{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:24:01Z","timestamp":1779207841320,"version":"3.51.4"},"reference-count":137,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>The prevalence of both organic valvular heart disease (VHD) and cardiac arrhythmias is high in the general population, and their coexistence is common. Both VHD and arrhythmias in the elderly lead to an elevated risk of hospitalization and use of health services. However, the relationships of the two conditions is not fully understood and our understanding of their coexistence in terms of contemporary management and prognosis is still limited. VHD-induced left ventricular dysfunction\/hypertrophy and left atrial dilation lead to both atrial and ventricular arrhythmias. On the other hand, arrhythmias can be considered as an independent condition resulting from a coexisting ischemic or non-ischemic substrate or idiopathic ectopy. Both atrial and ventricular VHD-induced arrhythmias may contribute to clinical worsening and be a turning point in the natural history of VHD. Symptoms developed in patients with VHD are not specific and may be attributable to hemodynamical consequences of valve disease but also to other cardiac conditions including arrhythmias which are notably prevalent in this population. The issue how to distinguish symptoms related to VHD from those related to atrial fibrillation (AF) during decision making process remains challenging. Moreover, AF is a traditional limit of echocardiography and an important source of errors in assessment of the severity of VHD. Despite recent progress in understanding the pathophysiology and prognosis of postoperative AF, many questions remain regarding its prevention and management. Furthermore, life-threatening ventricular arrhythmias can predispose patients with VHD to sudden cardiac death. Evidence for a putative link between arrhythmias and outcome in VHD is growing but available data on targeted therapies for VHD-related arrhythmias, including monitoring and catheter ablation, is scarce. Despite growing evidences, more research focused on the prognosis and optimal management of VHD-related arrhythmias is still required. We aimed to review the current evidence and identify gaps in knowledge about the prevalence, prognostic considerations, and treatment of atrial and ventricular arrhythmias in common subtypes of organic VHD.<\/jats:p>","DOI":"10.3389\/fcvm.2022.792559","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T06:15:33Z","timestamp":1644905733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Arrhythmias in Patients With Valvular Heart Disease: Gaps in Knowledge and the Way Forward"],"prefix":"10.3389","volume":"9","author":[{"given":"Maciej","family":"Kubala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"de Chillou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohann","family":"Bohbot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Lancellotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Enriquez-Sarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Tribouilloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary presentation and management of valvular heart disease: the EURObservational Research Programme Valvular Heart Disease II Survey","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s10554-011-9804-7","article-title":"Changing demographics of valvular heart disease and impact on surgical and transcatheter valve therapies","volume":"27","author":"Vahanian","year":"2011","journal-title":"Int J Cardiovasc Imaging."},{"key":"B3","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1161\/01.cir.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: the Framingham Heart Study","volume":"98","author":"Benjamin","year":"1998","journal-title":"Circulation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1093\/europace\/euz220","article-title":"Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis","volume":"21","author":"Banerjee","year":"2019","journal-title":"Europace."},{"key":"B5","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1161\/01.cir.25.6.947","article-title":"Electrocardiographic findings in 122,043 individuals","volume":"25","author":"Hiss","year":"1962","journal-title":"Circulation."},{"key":"B6","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jacc.2018.10.067","article-title":"Long-term implications of atrial fibrillation in patients with degenerative mitral regurgitation","volume":"73","author":"Grigioni","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/0002-8703(87)90958-6","article-title":"Arrhythmias and sudden death in mitral valve prolapse","volume":"113","author":"Kligfield","year":"1987","journal-title":"Am Heart J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/0735-1097(88)90164-7","article-title":"Long-term follow-up of idiopathic mitral valve prolapse in 300 patients: a prospective study","volume":"11","author":"Duren","year":"1988","journal-title":"J Am Coll Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1016\/s0735-1097(99)00474-x","article-title":"Sudden death in mitral regurgitation due to flail leaflet","volume":"34","author":"Grigioni","year":"1999","journal-title":"J Am Coll Cardiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.jacc.2011.01.049","article-title":"Sudden death in young adults: an autopsy-based series of a population undergoing active surveillance","volume":"58","author":"Eckart","year":"2011","journal-title":"J Am Coll Cardiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395.","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","author":"Vahanian","year":"2021","journal-title":"Eur Heart J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1161\/CIR.0000000000000923","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation."},{"key":"B13","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1378\/chest.113.2.482","article-title":"Ventricular arrhythmias in adult aortic stenosis: prevalence, mechanisms, and clinical relevance","volume":"113","author":"Sorgato","year":"1998","journal-title":"Chest."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e005030","DOI":"10.1161\/CIRCIMAGING.116.005030","article-title":"Morphofunctional abnormalities of mitral annulus and arrhythmic mitral valve prolapse","volume":"9","author":"Perazzolo Marra","year":"2016","journal-title":"Circ Cardiovasc Imaging."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e002989","DOI":"10.1161\/CIRCIMAGING.114.002989","article-title":"Dynamic phenotypes of degenerative myxomatous mitral valve disease: quantitative 3-dimensional echocardiographic study","volume":"8","author":"Clavel","year":"2015","journal-title":"Circ Cardiovasc Imaging."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1056\/NEJM199611073351902","article-title":"Clinical outcome of mitral regurgitation due to flail leaflet","volume":"335","author":"Ling","year":"1996","journal-title":"N Engl J Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/s0735-1097(02)01922-8","article-title":"Atrial fibrillation complicating the course of degenerative mitral regurgitation: determinants and long-term outcome","volume":"40","author":"Grigioni","year":"2002","journal-title":"J Am Coll Cardiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1161\/CIRCULATIONAHA.111.055905","article-title":"Late results of percutaneous mitral commissurotomy up to 20 years: development and validation of a risk score predicting late functional results from a series of 912 patients","volume":"125","author":"Bouleti","year":"2012","journal-title":"Circulation."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.amjcard.2015.08.018","article-title":"Determinants and prognosis of atrial fibrillation in patients with aortic stenosis","volume":"116","author":"Levy","year":"2015","journal-title":"Am J Cardiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1161\/CIRCULATIONAHA.114.011929","article-title":"Arrhythmia burden in elderly patients with severe aortic stenosis as determined by continuous electrocardiographic recording: toward a better understanding of arrhythmic events after transcatheter aortic valve replacement","volume":"131","author":"Urena","year":"2015","journal-title":"Circulation."},{"key":"B22","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1136\/heartjnl-2019-314996","article-title":"Atrial fibrillation is not an independent predictor of outcome in patients with aortic stenosis","volume":"106","author":"Zhang","year":"2020","journal-title":"Heart."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1093\/eurheartj\/ehw456","article-title":"Atrial fibrillation in patients undergoing transcatheter aortic valve implantation: epidemiology, timing, predictors, and outcome","volume":"38","author":"Tarantini","year":"2017","journal-title":"Eur Heart J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1161\/01.cir.99.14.1851","article-title":"Mortality and morbidity of aortic regurgitation in clinical practice. A long-term follow-up study","volume":"99","author":"Dujardin","year":"1999","journal-title":"Circulation."},{"key":"B25","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/s0735-1097(97)00205-2","article-title":"Optimizing timing of surgical correction in patients with severe aortic regurgitation: role of symptoms","volume":"30","author":"Klodas","year":"1997","journal-title":"J Am Coll Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1093\/eurheartj\/ehaa643","article-title":"Isolated tricuspid valve surgery: impact of aetiology and clinical presentation on outcomes","volume":"41","author":"Dreyfus","year":"2020","journal-title":"Eur Heart J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.echo.2017.09.010","article-title":"Clinical outcome of isolated tricuspid regurgitation in patients with preserved left ventricular ejection fraction and pulmonary hypertension","volume":"31","author":"Bar","year":"2018","journal-title":"J Am Soc Echocardiogr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1093\/eurheartj\/ehaa192","article-title":"Functional tricuspid regurgitation of degenerative mitral valve disease: a crucial determinant of survival","volume":"41","author":"Essayagh","year":"2020","journal-title":"Eur Heart J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.acvd.2019.06.011","article-title":"Characteristics and prognosis of patients with significant tricuspid regurgitation","volume":"112","author":"Bohbot","year":"2019","journal-title":"Arch Cardiovasc Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1093\/ehjci\/jez024","article-title":"Mid-term outcome of severe tricuspid regurgitation: are there any differences according to mechanism and severity?","volume":"20","author":"Santoro","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging."