{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:13:22Z","timestamp":1788174802063,"version":"build-2803163510"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence regarding favorable treatment of patients with functional mitral regurgitation (FMR) using transcatheter edge-to-edge repair (TEER) is constantly growing. However, there is only few data directly comparing TEER and surgical mitral valve repair (SMVr).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare baseline characteristics, short-term and 1-year outcomes in FMR patients undergoing mitral valve (MV) TEER or SMVr using a meta-analytic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic database search identified 1,703 studies reporting on TEER or SMVr for treatment of FMR between January 2010 and December 2020. A meta-analytic approach was used to compare outcomes from single-arm and randomized studies based on measures by means of their corresponding 95% confidence intervals (CI). Statistical significance was assumed if CIs did not overlap. A total of 21 TEER and 37 SMVr studies comprising 4,304 and 3,983 patients were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the TEER cohort presented with higher age (72.0 \u00b1 1.7 vs. 64.7 \u00b1 4.7 years, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), greater burden of comorbidities like hypertension (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), atrial fibrillation (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), lung disease (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) and chronic renal disease (<jats:italic>p<\/jats:italic> = 0.005) as well as poorer left ventricular ejection fraction (30.9 \u00b1 5.7 vs. 36.6 \u00b1 5.3%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). In-hospital mortality was significantly lower with TEER [3% (95%-CI 0.02\u20130.03) vs. 5% (95%-CI 0.04\u20130.07)] and 1-year mortality did not differ significantly [18% (95%-CI 0.15\u20130.21) vs. 11% (0.07\u20130.18)]. NYHA [1.06 (95%-CI 0.87\u20131.26) vs. 1.15 (0.74\u20131.56)] and MR reduction [1.74 (95%-CI 1.52\u20131.97) vs. 2.08 (1.57\u20132.59)] were comparable between both cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite considerably higher age and comorbidity burden, in-hospital mortality was significantly lower in FMR patients treated with TEER, whereas a tendency toward increased 1-year mortality was observed in this high-risk population. In terms of functional status and MR grade reduction, comparable 1-year results were achieved.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.1063070","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T05:24:14Z","timestamp":1674624254000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of transcatheter edge-to-edge and surgical repair in patients with functional mitral regurgitation using a meta-analytic 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