{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:55:26Z","timestamp":1790088926159,"version":"4.0.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal revascularization strategy in patients with ST-segment elevation myocardial infarction (STEMI) complicating by cardiogenic shock (CS) remains controversial. This study aims to evaluate the clinical outcomes of multivessel percutaneous coronary intervention (MV-PCI) compared to culprit vessel-only PCI (CO-PCI) for the treatment, only in patients with STEMI with CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted. Studies assessed the efficacy outcomes of short (in-hospital or 30 days)\/long-term mortality, cardiac death, myocardial reinfarction, repeat revascularization, and safety outcomes of stroke, bleeding, acute renal failure with MV-PCI vs. CO-PCI in patients with STEMI with CS were included. The publication bias and sensitivity analysis were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 studies were included in this meta-analysis. There was no significant difference in short- and long-term mortality in patients treated with MV-PCI compared to CO-PCI group [odds ratio (OR) = 1.17; 95% confidence interval (CI), 0.92\u20131.48; OR = 0.86; 95% CI, 0.58\u20131.28]. Similarly, there were no significant differences in cardiac death (OR = 0.67; 95% CI, 0.44\u20131.00), myocardial reinfarction (OR = 1.24; 95% CI, 0.77\u20132.00), repeat revascularization (OR = 0.75; 95% CI, 0.40\u20131.42), bleeding (OR = 1.53; 95% CI, 0.53\u20134.43), or stroke (OR = 1.42; 95% CI, 0.90\u20132.23) between the two groups. There was a higher risk in acute renal failure (OR = 1.33; 95% CI, 1.04\u20131.69) in patients treated with MV-PCI when compared with CO-PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta-analysis suggests that there may be no significant benefit for patients with STEMI complicating CS treated with MV-PCI compared with CO-PCI, and patients are at increased risk of developing acute renal failure after MV-PCI intervention.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.735636","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T05:04:54Z","timestamp":1649999094000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multivessel vs. Culprit Vessel-Only Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction in Patients With Cardiogenic Shock: An Updated Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Bingquan","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"280","DOI":"10.4244\/EIJY14M08_04","article-title":"Immediate multivessel percutaneous coronary intervention versus culprit lesion intervention in patients with acute myocardial infarction complicated by cardiogenic shock: results of the ALKK-PCI registry.","volume":"11","author":"Zeymer","year":"2015","journal-title":"Eurointervention."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000590","article-title":"Trends in incidence, management, and outcomes of cardiogenic shock complicating ST-elevation myocardial infarction in the United States.","volume":"3","author":"Kolte","year":"2014","journal-title":"J Am Heart Assoc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1161\/CIRCOUTCOMES.113.000262","article-title":"Differences in the profile, treatment, and prognosis of patients with cardiogenic shock by myocardial infarction classification: a report from NCDR.","volume":"6","author":"Anderson","year":"2013","journal-title":"Circ Cardiovasc Qual Outcomes."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1001\/jama.295.21.2511","article-title":"Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction.","volume":"295","author":"Hochman","year":"2006","journal-title":"JAMA."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/s0735-1097(03)01051-9","article-title":"Correlates of one-year survival inpatients with cardiogenic shock complicating acute myocardial infarction: angiographic findings from the SHOCK trial.","volume":"42","author":"Sanborn","year":"2003","journal-title":"J Am Coll Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/s0735-1097(00)00873-1","article-title":"Angiographic findings and clinical correlates in patients with cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK trial registry. 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