},{"key":"B31","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jcmg.2018.09.027","article-title":"Morphologic types of tricuspid regurgitation: characteristics and prognostic implications","volume":"12","author":"Prihadi","year":"2019","journal-title":"JACC Cardiovasc Imaging."},{"key":"B32","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/ehjci\/jez216","article-title":"Tricuspid regurgitation and long-term clinical outcomes","volume":"21","author":"Chorin","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging."},{"key":"B33","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.echo.2006.09.013","article-title":"Echocardiography-based spectrum of severe tricuspid regurgitation: the frequency of apparently idiopathic tricuspid regurgitation","volume":"20","author":"Mutlak","year":"2007","journal-title":"J Am Soc Echocardiogr."},{"key":"B34","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jcmg.2018.06.014","article-title":"Burden of tricuspid regurgitation in patients diagnosed in the community setting","volume":"12","author":"Topilsky","year":"2019","journal-title":"JACC Cardiovasc Imaging."},{"key":"B35","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ijcard.2011.09.064","article-title":"Prognostic importance of atrial fibrillation in asymptomatic aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis study","volume":"166","author":"Greve","year":"2013","journal-title":"Int J Cardiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1161\/01.cir.84.4.1625","article-title":"Serial long-term assessment of the natural history of asymptomatic patients with chronic aortic regurgitation and normal left ventricular systolic function","volume":"84","author":"Bonow","year":"1991","journal-title":"Circulation."},{"key":"B37","doi-asserted-by":"publisher","first-page":"885","DOI":"10.7326\/0003-4819-128-11-199806010-00001","article-title":"Predictors of systemic embolism in patients with mitral stenosis. A prospective study","volume":"128","author":"Chiang","year":"1998","journal-title":"Ann Intern Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.amjcard.2006.03.067","article-title":"Prognostic value of preoperative atrial fibrillation in patients with aortic stenosis and low ejection fraction having aortic valve replacement","volume":"98","author":"Levy","year":"2006","journal-title":"Am J Cardiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1016\/j.jcin.2019.06.019","article-title":"Impact of pre-existing and new-onset atrial fibrillation on outcomes after transcatheter aortic valve replacement","volume":"12","author":"Mentias","year":"2019","journal-title":"JACC Cardiovasc Interv."},{"key":"B40","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1161\/01.cir.99.3.400","article-title":"Impact of preoperative symptoms on survival after surgical correction of organic mitral regurgitation: rationale for optimizing surgical indications","volume":"99","author":"Tribouilloy","year":"1999","journal-title":"Circulation."},{"key":"B41","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.ijcard.2014.10.040","article-title":"Twenty year follow-up after successful percutaneous balloon mitral valvuloplasty in a large contemporary series of patients with mitral stenosis","volume":"177","author":"Tomai","year":"2014","journal-title":"Int J Cardiol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.11.055.","article-title":"Atrial fibrillation in severe aortic stenosis: prognostic value and results of aortic valve replacement","author":"Kubala","year":"2021","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1093\/eurheartj\/eht250","article-title":"Impact of ageing on presentation and outcome of mitral regurgitation due to flail leaflet: a multicentre international study","volume":"34","author":"Avierinos","year":"2013","journal-title":"Eur Heart J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1016\/s0735-1097(00)00982-7","article-title":"Incidence and predictors of atrial flutter in the general population","volume":"36","author":"Granada","year":"2000","journal-title":"J Am Coll Cardiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/s0735-1097(85)80497-6","article-title":"Atrial flutter in the young: a collaborative study of 380 cases","volume":"6","author":"Garson","year":"1985","journal-title":"J Am Coll Cardiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.hrthm.2016.12.002","article-title":"Postoperative atrial tachycardias after mitral valve surgery: Mechanisms and outcomes of catheter ablation","volume":"14","author":"Enriquez","year":"2017","journal-title":"Heart Rhythm."