{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:38:40Z","timestamp":1790750320917,"version":"4.1.0"},"reference-count":293,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1161200"],"award-info":[{"award-number":["APP1161200"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2010203"],"award-info":[{"award-number":["APP2010203"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP188591"],"award-info":[{"award-number":["APP188591"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130423"],"award-info":[{"award-number":["R01HL130423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL135093"],"award-info":[{"award-number":["R01HL135093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL148167-01A1"],"award-info":[{"award-number":["R01HL148167-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009287","name":"NSW Health","doi-asserted-by":"publisher","award":["RG193092"],"award-info":[{"award-number":["RG193092"]}],"id":[{"id":"10.13039\/501100009287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009287","name":"NSW Health","doi-asserted-by":"publisher","award":["RG212159"],"award-info":[{"award-number":["RG212159"]}],"id":[{"id":"10.13039\/501100009287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009287","name":"NSW Health","doi-asserted-by":"publisher","award":["RG194194"],"award-info":[{"award-number":["RG194194"]}],"id":[{"id":"10.13039\/501100009287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP160103993"],"award-info":[{"award-number":["DP160103993"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>\n                    Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the intramural accumulation of blood, are a family of catastrophic disorders causing major, potentially fatal sequelae. Involving diverse vascular beds, including the aorta or coronary, cervical, pulmonary, and visceral arteries, each type of dissection is devastating in its own way. Traditionally they have been studied in isolation, rather than collectively, owing largely to the distinct clinical consequences of dissections in different anatomical locations \u2013 such as stroke, myocardial infarction, and renal failure. Here, we review the shared and unique features of these arteriopathies to provide a better understanding of this family of disorders. Arterial dissections occur commonly in the young to middle-aged, and often in conjunction with hypertension and\/or migraine; the latter suggesting they are part of a generalized vasculopathy. Genetic studies as well as cellular and molecular investigations of arterial dissections reveal striking similarities between dissection types, particularly their pathophysiology, which includes the presence or absence of an intimal tear and vasa vasorum dysfunction as a cause of intramural hemorrhage. Pathway perturbations common to all types of dissections include disruption of TGF-\u03b2 signaling, the extracellular matrix, the cytoskeleton or metabolism, as evidenced by the finding of mutations in critical genes regulating these processes, including\n                    <jats:italic>LRP1<\/jats:italic>\n                    , collagen genes, fibrillin and TGF-\u03b2 receptors, or their coupled pathways. Perturbances in these connected signaling pathways contribute to phenotype switching in endothelial and vascular smooth muscle cells of the affected artery, in which their physiological quiescent state is lost and replaced by a proliferative activated phenotype. Of interest, dissections in various anatomical locations are associated with distinct sex and age predilections, suggesting involvement of gene and environment interactions in disease pathogenesis. Importantly, these cellular mechanisms are potentially therapeutically targetable. Consideration of arterial dissections as a collective pathology allows insight from the better characterized dissection types, such as that involving the thoracic aorta, to be leveraged to inform the less common forms of dissections, including the potential to apply known therapeutic interventions already clinically available for the former.\n                  <\/jats:p>","DOI":"10.3389\/fcvm.2022.1055862","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T01:57:24Z","timestamp":1670291844000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Arterial dissections: Common features and new perspectives"],"prefix":"10.3389","volume":"9","author":[{"given":"Monique","family":"Bax","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Romanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerat","family":"Junday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Giannoulatou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Martinac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Kovacic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siiri E.","family":"Iismaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1161\/CIRCRESAHA.118.312436","article-title":"Genetics of thoracic and abdominal aortic diseases: aneurysms, dissections, and ruptures.","volume":"124","author":"Pinard","year":"2019","journal-title":"Circ Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1161\/01.RES.20.1.99","article-title":"A lamellar unit of aortic medial structure and function in mammals.","volume":"20","author":"Wolinsky","year":"1967","journal-title":"Circ Res."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00375","article-title":"Elastic and muscular arteries differ in structure, basal no production and voltage-gated Ca2+-Channels.","volume":"6","author":"Leloup","year":"2015","journal-title":"Front Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1161\/01.RES.20.4.409","article-title":"Nature of species differences in the medial distribution of aortic vasa vasorum in mammals.","volume":"20","author":"Wolinsky","year":"1967","journal-title":"Circ Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"H2019","DOI":"10.1152\/ajpheart.00399.2003","article-title":"Impact of coronary vasa vasorum functional structure on coronary vessel wall perfusion distribution.","volume":"285","author":"G\u00f6ssl","year":"2003","journal-title":"Am J Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1161\/CIRCULATIONAHA.113.007189","article-title":"Vasa vasorum in normal and diseased arteries.","volume":"129","author":"Mulligan-Kehoe","year":"2014","journal-title":"Circulation."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1002\/ar.a.20098","article-title":"Three-dimensional arrangement of the vasa vasorum in explanted segments of the aged human great saphenous vein: scanning electron microscopy and three-dimensional morphometry of vascular corrosion casts.","author":"Lametschwandtner","year":"2004","journal-title":"Anat Rec."},{"key":"B8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.aanat.2019.02.006","article-title":"Morphology of the vasa vasorum in coronary arteries of the porcine heart: a new insight.","volume":"223","author":"Patzelt","year":"2019","journal-title":"Ann Anat."},{"key":"B9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/1050-1738(96)00008-4","article-title":"Structure and function of vasa vasorum.","volume":"6","author":"Williams","year":"1996","journal-title":"Trends Cardiovasc Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.3390\/ijms160511574","article-title":"Vasa vasorum in atherosclerosis and clinical significance.","volume":"16","author":"Xu","year":"2015","journal-title":"Int J Mol Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"H126","DOI":"10.1152\/ajpheart.1988.254.1.H126","article-title":"Blood flow through new microvessels: factors that affect regrowth of vasa vasorum.","volume":"254","author":"Williams","year":"1988","journal-title":"Am J Physiol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1978.58.2.397","article-title":"Mechanical properties of arteries.","volume":"58","author":"Dobrin","year":"1978","journal-title":"Physiol Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1053\/apmr.2002.33985","article-title":"The Law of Laplace and its relevance to contemporary medicine and rehabilitation.","volume":"83","author":"Basford","year":"2002","journal-title":"Arch Phys Med Rehabil."},{"key":"B14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1152\/ajplegacy.1951.164.2.319","article-title":"On the physical equilibrium of small blood vessels.","volume":"164","author":"Burton","year":"1951","journal-title":"Am J Physiol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6364","article-title":"On vasa vasorum: a history of advances in understanding the vessels of vessels.","volume":"8","author":"Phillippi","year":"2022","journal-title":"Sci Adv."},{"key":"B16","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.eng.2020.03.019","article-title":"Bioprinting of small-diameter blood vessels.","volume":"7","author":"Cao","year":"2021","journal-title":"Engineering."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02285-w","article-title":"Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology.","volume":"4","author":"Dessalles","year":"2021","journal-title":"Commun Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cardiores.2007.06.020","article-title":"The dynamic vasa vasorum.","volume":"75","author":"Ritman","year":"2007","journal-title":"Cardiovasc Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.jvs.2004.06.032","article-title":"Adventitial vasa vasorum heterogeneity among different vascular beds.","volume":"40","author":"Galili","year":"2004","journal-title":"J Vasc Surg."},{"key":"B20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2007.09.015","article-title":"Differential distribution of vasa vasorum in different vascular beds in humans.","volume":"199","author":"Hildebrandt","year":"2008","journal-title":"Atherosclerosis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1002\/jmri.22512","article-title":"Assessment of flow instabilities in the healthy aorta using flow-sensitive MRI.","volume":"33","author":"Stalder","year":"2011","journal-title":"J Magnet Reson Imaging."