{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:49:30Z","timestamp":1753890570095,"version":"3.41.2"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic kidney disease (CKD) patients have a high prevalence of coronary artery disease and a high risk of cardiovascular events. The present study assessed the value of the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score for predicting mortality among hospitalized acute coronary syndrome (ACS) patients with CKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study that included CKD patients who were hospitalized for ACS from January 2015 to May 2020. The CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score for each eligible patient was determined. Patients were stratified into two groups according to CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score: &amp;lt;6 (low) and \u22656 (high). The primary endpoint was all-cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 313 eligible patients were included in the study, with a mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASC score of 4.55 \u00b1 1.68. A total of 220 and 93 patients were assigned to the low and high CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score groups, respectively. The most common reason for hospitalization was unstable angina (39.3%), followed by non-ST-elevation myocardial infarction (35.8%) and ST-elevation myocardial infarction (24.9%). A total of 67.7% of the patients (212\/313) received coronary reperfusion therapy during hospitalization. The median follow-up time was 23.0 months (interquartile range: 12\u201338 months). A total of 94 patients (30.0%) died during follow-up. The high score group had a higher mortality rate than the low score group (46.2 vs. 23.2%, respectively; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). The cumulative incidence of all-cause death was higher in the high score group than in the low score group (Log-rank test, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). Multivariate Cox regression analysis indicated that CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc scores were positively associated with all-cause mortality (hazard ratio: 2.02, 95% confidence interval: 1.26\u20133.27, <jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score is an independent predictive factor for all-cause mortality in CKD patients who are hospitalized with ACS. This simple and practical scoring system may be useful for the early identification of patients with a high risk of death.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.790193","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T05:12:34Z","timestamp":1647407554000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive Value of the CHA2DS2-VASc Score for Mortality in Hospitalized Acute Coronary Syndrome Patients With Chronic Kidney 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