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Fortunately, the use of left ventricular assist devices (LVADs), a variant of mechanical circulatory support has been on the rise in recent years. The expansion of LVADs has led them to be incorporated into a variety of clinical settings, based on the goals of therapy for patients ailing from heart failure. However, with an increase in the use of LVADs, there are a host of complications that arise with it. One such complication is the development and progression of aortic regurgitation (AR) which is noted to adversely influence patient outcomes and compromise pump benefits leading to increased morbidity and mortality. The underlying mechanisms are likely multifactorial and involve the aortic root-aortic valve (AV) complex, as well as the LVAD device, patient, and other factors, all of them alter the physiological mechanics of the heart resulting in AV dysfunction. Thus, it is imperative to screen patients before LVAD implantation for AR, as moderate or greater AR requires a concurrent intervention at the time of LVADs implantation. No current strict guidelines were identified in the literature search on how to actively manage and limit the development and\/or progression of AR, due to the limited information. However, some recommendations include medical management by targeting fluid overload and arterial blood pressure, along with adjusting the settings of the LVADs device itself. Surgical interventions are to be considered depending on patient factors, goals of care, and the underlying pathology. These interventions include the closure of the AV, replacement of the valve, and percutaneous approach<jats:italic>via<\/jats:italic>percutaneous occluding device or transcatheter aortic valve implantation. In the present review, we describe the interaction between AV and LVAD placement, in terms of patient management and prognosis. Also it is provided a comprehensive echocardiographic strategy for the precise assessment of AV regurgitation severity.<\/jats:p>","DOI":"10.3389\/fcvm.2022.1094796","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T13:07:49Z","timestamp":1673356069000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Reciprocal interferences of the left ventricular assist device and the aortic valve competence"],"prefix":"10.3389","volume":"9","author":[{"given":"Olga","family":"Vriz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Shaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"El-Shaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Feras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdalla","family":"Eltayeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani","family":"Alsergnai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naji","family":"Kholaif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mosaad","family":"Al Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimpna","family":"Albert-Brotons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre Rudiger","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix Wang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.jchf.2020.01.014","article-title":"Advanced heart failure: epidemiology, diagnosis, and therapeutic approaches.","volume":"8","author":"Truby","year":"2020","journal-title":"JACC Heart Fail."},{"key":"B2","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.healun.2013.08.006","article-title":"The registry of the international society for heart and lung transplantation: thirtieth official adult heart transplant report\u20132013; focus theme: age.","volume":"32","author":"Lund","year":"2013","journal-title":"J Heart Lung Transplant."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1067\/mtc.2001.118274","article-title":"Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation.","volume":"122","author":"Frazier","year":"2001","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1161\/CIR.0b013e3182769a54","article-title":"Recommendations for the use of mechanical circulatory support: device strategies and patient selection: a scientific statement from the American heart association.","volume":"126","author":"Peura","year":"2012","journal-title":"Circulation."},{"key":"B5","doi-asserted-by":"publisher","first-page":"S147","DOI":"10.1055\/s-2007-965414","article-title":"Alternatives to heart transplantation. 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