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/ma14237402","article-title":"Hemodynamics challenges for the navigation of medical microbots for the treatment of CVDs.","volume":"14","author":"Doutel","year":"2021","journal-title":"Materials."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1142\/S0219519411004666","article-title":"An improved model for reduced-order physiological fluid flows.","volume":"12","author":"San","year":"2012","journal-title":"J Mech Med Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1002\/ar.a.10060","article-title":"Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries: vasa vasorum in coronary arteries.","author":"G\u00f6ssl","year":"2003","journal-title":"Anat Rec."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.85.1.391","article-title":"A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the committee on vascular lesions of the council on arteriosclerosis, American heart association.","volume":"85","author":"Stary","year":"1992","journal-title":"Circulation."},{"key":"B26","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1161\/01.ATV.18.5.717","article-title":"Vascular endothelial cell regulation of extracellular matrix collagen: role of nitric oxide.","volume":"18","author":"Myers","year":"1998","journal-title":"ATVB."},{"key":"B27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0165-6147(91)90510-Y","article-title":"Modulation of platelet aggregation by an L-arginine-nitric oxide pathway.","volume":"12","author":"Radomski","year":"1991","journal-title":"Trends Pharmacol Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1172\/JCI114081","article-title":"Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.","volume":"83","author":"Garg","year":"1989","journal-title":"J Clin Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1161\/01.RES.78.2.225","article-title":"Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells.","volume":"78","author":"Sarkar","year":"1996","journal-title":"Circ Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"s3","DOI":"10.2450\/2011.002S","article-title":"Role of von Willebrand factor in the haemostasis.","volume":"9","author":"Peyvandi","year":"2011","journal-title":"Blood Transfus."},{"key":"B31","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.biochem.67.1.395","article-title":"Biochemistry and genetics of von willebrand factor.","volume":"67","author":"Sadler","year":"1998","journal-title":"Annu Rev Biochem."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2020.1781427","article-title":"Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins.","volume":"9","author":"Boyer","year":"2020","journal-title":"J Extracell Vesicles."},{"key":"B33","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3109\/03014460.2013.807878","article-title":"An estimation of the number of cells in the human body.","volume":"40","author":"Bianconi","year":"2013","journal-title":"Ann Hum Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","article-title":"Dynamics of cell generation and turnover in the human heart.","volume":"161","author":"Bergmann","year":"2015","journal-title":"Cell."},{"key":"B35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41591-020-01182-9","article-title":"The distribution of cellular turnover in the human body.","volume":"27","author":"Sender","year":"2021","journal-title":"Nat Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/978-0-387-84828-0_176","article-title":"Mechanisms of Endothelial Activation.","author":"Waitkus","year":"2014","journal-title":"Encyclopedia of Medical Immunology."},{"key":"B37","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation.","volume":"7","author":"Pober","year":"2007","journal-title":"Nat Rev Immunol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.04.014","article-title":"Severe COVID-19 infection associated with endothelial activation.","volume":"190","author":"Escher","year":"2020","journal-title":"Thromb Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1161\/CIRCULATIONAHA.119.041433","article-title":"Single-cell RNA-seq unveils unique transcriptomic signatures of organ-specific endothelial cells.","volume":"142","author":"Paik","year":"2020","journal-title":"Circulation."},{"key":"B40","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.cell.2020.01.015","article-title":"Single-cell transcriptome atlas of murine endothelial cells.","volume":"180","author":"Kalucka","year":"2020","journal-title":"Cell."},{"key":"B41","doi-asserted-by":"publisher","first-page":"C326","DOI":"10.1152\/ajpcell.00128.2018","article-title":"Integrated proteomics and metabolomics analysis reveals differential lipid metabolism in human umbilical vein endothelial cells under high and low shear stress.","volume":"317","author":"Venturini","year":"2019","journal-title":"Am J Physiol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69451-8","article-title":"Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets.","volume":"10","author":"Hartman","year":"2020","journal-title":"Sci Rep."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177951","article-title":"Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention.","volume":"12","author":"Yang","year":"2017","journal-title":"PLoS One."},{"key":"B44","doi-asserted-by":"publisher","first-page":"H613","DOI":"10.1152\/ajpheart.00220.2020","article-title":"Metabolism of vascular smooth muscle cells in vascular diseases.","volume":"319","author":"Shi","year":"2020","journal-title":"Am J Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"15345","DOI":"10.1073\/pnas.232551499","article-title":"Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA.","volume":"99","author":"Neese","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B46","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/BF03085963","article-title":"Regulation and characteristics of vascular smooth muscle cell phenotypic diversity.","volume":"15","author":"Rensen","year":"2007","journal-title":"Neth Heart J."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2014.00072","article-title":"Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation.","volume":"2","author":"Chiong","year":"2014","journal-title":"Front Cell Dev Biol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108115","article-title":"Impaired glutathione redox system paradoxically suppresses angiotensin ii-induced vascular remodeling.","volume":"9","author":"Izawa","year":"2014","journal-title":"PLoS One."},{"key":"B49","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1161\/01.ATV.0000150649.39934.13","article-title":"Oxidative stress and vascular disease.","volume":"25","author":"Madamanchi","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1161\/CIRCRESAHA.109.193656","article-title":"Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor \u03b1\/\u03b4 activations by prostacyclin released by sheared endothelial cells.","volume":"105","author":"Tsai","year":"2009","journal-title":"Circ Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1161\/01.RES.75.4.669","article-title":"Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo.","volume":"75","author":"Frid","year":"1994","journal-title":"Circ Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1161\/CIRCULATIONAHA.113.002887","article-title":"Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity.","volume":"128","author":"Liu","year":"2013","journal-title":"Circulation."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.599415","article-title":"Role of vascular smooth muscle cell plasticity and interactions in vessel wall inflammation.","volume":"11","author":"Sorokin","year":"2020","journal-title":"Front Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1161\/ATVBAHA.120.314670","article-title":"Single-cell transcriptomic profiling of vascular smooth muscle cell phenotype modulation in marfan syndrome aortic aneurysm.","volume":"40","author":"Pedroza","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.bbagrm.2014.06.004","article-title":"Epigenetic regulation of smooth muscle cell plasticity.","volume":"1849","author":"Liu","year":"2015","journal-title":"Biochim Biophys Acta."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1698.e","DOI":"10.1016\/j.jvs.2012.05.084","article-title":"Association of smooth muscle cell phenotypes with extracellular matrix disorders in thoracic aortic dissection.","volume":"56","author":"Wang","year":"2012","journal-title":"J Vasc Surg."},{"key":"B57","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/micc.12294","article-title":"Small artery elastin distribution and architecture-focus on three dimensional organization.","volume":"23","author":"Hill","year":"2016","journal-title":"Microcirculation."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/0741-5214(93)90676-D","article-title":"The effect of endothelial cell coculture on smooth muscle cell proliferation.","volume":"17","author":"Fillinger","year":"1993","journal-title":"Vasc Surg."},{"key":"B59","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1136\/hrt.2004.055111","article-title":"Aortic dimensions and the risk of dissection.","volume":"92","author":"Erbel","year":"2006","journal-title":"Heart."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.amjcard.2005.06.059","article-title":"Gender differences in carotid intima-media thickness in patients with suspected coronary artery disease.","volume":"96","author":"Kablak-Ziembicka","year":"2005","journal-title":"Am J Cardiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1161\/CIRCULATIONAHA.120.051231","article-title":"Sex-stratified gene regulatory networks reveal female key driver genes of atherosclerosis involved in smooth muscle cell phenotype switching.","volume":"143","author":"Hartman","year":"2021","journal-title":"Circulation."