perkins","year":"2021","journal-title":"Resuscitation."},{"key":"B8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s12181-020-00419-8","article-title":"Kurzversion der 2. 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