},{"key":"B47","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/jce.12059","article-title":"Macroreentrant atrial tachycardia in patients without previous atrial surgery or catheter ablation: clinical and electrophysiological characteristics of scar-related left atrial anterior wall reentry","volume":"24","author":"Fukamizu","year":"2013","journal-title":"J Cardiovasc Electrophysiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1093\/eurheartj\/eht194","article-title":"Human atrial fibrillation substrate: towards a specific fibrotic atrial cardiomyopathy","volume":"34","author":"Kottkamp","year":"2013","journal-title":"Eur Heart J."},{"key":"B49","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.CIR.92.7.1954","article-title":"Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats","volume":"92","author":"Wijffels","year":"1995","journal-title":"Circulation."},{"key":"B50","doi-asserted-by":"publisher","first-page":"6542028","DOI":"10.1155\/2020\/6542028","article-title":"Analysis of atrial fibrillation treatment regimes in a multicenter cohort of transcatheter edge-to-edge mitral valve repair patients","volume":"2020","author":"Waechter","year":"2020","journal-title":"J Interv Cardiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.amjcard.2015.02.027","article-title":"Usefulness of preoperative atrial fibrillation to predict outcome and left ventricular dysfunction after valve repair for mitral valve prolapse","volume":"115","author":"Szymanski","year":"2015","journal-title":"Am J Cardiol."},{"key":"B52","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0022-5223(12)70085-5","article-title":"Outcome of mitral valve repair in patients with preoperative atrial fibrillation. Should the maze procedure be combined with mitral valvuloplasty?","volume":"107","author":"Chua","year":"1994","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1161\/01.cir.96.6.1819","article-title":"Early surgery in patients with mitral regurgitation due to flail leaflets: a long-term outcome study","volume":"96","author":"Ling","year":"1997","journal-title":"Circulation."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1016\/j.athoracsur.2012.05.105","article-title":"Longitudinal outcome of isolated mitral repair in older patients: results from 14,604 procedures performed from 1991 to 2007","volume":"94","author":"Badhwar","year":"2012","journal-title":"Ann Thorac Surg."},{"key":"B55","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.jacc.2019.06.032","article-title":"Prognostic implications of left atrial enlargement in degenerative mitral regurgitation","volume":"74","author":"Essayagh","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1161\/CIRCIMAGING.110.961011","article-title":"Left atrial size is a potent predictor of mortality in mitral regurgitation due to flail leaflets: results from a large international multicenter study","volume":"4","author":"Rusinaru","year":"2011","journal-title":"Circ Cardiovasc Imaging."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e006475","DOI":"10.1161\/JAHA.117.006475","article-title":"Prevalence, characteristics, and outcomes of valvular heart disease in patients with atrial fibrillation: insights from the ORBIT-AF (Outcomes registry for better informed treatment for atrial fibrillation)","volume":"6","author":"Thomas","year":"2017","journal-title":"J Am Heart Assoc."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e009317","DOI":"10.1161\/CIRCIMAGING.119.009317","article-title":"Reverse remodeling of the mitral valve complex after radiofrequency catheter ablation for atrial fibrillation: a serial 3-dimensional echocardiographic study","volume":"12","author":"Nishino","year":"2019","journal-title":"Circ Cardiovasc Imaging."},{"key":"B59","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/jocs.16120","article-title":"Mechanism of improvement in atrial functional mitral regurgitation after catheter ablation for atrial fibrillation: three-dimensional analysis using multislice computed tomography","volume":"37","author":"Tsujisaka","year":"2021","journal-title":"J Card Surg."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.athoracsur.2016.10.076","article-title":"The society of thoracic surgeons 2017 clinical practice guidelines for the surgical treatment of atrial fibrillation","volume":"103","author":"Badhwar","year":"2017","journal-title":"Ann Thorac Surg."},{"key":"B62","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.athoracsur.2020.05.125","article-title":"Variability and utilization of concomitant atrial fibrillation ablation during mitral valve surgery","volume":"111","author":"Mehaffey","year":"2021","journal-title":"Ann Thorac Surg."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1056\/NEJMoa1500528","article-title":"Surgical ablation of atrial fibrillation during mitral-valve surgery","volume":"372","author":"Gillinov","year":"2015","journal-title":"N Engl J Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"I20","DOI":"10.1161\/CIRCULATIONAHA.104.526301","article-title":"Effectiveness of the maze procedure using cooled-tip radiofrequency ablation in patients with permanent atrial fibrillation and rheumatic mitral valve disease","volume":"112","author":"Abreu Filho","year":"2005","journal-title":"Circulation."