{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:28:58Z","timestamp":1792459738299,"version":"4.5.0"},"reference-count":345,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Prolonged critical care stays commonly follow trauma, severe burn injury, sepsis, ARDS, and complications of major surgery. Although patients leave critical care following homeostatic recovery, significant additional diseases affect these patients during and beyond the convalescent phase. New cardiovascular and renal disease is commonly seen and roughly one third of all deaths in the year following discharge from critical care may come from this cluster of diseases. During prolonged critical care stays, the immunometabolic, inflammatory and neurohumoral response to severe illness in conjunction with resuscitative treatments primes the immune system and parenchymal tissues to develop a long-lived pro-inflammatory and immunosenescent state. This state is perpetuated by persistent Toll-like receptor signaling, free radical mediated isolevuglandin protein adduct formation and presentation by antigen presenting cells, abnormal circulating HDL and LDL isoforms, redox and metabolite mediated epigenetic reprogramming of the innate immune arm (trained immunity), and the development of immunosenescence through T-cell exhaustion\/anergy through epigenetic modification of the T-cell genome. Under this state, tissue remodeling in the vascular, cardiac, and renal parenchymal beds occurs through the activation of pro-fibrotic cellular signaling pathways, causing vascular dysfunction and atherosclerosis, adverse cardiac remodeling and dysfunction, and proteinuria and accelerated chronic kidney disease.<\/jats:p>","DOI":"10.3389\/fcvm.2022.854421","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T06:05:25Z","timestamp":1657865125000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Mechanisms of Post-critical Illness Cardiovascular Disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Andrew","family":"Owen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimin M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor N.","family":"Bangash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0140-6736(10)60446-1","article-title":"Critical care and the global burden of critical illness in adults","volume":"376","author":"Adhikari","year":"2010","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1164\/rccm.201012-2042ED","article-title":"The functional costs of ICU survivorship","volume":"183","author":"Needham","year":"2011","journal-title":"Am J Respir Crit Care Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1097\/CCM.0000000000004586","article-title":"Society of critical care medicine's international consensus conference on prediction and identification of long-term impairments after critical illness","volume":"48","author":"Mikkelsen","year":"2020","journal-title":"Crit Care Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1177\/1751143715609954","article-title":"on behalf of the JLA Intensive Care Research Priority Setting Partnership. Research priorities by professional background - a detailed analysis of the james lind alliance priority setting partnership","volume":"17","author":"Arulkumaran","year":"2016","journal-title":"J Intensive Care Soc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1001\/jama.2010.216","article-title":"Three-year outcomes for medicare beneficiaries who survive intensive care","volume":"303","author":"Wunsch","year":"2010","journal-title":"JAMA."},{"key":"B6","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s00134-013-3186-3","article-title":"One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome","volume":"40","author":"Wang","year":"2014","journal-title":"Intensive Care Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s13054-015-0986-6","article-title":"One-year survival and resource use after critical illness: impact of organ failure and residual organ dysfunction in a cohort study in Brazil","volume":"19","author":"Ranzani","year":"2015","journal-title":"Crit Care."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1164\/rccm.200712-1777OC","article-title":"Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis","volume":"177","author":"Yende","year":"2008","journal-title":"Am J Respir Crit Care Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1136\/thoraxjnl-2017-210109","article-title":"Late mortality after acute hypoxic respiratory failure","volume":"73","author":"Prescott","year":"2017","journal-title":"Thorax."},{"key":"B10","doi-asserted-by":"publisher","first-page":"i2375","DOI":"10.1136\/bmj.i2375","article-title":"Late mortality after sepsis: propensity matched cohort study","volume":"353","author":"Prescott","year":"2016","journal-title":"BMJ."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e194900","DOI":"10.1001\/jamanetworkopen.2019.4900","article-title":"Risk factors at index hospitalization associated with longer-term mortality in adult sepsis survivors","volume":"2","author":"Shankar-Hari","year":"2019","journal-title":"JAMA Netw Open."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/S2213-2600(20)30457-4","article-title":"COVID-19 recovery: potential treatments for post-intensive care syndrome","volume":"8","author":"Bangash","year":"2020","journal-title":"Lancet Respir Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"R154","DOI":"10.1186\/cc5086","article-title":"Causes of death and determinants of outcome in critically ill patients","volume":"10","author":"Mayr","year":"2006","journal-title":"Crit Care."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e2134290","DOI":"10.1001\/jamanetworkopen.2021.34290","article-title":"Epidemiology and costs of postsepsis morbidity, nursing care dependency, and mortality in Germany, 2013 to 2017","volume":"4","author":"Fleischmann-Struzek","year":"2021","journal-title":"JAMA Netw Open."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1161\/CIRCULATIONAHA.115.016950","article-title":"Retrospective analysis of long-term outcomes after combat injury: a hidden cost of war","volume":"132","author":"Stewart","year":"2015","journal-title":"Circulation."},{"key":"B16","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.burns.2015.08.020","article-title":"Understanding the long-term impacts of burn on the cardiovascular system","volume":"42","author":"Duke","year":"2016","journal-title":"Burns."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/j.burns.2016.06.005","article-title":"Increased admissions for diabetes mellitus after burn","volume":"42","author":"Duke","year":"2016","journal-title":"Burns."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e0159944","DOI":"10.1371\/journal.pone.0159944","article-title":"Trends in one-year outcomes of dialysis-requiring acute kidney injury in Denmark 2005-2012: a population-based nationwide study","volume":"11","author":"Carlson","year":"2016","journal-title":"PLoS ONE."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1001601","DOI":"10.1371\/journal.pmed.1001601","article-title":"Long-term survival and dialysis dependency following acute kidney injury in intensive care: extended follow-up of a randomized controlled trial","volume":"11","author":"Gallagher","year":"2014","journal-title":"PLoS Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1164\/rccm.201307-1321OC","article-title":"Risk of cardiovascular events in survivors of severe sepsis","volume":"189","author":"Yende","year":"2014","journal-title":"Am J Respir Crit Care Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1001\/jama.2014.18229","article-title":"Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease","volume":"313","author":"Corrales-Medina","year":"2015","journal-title":"JAMA."