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1042\/BJ20150844","article-title":"The arterial microenvironment: the where and why of atherosclerosis.","volume":"473","author":"Yurdagul","year":"2016","journal-title":"Biochem J."},{"key":"B63","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.115.14.2817","article-title":"Elastic fibres.","volume":"115","author":"Kielty","year":"2002","journal-title":"J Cell Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1152\/physrev.00041.2008","article-title":"Vascular extracellular matrix and arterial mechanics.","volume":"89","author":"Wagenseil","year":"2009","journal-title":"Physiol Rev."},{"key":"B65","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/S1050-1738(03)00065-3","article-title":"New insights into elastin and vascular disease.","volume":"13","author":"Brooke","year":"2003","journal-title":"Trends Cardiovasc Med."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.014647","article-title":"The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.","volume":"11","author":"Naba","year":"2012","journal-title":"Mol Cell Proteomics."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.708656","article-title":"Extracellular matrix protein ratios in the human heart and vessels: how to distinguish pathological from physiological changes?","volume":"12","author":"Wittig","year":"2021","journal-title":"Front Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2147\/VHRM.S9472","article-title":"Blood flow interplays with elastin: collagen and MMP: TIMP ratios to maintain healthy vascular structure and function.","volume":"2010","author":"Basu","year":"2010","journal-title":"Vasc Health Risk Manag."},{"key":"B69","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0070-2153(04)62006-0","author":"Kelleher","year":"2004","journal-title":"Vascular Extracellular Matrix and Aortic Development: Current Topics in Developmental Biology."},{"key":"B70","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1136\/thx.41.8.577","article-title":"Elastin and the lung.","volume":"41","author":"Starcher","year":"1986","journal-title":"Thorax."},{"key":"B71","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1083\/jcb.107.1.307","article-title":"Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells.","volume":"107","author":"Hedin","year":"1988","journal-title":"J Cell Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1161\/01.RES.88.5.460","article-title":"Fibrillar collagen specifically regulates human vascular smooth muscle cell genes involved in cellular responses and the pericellular matrix environment.","volume":"88","author":"Ichii","year":"2001","journal-title":"Circ Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/s0967-2109(97)00004-5","article-title":"Inhibitory effect of type 1 collagen gel containing alpha-elastin on proliferation and migration of vascular smooth muscle and endothelial cells.","volume":"5","author":"Ito","year":"1997","journal-title":"Cardiovasc Surg."},{"key":"B74","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1242\/dev.00223","article-title":"A critical role for elastin signaling in vascular morphogenesis and disease.","volume":"130","author":"Karnik","year":"2003","journal-title":"Development."},{"key":"B75","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.bpj.2011.06.051","article-title":"Cell-cell interactions mediate the response of vascular smooth muscle cells to substrate stiffness.","volume":"101","author":"Sazonova","year":"2011","journal-title":"Biophys J."},{"key":"B76","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1152\/physiol.00026.2017","article-title":"Stem cell differentiation is regulated by extracellular matrix mechanics.","volume":"33","author":"Smith","year":"2018","journal-title":"Physiology."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45352-3","article-title":"Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem\/stromal cells (hMSCs) through mechanotransduction.","volume":"9","author":"Gerardo","year":"2019","journal-title":"Sci Rep."},{"key":"B78","doi-asserted-by":"publisher","first-page":"11190","DOI":"10.1073\/pnas.1611324113","article-title":"Vascular smooth muscle cell durotaxis depends on extracellular matrix composition.","volume":"113","author":"Hartman","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1021\/acsabm.0c00100","article-title":"Extracellular matrix proteins and substrate stiffness synergistically regulate vascular smooth muscle cell migration and cortical cytoskeleton organization.","volume":"3","author":"Rickel","year":"2020","journal-title":"ACS Appl Biol Mater."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022210","article-title":"TGF-\u03b2 signaling in control of cardiovascular function.","volume":"10","author":"Goumans","year":"2018","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature10152","article-title":"Latent TGF-\u03b2 structure and activation.","volume":"474","author":"Shi","year":"2011","journal-title":"Nature."},{"key":"B82","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00441-011-1222-6","article-title":"Regulation of endothelial cell plasticity by TGF-\u03b2.","volume":"347","author":"van Meeteren","year":"2012","journal-title":"Cell Tissue Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"10623","DOI":"10.1073\/pnas.1434429100","article-title":"Endothelial cell diversity revealed by global expression profiling.","volume":"100","author":"Chi","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B84","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/vec.12925","article-title":"The endothelial glycocalyx: structure and function in health and critical illness.","volume":"30","author":"Gaudette","year":"2020","journal-title":"J Vet Emerg Crit Care."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00253","article-title":"The emerging role of the mammalian glycocalyx in functional membrane organization and immune system regulation.","volume":"8","author":"M\u00f6ckl","year":"2020","journal-title":"Front Cell Dev Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1136\/heartjnl-2019-315320","article-title":"Sex-specific distributions and determinants of thoracic aortic diameters in the elderly.","volume":"106","author":"Bons","year":"2020","journal-title":"Heart."},{"key":"B87","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0002-8703(00)90043-7","article-title":"Sex differences in coronary artery size assessed by intravascular ultrasound.","volume":"139","author":"Sheifer","year":"2000","journal-title":"Am Heart J."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2021.791208","article-title":"Sex differences in large artery stiffness: implications for cerebrovascular dysfunction and Alzheimer\u2019s disease.","volume":"2","author":"Kehmeier","year":"2021","journal-title":"Front Aging."},{"key":"B89","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1097\/00004872-200112000-00014","article-title":"Women exhibit a greater age-related increase in proximal aortic stiffness than men.","volume":"19","author":"Waddell","year":"2001","journal-title":"J Hypertens."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.762437","article-title":"Vascular stiffness in aging and disease.","volume":"12","author":"Vatner","year":"2021","journal-title":"Front Physiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1161\/01.HYP.0000187016.06549.96","article-title":"Sex steroids modulate human aortic smooth muscle cell matrix protein deposition and matrix metalloproteinase expression.","volume":"46","author":"Natoli","year":"2005","journal-title":"Hypertension."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1161\/ATVBAHA.119.313622","article-title":"Arterial stiffness accelerates within 1 year of the final menstrual period: the SWAN Heart study.","volume":"40","author":"Samargandy","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1161\/01.STR.25.4.889","article-title":"Neurovascular manifestations of heritable connective tissue disorders. A review.","volume":"25","author":"Schievink","year":"1994","journal-title":"Stroke."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000491","article-title":"Outcomes of patients with spontaneous coronary artery dissection.","volume":"3","author":"McGrath-Cadell","year":"2016","journal-title":"Open Heart."},{"key":"B95","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1177\/1538574419864783","article-title":"A Rare case of 7 simultaneous arterial dissections and review of the literature.","volume":"53","author":"Amitai Komem","year":"2019","journal-title":"Vasc Endovascular Surg."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0769-7","article-title":"Fatal thoracic aortic aneurysm and dissection in a large family with a novel MYLK gene mutation: delineation of the clinical phenotype.","volume":"13","author":"Shalata","year":"2018","journal-title":"Orphanet J Rare Dis."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0872","article-title":"Identification of susceptibility loci for spontaneous coronary artery dissection.","volume":"5","author":"Turley","year":"2020","journal-title":"JAMA Cardiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/gim.2014.72","article-title":"Survival is affected by mutation type and molecular mechanism in vascular Ehlers\u2013Danlos syndrome (EDS type IV).","volume":"16","author":"Pepin","year":"2014","journal-title":"Genet Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nature10145","article-title":"Lessons on the pathogenesis of aneurysm from heritable conditions.","volume":"473","author":"Lindsay","year":"2011","journal-title":"Nature."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.53","article-title":"Aortic dissection.","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat Rev Dis Prim."},{"key":"B101","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/S0022-5223(19)33323-9","article-title":"Surgical management of dissecting aneurysms of the aorta.","volume":"49","author":"De Bakey","year":"1965","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B102","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0003-4975(10)65594-4","article-title":"Management of acute aortic dissections.","volume":"10","author":"Daily","year":"1970","journal-title":"Ann Thorac Surg."