},{"key":"B65","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1053\/euhj.2001.2841","article-title":"Efficacy of an additional MAZE procedure using cooled-tip radiofrequency ablation in patients with chronic atrial fibrillation and mitral valve disease. A randomized, prospective trial","volume":"23","author":"Deneke","year":"2002","journal-title":"Eur Heart J."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.jacc.2019.02.062","article-title":"Pacemaker implantation after mitral valve surgery with atrial fibrillation ablation","volume":"73","author":"DeRose","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1093\/ejcts\/ezz289","article-title":"Beneficial effect of left atrial appendage closure during cardiac surgery: a meta-analysis of 280 585 patients","volume":"57","author":"Martin Gutierrez","year":"2020","journal-title":"Eur J Cardiothorac Surg."},{"key":"B68","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10840-018-0458-4","article-title":"Left atrial appendage exclusion during mitral valve surgery and stroke in atrial fibrillation","volume":"53","author":"Abrich","year":"2018","journal-title":"J Interv Card Electrophysiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.jtcvs.2018.03.017","article-title":"Concomitant surgical closure of left atrial appendage: a systematic review and meta-analysis","volume":"156","author":"Ando","year":"2018","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B70","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.athoracsur.2013.07.073","article-title":"Left atrial appendage resection versus preservation during the surgical ablation of atrial fibrillation","volume":"97","author":"Lee","year":"2014","journal-title":"Ann Thorac Surg."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1161\/01.CIR.0000145121.25259.54","article-title":"Atrial fibrillation after surgical correction of mitral regurgitation in sinus rhythm: incidence, outcome, and determinants","volume":"110","author":"Kernis","year":"2004","journal-title":"Circulation."},{"key":"B72","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/jce.12433","article-title":"Catheter ablation of atrial fibrillation in patients with mechanical mitral valve: long-term outcome of single procedure of pulmonary vein antrum isolation with or without nonpulmonary vein trigger ablation","volume":"25","author":"Bai","year":"2014","journal-title":"J Cardiovasc Electrophysiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"569","DOI":"10.5603\/CJ.a2014.0016","article-title":"Incidence, predictors, and evolution of conduction disorders and atrial arrhythmias after contemporary mitral valve repair","volume":"21","author":"Viles-Gonzalez","year":"2014","journal-title":"Cardiol J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1111\/jocs.14745","article-title":"Prevalence of intra-atrial reentrant tachycardia following mitral valve surgery: relationship to surgical approach","volume":"35","author":"Gandhavadi","year":"2020","journal-title":"J Card Surg."},{"key":"B75","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/jce.12406","article-title":"Atrial arrhythmias following surgical AF ablation: electrophysiological findings, ablation strategies, and clinical outcome","volume":"25","author":"Huo","year":"2014","journal-title":"J Cardiovasc Electrophysiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1056\/NEJM198511213132101","article-title":"Echocardiographically documented mitral-valve prolapse. Long-term follow-up of 237 patients","volume":"313","author":"Nishimura","year":"1985","journal-title":"N Engl J Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/0002-8703(83)90706-8","article-title":"Mitral valve prolapse in the general population","volume":"106","author":"Savage","year":"1983","journal-title":"Am Heart J."},{"key":"B78","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jacc.2013.02.060","article-title":"Malignant bileaflet mitral valve prolapse syndrome in patients with otherwise idiopathic out-of-hospital cardiac arrest","volume":"62","author":"Sriram","year":"2013","journal-title":"J Am Coll Cardiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1161\/CIRCULATIONAHA.115.016291","article-title":"Arrhythmic mitral valve prolapse and sudden cardiac death","volume":"132","author":"Basso","year":"2015","journal-title":"Circulation."},{"key":"B80","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.jacc.2020.06.029","article-title":"Presentation and outcome of arrhythmic mitral valve prolapse","volume":"76","author":"Essayagh","year":"2020","journal-title":"J Am Coll Cardiol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1161\/CIRCULATIONAHA.118.033488","article-title":"Common phenotype in patients with mitral valve prolapse who experienced sudden cardiac death","volume":"138","author":"Hourdain","year":"2018","journal-title":"Circulation."},{"key":"B82","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/j.jcmg.2021.04.029","article-title":"The mitral annular disjunction of mitral valve prolapse","volume":"14","author":"Essayagh","year":"2021","journal-title":"JACC Cardiovasc Imaging."