},{"key":"B22","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1056\/NEJMoa1702090","article-title":"Acute myocardial infarction after laboratory-confirmed influenza infection","volume":"378","author":"Kwong","year":"2018","journal-title":"N Engl J Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/cid\/cix248","article-title":"Risk of acute coronary heart disease after sepsis hospitalization in the reasons for geographic and racial differences in stroke (REGARDS) cohort","volume":"65","author":"Wang","year":"2017","journal-title":"Clin Infect Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00134-021-06479-y","article-title":"Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis","volume":"47","author":"Kosyakovsky","year":"2021","journal-title":"Intensive Care Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1177\/2047487317724009","article-title":"Severe infections and subsequent delayed cardiovascular disease","volume":"24","author":"Bergh","year":"2017","journal-title":"Eur J Prev Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1053\/j.ajkd.2011.10.048","article-title":"Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study","volume":"59","author":"Mammen","year":"2012","journal-title":"Am J Kidney Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1056\/NEJMoa1700993","article-title":"History of childhood kidney disease and risk of adult end-stage renal disease","volume":"378","author":"Calderon-Margalit","year":"2018","journal-title":"N Engl J Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S2352-4642(17)30122-0","article-title":"Long-term effect of critical illness after severe paediatric burn injury on cardiac function in adolescent survivors: an observational study","volume":"1","author":"Hundeshagen","year":"2017","journal-title":"Lancet Child Adolesc Health."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e1323","DOI":"10.1542\/peds.2015-1945","article-title":"Long-term effects of pediatric burns on the circulatory system","volume":"136","author":"Duke","year":"2015","journal-title":"Pediatrics."},{"key":"B31","doi-asserted-by":"publisher","first-page":"j2099","DOI":"10.1136\/bmj.j2099","article-title":"Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study","volume":"357","author":"Hippisley-Cox","year":"2017","journal-title":"BMJ."},{"key":"B32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/ejhf.32","article-title":"Predicting survival in heart failure: validation of the MAGGIC heart failure risk score in 51,043 patients from the Swedish heart failure registry","volume":"16","author":"Sartipy","year":"2014","journal-title":"Eur J Heart Fail."},{"key":"B33","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1161\/HYPERTENSIONAHA.109.132373","article-title":"Validating the framingham hypertension risk score: results from the whitehall II study","volume":"54","author":"Kivimaki","year":"2009","journal-title":"Hypertension."},{"key":"B34","doi-asserted-by":"publisher","first-page":"f2573","DOI":"10.1136\/bmj.f2573","article-title":"Derivation and validation of QStroke score for predicting risk of ischaemic stroke in primary care and comparison with other risk scores: a prospective open cohort study","volume":"346","author":"Hippisley-Cox","year":"2013","journal-title":"BMJ."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1681\/ASN.2013070750","article-title":"Mid-adulthood risk factor profiles for CKD","volume":"25","author":"McMahon","year":"2014","journal-title":"J Am Soc Nephrol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1126\/science.106.2748.190","article-title":"Atherosclerosis and alimentary hyperlipemia","volume":"106","author":"Moreton","year":"1947","journal-title":"Science."},{"key":"B37","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1161\/HYPERTENSIONAHA.111.177766","article-title":"Historical trends and milestones in hypertension research: a model of the process of translational research","volume":"58","author":"Kotchen","year":"2011","journal-title":"Hypertension."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1056\/NEJMe0807235","article-title":"Elevated C-reactive protein in atherosclerosis\u2013chicken or egg?","volume":"359","author":"Schunkert","year":"2008","journal-title":"N Engl J Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2013an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13075-017-1439-1","article-title":"Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis","volume":"19","author":"Deyab","year":"2017","journal-title":"Arthritis Res Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1161\/HYPERTENSIONAHA.109.143982","article-title":"Tumor necrosis factor-alpha antagonists improve aortic stiffness in patients with inflammatory arthropathies: a controlled study","volume":"55","author":"Angel","year":"2010","journal-title":"Hypertension."},{"key":"B42","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1186\/s13054-014-0469-1","article-title":"Effects of intra-abdominal sepsis on atherosclerosis in mice","volume":"18","author":"Kaynar","year":"2014","journal-title":"Crit Care."},{"key":"B43","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.atherosclerosis.2016.07.909","article-title":"Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-\/- mice","volume":"255","author":"Fuijkschot","year":"2016","journal-title":"Atherosclerosis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","article-title":"Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial","volume":"391","author":"Ridker","year":"2018","journal-title":"Lancet."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1161\/CIRCRESAHA.117.311984","article-title":"CANTOS trial validates the inflammatory pathogenesis of atherosclerosis: setting the stage for a new chapter in therapeutic targeting","volume":"121","author":"Weber","year":"2017","journal-title":"Circ Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11908-016-0544-7","article-title":"Understanding long-term outcomes following sepsis: implications and challenges","volume":"18","author":"Shankar-Hari","year":"2016","journal-title":"Curr Infect Dis Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1161\/ATVBAHA.106.138743","article-title":"Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events","volume":"27","author":"Pussinen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"392","DOI":"10.2337\/dc10-1676","article-title":"Endotoxemia is associated with an increased risk of incident diabetes","volume":"34","author":"Pussinen","year":"2011","journal-title":"Diabetes Care."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e013628","DOI":"10.1161\/JAHA.119.013628","article-title":"Serum lipopolysaccharide-binding protein levels and the incidence of cardiovascular disease in a general japanese population: the hisayama study","volume":"8","author":"Asada","year":"2019","journal-title":"J Am Heart Assoc."},{"key":"B52","doi-asserted-by":"publisher","first-page":"13018","DOI":"10.1074\/jbc.271.22.13018","article-title":"Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase","volume":"271","author":"Peraldi","year":"1996","journal-title":"J Biol Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1084\/jem.20111354","article-title":"Host response to injury large-scale collaborative research, a genomic storm in critically injured humans","volume":"208","author":"Xiao","year":"2011","journal-title":"J Exp Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.freeradbiomed.2005.10.054","article-title":"The role of oxidative stress in adult critical care","volume":"40","author":"Crimi","year":"2006","journal-title":"Free Radic Biol Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1126\/science.1106830","article-title":"Myeloperoxidase, a leukocyte-derived vascular NO oxidase","volume":"296","author":"Eiserich","year":"2002","journal-title":"Science."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1172\/JCI67478","article-title":"Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex","volume":"123","author":"Huang","year":"2013","journal-title":"J Clin Invest."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1096\/fj.03-0086com","article-title":"Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo","volume":"17","author":"Poliakov","year":"2003","journal-title":"FASEB J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1089\/ars.2014.6078","article-title":"Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts","volume":"22","author":"Guo","year":"2015","journal-title":"Antioxid Redox Signal."},{"key":"B59","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1050-1738(00)00040-2","article-title":"Isolevuglandin-protein adducts in oxidized low density lipoprotein and human plasma: a strong connection with cardiovascular disease","volume":"10","author":"Salomon","year":"2000","journal-title":"Trends Cardiovasc Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1172\/JCI80761","article-title":"Immune activation caused by vascular oxidation promotes fibrosis and hypertension","volume":"126","author":"Wu","year":"2016","journal-title":"J Clin Invest."