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.7.897","article-title":"The international registry of acute aortic dissection (IRAD): new insights into an old disease.","volume":"283","author":"Hagan","year":"2000","journal-title":"JAMA."},{"key":"B104","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1148\/radiol.14131457","article-title":"Aortic arch dissection: a controversy of classification.","volume":"271","author":"Lempel","year":"2014","journal-title":"Radiology."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.00037","article-title":"A new clinically driven classification for acute aortic dissection.","volume":"7","author":"Qanadli","year":"2020","journal-title":"Front Surg."},{"key":"B106","doi-asserted-by":"crossref","DOI":"10.1017\/UPO9781922064004","author":"Fitridge","year":"2011","journal-title":"Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists."},{"key":"B107","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.xjon.2020.12.012","article-title":"Aortic dissection is a disease of the vasa vasorum.","volume":"5","author":"Haverich","year":"2021","journal-title":"JTCVS Open."},{"key":"B108","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/s1010-7940(00)00382-1","article-title":"Effect of impaired vasa vasorum flow on the structure and mechanics of the thoracic aorta: implications for the pathogenesis of aortic dissectionq.","volume":"17","author":"Angouras","year":"2000","journal-title":"Eur J Cardiothor Surg."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001513","article-title":"Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study.","volume":"4","author":"Landenhed","year":"2015","journal-title":"J Am Heart Assoc."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32100-2","article-title":"Tobacco smoking and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies.","volume":"8","author":"Aune","year":"2018","journal-title":"Sci Rep."},{"key":"B111","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.atherosclerosis.2017.06.022","article-title":"Passive smoking and mortality from aortic dissection or aneurysm.","volume":"263","author":"Kihara","year":"2017","journal-title":"Atherosclerosis."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e111","DOI":"10.1016\/j.athoracsur.2013.05.096","article-title":"Recurrent tamponade and aortic dissection in syphilis.","volume":"96","author":"Stansal","year":"2013","journal-title":"Ann Thorac Surg."},{"key":"B113","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.neurol.2007.12.007","article-title":"M\u00e9ningovascularite d\u2019origine syphilitique : \u00e9tude de cinq cas.","volume":"164","author":"Bourazza","year":"2008","journal-title":"Rev Neurol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.2147\/NDT.S106845","article-title":"Bilateral internal carotid artery dissection associated with prior syphilis: a case report and review of the literature.","volume":"12","author":"Marangi","year":"2016","journal-title":"Neuropsychiatr Dis Treat."},{"key":"B115","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1136\/heartjnl-2020-317912","article-title":"Place and causes of acute cardiovascular mortality during the COVID-19 pandemic.","volume":"107","author":"Wu","year":"2021","journal-title":"Heart."},{"key":"B116","doi-asserted-by":"publisher","first-page":"342","DOI":"10.2310\/6670.2009.00023","article-title":"Cardiovascular involvement of ankylosing spondylitis: report of three cases.","volume":"17","author":"Yuan","year":"2009","journal-title":"Vascular."},{"key":"B117","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/ATVBAHA.116.303229","article-title":"Altered smooth muscle cell force generation as a driver of thoracic aortic aneurysms and dissections.","volume":"37","author":"Milewicz","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"099","DOI":"10.1055\/s-0039-3400233","article-title":"Genes associated with thoracic aortic aneurysm and dissection: 2019 update and clinical implications.","volume":"7","author":"Faggion Vinholo","year":"2019","journal-title":"Aorta."},{"key":"B119","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1038\/ng.2348","article-title":"TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome.","volume":"44","author":"Boileau","year":"2012","journal-title":"Nat Genet."},{"key":"B120","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jjcc.2019.03.014","article-title":"Genetic basis of hereditary thoracic aortic aneurysms and dissections.","volume":"74","author":"Takeda","year":"2019","journal-title":"J Cardiol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/7857043","article-title":"99-case study of sporadic aortic dissection by whole exome sequencing indicated novel disease-associated genes and variants in chinese population.","volume":"2020","author":"Wang","year":"2020","journal-title":"Biomed Res Int."},{"key":"B122","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.avsg.2010.10.001","article-title":"Downregulation of FHL1 expression in thoracic aortic dissection: implications in aortic wall remodeling and pathogenesis of thoracic aortic dissection.","volume":"25","author":"Weng","year":"2011","journal-title":"Ann Vasc Surg."},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1038\/29814","article-title":"Smad3 and Smad4 cooperate with c-Jun\/c-Fos to mediate TFG-b-induced transcription.","volume":"394","author":"Zhang","year":"1998","journal-title":"Nature."},{"key":"B124","doi-asserted-by":"publisher","first-page":"013","DOI":"10.1055\/s-0038-1639612","article-title":"Genes associated with thoracic aortic aneurysm and dissection: 2018 update and clinical implications.","volume":"6","author":"Brownstein","year":"2018","journal-title":"Aorta."},{"key":"B125","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1093\/cvr\/cvy006","article-title":"From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta.","volume":"114","author":"Michel","year":"2018","journal-title":"Cardiovasc Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.ajhg.2016.06.034","article-title":"Genetic variants in LRP1 and ULK4 are associated with acute aortic dissections.","volume":"99","author":"Guo","year":"2016","journal-title":"Am J Hum Genet."},{"key":"B127","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.matbio.2019.12.001","article-title":"Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-\u03b21 from ECM stores.","volume":"88","author":"Schnieder","year":"2020","journal-title":"Matrix Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1172\/JCI83778","article-title":"FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.","volume":"126","author":"Kuang","year":"2016","journal-title":"J Clin Invest."},{"key":"B129","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.1167\/iovs.08-2243","article-title":"Persistent FoxE3 expression blocks cytoskeletal remodeling and organelle degradation during lens fiber differentiation.","volume":"49","author":"Landgren","year":"2008","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ajhg.2014.11.015","article-title":"MAT2A mutations predispose individuals to thoracic aortic aneurysms.","volume":"96","author":"Guo","year":"2015","journal-title":"Am J Hum Genet."},{"key":"B131","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.ebiom.2019.03.058","article-title":"TGF-\u03b21\/p65\/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.","volume":"42","author":"Wang","year":"2019","journal-title":"EBioMedicine."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1341.e","DOI":"10.1016\/j.jvs.2010.11.113","article-title":"A microRNA profile comparison between thoracic aortic dissection and normal thoracic aorta indicates the potential role of microRNAs in contributing to thoracic aortic dissection pathogenesis.","volume":"53","author":"Liao","year":"2011","journal-title":"J Vasc Surg."},{"key":"B133","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1161\/01.RES.0000108263.74520.15","article-title":"Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture.","volume":"94","author":"Rahkonen","year":"2004","journal-title":"Circ Res."},{"key":"B134","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.ajhg.2014.10.018","article-title":"MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections.","volume":"95","author":"Barbier","year":"2014","journal-title":"Am J Hum Genet."},{"key":"B135","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1161\/CIRCRESAHA.115.307130","article-title":"LOX mutations predispose to thoracic aortic aneurysms and dissections.","volume":"118","author":"Guo","year":"2016","journal-title":"Circ Res."},{"key":"B136","doi-asserted-by":"publisher","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis.","volume":"105","author":"van Rooij","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-019-0080-7","article-title":"HDAC6 is associated with the formation of aortic dissection in human.","volume":"25","author":"Guo","year":"2019","journal-title":"Mol Med."},{"key":"B138","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jss.2014.03.027","article-title":"Matrix metalloproteinase levels in chronic thoracic aortic dissection.","volume":"189","author":"Zhang","year":"2014","journal-title":"J Surg Res."},{"key":"B139","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jacbts.2019.10.010","article-title":"Genetic deletion of Socs3 in smooth muscle cells ameliorates aortic dissection in mice.","volume":"5","author":"Hirakata","year":"2020","journal-title":"JACC Basic Transl Sci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"65.e","DOI":"10.1016\/j.jtcvs.2007.11.017","article-title":"A proteomic study of the aortic media in human thoracic aortic dissection: implication for oxidative stress.","volume":"136","author":"Liao","year":"2008","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B141","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1002\/1873-3468.13081","article-title":"The tale of two talins - two isoforms to fine-tune integrin signalling.","volume":"592","author":"Gough","year":"2018","journal-title":"FEBS Lett."