{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:05:16Z","timestamp":1785470716635,"version":"3.56.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the need for cardiac monitoring in unselected patients recovered from COVID-19 and to estimate the risk of heart complications after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>During March 2020 and January 2021, 106 patients who had recovered from SARS-CoV-2 (alpha and beta variants) were enrolled in prospective observational cohort study CoSuBr (Covid Survivals in Brno). The diagnosis was based on a reverse transcription-polymerase chain reaction swab test of the upper respiratory tract. Demographic parameters, patient history, clinical evaluation, cardiac biomarkers, ECG and echocardiography were recorded during three visits (Visit 1 at least 6 weeks after infection, Visit 2 three months later, and Visit 3 one year after Visit 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>58.5% of the study group (<jats:italic>n<\/jats:italic> = 106) were female, while the mean age was 46 years (range 18\u201377 years). The mean time interval between the onset of infection and the follow-up visit was 107 days. One quarter (24.5%) of the patients required hospitalization during the acute phase of the disease; the rest recovered at home. 74% suffered a mild form of the disease, with 4.8, 18.1, and 2.9% suffering moderate, severe, and critical forms, respectively. At the time of enrolment, 64.2% of the patients reported persistent symptoms, while more than half of the whole group (50.9%) mentioned at least one symptom of possible cardiac origin (breathing problems, palpitations, exercise intolerance, fatigue). In the 1-year follow-up after COVID-19 infection, left ventricle ejection fraction showed no significant decrease [median (IQR) change was \u22121.0 (\u22126.0; 4.0)%, <jats:italic>p<\/jats:italic> = 0.150], and there were no changes of troponin (mean change \u22120.1 \u00b1 1.72 ng\/L; <jats:italic>p<\/jats:italic> = 0.380) or NT-proBNP [median (IQR) change 2.0 (\u221220.0; 29.0) pg\/mL; <jats:italic>p<\/jats:italic> = 0.315]. There was a mild decrease in right ventricle end diastolic diameter (-mean change 2.3 \u00b1 5.61 mm, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), while no right ventricle dysfunction was detected. There was very mild progress in left ventricle diastolic diameter [median (IQR) change 1.0 (\u22121.0; 4.0) mm; <jats:italic>p<\/jats:italic> = 0.001] between V1 and V3, mild enlargement of the left atrium (mean change 1.2 \u00b1 4.17 mm; <jats:italic>p<\/jats:italic> = 0.021) and a non-significant trend to impairment of left ventricle diastolic dysfunction. There was a mild change in pulmonary artery systolic pressure [median (IQR) change 3.0 (\u22122.0; 8.0) mmHg; <jats:italic>p<\/jats:italic> = 0.038].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite a lot of information regarding cardiac impairment due to SARS-CoV2, our study does not suggest an increased risk for developing clinically significant heart changes during the 1-year follow-up. Based on our results, routine echocardiography and biomarkers collection is currently not recommended after COVID-19 recovery.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.1067943","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T05:48:28Z","timestamp":1671601708000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac sequelae after COVID-19: Results of a 1-year follow-up study with echocardiography and biomarkers"],"prefix":"10.3389","volume":"9","author":[{"given":"Gabriela","family":"Matejova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Radvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elis","family":"Bartecku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kamenik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lumir","family":"Koc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Horinkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubica","family":"Sykorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radka","family":"Stepanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Kala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3026","article-title":"Management of post-acute Covid-19 in primary care.","volume":"370","author":"Greenhalgh","year":"2020","journal-title":"BMJ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/jmv.26368","article-title":"Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection.","volume":"93","author":"Halpin","year":"2021","journal-title":"J Med Virol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4037\/aacnacc2021492","article-title":"Post-COVID-19 syndrome: theoretical basis, identification, and management.","volume":"32","author":"Scordo","year":"2021","journal-title":"AACN Adv Crit Care."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02116-3","article-title":"Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes.","volume":"1","author":"Zhang","year":"2022","journal-title":"Nat Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1002\/ehf2.13466","article-title":"Late phase of COVID-19 pandemic in general cardiology. 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