{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:21:28Z","timestamp":1788405688948,"version":"build-2803163510"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The thioflavin T derivative, <jats:sup>11<\/jats:sup>C-Pittsburgh-B (PIB), is used for Alzheimer's disease imaging because it specifically binds to \u03b2-amyloid protein deposits in the brain. The aim of this study was to estimate the diagnostic value of combined <jats:sup>11<\/jats:sup>C-PIB positron emission tomography\/magnetic resonance (PET\/MR) in cardiac amyloidosis (CA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 23 heart failure patients with suspected CA based on echocardiographic and electrocardiograph findings. All patients underwent cardiac <jats:sup>11<\/jats:sup>C-PIB PET\/MR and non-cardiac biopsy within one week. We also enrolled eight healthy volunteers that underwent cardiac <jats:sup>11<\/jats:sup>C-PIB PET\/MR as a control group. The cardiac magnetic resonance (CMR) protocol included cine imaging, late gadolinium enhancement (LGE), and native and post-contrast T1 mapping. Extracellular volume (ECV) was measured using pre- and post-contrast T1 mapping images. LVEF, IVSD, LVPW, LVmass, LVESV, LVEDV, native T1 value, ECV, and maximum uptake of myocardial tissue-to-blood background ratio (TBR) values were obtained from PET\/MR images in all patients and healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen out of twenty-three heart failure patients were clinically diagnosed with CA. The remaining 10 patients were CA-negative (non-CA patient group). Twelve of the thirteen CA patients showed diffuse transmural LGE patterns, whereas LGE was either absent or patchy in the non-CA patients. The diagnostic sensitivity and specificity of TBRmax were 92.3 and 100%, respectively, at a cut-off value of 1.09. Several CMR imaging parameters (LVEF, IVSD, LVmass, LVEDV, LVESV, LVPW, native T1 value and ECV) and TBR showed significant differences between CA patients, non-CA patients, and healthy controls (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Native T1 mapping values positively correlated with TBRmax values in CA and non-CA patients (<jats:italic>r<\/jats:italic> = 0.38, <jats:italic>P<\/jats:italic> = 0.0004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:sup>11<\/jats:sup>C-PIB PET\/MRI is a valuable tool for the accurate and non-invasive diagnosis of CA because it distinguishes CA patients from non-CA patients and healthy subjects with high specificity and sensitivity. Moreover, native T1 mapping values positively correlated with TBRmax values in CA and non-CA patients. In the future, larger cohort studies are necessary to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.830572","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T08:03:06Z","timestamp":1647417786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Diagnostic Value of 11C-PIB PET\/MR in Cardiac 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