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0588-0","article-title":"Downregulation of Talin-1 expression associates with increased proliferation and migration of vascular smooth muscle cells in aortic dissection.","volume":"17","author":"Wei","year":"2017","journal-title":"BMC Cardiovasc Disord."},{"key":"B143","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/humu.22802","article-title":"Performant mutation identification using targeted next-generation sequencing of 14 thoracic aortic aneurysm genes.","volume":"36","author":"Proost","year":"2015","journal-title":"Hum Mutat."},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052833","article-title":"Notch signaling in descending thoracic aortic aneurysm and dissection.","volume":"7","author":"Zou","year":"2012","journal-title":"PLoS One."},{"key":"B145","doi-asserted-by":"publisher","first-page":"7666","DOI":"10.1074\/jbc.M512552200","article-title":"Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.","volume":"281","author":"McGrath","year":"2006","journal-title":"J Biol Chem."},{"key":"B146","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.fob.2015.08.011","article-title":"FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy.","volume":"5","author":"Lee","year":"2015","journal-title":"FEBS Open Bio."},{"key":"B147","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.bbrc.2009.11.145","article-title":"Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells.","volume":"391","author":"Amirak","year":"2010","journal-title":"Biochem Biophys Res Commun."},{"key":"B148","doi-asserted-by":"publisher","first-page":"19966","DOI":"10.1074\/jbc.M500917200","article-title":"Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells.","volume":"280","author":"Kaplan-Albuquerque","year":"2005","journal-title":"J Biol Chem."},{"key":"B149","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.str.2020.10.005","article-title":"Marveling at the Incredible ULK4.","volume":"28","author":"Eyers","year":"2020","journal-title":"Structure."},{"key":"B150","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1161\/CIRCULATIONAHA.111.085977","article-title":"Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young finns study.","volume":"126","author":"Juhola","year":"2012","journal-title":"Circulation."},{"key":"B151","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/ng.622","article-title":"Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.","volume":"42","author":"Gretarsdottir","year":"2010","journal-title":"Nat Genet."},{"key":"B152","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.120.051171","article-title":"Extracellular tuning of mitochondrial respiration leads to aortic aneurysm.","volume":"143","author":"Oller","year":"2021","journal-title":"Circulation."},{"key":"B153","author":"Callewaert","year":"1993","journal-title":"Arterial Tortuosity Syndrome."},{"key":"B154","doi-asserted-by":"publisher","first-page":"6769","DOI":"10.1093\/hmg\/ddv382","article-title":"GLUT10 deficiency leads to oxidative stress and non-canonical \u03b1v\u03b23 integrin-mediated TGF\u03b2 signalling associated with extracellular matrix disarray in arterial tortuosity syndrome skin fibroblasts.","volume":"24","author":"Zoppi","year":"2015","journal-title":"Hum Mol Genet."},{"key":"B155","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/ng1764","article-title":"Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome.","volume":"38","author":"Coucke","year":"2006","journal-title":"Nat Genet."},{"key":"B156","doi-asserted-by":"publisher","first-page":"10092","DOI":"10.1074\/jbc.RA120.013753","article-title":"Group V secreted phospholipase A2 plays a protective role against aortic dissection.","volume":"295","author":"Watanabe","year":"2020","journal-title":"J Biol Chem."},{"key":"B157","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S1443-9506(18)30060-X","article-title":"The mystery and enigma of spontaneous coronary artery dissection.","volume":"27","author":"Graham","year":"2018","journal-title":"Heart Lung Circ."},{"key":"B158","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1177\/2048872613504310","article-title":"Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome.","volume":"5","author":"Nishiguchi","year":"2016","journal-title":"Eur Heart J."},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.artres.2018.04.002","article-title":"A comparative study of vasa vasorum density among coronary arteries.","volume":"22","author":"Panchagnula","year":"2018","journal-title":"Artery Res."},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.11.030","article-title":"Proliferation of coronary adventitial vasa vasorum in patients with spontaneous coronary artery dissection.","volume":"9","author":"Kwon","year":"2016","journal-title":"JACC Cardiovasc Imaging."},{"key":"B161","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ijcard.2020.08.076","article-title":"Systematic review and meta-analysis of the clinical characteristics and outcomes of spontanous coronary artery dissection.","volume":"322","author":"Franke","year":"2021","journal-title":"Int J Cardiol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jccase.2019.01.006","article-title":"A case of spontaneous coronary artery dissection with early de novo recurrence.","volume":"20","author":"Okura","year":"2019","journal-title":"J Cardiol Cases."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1093\/eurheartj\/ehz007","article-title":"Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes.","volume":"40","author":"Saw","year":"2019","journal-title":"Eur Heart J."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1136\/heartjnl-2022-320830","article-title":"Clinical outcomes in spontaneous coronary artery dissection.","volume":"108","author":"Garcia-Guimaraes","year":"2022","journal-title":"Heart."},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26174-2","article-title":"Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases.","volume":"12","author":"Georges","year":"2021","journal-title":"Nat Commun."},{"key":"B166","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.hlc.2020.05.110","article-title":"Spontaneous coronary artery dissection and fibromuscular dysplasia: vasculopathies with a predilection for women.","volume":"30","author":"Iismaa","year":"2020","journal-title":"Heart Lung Circ."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.jacc.2014.07.014","article-title":"Coronary artery manifestations of fibromuscular dysplasia.","volume":"64","author":"Michelis","year":"2014","journal-title":"J Am Coll Cardiol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"e523","DOI":"10.1161\/CIR.0000000000000564","article-title":"Spontaneous coronary artery dissection: current state of the science: a scientific statement from the american heart association.","volume":"137","author":"Hayes","year":"2018","journal-title":"Circulation."},{"key":"B169","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jccase.2016.01.004","article-title":"Rare case of asymptomatic spontaneous coronary artery dissection.","volume":"13","author":"Rafiq","year":"1999","journal-title":"J Cardiol Cases."},{"key":"B170","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.1093\/eurheartj\/ehaa813","article-title":"Spontaneous coronary artery dissection after COVID-19 infection presenting with ST segment elevation.","volume":"41","author":"Cannata","year":"2020","journal-title":"Eur Heart J."},{"key":"B171","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jacc.2018.09.085","article-title":"Association of the PHACTR1\/EDN1 genetic locus with spontaneous coronary artery dissection.","volume":"73","author":"Adlam","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1161\/CIRCGEN.121.003527","article-title":"Exploring the genetic architecture of spontaneous coronary artery dissection using whole-genome sequencing.","volume":"15","author":"Tarr","year":"2022","journal-title":"Circ Genom Precis Med."},{"key":"B173","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ijcard.2020.04.049","article-title":"Non-invasive assessment of endothelial function in patients with spontaneous coronary artery dissection: a case-control study.","volume":"1","author":"Mori","year":"2020","journal-title":"Int J Cardiol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1177\/2048872618795255","article-title":"Coronary endothelial function and spontaneous coronary artery dissection.","volume":"9","author":"Waterbury","year":"2020","journal-title":"Eur Heart J."},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.120.003030","article-title":"Spontaneous coronary artery dissection: insights on rare genetic variation from genome sequencing.","volume":"13","author":"Carss","year":"2020","journal-title":"Circ Genom Precis Med."},{"key":"B176","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ijcard.2019.12.015","article-title":"The value of plasma fibrillin-1 level in patients with spontaneous coronary artery dissection.","volume":"302","author":"Hui","year":"2020","journal-title":"Int J Cardiol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/CIRCRESAHA.113.301498","article-title":"Thoracic aortic aneurysm frequency and dissection are associated with fibrillin-1 fragment concentrations in circulation.","volume":"113","author":"Marshall","year":"2013","journal-title":"Circ Res."},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000448","article-title":"LRP1 Functions as an atheroprotective integrator of TGF\u03b2 and PDGF signals in the vascular wall: implications for Marfan syndrome.","volume":"2","author":"Boucher","year":"2007","journal-title":"PLoS One."