{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:11:17Z","timestamp":1784664677785,"version":"3.55.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to investigate the predicting value of platelet distribution width (PDW) and fibrinogen for in-stent restenosis (ISR) in patients with stable angina pectoris and type 2 diabetes mellitus (T2DM) after drug-eluting stent (DES) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 161 patients who were readmitted with recurrent chest pain and successfully reviewed for coronary angiography and were divided into the ISR and non-ISR groups. We compared the levels of PDW and fibrinogen between the two groups. Logistic regression was used for analyzing independent predictors of ISR. The receiver operating characteristic (ROC) curve analysis was used to determine the optimum cutoff points of PDW and fibrinogen to predict ISR. The Kaplan\u2013Meier survival curves for target lesion failure (TLF) by levels of PDW and fibrinogen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The multivariate logistic regression analysis showed that PDW and fibrinogen were independent predictors of ISR [odds ratio (OR) = 1.209, 95% CI: 1.024\u20131.427, <jats:italic>p<\/jats:italic> = 0.025; OR = 1.006, 95% CI: 1.002\u20131.011, <jats:italic>p<\/jats:italic> = 0.010, respectively]. The ROC analyses showed that PDW \u2265 13.15% and fibrinogen \u2265 333.5 mg\/dl were predictive of ISR in patients with stable angina pectoris and T2DM after DES implantation. However, the Kaplan\u2013Meier estimate for TLF showed no statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher levels of PDW and fibrinogen were associated with the incidence of ISR in patients with stable angina with T2DM after DES implantation, but were not independent predictors of TLF.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.710804","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T22:40:21Z","timestamp":1647988821000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of Platelet Distribution Width and Fibrinogen in Predicting In-stent Restenosis With Stable Angina and Type 2 Patients With Diabetes Mellitus"],"prefix":"10.3389","volume":"9","author":[{"given":"Dayang","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/heartjnl-2013-304933","article-title":"Incidence and predictors of restenosis after coronary stenting in 10,004 patients with surveillance angiography","volume":"100","author":"Cassese","year":"2014","journal-title":"Heart."},{"key":"B2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.iccl.2016.02.002","article-title":"Antiproliferative drugs for restenosis prevention","volume":"5","author":"Habib","year":"2016","journal-title":"Interv Cardiol Clin."},{"key":"B3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0140-6736(86)90111-X","article-title":"Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study","volume":"2","author":"Meade","year":"1986","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1001\/jama.1987.03400090067035","article-title":"Fibrinogen and risk of cardiovascular disease: the Framingham Study","volume":"258","author":"Kannel","year":"1987","journal-title":"J Am Med Assoc."},{"key":"B5","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1056\/NEJM198408233110804","article-title":"Fibrinogen as a risk factor for stroke and myocardial infarction","volume":"311","author":"Wilhelmsen","year":"1984","journal-title":"N Engl J Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1161\/01.CIR.83.3.836","article-title":"Fibrinogen, viscosity and white blood cell count are major risk factors for ischemic heart disease. 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