},{"key":"B83","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000347085","article-title":"Nonischemic mitral regurgitation: prognostic value of nonsustained ventricular tachycardia after mitral valve surgery","volume":"124","author":"Olafiranye","year":"2013","journal-title":"Cardiology."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J."},{"key":"B85","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1161\/01.cir.96.2.500","article-title":"Patients with valvular heart disease presenting with sustained ventricular tachyarrhythmias or syncope: results of programmed ventricular stimulation and long-term follow-up","volume":"96","author":"Martinez-Rubio","year":"1997","journal-title":"Circulation."},{"key":"B86","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.echo.2020.01.016","article-title":"Mitral valve prolapse patients with less than moderate mitral regurgitation exhibit early cardiac chamber remodeling","volume":"33","author":"Yang","year":"2020","journal-title":"J Am Soc Echocardiogr."},{"key":"B87","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/pace.13613","article-title":"Management and outcomes in mitral valve prolapse with ventricular arrhythmias undergoing ablation and\/or implantation of ICDs","volume":"42","author":"Bumgarner","year":"2019","journal-title":"Pacing Clin Electrophysiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/pace.13363","article-title":"Catheter ablation of papillary muscle arrhythmias: Implications of mitral valve prolapse and systolic dysfunction","volume":"41","author":"Lee","year":"2018","journal-title":"Pacing Clin Electrophysiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1111\/jce.13900","article-title":"Papillary muscle ventricular arrhythmias in patients with arrhythmic mitral valve prolapse: electrophysiologic substrate and catheter ablation outcomes","volume":"30","author":"Enriquez","year":"2019","journal-title":"J Cardiovasc Electrophysiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1111\/jce.13716","article-title":"Percutaneous cryoablation for papillary muscle ventricular arrhythmias after failed radiofrequency catheter ablation","volume":"29","author":"Gordon","year":"2018","journal-title":"J Cardiovasc Electrophysiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"e004005","DOI":"10.1161\/CIRCEP.116.004005","article-title":"Sites of successful ventricular fibrillation ablation in bileaflet mitral valve prolapse syndrome","volume":"9","author":"Syed","year":"2016","journal-title":"Circ Arrhythm Electrophysiol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.jacc.2017.10.053","article-title":"2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"72","author":"Al-Khatib","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.jacc.2014.02.537","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Nishimura","year":"2014","journal-title":"J Am Coll Cardiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s00059-012-3672-3","article-title":"The acute effect of percutaneous mitral balloon valvuloplasty on atrial electromechanical delay and P-wave dispersion in patients with mitral stenosis","volume":"38","author":"Demirkan","year":"2013","journal-title":"Herz."},{"key":"B95","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10840-019-00538-7","article-title":"Long-term outcomes of radiofrequency catheter ablation for atrial fibrillation in rheumatic heart disease patients with mild mitral stenosis","volume":"56","author":"Chen","year":"2019","journal-title":"J Interv Card Electrophysiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1056\/NEJMoa2029603","article-title":"Rivaroxaban in patients with atrial fibrillation and a bioprosthetic mitral valve","volume":"383","author":"Guimaraes","year":"2020","journal-title":"N Engl J Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1161\/STROKEAHA.114.005296","article-title":"Stroke in patients with aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis study","volume":"45","author":"Greve","year":"2014","journal-title":"Stroke."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.11.012.","article-title":"Refining risk stratification in severe aortic stenosis with left atrial volume and atrial fibrillation","author":"Kubala","year":"2022","journal-title":"J Am Coll Cardiovasc Imag."},{"key":"B99","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1016\/j.jcin.2020.05.049","article-title":"Valvular and nonvalvular atrial fibrillation in patients undergoing transcatheter aortic valve replacement","volume":"13","author":"Okuno","year":"2020","journal-title":"JACC Cardiovasc Interv."},{"key":"B100","doi-asserted-by":"publisher","first-page":"e006557","DOI":"10.1161\/CIRCIMAGING.117.006557","article-title":"Metoprolol reduces hemodynamic and metabolic overload in asymptomatic aortic valve stenosis patients: a randomized trial","volume":"10","author":"Hansson","year":"2017","journal-title":"Circ Cardiovasc Imaging."},{"key":"B101","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.hrcr.2016.09.006","article-title":"Bicuspid aortic valve supporting supravalvular \u201csubstrate\u201d for multiple ventricular tachycardias","volume":"3","author":"Kumar","year":"2017","journal-title":"HeartRhythm Case Rep."