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1089\/ars.2014.6154","article-title":"Isolevuglandin adducts in disease","volume":"22","author":"Salomon","year":"2015","journal-title":"Antioxid Redox Signal."},{"key":"B62","doi-asserted-by":"publisher","first-page":"9176","DOI":"10.1074\/jbc.RA117.001099","article-title":"Modification by isolevuglandins, highly reactive gamma-ketoaldehydes, deleteriously alters HDL structure and function","volume":"293","author":"May-Zhang","year":"2018","journal-title":"J Biol Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/SHK.0b013e318217025a","article-title":"Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis","volume":"36","author":"Ware","year":"2011","journal-title":"Shock."},{"key":"B64","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1161\/01.RES.0000146094.59640.13","article-title":"Antiinflammatory properties of HDL","volume":"95","author":"Barter","year":"2004","journal-title":"Circ Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.4049\/jimmunol.1600702","article-title":"Blood-Borne lipopolysaccharide is rapidly eliminated by liver sinusoidal endothelial cells via high-density lipoprotein","volume":"197","author":"Yao","year":"2016","journal-title":"J Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"17842","DOI":"10.1074\/jbc.REV120.015254","article-title":"Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery","volume":"295","author":"Munford","year":"2020","journal-title":"J Biol Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.immuni.2013.02.009","article-title":"Abnormal high-density lipoprotein induces endothelial dysfunction via activation of toll-like receptor-2","volume":"38","author":"Speer","year":"2013","journal-title":"Immunity."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1681\/ASN.2013111212","article-title":"HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype","volume":"25","author":"Shroff","year":"2014","journal-title":"J Am Soc Nephrol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1161\/CIRCULATIONAHA.108.836346","article-title":"Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy","volume":"121","author":"Sorrentino","year":"2010","journal-title":"Circulation."},{"key":"B70","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13054-018-2090-1","article-title":"Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival","volume":"22","author":"Winkler","year":"2018","journal-title":"Crit Care."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1093\/eurheartj\/ehx118","article-title":"Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease","volume":"38","author":"Zewinger","year":"2017","journal-title":"Eur Heart J."},{"key":"B72","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/CCM.0000000000000553","article-title":"International study on microcirculatory shock occurrence in acutely ill patients","volume":"43","author":"Vellinga","year":"2015","journal-title":"Crit Care Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e198686","DOI":"10.1001\/jamanetworkopen.2019.8686","article-title":"Long-term host immune response trajectories among hospitalized patients with sepsis","volume":"2","author":"Yende","year":"2019","journal-title":"JAMA Netw Open."},{"key":"B74","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S1074-7613(00)80334-9","article-title":"Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment","volume":"6","author":"Romano","year":"1997","journal-title":"Immunity."},{"key":"B75","doi-asserted-by":"publisher","first-page":"22351","DOI":"10.1073\/pnas.2010229117","article-title":"IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome","volume":"117","author":"Kang","year":"2020","journal-title":"Proc Natl Acad Sci USA."},{"key":"B76","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1097\/TA.0000000000001758","article-title":"Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients","volume":"84","author":"Stortz","year":"2018","journal-title":"J Trauma Acute Care Surg."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1681\/ASN.2005121288","article-title":"Microalbuminuria and risk for cardiovascular disease: analysis of potential mechanisms","volume":"17","author":"Stehouwer","year":"2006","journal-title":"J Am Soc Nephrol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2020.06.005","article-title":"Ikk2-mediated inflammatory activation of arterial endothelial cells promotes the development and progression of atherosclerosis","volume":"307","author":"Mussbacher","year":"2020","journal-title":"Atherosclerosis."},{"key":"B79","doi-asserted-by":"publisher","first-page":"16556","DOI":"10.1073\/pnas.1218219110","article-title":"NF-kappaB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-kappaB in immune-mediated diseases","volume":"110","author":"Sehnert","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B80","doi-asserted-by":"publisher","first-page":"eabd7819","DOI":"10.1126\/sciadv.abd7819","article-title":"High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging","volume":"7","author":"Chen","year":"2021","journal-title":"Sci Adv."},{"key":"B81","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/eurheartj\/ehy856","article-title":"Fourth universal definition of myocardial infarction 2018","volume":"40","author":"Thygesen","year":"2019","journal-title":"Eur Heart J."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1097\/01.CCM.0000166607.22550.87","article-title":"Myocardial ischemia, cardiac troponin, and long-term survival of high-cardiac risk critically ill intensive care unit patients","volume":"33","author":"Landesberg","year":"2005","journal-title":"Crit Care Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1161\/CIRCULATIONAHA.117.030114","article-title":"Perioperative myocardial injury after noncardiac surgery: incidence, mortality, and characterization","volume":"137","author":"Puelacher","year":"2018","journal-title":"Circulation."},{"key":"B84","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13054-017-1800-4","article-title":"Early troponin I in critical illness and its association with hospital mortality: a cohort study","volume":"21","author":"Docherty","year":"2017","journal-title":"Crit Care."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1213\/ANE.0000000000002580","article-title":"Unexpected cardiac computed tomography findings in patients with postoperative myocardial injury","volume":"126","author":"Grobben","year":"2018","journal-title":"Anesth Analg."},{"key":"B86","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1097\/00005373-200005000-00018","article-title":"Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma","volume":"48","author":"Bertinchant","year":"2000","journal-title":"J Trauma."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1161\/01.CIR.92.8.2183","article-title":"Cardiac beta-adrenergic neuroeffector systems in acute myocardial dysfunction related to brain injury. Evidence for catecholamine-mediated myocardial damage","volume":"92","author":"White","year":"1995","journal-title":"Circulation."},{"key":"B88","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/CCM.0000000000001473","article-title":"Sequential N-terminal Pro-B-type natriuretic peptide and high-sensitivity cardiac troponin measurements during albumin replacement in patients with severe sepsis or septic shock","volume":"44","author":"Masson","year":"2016","journal-title":"Crit Care Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.clinbiochem.2017.02.007","article-title":"Clearance of cardiac troponin T with and without kidney function","volume":"50","author":"Friden","year":"2017","journal-title":"Clin Biochem."},{"key":"B90","doi-asserted-by":"publisher","first-page":"6791","DOI":"10.1038\/s41598-020-63744-8","article-title":"The liver and kidneys mediate clearance of cardiac troponin in the rat","volume":"10","author":"Muslimovic","year":"2020","journal-title":"Sci Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1161\/CIRCULATIONAHA.117.029986","article-title":"Origin of cardiac troponin T elevations in chronic kidney disease","volume":"136","author":"van der Linden","year":"2017","journal-title":"Circulation."