{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:06:18Z","timestamp":1787742378523,"version":"build-2784847793"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We compared the efficacy of single phase-computed tomography pulmonary angiography (SP-CTPA) and dual phase-computed tomography pulmonary angiography (DP-CTPA) for the diagnosis of pulmonary embolism (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 1,019 consecutive patients (359 with PE) who underwent DP-CTPA (phase I: pulmonary artery phase; phase II: aortic phase) for suspected PE between January and October 2021. Phase I of DP-CTPA was used as SP-CTPA, and the final clinical diagnosis (FCD) was used as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred fifty-two cases of PE were detected by both methods, with the same sensitivity of 98.1% (99.6\u201399.5%). Using SP-CTPA, 142 cases [13 pulmonary insufficiency artifacts (PIA) and 129 systemic-pulmonary shunt artifacts (S-PSA)] were false-positive with specificity of 78.5% (75.3\u201381.6%). No false-positive was found with DP-CTPA, with specificity of 100%, positive predictive value of 1, and negative predictive value of 0.990 (Net Reclassification Improvement = 0.215; <jats:italic>P<\/jats:italic> &amp;lt; 0.05). According to FCD, the positive results of SP-CTPA were divided into PIA, S-PSA, and true-positive (TP<jats:sub>SP\u2212CTPA<\/jats:sub>) groups, and pairwise comparisons were performed. The bronchiectasis and hemoptysis rate in S-PSA group was higher than that in PIA and TP groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.001), and the pulmonary hypertension (PH) rate in PIA group was higher than that in S-PSA and TP groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnostic efficiency of DP-CTPA for the diagnosis of PE was high. SP-CTPA may misdiagnose PIA (common in patients with PH) and S-PSA (common in patients with bronchiectasis and hemoptysis) as PE.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.846805","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T08:57:22Z","timestamp":1645779442000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparative Study of Diagnostic Efficacy of Single Phase-Computed Tomography Pulmonary Angiography and Dual Phase-Computed Tomography Pulmonary Angiography in the Diagnosis of Pulmonary Embolism"],"prefix":"10.3389","volume":"9","author":[{"given":"Xuechun","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01647-2019","article-title":"2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS): the task force for the diagnosis and management of acute pulmonary embolism of the European society of cardiology (ESC)","volume":"54","author":"Konstantinides","year":"2019","journal-title":"Eur Resp J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/bmb\/ldw006","article-title":"Contemporary management of acute and chronic deep venous thrombosis","volume":"117","author":"Saha","year":"2016","journal-title":"Br Med Bull."},{"key":"B3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1053\/j.tvir.2017.07.002","article-title":"Pathophysiology, stratification, and natural history of pulmonary embolism","volume":"20","author":"Giordano","year":"2017","journal-title":"Tech Vasc Interv Radiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"Cd010222","DOI":"10.1002\/14651858.CD010222.pub4","article-title":"Anticoagulant treatment for subsegmental pulmonary embolism","volume":"2","author":"Yoo","year":"2020","journal-title":"Cochrane Database Syst Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.115.306841","article-title":"Global burden of thrombosis: epidemiologic aspects","volume":"118","author":"Wendelboe","year":"2016","journal-title":"Circ Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1093\/eurheartj\/ehz236","article-title":"Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany","volume":"41","author":"Keller","year":"2020","journal-title":"Eur Heart J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1378\/chest.13-0308","article-title":"Correlation between early direct communication of positive CT pulmonary angiography findings and improved clinical outcomes","volume":"144","author":"Kumamaru","year":"2013","journal-title":"Chest."},{"key":"B8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/imj.14145","article-title":"Acute pulmonary embolism: a concise review of diagnosis and management","volume":"49","author":"Hepburn-Brown","year":"2019","journal-title":"Intern Med J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1007\/s00330-015-3679-2","article-title":"Computed tomography of acute pulmonary embolism: state-of-the-art","volume":"25","author":"Zhang","year":"2015","journal-title":"Eur Radiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1016\/S0140-6736(16)30514-1","article-title":"Deep vein thrombosis and pulmonary embolism","volume":"388","author":"Di Nisio","year":"2016","journal-title":"Lancet."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190995","article-title":"Minimizing contrast media dose in CT pulmonary angiography with high-pitch technique","volume":"93","author":"Alobeidi","year":"2020","journal-title":"Br J Radiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"20160021","DOI":"10.1259\/bjrcr.20160021","article-title":"Clot or not? 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