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/s0735-1097(01)01127-5","article-title":"Ventricular tachycardias arising from the aortic sinus of valsalva: an under-recognized variant of left outflow tract ventricular tachycardia","volume":"37","author":"Kanagaratnam","year":"2001","journal-title":"J Am Coll Cardiol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/europace\/euu362","article-title":"Ventricular arrhythmias in aortic valve stenosis before and after transcatheter aortic valve implantation","volume":"17","author":"Tempio","year":"2015","journal-title":"Europace."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.jcin.2020.03.031","article-title":"Prolonged continuous electrocardiographic monitoring prior to transcatheter aortic valve replacement: the PARE Study","volume":"13","author":"Asmarats","year":"2020","journal-title":"JACC Cardiovasc Interv."},{"key":"B105","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.hrcr.2016.12.005","article-title":"Bundle branch reentrant ventricular tachycardia after transcatheter aortic valve replacement","volume":"3","author":"Singh","year":"2017","journal-title":"HeartRhythm Case Rep."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1161\/CIRCULATIONAHA.107.703157","article-title":"Sustained ventricular tachycardia associated with corrective valve surgery","volume":"116","author":"Eckart","year":"2007","journal-title":"Circulation."},{"key":"B107","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/joa3.12502","article-title":"Incidence of outflow tract ventricular tachycardia long after surgical aortic valve replacement","volume":"37","author":"Goto","year":"2021","journal-title":"J Arrhythm."},{"key":"B108","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0167-5273(92)90081-d","article-title":"Ventricular arrhythmias in aortic valve disease: a further marker of impaired left ventricular function","volume":"34","author":"Martinez-Useros","year":"1992","journal-title":"Int J Cardiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1161\/CIRCULATIONAHA.104.495903","article-title":"Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up","volume":"111","author":"Pellikka","year":"2005","journal-title":"Circulation."},{"key":"B110","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00392-006-0343-5","article-title":"Bundle branch reentrant tachycardia in a patient with a calcified bicuspid aortic valve and normal ventricular function","volume":"95","author":"Fuller","year":"2006","journal-title":"Clin Res Cardiol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/s0735-1097(98)00187-9","article-title":"A population-based prospective evaluation of risk of sudden cardiac death after operation for common congenital heart defects","volume":"32","author":"Silka","year":"1998","journal-title":"J Am Coll Cardiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e010735","DOI":"10.1161\/JAHA.118.010735","article-title":"Exercise treadmill testing in moderate or severe aortic stenosis: the left ventricular correlates of an exaggerated blood pressure rise","volume":"7","author":"Saeed","year":"2018","journal-title":"J Am Heart Assoc."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","article-title":"2018 ESC guidelines for the diagnosis and management of syncope","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1056\/NEJMra000650","article-title":"Sudden death due to cardiac arrhythmias","volume":"345","author":"Huikuri","year":"2001","journal-title":"N Engl J Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1111\/j.1540-8167.2012.02394.x","article-title":"Implantable cardioverter defibrillators in patients with valvular cardiomyopathy","volume":"23","author":"Valles","year":"2012","journal-title":"J Cardiovasc Electrophysiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ijcard.2008.12.144","article-title":"Therapy success and survival in patients with valvular heart disease and implantable cardioverter defibrillator","volume":"144","author":"Rosenheck","year":"2010","journal-title":"Int J Cardiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1093\/eurheartj\/ehp226","article-title":"Effectiveness of cardiac resynchronization therapy in heart failure patients with valvular heart disease: comparison with patients affected by ischaemic heart disease or dilated cardiomyopathy. The InSync\/InSync ICD Italian Registry","volume":"30","author":"Boriani","year":"2009","journal-title":"Eur Heart J."},{"key":"B118","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jacep.2018.08.008","article-title":"Electrophysiologic substrate, safety, procedural approaches, and outcomes of catheter ablation for ventricular tachycardia in patients after aortic valve replacement","volume":"5","author":"Liang","year":"2019","journal-title":"JACC Clin Electrophysiol."},{"key":"B119","first-page":"145","article-title":"Ventricular arrhythmias in aortic valve disease before and after aortic valve replacement","volume":"47","author":"Michel","year":"1992","journal-title":"Acta Cardiol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1161\/01.cir.97.6.525","article-title":"Prediction of indications for valve replacement among asymptomatic or minimally symptomatic patients with chronic aortic regurgitation and normal left ventricular performance","volume":"97","author":"Borer","year":"1998","journal-title":"Circulation."