},{"key":"B92","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/eurheartj\/ehr351","article-title":"Diastolic dysfunction and mortality in severe sepsis and septic shock","volume":"33","author":"Landesberg","year":"2012","journal-title":"Eur Heart J."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1097\/CCM.0000000000002641","article-title":"Prevalence and prognostic association of circulating troponin in the acute respiratory distress syndrome","volume":"45","author":"Metkus","year":"2017","journal-title":"Crit Care Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1097\/SHK.0000000000000811","article-title":"Cardiac troponin release is associated with biomarkers of inflammation and ventricular dilatation during critical illness","volume":"47","author":"Ostermann","year":"2017","journal-title":"Shock."},{"key":"B95","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.bja.2018.09.002","article-title":"Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery","volume":"122","author":"Ackland","year":"2019","journal-title":"Br J Anaesth."},{"key":"B96","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13054-017-1605-5","article-title":"Shock induced endotheliopathy (SHINE) in acute critical illness - a unifying pathophysiologic mechanism","volume":"21","author":"Johansson","year":"2017","journal-title":"Crit Care."},{"key":"B97","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/TA.0000000000000694","article-title":"Admission biomarkers of trauma-induced secondary cardiac injury predict adverse cardiac events and are associated with plasma catecholamine levels","volume":"79","author":"Naganathar","year":"2015","journal-title":"J Trauma Acute Care Surg."},{"key":"B98","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.bja.2020.05.066","article-title":"MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study","volume":"125","author":"May","year":"2020","journal-title":"Br J Anaesth."},{"key":"B99","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1097\/CCM.0000000000005315","article-title":"Hyperdynamic left ventricular ejection fraction in ICU patients with sepsis","volume":"50","author":"Chotalia","year":"2021","journal-title":"Crit Care Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1097\/ALN.0000000000002107","article-title":"Etiology of acute coronary syndrome after noncardiac surgery","volume":"128","author":"Helwani","year":"2018","journal-title":"Anesthesiology."},{"key":"B101","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.bja.2017.11.063","article-title":"Incidence of thrombosis in perioperative and non-operative myocardial infarction","volume":"120","author":"Sheth","year":"2018","journal-title":"Br J Anaesth."},{"key":"B102","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1378\/chest.128.1.296","article-title":"Left ventricular apical ballooning due to severe physical stress in patients admitted to the medical ICU","volume":"128","author":"Park","year":"2005","journal-title":"Chest."},{"key":"B103","doi-asserted-by":"publisher","first-page":"6044","DOI":"10.12659\/MSM.908529","article-title":"NF-kappaB-Gasdermin D (GSDMD) axis couples oxidative stress and NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis following myocardial infarction","volume":"24","author":"Lei","year":"2018","journal-title":"Med Sci Monit."},{"key":"B104","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/s41419-020-03157-7","article-title":"Membrane nanotubes facilitate the propagation of inflammatory injury in the heart upon overactivation of the beta-adrenergic receptor","volume":"11","author":"Shen","year":"2020","journal-title":"Cell Death Dis."},{"key":"B105","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jacbts.2017.03.008","article-title":"Troponin release following brief myocardial ischemia: apoptosis versus necrosis","volume":"2","author":"Amgalan","year":"2017","journal-title":"JACC Basic Transl Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/nm.4428","article-title":"IRF3 and type I interferons fuel a fatal response to myocardial infarction","volume":"23","author":"King","year":"2017","journal-title":"Nat Med."},{"key":"B107","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature."},{"key":"B108","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.immuni.2020.02.002","article-title":"mtDNA activates cGAS signaling and suppresses the YAP-mediated endothelial cell proliferation program to promote inflammatory injury","volume":"52","author":"Huang","year":"2020","journal-title":"Immunity."},{"key":"B109","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/SHK.0b013e318289376b","article-title":"Histologic pathologies of the myocardium in septic shock: a prospective observational study","volume":"39","author":"Schmittinger","year":"2013","journal-title":"Shock."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1164\/rccm.201304-0744LE","article-title":"Nonischemic myocardial changes detected by cardiac magnetic resonance in critical care patients with sepsis","volume":"188","author":"Siddiqui","year":"2013","journal-title":"Am J Respir Crit Care Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","article-title":"Macrophages facilitate electrical conduction in the heart","volume":"169","author":"Hulsmans","year":"2017","journal-title":"Cell."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1097\/01.CCM.0000281454.97901.01","article-title":"Reduction of gap and adherens junction proteins and intercalated disc structural remodeling in the hearts of mice submitted to severe cecal ligation and puncture sepsis","volume":"35","author":"Celes","year":"2007","journal-title":"Crit Care Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"e0187327","DOI":"10.1371\/journal.pone.0187327","article-title":"Early structural changes of the heart after experimental polytrauma and hemorrhagic shock","volume":"12","author":"Braun","year":"2017","journal-title":"PLoS ONE."},{"key":"B114","doi-asserted-by":"publisher","first-page":"e130091","DOI":"10.1172\/jci.insight.130091","article-title":"S-nitrosylation of connexin43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice","volume":"4","author":"Lillo","year":"2019","journal-title":"JCI Insight."},{"key":"B115","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1097\/CCM.0000000000002325","article-title":"New-Onset atrial fibrillation in the critically ill","volume":"45","author":"Moss","year":"2017","journal-title":"Crit Care Med."},{"key":"B116","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ijcard.2018.03.051","article-title":"New-onset atrial fibrillation in critically ill patients and its association with mortality: a report from the FROG-ICU study","volume":"266","author":"Arrigo","year":"2018","journal-title":"Int J Cardiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1016\/S0140-6736(18)30832-8","article-title":"Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial","volume":"391","author":"Devereaux","year":"2018","journal-title":"Lancet."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1378\/chest.14-0003","article-title":"Long-term outcomes following development of new-onset atrial fibrillation during sepsis","volume":"146","author":"Walkey","year":"2014","journal-title":"Chest."},{"key":"B119","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12933-020-01105-5","article-title":"SGLT2 inhibitors and atrial fibrillation in type 2 diabetes: a systematic review with meta-analysis of 16 randomized controlled trials","volume":"19","author":"Li","year":"2020","journal-title":"Cardiovasc Diabetol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1161\/CIRCRESAHA.120.316710","article-title":"Atrial Myocyte NLRP3\/CaMKII nexus forms a substrate for postoperative atrial fibrillation","volume":"127","author":"Heijman","year":"2020","journal-title":"Circ Res."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1016\/j.jacc.2016.03.543","article-title":"Pheochromocytoma is characterized by catecholamine-mediated myocarditis, focal and diffuse myocardial fibrosis, myocardial dysfunction","volume":"67","author":"Ferreira","year":"2016","journal-title":"J Am Coll Cardiol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1161\/CIRCULATIONAHA.118.037975","article-title":"Myocardial and systemic inflammation in acute stress-induced (takotsubo) cardiomyopathy","volume":"139","author":"Scally","year":"2018","journal-title":"Circulation."