{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:12:02Z","timestamp":1787026322541,"version":"build-2736575974"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Takotsubo cardiomyopathy (TTC) is a rare entity after cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe patients\u2019 profile who developed postoperative TTC after cardiac surgery, management, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic literature search to extract cases of TTC after adult cardiac surgery (from 1990 to 2021). Additionally, we extracted all cases of TTC in a prospective single-center cohort database of 10,000+ patients (from 2007 to 2019). We then combined all cases in a single cohort to describe its clinical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 694 screened articles, we retained 71 individual cases published in 20 distinct articles (19 cases reports and 1 case-series). We combined these to 10 cases extracted from our cohort [among 10,682 patients (0.09%)]. Overall, we included 81 cases. Patients were aged 68 \u00b1 10 years-old and 64\/81 (79%) were women. Surgery procedures included mitral valve and\/or tricuspid valve surgery in 70\/81, 86%. TTC was diagnosed in the first days after surgery [median 4 (1\u20134) days]. Incidence of cardiogenic shock, defined as requirement of vasopressor and\/or inotropic support was 24\/29, 83% (data available on 29\/81 patients). Refractory cardiogenic appeared in 5\/81, 6% who required implantation of arterio-venous extra-corporeal membrane oxygenation, and 6\/81, 7%, intra-aortic balloon pump. In-hospital mortality was 5\/81, 6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review, based on case reports and case series, showed that postoperative TTC appears as a rare complication after cardiac surgery and mainly occurred after mitral and\/or tricuspid valve repair procedures. In this population, TTC is associated with high rate of cardiogenic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2022.1067444","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T15:40:13Z","timestamp":1673365213000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Takotsubo cardiomyopathy after cardiac surgery: A case-series and systematic review of 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