},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(18)30664-8","article-title":"Identifying genetic causes of spontaenous coronary artery dissection by whole genome sequencing in related individuals.","volume":"71","author":"Fahey","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ajhg.2016.11.008","article-title":"Loss-of-Function mutations in YY1AP1 lead to grange syndrome and a fibromuscular dysplasia-like vascular disease.","volume":"100","author":"Guo","year":"2017","journal-title":"Am J Hum Genet."},{"key":"B181","doi-asserted-by":"publisher","first-page":"35633","DOI":"10.1074\/jbc.M114.596411","article-title":"The anti-proliferative function of the TGF-\u03b21 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3.","volume":"289","author":"Li","year":"2014","journal-title":"J Biol Chem."},{"key":"B182","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1016\/j.ejca.2012.04.016","article-title":"Transforming growth factor-\u03b21 attenuates junctional adhesion molecule-A and contributes to breast cancer cell invasion.","volume":"48","author":"Wang","year":"2012","journal-title":"Eur J Cancer."},{"key":"B183","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3892\/ijmm_00000019","article-title":"Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (Review).","volume":"22","author":"Katoh","year":"1998","journal-title":"Int J Mol Med."},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00540-x","article-title":"GLI3: a mediator of genetic diseases, development and cancer.","volume":"18","author":"Matissek","year":"2020","journal-title":"Cell Commun Signal."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.0001","article-title":"Fibrillar collagen variants in spontaneous coronary artery dissection.","volume":"7","author":"Zekavat","year":"2022","journal-title":"JAMA Cardiol."},{"key":"B186","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ng0697-174","article-title":"SOX9 directly regulates the type-II collagen gene.","volume":"16","author":"Bell","year":"1997","journal-title":"Nat Genet."},{"key":"B187","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/tra.12826","article-title":"Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.","volume":"23","author":"Lu","year":"2021","journal-title":"Traffic."},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17558-x","article-title":"Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction.","volume":"11","author":"Saw","year":"2020","journal-title":"Nat Commun."},{"key":"B189","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1053\/j.gastro.2019.07.036","article-title":"ECM1 prevents activation of transforming growth factor \u03b2, hepatic stellate cells, and fibrogenesis in mice.","volume":"157","author":"Fan","year":"2019","journal-title":"Gastroenterology."},{"key":"B190","doi-asserted-by":"publisher","first-page":"6055","DOI":"10.1038\/onc.2015.54","article-title":"ECM1 regulates tumor metastasis and CSC-like property through stabilization of \u03b2-catenin.","volume":"34","author":"Lee","year":"2015","journal-title":"Oncogene."},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5955","article-title":"ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis.","volume":"53","author":"Gabriel","year":"2012","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B192","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jaccas.2019.11.058","article-title":"Spontaneous coronary artery dissection in females with the fragile X FMR1 premutation.","volume":"2","author":"McKenzie","year":"2020","journal-title":"JACC Case Rep."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1261\/rna.037945.112","article-title":"FMRP regulates actin filament organization via the armadillo protein p0071.","volume":"19","author":"Nolze","year":"2013","journal-title":"RNA."},{"key":"B194","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1002\/ajmg.a.36023","article-title":"High MMP-9 activity levels in fragile X syndrome are lowered by minocycline.","volume":"161","author":"Dziembowska","year":"2013","journal-title":"Am J Med Genet."},{"key":"B195","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/cge.13469","article-title":"Fragile X syndrome and connective tissue dysregulation.","volume":"95","author":"Ram\u00edrez-Cheyne","year":"2019","journal-title":"Clin Genet."},{"key":"B196","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/76109","article-title":"Mutations in ABCC6 cause pseudoxanthoma elasticum.","volume":"25","author":"Bergen","year":"2000","journal-title":"Nat Genet."},{"key":"B197","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41436-020-00945-6","article-title":"Reassessment of causality of ABCC6 missense variants associated with pseudoxanthoma elasticum based on Sherloc.","volume":"23","author":"Verschuere","year":"2021","journal-title":"Genet Med."},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0639-8","article-title":"Pseudoxanthoma elasticum.","volume":"12","author":"Germain","year":"2017","journal-title":"Orphanet J Rare Dis."},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092771","article-title":"Increased elastin degradation in pseudoxanthoma elasticum is associated with peripheral arterial disease independent of calcification.","volume":"9","author":"Bartstra","year":"2020","journal-title":"J Clin Med."},{"key":"B200","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1590\/abd1806-4841.20175972","article-title":"Ultrastructural aspects of pseudoxanthoma elasticum.","volume":"92","author":"de Almeida","year":"2017","journal-title":"An Bras Dermatol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1007\/s10103-020-03027-w","article-title":"Nonlinear optical microscopy is a novel tool for the analysis of cutaneous alterations in pseudoxanthoma elasticum.","volume":"35","author":"Kiss","year":"2020","journal-title":"Lasers Med Sci."},{"key":"B202","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.atherosclerosis.2016.11.012","article-title":"Prevalence and severity of arterial calcifications in pseudoxanthoma elasticum (PXE) compared to hospital controls. Novel insights into the vascular phenotype of PXE.","volume":"256","author":"Kranenburg","year":"2017","journal-title":"Atherosclerosis."},{"key":"B203","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/CIRCGEN.118.002437","article-title":"Rare missense variants in TLN1 are associated with familial and sporadic spontaneous coronary artery dissection.","volume":"12","author":"Turley","year":"2019","journal-title":"Circ Genom Precis Med."},{"key":"B204","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1161\/ATVBAHA.117.309521","article-title":"LRP1-dependent BMPER signaling regulates lipopolysaccharide-induced vascular inflammation.","volume":"37","author":"Lockyer","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1074\/jbc.M210250200","article-title":"NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.","volume":"278","author":"Johnson","year":"2003","journal-title":"J Biol Chem."},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2020.106775","article-title":"Hdac9 inhibits medial artery calcification through down-regulation of osterix.","volume":"132","author":"He","year":"2020","journal-title":"Vasc Pharmacol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/ng.1081","article-title":"Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.","volume":"44","author":"The International Stroke Genetics Consortium [ISGC], The Wellcome Trust Case Control Consortium 2 (WTCCC2), Bellenguez","year":"2012","journal-title":"Nat Genet."},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03394-7","article-title":"An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm.","volume":"9","author":"Lino Cardenas","year":"2018","journal-title":"Nat Commun."},{"key":"B209","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s10545-011-9411-8","article-title":"Understanding pyrroline-5-carboxylate synthetase deficiency: clinical, molecular, functional, and expression studies, structure-based analysis, and novel therapy with arginine.","volume":"35","author":"Martinelli","year":"2012","journal-title":"J Inherit Metab Dis."},{"key":"B210","doi-asserted-by":"publisher","first-page":".e1","DOI":"10.1016\/j.jaad.2011.01.004","article-title":"Cutis laxa: a review.","volume":"66","author":"Berk","year":"2012","journal-title":"J Am Acad Dermatol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jacc.2019.04.062","article-title":"Association of TSR1 variants and spontaneous coronary artery dissection.","volume":"74","author":"Sun","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jacc.2019.06.005","article-title":"Pathogenic TSR1 gene variants in patients with spontaneous coronary artery dissection.","volume":"74","author":"Grond-Ginsbach","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1111\/jcmm.13750","article-title":"The oncogenic potentials and diagnostic significance of long non-coding RNA LINC00310 in breast cancer.","volume":"22","author":"Li","year":"2018","journal-title":"J Cell Mol Med."},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172924","article-title":"The role of circadian clock gene BMAL1 in vascular proliferation.","volume":"872","author":"Takaguri","year":"2020","journal-title":"Eur J Pharmacol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1161\/STROKEAHA.113.001057","article-title":"Differences and similarities between spontaneous dissections of the internal carotid artery and the vertebral artery.","volume":"44","author":"von Babo","year":"2013","journal-title":"Stroke."},{"key":"B216","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S1474-4422(09)70084-5","article-title":"Cervical-artery dissections: predisposing factors, diagnosis, and outcome.","volume":"8","author":"Debette","year":"2009","journal-title":"Lancet Neurol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1196\/annals.1444.015","article-title":"Cervical arterial dissection.","volume":"1142","author":"Menon","year":"2008","journal-title":"Ann N Y Acad Sci."