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1161\/CIRCRESAHA.118.312910","article-title":"Heme oxygenase-1 in macrophages drives septic cardiac dysfunction via suppressing lysosomal degradation of inducible nitric oxide synthase","volume":"122","author":"Jia","year":"2018","journal-title":"Circ Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1084\/jem.20171274","article-title":"Cardiac macrophages promote diastolic dysfunction","volume":"215","author":"Hulsmans","year":"2018","journal-title":"J Exp Med."},{"key":"B125","doi-asserted-by":"publisher","first-page":"H149","DOI":"10.1152\/ajpheart.00052.2016","article-title":"Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase","volume":"313","author":"Dal-Secco","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1161\/CIRCULATIONAHA.117.031841","article-title":"Persistent long-term structural, functional, and metabolic changes after stress-induced (takotsubo) cardiomyopathy","volume":"137","author":"Scally","year":"2018","journal-title":"Circulation."},{"key":"B128","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1161\/CIRCULATIONAHA.118.034646","article-title":"A simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction","volume":"138","author":"Reddy","year":"2018","journal-title":"Circulation."},{"key":"B129","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jacbts.2019.06.005","article-title":"Acute kidney injury induces remote cardiac damage and dysfunction through the galectin-3 pathway","volume":"4","author":"Prud'homme","year":"2019","journal-title":"JACC Basic Transl Sci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"e003804","DOI":"10.1161\/CIRCHEARTFAILURE.116.003804","article-title":"Plasma and cardiac galectin-3 in patients with heart failure reflects both inflammation and fibrosis: implications for its use as a biomarker","volume":"10","author":"Besler","year":"2017","journal-title":"Circ Heart Fail."},{"key":"B131","doi-asserted-by":"publisher","first-page":"R24","DOI":"10.1186\/cc8887","article-title":"Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis","volume":"14","author":"Doerschug","year":"2010","journal-title":"Crit Care."},{"key":"B132","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1164\/ajrccm.160.2.9810073","article-title":"Inappropriate sympathetic activation at onset of septic shock: a spectral analysis approach","volume":"160","author":"Annane","year":"1999","journal-title":"Am J Respir Crit Care Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jchf.2014.08.002","article-title":"The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries","volume":"3","author":"Calvier","year":"2015","journal-title":"JACC Heart Fail."},{"key":"B134","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1161\/ATVBAHA.112.300569","article-title":"Galectin-3 mediates aldosterone-induced vascular fibrosis","volume":"33","author":"Calvier","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1111\/bph.14674","article-title":"Stimulation of beta-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway","volume":"176","author":"Zhao","year":"2019","journal-title":"Br J Pharmacol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306010","article-title":"Renal denervation prevents immune cell activation and renal inflammation in angiotensin ii-induced hypertension","volume":"117","author":"Xiao","year":"2015","journal-title":"Circ Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1172\/JCI74084","article-title":"DC isoketal-modified proteins activate T cells and promote hypertension","volume":"124","author":"Kirabo","year":"2014","journal-title":"J Clin Invest."},{"key":"B138","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00134-019-05919-0","article-title":"Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study","volume":"46","author":"Hoste","year":"2020","journal-title":"Intensive Care Med."},{"key":"B139","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/nrneph.2017.2","article-title":"Acute kidney disease and renal recovery: consensus report of the acute disease quality initiative (ADQI) 16 workgroup","volume":"13","author":"Chawla","year":"2017","journal-title":"Nat Rev Nephrol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"e123563","DOI":"10.1172\/jci.insight.123563","article-title":"TGF-beta promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration","volume":"3","author":"Chung","year":"2018","journal-title":"JCI Insight."},{"key":"B141","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41419-018-0936-8","article-title":"RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"B142","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41586-020-2941-1","article-title":"Decoding myofibroblast origins in human kidney fibrosis","volume":"589","author":"Kuppe","year":"2020","journal-title":"Nature."},{"key":"B143","doi-asserted-by":"publisher","first-page":"100841","DOI":"10.1016\/j.isci.2020.100841","article-title":"Principles of cell circuits for tissue repair and fibrosis","volume":"23","author":"Adler","year":"2020","journal-title":"iScience."},{"key":"B144","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nri2536","article-title":"Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation","volume":"9","author":"Rabinovich","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1038\/s41591-018-0194-4","article-title":"Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease","volume":"24","author":"Qiu","year":"2018","journal-title":"Nat Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"e123151","DOI":"10.1172\/jci.insight.123151","article-title":"Transcriptional trajectories of human kidney injury progression","volume":"3","author":"Cippa","year":"2018","journal-title":"JCI Insight."},{"key":"B147","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1152\/physiolgenomics.00037.2017","article-title":"Comparison of acute kidney injury of different etiology reveals in-common mechanisms of tissue damage","volume":"50","author":"Hultstrom","year":"2018","journal-title":"Physiol Genomics."},{"key":"B148","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1007\/s00134-018-5160-6","article-title":"Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury","volume":"44","author":"Gayat","year":"2018","journal-title":"Intensive Care Med."},{"key":"B149","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1136\/pgmj.21.240.287","article-title":"The aetiology of essential hypertension","volume":"21","author":"Lockett","year":"1945","journal-title":"Postgrad Med J."},{"key":"B150","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1681\/ASN.2017010055","article-title":"Relationship of kidney injury biomarkers with long-term cardiovascular outcomes after cardiac surgery","volume":"28","author":"Parikh","year":"2017","journal-title":"J Am Soc Nephrol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13054-017-1674-5","article-title":"Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis","volume":"21","author":"Haines","year":"2017","journal-title":"Crit Care."},{"key":"B152","doi-asserted-by":"publisher","first-page":"e135821","DOI":"10.1172\/JCI135821","article-title":"Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs","volume":"131","author":"Solagna","year":"2021","journal-title":"J Clin Invest."},{"key":"B153","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cmet.2018.07.018","article-title":"The MIC-1\/GDF15-GFRAL pathway in energy homeostasis: implications for obesity, cachexia, and other associated diseases","volume":"28","author":"Tsai","year":"2018","journal-title":"Cell Metab."},{"key":"B154","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cardiores.2005.11.014","article-title":"Changes in cardiac lipid metabolism during sepsis: the essential role of very low-density lipoprotein receptors","volume":"69","author":"Jia","year":"2006","journal-title":"Cardiovasc Res."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.cell.2019.07.033","article-title":"GDF15 is an inflammation-induced central mediator of tissue tolerance","volume":"178","author":"Luan","year":"2019","journal-title":"Cell."