},{"key":"B121","doi-asserted-by":"publisher","first-page":"e004897","DOI":"10.1161\/CIRCIMAGING.116.004897","article-title":"Functional tricuspid regurgitation caused by chronic atrial fibrillation: a real-time 3-dimensional transesophageal echocardiography study","volume":"10","author":"Utsunomiya","year":"2017","journal-title":"Circ Cardiovasc Imaging."},{"key":"B122","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4250\/jcu.2015.23.3.136","article-title":"Clinical and echocardiographic factors affecting tricuspid regurgitation severity in the patients with lone atrial fibrillation","volume":"23","author":"Park","year":"2015","journal-title":"J Cardiovasc Ultrasound."},{"key":"B123","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1161\/CIRCIMAGING.111.967919","article-title":"Clinical context and mechanism of functional tricuspid regurgitation in patients with and without pulmonary hypertension","volume":"5","author":"Topilsky","year":"2012","journal-title":"Circ Cardiovasc Imaging."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.jcmg.2014.07.018","article-title":"Clinical outcome of isolated tricuspid regurgitation","volume":"7","author":"Topilsky","year":"2014","journal-title":"JACC Cardiovasc Imaging."},{"key":"B125","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.echo.2020.08.018","article-title":"Natural course of nonsevere secondary tricuspid regurgitation","volume":"34","author":"Spinka","year":"2021","journal-title":"J Am Soc Echocardiogr."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/ejhf.1547","article-title":"Aetiology-based clinical scenarios predict outcomes of transcatheter edge-to-edge tricuspid valve repair of functional tricuspid regurgitation","volume":"21","author":"Schlotter","year":"2019","journal-title":"Eur J Heart Fail."},{"key":"B127","doi-asserted-by":"publisher","first-page":"e007663","DOI":"10.1161\/CIRCEP.119.007663","article-title":"Arrhythmia mechanisms and outcomes of ablation in pediatric patients with congenital heart disease","volume":"12","author":"Houck","year":"2019","journal-title":"Circ Arrhythm Electrophysiol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.jcmg.2018.10.036","article-title":"Tricuspid valve imaging and intervention in pediatric and adult patients with congenital heart disease","volume":"12","author":"Qureshi","year":"2019","journal-title":"JACC Cardiovasc Imaging."},{"key":"B129","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1093\/ehjci\/jet105","article-title":"Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging","volume":"14","author":"Lancellotti","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging."},{"key":"B130","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J Am Soc Echocardiogr."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ejechocard\/jen303","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"10","author":"Baumgartner","year":"2009","journal-title":"Eur J Echocardiogr."},{"key":"B132","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/s0002-9149(98)00498-6","article-title":"Analysis of risk factors for development of atrial fibrillation early after cardiac valvular surgery","volume":"82","author":"Asher","year":"1998","journal-title":"Am J Cardiol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/europace\/eur208","article-title":"Post-operative atrial fibrillation: a maze of mechanisms","volume":"14","author":"Maesen","year":"2012","journal-title":"Europace."},{"key":"B134","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1016\/j.athoracsur.2011.06.079","article-title":"New-onset postoperative atrial fibrillation predicts late mortality after mitral valve surgery","volume":"92","author":"Bramer","year":"2011","journal-title":"Ann Thorac Surg."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1093\/eurheartj\/ehl272","article-title":"Interventions for prevention of post-operative atrial fibrillation and its complications after cardiac surgery: a meta-analysis","volume":"27","author":"Burgess","year":"2006","journal-title":"Eur Heart J."},{"key":"B136","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1093\/eurheartj\/ehq319","article-title":"COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial","volume":"31","author":"Imazio","year":"2010","journal-title":"Eur Heart J."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1056\/NEJMoa1915152","article-title":"Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation","volume":"382","author":"Nijenhuis","year":"2020","journal-title":"N Engl J Med."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.792559\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T06:15:41Z","timestamp":1644905741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.792559\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":137,"alternative-id":["10.3389\/fcvm.2022.792559"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.792559","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,15]]},"article-number":"792559"}}