},{"key":"B218","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1161\/STROKEAHA.119.026362","article-title":"High-resolution magnetic resonance imaging of cervicocranial artery dissection: imaging features associated with stroke.","volume":"50","author":"Wu","year":"2019","journal-title":"Stroke."},{"key":"B219","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1212\/WNL.57.1.24","article-title":"Pathogenesis of cervical artery dissections: association with connective tissue abnormalities.","volume":"57","author":"Brandt","year":"2001","journal-title":"Neurology."},{"key":"B220","author":"Liebeskind","year":"2003","journal-title":"Cervicocephalic Arterial Dissections, in: Neurological Therapeutics: Principles and Practice."},{"key":"B221","doi-asserted-by":"publisher","first-page":"e2047","DOI":"10.1212\/WNL.0000000000010710","article-title":"Extracellular matrix protein signature of recurrent spontaneous cervical artery dissection.","volume":"95","author":"Mayer-Suess","year":"2020","journal-title":"Neurology."},{"key":"B222","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1212\/WNL.0b013e318217e71c","article-title":"The outer arterial wall layers are primarily affected in spontaneous cervical artery dissection.","volume":"76","author":"Volker","year":"2011","journal-title":"Neurology."},{"key":"B223","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1212\/01.wnl.0000237341.30854.6a","article-title":"Gender differences in spontaneous cervical artery dissection.","volume":"67","author":"Arnold","year":"2006","journal-title":"Neurology."},{"key":"B224","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1161\/01.STR.25.8.1704","article-title":"Familial aggregation of cervical artery dissection and cerebral aneurysm.","volume":"25","author":"Majamaa","year":"1994","journal-title":"Stroke."},{"key":"B225","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1136\/jnnp.2005.063107","article-title":"Arterial hypertension as risk factor for spontaneous cervical artery dissection. A case-control study.","volume":"77","author":"Pezzini","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B226","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1526-4610.1989.hed2909560.x","article-title":"Migraine\u2013a risk factor for dissection of cervical arteries.","volume":"29","author":"D\u2019Anglejan-Chatillon","year":"1989","journal-title":"Headache."},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5704","article-title":"Association between migraine and cervical artery dissection: the Italian project on stroke in young adults.","volume":"74","author":"De Giuli","year":"2017","journal-title":"JAMA Neurol."},{"key":"B228","doi-asserted-by":"publisher","first-page":"e79","DOI":"10.1161\/01.STR.0000078309.56307.5C","article-title":"Infection and the risk of spontaneous cervical artery dissection: a case-control study.","volume":"34","author":"Guillon","year":"2003","journal-title":"Stroke."},{"key":"B229","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1097\/00006123-199610000-00006","article-title":"Intracranial aneurysms and cervicocephalic arterial dissections associated with congenital heart disease.","volume":"39","author":"Schievink","year":"1996","journal-title":"Neurosurgery."},{"key":"B230","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/2396987317693402","article-title":"Next generation sequencing analysis of patients with familial cervical artery dissection.","volume":"2","author":"Grond-Ginsbach","year":"2017","journal-title":"Eur Stroke J."},{"key":"B231","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1007\/s00415-016-8101-8","article-title":"TGFBR2 mutation and MTHFR-C677T polymorphism in a Mexican mestizo population with cervico-cerebral artery dissection.","volume":"263","author":"Ruiz-Franco","year":"2016","journal-title":"J Neurol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/ejhg.2012.82","article-title":"Copy number variation in patients with cervical artery dissection.","volume":"20","author":"Grond-Ginsbach","year":"2012","journal-title":"Eur J Hum Genet."},{"key":"B233","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/ng.3154","article-title":"Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.","volume":"47","author":"Debette","year":"2015","journal-title":"Nat Genet."},{"key":"B234","doi-asserted-by":"publisher","first-page":"e459","DOI":"10.1161\/STROKEAHA.108.534669","article-title":"The genetics of cervical artery dissection: a systematic review.","volume":"40","author":"Debette","year":"2009","journal-title":"Stroke."},{"key":"B235","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1007\/s00415-002-0745-x","article-title":"Analysis of the COL3A1 gene in patients with spontaneous cervical artery dissections.","volume":"249","author":"von Pein","year":"2002","journal-title":"J Neurol."},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000208411.01172.0b","article-title":"The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection.","volume":"66","author":"Longoni","year":"2006","journal-title":"Neurology."},{"key":"B237","doi-asserted-by":"publisher","first-page":"e289","DOI":"10.1161\/01.CIR.0000165142.37711.E7","article-title":"Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.","volume":"111","author":"Varga","year":"2005","journal-title":"Circulation."},{"key":"B238","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1159\/000104479","article-title":"Mild hyperhomocysteinemia and low folate concentrations as risk factors for cervical arterial dissection.","volume":"24","author":"Arauz","year":"2007","journal-title":"Cerebrovasc Dis."},{"key":"B239","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.hrtlng.2019.02.007","article-title":"Pulmonary artery dissection\u2013a review of 150 cases.","volume":"48","author":"Fernando","year":"2019","journal-title":"Heart Lung."},{"key":"B240","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/path.1710980104","article-title":"Dissecting aneurysm of the pulmonary artery.","volume":"98","author":"Shilkin","year":"1969","journal-title":"J. Pathol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1046\/j.1365-2559.2001.01129.x","article-title":"Pulmonary artery dissection in patients without underlying pulmonary hypertension.","volume":"38","author":"Inayama","year":"2001","journal-title":"Histopathology."},{"key":"B242","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1136\/hrt.2004.045799","article-title":"Pulmonary artery dissection: an emerging cardiovascular complication in surviving patients with chronic pulmonary hypertension.","volume":"91","author":"Khattar","year":"2005","journal-title":"Heart."},{"key":"B243","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1136\/hrt.68.12.616","article-title":"Pulmonary artery rupture in pregnancy complicating patent ductus arteriosus.","volume":"68","author":"Green","year":"1992","journal-title":"Heart."},{"key":"B244","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.5694\/j.1326-5377.1967.tb27334.x","article-title":"Dissecting aneurysm of the pulmonary artery with multiple cardiovascular abnormalities and pulmonary hypertension.","volume":"2","author":"Best","year":"1967","journal-title":"Med J Aust."},{"key":"B245","doi-asserted-by":"publisher","first-page":"350","DOI":"10.21037\/cdt.2018.04.01","article-title":"Pulmonary artery aneurysms: diagnosis & endovascular therapy.","volume":"8","author":"Park","year":"2018","journal-title":"Cardiovasc Diagn Ther."},{"key":"B246","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1067\/mtc.2001.112634","article-title":"Rupture and dissection in pulmonary artery aneurysms: incidence, cause, and treatment\u2013review and case report.","volume":"121","author":"Senbaklavaci","year":"2001","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.4076\/1752-1947-3-7426","article-title":"Idiopathic pulmonary artery dissection: a case report.","volume":"3","author":"Mohammad","year":"2009","journal-title":"J Med Case Rep."},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.4.605","article-title":"Spontaneous renal artery dissection as a cause of acute renal infarction: clinical and MDCT findings.","volume":"32","author":"Yoon","year":"2017","journal-title":"J Korean Med Sci."},{"key":"B249","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1177\/000331970005100710","article-title":"Isolated dissection of the celiac artery: a case report.","volume":"51","author":"Matsuo","year":"2000","journal-title":"Angiology."},{"key":"B250","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/ckj\/sfs047","article-title":"Spontaneous renal artery dissection with renal infarction.","volume":"5","author":"Renaud","year":"2012","journal-title":"Clin Kidney J."},{"key":"B251","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0022-5347(17)70262-5","article-title":"A case of renal hypertension.","volume":"52","author":"Bumpus","year":"1944","journal-title":"J Urol."},{"key":"B252","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/896706","article-title":"Isolated spontaneous renal artery dissection presented with flank pain.","volume":"2015","author":"Gandhi","year":"2015","journal-title":"Case Rep Radiol."},{"key":"B253","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3941\/jrcr.v4i4.408","article-title":"Spontaneous celiac artery dissection and its management.","volume":"4","author":"Vaidya","year":"2010","journal-title":"Radiol Case."},{"key":"B254","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.jvs.2014.01.040","article-title":"Options for treatment of spontaneous mesenteric artery dissection.","volume":"59","author":"Garrett","year":"2014","journal-title":"J Vasc Surg."