},{"key":"B156","doi-asserted-by":"publisher","first-page":"E802","DOI":"10.1152\/ajpendo.2000.278.5.E802","article-title":"Utilization of very low density lipoprotein by rat heart: the effect of endotoxin","volume":"278","author":"Bennett","year":"2000","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/s41591-020-0945-x","article-title":"Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice","volume":"26","author":"Suriben","year":"2020","journal-title":"Nat Med."},{"key":"B158","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/thoraxjnl-2014-206225","article-title":"Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs","volume":"70","author":"Bloch","year":"2015","journal-title":"Thorax."},{"key":"B159","doi-asserted-by":"publisher","first-page":"3630568","DOI":"10.1155\/2020\/3630568","article-title":"Utility of plasma GDF-15 for diagnosis and prognosis assessment of ICU-acquired weakness in mechanically ventilated patients: prospective observational study","volume":"2020","author":"Xie","year":"2020","journal-title":"Biomed Res Int."},{"key":"B160","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41580-018-0068-0","article-title":"Linking cellular stress responses to systemic homeostasis","volume":"19","author":"Galluzzi","year":"2018","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1186\/s13054-020-03254-1","article-title":"The clinical potential of GDF15 as a \u201cready-to-feed indicator\u201d for critically ill adults","volume":"24","author":"Van Dyck","year":"2020","journal-title":"Crit Care."},{"key":"B162","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1164\/rccm.200909-1395OC","article-title":"Alterations in adipose tissue during critical illness: an adaptive and protective response?","volume":"182","author":"Langouche","year":"2010","journal-title":"Am J Respir Crit Care Med."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1130.e5","DOI":"10.1016\/j.jcrc.2014.06.003","article-title":"Adipose tissue lipolysis and circulating lipids in acute and subacute critical illness: effects of shock and treatment","volume":"29","author":"Ilias","year":"2014","journal-title":"J Crit Care."},{"key":"B164","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/MOL.0000000000000577","article-title":"Molecular regulation of plasma lipid levels during systemic inflammation and sepsis","volume":"30","author":"Trinder","year":"2019","journal-title":"Curr Opin Lipidol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.immuni.2017.11.009","article-title":"White Adipose tissue is a reservoir for memory T cells and promotes protective memory responses to infection","volume":"47","author":"Han","year":"2017","journal-title":"Immunity."},{"key":"B166","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1186\/cc6929","article-title":"Quantification of lean and fat tissue repletion following critical illness: a case report","volume":"12","author":"Reid","year":"2008","journal-title":"Crit Care."},{"key":"B167","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cmet.2006.11.008","article-title":"Fat uses a TOLL-road to connect inflammation and diabetes","volume":"4","author":"Kim","year":"2006","journal-title":"Cell Metab."},{"key":"B168","doi-asserted-by":"publisher","first-page":"e0165923","DOI":"10.1371\/journal.pone.0165923","article-title":"Stress induced hyperglycemia and the subsequent risk of type 2 diabetes in survivors of critical illness","volume":"11","author":"Plummer","year":"2016","journal-title":"PLoS ONE."},{"key":"B169","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jcrc.2019.10.014","article-title":"The influence of clinical variables on the risk of developing chronic conditions in ICU survivors","volume":"55","author":"van Beusekom","year":"2020","journal-title":"J Crit Care."},{"key":"B170","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1136\/heartjnl-2021-320296","article-title":"Association between combat-related traumatic injury and cardiovascular risk","volume":"108","author":"Boos","year":"2021","journal-title":"Heart."},{"key":"B171","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrneph.2016.145","article-title":"The impact of insulin resistance on the kidney and vasculature","volume":"12","author":"Artunc","year":"2016","journal-title":"Nat Rev Nephrol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"480","DOI":"10.2337\/diabetes.55.02.06.db05-1103","article-title":"Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo","volume":"55","author":"Nieuwdorp","year":"2006","journal-title":"Diabetes."},{"key":"B173","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1210\/jcem-69-2-317","article-title":"Severity, duration, and mechanisms of insulin resistance during acute infections","volume":"69","author":"Yki-Jarvinen","year":"1989","journal-title":"J Clin Endocrinol Metab."},{"key":"B174","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/CIRCRESAHA.120.316653","article-title":"Transient intermittent hyperglycemia accelerates atherosclerosis by promoting myelopoiesis","volume":"127","author":"Flynn","year":"2020","journal-title":"Circ Res."},{"key":"B175","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.bbrc.2020.11.018","article-title":"Critical role of glutamine metabolism in cardiomyocytes under oxidative stress","volume":"534","author":"Watanabe","year":"2021","journal-title":"Biochem Biophys Res Commun."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.cmet.2018.03.002","article-title":"Rewiring of glutamine metabolism is a bioenergetic adaptation of human cells with mitochondrial DNA mutations","volume":"27","author":"Chen","year":"2018","journal-title":"Cell Metab."},{"key":"B177","doi-asserted-by":"publisher","first-page":"101907","DOI":"10.1016\/j.redox.2021.101907","article-title":"Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness","volume":"41","author":"McKenna","year":"2021","journal-title":"Redox Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"195ra95","DOI":"10.1126\/scitranslmed.3005893","article-title":"An integrated clinico-metabolomic model improves prediction of death in sepsis","volume":"5","author":"Langley","year":"2013","journal-title":"Sci Transl Med."},{"key":"B179","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jhep.2019.11.009","article-title":"Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF","volume":"72","author":"Moreau","year":"2020","journal-title":"J Hepatol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1161\/01.CIR.75.3.533","article-title":"Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock","volume":"75","author":"Dhainaut","year":"1987","journal-title":"Circulation."},{"key":"B181","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature."},{"key":"B182","doi-asserted-by":"publisher","first-page":"eaay8085","DOI":"10.1126\/science.aay8085","article-title":"Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense","volume":"370","author":"Bosch","year":"2020","journal-title":"Science."},{"key":"B183","first-page":"435","article-title":"Lipid droplets and the management of cellular stress","volume":"92","author":"Jarc","year":"2019","journal-title":"Yale J Biol Med."},{"key":"B184","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1056\/NEJM199510263331702","article-title":"Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B","volume":"333","author":"McKenzie","year":"1995","journal-title":"N Engl J Med."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.3748\/wjg.14.1389","article-title":"Liver histology in ICU patients dying from sepsis: a clinico-pathological study","volume":"14","author":"Koskinas","year":"2008","journal-title":"World J Gastroenterol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.jhep.2018.12.037","article-title":"Hepatic PPARalpha is critical in the metabolic adaptation to sepsis","volume":"70","author":"Paumelle","year":"2019","journal-title":"J Hepatol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"7863","DOI":"10.1096\/fj.201802457RR","article-title":"Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis","volume":"33","author":"Gumucio","year":"2019","journal-title":"FASEB J."},{"key":"B188","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/01.shk.0000235141.05528.47","article-title":"Myocardial structural changes in long-term human severe sepsis\/septic shock may be responsible for cardiac dysfunction","volume":"27","author":"Rossi","year":"2007","journal-title":"Shock."