{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:02:09Z","timestamp":1774476129795,"version":"3.50.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"Preoperative peak oxygen uptake (V<\/mml:mtext>.<\/mml:mo><\/mml:mover><\/mml:math><\/jats:inline-formula>O2peak<\/jats:italic><\/jats:sub>) and ventilatory efficiency (V<\/mml:mtext>.<\/mml:mo><\/mml:mover><\/mml:math><\/jats:inline-formula>E<\/jats:italic><\/jats:sub>\/V<\/mml:mtext>.<\/mml:mo><\/mml:mover><\/mml:math><\/jats:inline-formula>CO2<\/jats:sub>slope) are related to the vital prognosis after cardiac transplantation (HTx). The objective of our study was to evaluate the effects of exercise-based cardiac rehabilitation (ECR) program on the preoperative exercise capacity of a HTx candidate. A male patient, aged 50\u201355 years, with chronic heart failure was placed on the HTx list and performed 12 weeks of intensive ECR (5 sessions-a-week). Our results showed that the cardiac index continuously increased between the onset and the end of ECR (1.40 vs. 2.53 L.min\u20131<\/jats:sup>.m2<\/jats:sup>). The first 20 sessions of ECR induced a V<\/mml:mtext>.<\/mml:mo><\/mml:mover><\/mml:math><\/jats:inline-formula>O2peak<\/jats:italic><\/jats:sub> increase (15.0 vs. 19.3 ml.min\u20131<\/jats:sup>.kg\u20131<\/jats:sup>, corresponding to 42.0 and 53.0% of its maximal predicted values, respectively). The peak V<\/mml:mtext>.<\/mml:mo><\/mml:mover><\/mml:math><\/jats:inline-formula>O2<\/jats:sub> plateaued between the 20th and the 40th ECR session (19.3 vs. 19.4 ml.min\u20131<\/jats:sup>.kg\u20131<\/jats:sup>) then progressively increased until the 60th ECR session to reach 25.7 ml.min\u20131<\/jats:sup>.kg\u20131<\/jats:sup>, i.e., 71.0% of the maximal predicted values. The slope of V<\/mml:mtext>.<\/mml:mo><\/mml:mover><\/mml:math><\/jats:inline-formula>E<\/jats:sub>\/V<\/mml:mtext>.<\/mml:mo><\/mml:mover><\/mml:math><\/jats:inline-formula>CO2<\/jats:sub> showed a biphasic response during the ECR program, with an increase between the onset and the 20th ECR session (58.02 vs. 70.48) and a decrease between the 20th and the 40th ECR session (70.48 vs. 40.94) to reach its minimal value at the 60th ECR session (31.97). After the first 40 sessions of the ECR program, the Seattle Heart Failure Model score predicted median survival time was estimated at 7.2 years. In conclusion, the improvement in exercise capacity and cardiorespiratory function following the ECR helped delay the heart transplant surgery in our patient awaiting heart transplantation.<\/jats:p>","DOI":"10.3389\/fcvm.2022.811458","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T05:06:26Z","timestamp":1652936786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Benefits of a Supervised Ambulatory Outpatient Program in a Cardiovascular Rehabilitation Unit Prior to a Heart Transplant: A Case Study"],"prefix":"10.3389","volume":"9","author":[{"given":"Antoine","family":"Poty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Krim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Garaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Marie","family":"Lepr\u00eatre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3978\/j.issn.2072-1439.2014.06.44","article-title":"Adult heart transplant: indications and outcomes.","volume":"6","author":"Alraies","year":"2014","journal-title":"J Thorac Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.healun.2019.08.004","article-title":"The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult heart transplantation report \u2014 2019; focus theme: donor and recipient size match.","volume":"38","author":"Khush","year":"2019","journal-title":"J Heart Lung Transplant."},{"key":"B3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1161\/01.CIR.62.1.55","article-title":"Cardiorespiratory responses of cardiac transplant patients to graded, symptom-limited exercise.","volume":"62","author":"Savin","year":"1980","journal-title":"Circulation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S1053-2498(02)00475-8","article-title":"Clinical predictors of exercise capacity 1 year after cardiac transplantation.","volume":"22","author":"Leung","year":"2003","journal-title":"J. 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