},{"key":"B255","doi-asserted-by":"publisher","first-page":"256","DOI":"10.15441\/ceem.15.030","article-title":"Spontaneous dissection of celiac trunk with concurrent splenic artery dissection.","volume":"2","author":"Lee","year":"2015","journal-title":"Clin Exp Emerg Med."},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6960","article-title":"Isolated renal artery dissection: a systematic review of case reports.","volume":"12","author":"Jha","year":"2020","journal-title":"Cureus."},{"key":"B257","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1161\/ATVBAHA.119.313885","article-title":"A novel recurrent COL5A1 genetic variant is associated with a dysplasia-associated arterial disease exhibiting dissections and fibromuscular dysplasia.","volume":"40","author":"Richer","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B258","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jvs.2008.03.002","article-title":"Isolated spontaneous dissection of the splanchnic arteries.","volume":"48","author":"Takayama","year":"2008","journal-title":"J Vasc Surg."},{"key":"B259","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1161\/ATVBAHA.118.310956","article-title":"Therapies for thoracic aortic aneurysms and acute aortic dissections: old controversies and new opportunities.","volume":"39","author":"Milewicz","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.122.003867","article-title":"Dissecting the genomics of spontaneous coronary artery dissection.","volume":"15","author":"Weldy","year":"2022","journal-title":"Circ Genom Precis Med."},{"key":"B261","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.jacc.2017.06.053","article-title":"Spontaneous coronary artery dissection\u2013clinical outcomes and risk of recurrence.","volume":"70","author":"Saw","year":"2017","journal-title":"J Am Coll Cardiol."},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab183","article-title":"Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications.","volume":"118","author":"Margaritis","year":"2021","journal-title":"Cardiovasc Res."},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00706","article-title":"Vasa vasorum angiogenesis: key player in the initiation and progression of atherosclerosis and potential target for the treatment of cardiovascular disease.","volume":"9","author":"Sedding","year":"2018","journal-title":"Front Immunol."},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0194-9","article-title":"The Ehlers\u2013Danlos syndromes.","volume":"6","author":"Malfait","year":"2020","journal-title":"Nat Rev Dis Prim."},{"key":"B265","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/gim.2017.138","article-title":"Vascular phenotypes in nonvascular subtypes of the Ehlers-Danlos syndrome: a systematic review.","volume":"20","author":"D\u2019hondt","year":"2018","journal-title":"Genet Med."},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031365","article-title":"Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: a national electronic cohort study and case\u2013control comparison.","volume":"9","author":"Demmler","year":"2019","journal-title":"BMJ Open."},{"key":"B267","doi-asserted-by":"publisher","first-page":"482","DOI":"10.2214\/AJR.11.6603","article-title":"Vascular complications of ehlers-danlos syndrome: CT findings.","volume":"198","author":"Chu","year":"2012","journal-title":"Am J Roentgenol."},{"key":"B268","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/GIM.0b013e3181e074f0","article-title":"Hereditary disorders of connective tissue: a guide to the emerging differential diagnosis.","volume":"12","author":"Murphy-Ryan","year":"2010","journal-title":"Genet Med."},{"key":"B269","article-title":"Marfan syndrome","author":"Harry","year":"1993","journal-title":"GeneReviews"},{"key":"B270","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nrm2262","article-title":"Extracellular control of TGF\u03b2 signalling in vascular development and disease.","volume":"8","author":"ten Dijke","year":"2007","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B271","article-title":"Pressure pulmonary artery aneurysm.","volume":"32","author":"Smalcelj","year":"2005","journal-title":"Texas Heart Inst J."},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181166","article-title":"Sex, pregnancy and aortic disease in Marfan syndrome.","volume":"12","author":"Renard","year":"2017","journal-title":"PLoS One."},{"key":"B273","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/gim.2014.11","article-title":"Loeys\u2013Dietz syndrome: a primer for diagnosis and management.","volume":"16","author":"MacCarrick","year":"2014","journal-title":"Genet Med."},{"key":"B274","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1002\/ajmg.a.36056","article-title":"A mutation in TGFB 3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys\u2013Dietz syndrome.","volume":"161","author":"Rienhoff","year":"2013","journal-title":"Am J Med Genet."},{"key":"B275","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00247-009-1252-3","article-title":"Loeys-Dietz syndrome.","volume":"39","author":"Malhotra","year":"2009","journal-title":"Pediatr Radiol."},{"key":"B276","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ejhg.2011.237","article-title":"Clinical utility gene card for: alport syndrome.","volume":"20","author":"Hertz","year":"2012","journal-title":"Eur J Hum Genet."},{"key":"B277","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nrneph.2012.259","article-title":"Alport syndrome\u2013insights from basic and clinical research.","volume":"9","author":"Kruegel","year":"2013","journal-title":"Nat Rev Nephrol."},{"key":"B278","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/1705927","article-title":"Spontaneous coronary artery dissection: a rare manifestation of alport syndrome.","volume":"2017","author":"Anuwatworn","year":"2017","journal-title":"Case Rep Cardiol."},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.120.010701","article-title":"Type A dissection in a patient with alport syndrome.","volume":"13","author":"Patel","year":"2020","journal-title":"Circ Cardiovasc Imaging."},{"key":"B280","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1177\/1358863X18821816","article-title":"First International Consensus on the diagnosis and management of fibromuscular dysplasia.","volume":"24","author":"Gornik","year":"2019","journal-title":"Vasc Med."},{"key":"B281","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1177\/1358863X18811596","article-title":"High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: the ARCADIA-POL study.","volume":"24","author":"Talarowska","year":"2019","journal-title":"Vasc Med."},{"key":"B282","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.jnma.2019.04.008","article-title":"Generalized vascular dissection on pathological examination in a patient with polycystic kidney disease and acute aortic dissection.","volume":"111","author":"Haruta","year":"2019","journal-title":"J Natl Med Assoc."},{"key":"B283","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3949\/ccjm.84a.16107","article-title":"Autosomal dominant polycystic kidney disease and the heart and brain.","volume":"84","author":"Krishnappa","year":"2017","journal-title":"Cleve Clin J Med."},{"key":"B284","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1083\/jcb.201006173","article-title":"The cell biology of polycystic kidney disease.","volume":"191","author":"Chapin","year":"2010","journal-title":"J Cell Biol."},{"key":"B285","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta.","volume":"16","author":"Sillence","year":"1979","journal-title":"J Med Genet."},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.52","article-title":"Osteogenesis imperfecta.","volume":"3","author":"Marini","year":"2017","journal-title":"Nat Rev Dis Prim."},{"key":"B287","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","article-title":"Osteogenesis imperfecta.","volume":"387","author":"Forlino","year":"2016","journal-title":"Lancet."},{"key":"B288","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bone.2019.01.022","article-title":"Aortic aneurysm\/dissection and osteogenesis imperfecta: four new families and review of the literature.","volume":"121","author":"Balasubramanian","year":"2019","journal-title":"Bone."},{"key":"B289","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/ajmg.a.61497","article-title":"Clinical manifestations of osteogenesis imperfecta in adulthood: an integrative review of quantitative studies and case reports.","volume":"182","author":"Chougui","year":"2020","journal-title":"Am J Med Genet."},{"key":"B290","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ng.934","article-title":"Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.","volume":"43","author":"LeMaire","year":"2011","journal-title":"Nat Genet."},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz746.0485","article-title":"P5539Genetic heterogeneity of spontaneous coronary artery dissection (SCAD).","volume":"40","author":"Giuliani","year":"2019","journal-title":"Eur Heart J."},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000653","article-title":"Migraine, stroke, and cervical arterial dissection: shared genetics for a triad of brain disorders with vascular involvement.","volume":"8","author":"Daghlas","year":"2022","journal-title":"Neurol Genet."},{"key":"B293","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.ajhg.2013.06.019","article-title":"Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections","volume":"93","author":"Guo","year":"2013","journal-title":"Am J Hum Genet."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.1055862\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T01:57:35Z","timestamp":1670291855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.1055862\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":293,"alternative-id":["10.3389\/fcvm.2022.1055862"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.1055862","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,6]]},"article-number":"1055862"}}