},{"key":"B189","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/SHK.0b013e31823f1a00","article-title":"Reduced peroxisome proliferator-activated receptor alpha expression is associated with decreased survival and increased tissue bacterial load in sepsis","volume":"37","author":"Standage","year":"2012","journal-title":"Shock."},{"key":"B190","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1136\/thoraxjnl-2017-211073","article-title":"Metabolic phenotype of skeletal muscle in early critical illness","volume":"73","author":"Puthucheary","year":"2018","journal-title":"Thorax."},{"key":"B191","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1523-1755.2005.00061.x","article-title":"Renal tubular triglyercide accumulation following endotoxic, toxic, ischemic injury","volume":"67","author":"Zager","year":"2005","journal-title":"Kidney Int."},{"key":"B192","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1194\/jlr.P040501","article-title":"Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy","volume":"55","author":"Herman-Edelstein","year":"2014","journal-title":"J Lipid Res."},{"key":"B193","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1681\/ASN.2017030350","article-title":"Impaired beta-oxidation and altered complex lipid fatty acid partitioning with advancing CKD","volume":"29","author":"Afshinnia","year":"2018","journal-title":"J Am Soc Nephrol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"e103397","DOI":"10.15252\/embj.2019103397","article-title":"Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis","volume":"39","author":"Chen","year":"2020","journal-title":"EMBO J."},{"key":"B195","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1016\/j.jacc.2006.09.013","article-title":"Are familial Mediterranean fever (FMF) patients at increased risk for atherosclerosis? Impaired endothelial function and increased intima media thickness are found in FMF","volume":"48","author":"Akdogan","year":"2006","journal-title":"J Am Coll Cardiol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41590-020-0705-6","article-title":"Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis","volume":"21","author":"Park","year":"2020","journal-title":"Nat Immunol."},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.10.012","article-title":"Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study","author":"Sanders","year":"2020","journal-title":"Br J Anaesth."},{"key":"B198","doi-asserted-by":"publisher","first-page":"H1553","DOI":"10.1152\/ajpheart.00158.2018","article-title":"Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury","volume":"315","author":"Toldo","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, necroptosis (PANoptosis)","volume":"10","author":"Christgen","year":"2020","journal-title":"Front Cell Infect Microbiol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1161\/CIRCULATIONAHA.118.035202","article-title":"Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation","volume":"138","author":"Yao","year":"2018","journal-title":"Circulation."},{"key":"B201","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1136\/thoraxjnl-2015-208114","article-title":"Systemic inflammation after critical illness: relationship with physical recovery and exploration of potential mechanisms","volume":"71","author":"Griffith","year":"2016","journal-title":"Thorax."},{"key":"B202","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.4049\/jimmunol.2000159","article-title":"IL-1R regulates disease tolerance and cachexia in toxoplasma gondii infection","volume":"204","author":"Melchor","year":"2020","journal-title":"J Immunol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/s42255-019-0150-8","article-title":"Mitochondrial DNA stress signalling protects the nuclear genome","volume":"1","author":"Wu","year":"2019","journal-title":"Nat Metab."},{"key":"B204","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2019.02.038","article-title":"Interleukin-1beta induces mtDNA release to activate innate immune signaling via cGAS-STING","volume":"74","author":"Aarreberg","year":"2019","journal-title":"Mol Cell"},{"key":"B205","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.3389\/fimmu.2018.02791","article-title":"Disease tolerance and pathogen resistance genes may underlie trypanosoma cruzi persistence and differential progression to chagas disease cardiomyopathy","volume":"9","author":"Chevillard","year":"2018","journal-title":"Front Immunol."},{"key":"B206","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1093\/eurheartj\/ehz542","article-title":"Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1beta inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis","volume":"41","author":"Ridker","year":"2020","journal-title":"Eur Heart J."},{"key":"B207","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1161\/CIRCULATIONAHA.119.044362","article-title":"Genetic interleukin 6 signaling deficiency attenuates cardiovascular risk in clonal hematopoiesis","volume":"141","author":"Bick","year":"2020","journal-title":"Circulation."},{"key":"B208","doi-asserted-by":"publisher","first-page":"54290","DOI":"10.18632\/oncotarget.11091","article-title":"NLRP3 inflammasome activation is involved in ang II-induced kidney damage via mitochondrial dysfunction","volume":"7","author":"Wen","year":"2016","journal-title":"Oncotarget."},{"key":"B209","doi-asserted-by":"publisher","first-page":"e3074","DOI":"10.1038\/cddis.2017.470","article-title":"NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension","volume":"8","author":"Sun","year":"2017","journal-title":"Cell Death Dis."},{"key":"B210","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/eurheartj\/ehx261","article-title":"IL-18 cleavage triggers cardiac inflammation and fibrosis upon beta-adrenergic insult","volume":"39","author":"Xiao","year":"2018","journal-title":"Eur Heart J."},{"key":"B211","doi-asserted-by":"publisher","first-page":"e94716","DOI":"10.1172\/jci.insight.94716","article-title":"Molecular characterization of the transition from acute to chronic kidney injury following ischemia\/reperfusion","volume":"2","author":"Liu","year":"2017","journal-title":"JCI Insight."},{"key":"B212","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/s41591-019-0590-4","article-title":"Single-cell immune landscape of human atherosclerotic plaques","volume":"25","author":"Fernandez","year":"2019","journal-title":"Nat Med."},{"key":"B213","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1084\/jem.20171773","article-title":"The immunology of hypertension","volume":"215","author":"Norlander","year":"2018","journal-title":"J Exp Med."},{"key":"B214","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1161\/HYPERTENSIONAHA.113.00689","article-title":"Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension","volume":"62","author":"Youn","year":"2013","journal-title":"Hypertension."},{"key":"B215","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13054-017-1934-4","article-title":"Protracted immune disorders at one year after ICU discharge in patients with septic shock","volume":"22","author":"Riche","year":"2018","journal-title":"Crit Care."},{"key":"B216","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41590-020-00834-9","article-title":"Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion","volume":"22","author":"Scharping","year":"2021","journal-title":"Nat Immunol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-021-03547-7","article-title":"An aged immune system drives senescence and ageing of solid organs","volume":"594","author":"Yousefzadeh","year":"2021","journal-title":"Nature."},{"key":"B218","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41591-019-0381-y","article-title":"A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring","volume":"25","author":"Alpert","year":"2019","journal-title":"Nat Med."},{"key":"B219","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s43587-021-00082-y","article-title":"An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging","volume":"1","author":"Sayed","year":"2021","journal-title":"Nat Aging."},{"key":"B220","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1001\/jama.2017.10569","article-title":"Effect of ganciclovir on IL-6 levels among cytomegalovirus-seropositive adults with critical illness: a randomized clinical trial","volume":"318","author":"Limaye","year":"2017","journal-title":"JAMA."},{"key":"B221","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1093\/cid\/cix120","article-title":"Epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock","volume":"64","author":"Ong","year":"2017","journal-title":"Clin Infect Dis."},{"key":"B222","doi-asserted-by":"publisher","first-page":"e55686","DOI":"10.1371\/journal.pone.0055686","article-title":"Cytomegalovirus seropositivity is associated with increased arterial stiffness in patients with chronic kidney disease","volume":"8","author":"Wall","year":"2013","journal-title":"PLoS ONE."},{"key":"B223","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/qjmed\/hcw026","article-title":"Cytomegalovirus infection is associated with an increase in systolic blood pressure in older individuals","volume":"109","author":"Firth","year":"2016","journal-title":"QJM."},{"key":"B224","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1365-2249.2011.04513.x","article-title":"Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the cardiovascular risk in young finns study","volume":"167","author":"Haarala","year":"2012","journal-title":"Clin Exp Immunol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.arr.2010.08.003","article-title":"Persistent viral infections and immune aging","volume":"10","author":"Brunner","year":"2011","journal-title":"Ageing Res Rev."},{"key":"B226","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1001\/jamainternmed.2017.0895","article-title":"Safety and efficacy of antiviral therapy for prevention of cytomegalovirus reactivation in immunocompetent critically ill patients: a randomized clinical trial","volume":"177","author":"Cowley","year":"2017","journal-title":"JAMA Intern Med."},{"key":"B227","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00281-017-0656-7","article-title":"Monocyte and macrophage immunometabolism in atherosclerosis","volume":"40","author":"Groh","year":"2018","journal-title":"Semin Immunopathol."},{"key":"B228","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1001\/jama.2016.2691","article-title":"Risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis","volume":"315","author":"van Vught","year":"2016","journal-title":"JAMA."},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.11.003","article-title":"AMPK regulates immunometabolism in sepsis","author":"Huang","year":"2017","journal-title":"Brain Behav Immun."},{"key":"B230","doi-asserted-by":"publisher","first-page":"4436","DOI":"10.1038\/ncomms5436","article-title":"PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis","volume":"5","author":"Yang","year":"2014","journal-title":"Nat Commun."},{"key":"B231","doi-asserted-by":"publisher","first-page":"13280","DOI":"10.1038\/ncomms13280","article-title":"PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation","volume":"7","author":"Xie","year":"2016","journal-title":"Nat Commun."},{"key":"B232","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1084\/jem.20150900","article-title":"The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease","volume":"213","author":"Shirai","year":"2016","journal-title":"J Exp Med."},{"key":"B233","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab."},{"key":"B234","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science."},{"key":"B235","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1038\/s41467-020-17402-2","article-title":"Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling","volume":"11","author":"Khatib-Massalha","year":"2020","journal-title":"Nat Commun"},{"key":"B236","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.cell.2017.11.025","article-title":"Metabolic induction of trained immunity through the mevalonate pathway","volume":"172","author":"Bekkering","year":"2018","journal-title":"Cell."},{"key":"B237","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S2213-2600(18)30177-2","article-title":"Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial","volume":"6","author":"Calfee","year":"2018","journal-title":"Lancet Respir Med."},{"key":"B238","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.atherosclerosis.2016.10.019","article-title":"Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo","volume":"254","author":"Bekkering","year":"2016","journal-title":"Atherosclerosis."},{"key":"B239","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1093\/cvr\/cvz137","article-title":"Aldosterone induces trained immunity: the role of fatty acid synthesis","volume":"116","author":"van der Heijden","year":"2020","journal-title":"Cardiovasc Res."},{"key":"B240","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1161\/CIRCRESAHA.119.315800","article-title":"Catecholamines induce trained immunity in monocytes in vitro and in vivo","volume":"127","author":"van der Heijden","year":"2020","journal-title":"Circ Res"},{"key":"B241","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell."},{"key":"B242","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.immuni.2017.04.016","article-title":"Metabolic and epigenetic coordination of T cell and macrophage immunity","volume":"46","author":"Phan","year":"2017","journal-title":"Immunity."},{"key":"B243","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature."},{"key":"B244","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41419-018-0708-5","article-title":"Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling","volume":"9","author":"Lu","year":"2018","journal-title":"Cell Death Dis."},{"key":"B245","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cell.2017.08.041","article-title":"Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages","volume":"171","author":"Wang","year":"2017","journal-title":"Cell."},{"key":"B246","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fimmu.2018.00270","article-title":"Metabolic modulation in macrophage effector function","volume":"9","author":"Diskin","year":"2018","journal-title":"Front Immunol."},{"key":"B247","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/nature06322","article-title":"mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex","volume":"450","author":"Cunningham","year":"2007","journal-title":"Nature."},{"key":"B248","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature."},{"key":"B249","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.cell.2017.08.018","article-title":"Mitochondrial priming by CD28","volume":"171","author":"Klein Geltink","year":"2017","journal-title":"Cell."},{"key":"B250","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.it.2017.08.006","article-title":"Mitochondrial dynamics at the interface of immune cell metabolism and function","volume":"39","author":"Rambold","year":"2018","journal-title":"Trends Immunol."},{"key":"B251","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2016.05.035","article-title":"Mitochondrial dynamics controls T cell fate through metabolic programming","volume":"166","author":"Buck","year":"2016","journal-title":"Cell."},{"key":"B252","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cell.2017.06.007","article-title":"De novo epigenetic programs inhibit PD-1 blockade-mediated T cell rejuvenation","volume":"170","author":"Ghoneim","year":"2017","journal-title":"Cell."},{"key":"B253","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/ni.3398","article-title":"Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis","volume":"17","author":"Cheng","year":"2016","journal-title":"Nat Immunol."},{"key":"B254","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1161\/ATVBAHA.120.314037","article-title":"Metabolic reprogramming in immune response and tissue inflammation","volume":"40","author":"Sun","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B255","doi-asserted-by":"publisher","first-page":"e55800","DOI":"10.7554\/eLife.55800","article-title":"Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells","volume":"9","author":"Jensen","year":"2020","journal-title":"Elife."},{"key":"B256","doi-asserted-by":"publisher","first-page":"eaar3932","DOI":"10.1126\/science.aar3932","article-title":"An evolutionary perspective on immunometabolism","volume":"363","author":"Wang","year":"2019","journal-title":"Science."},{"key":"B257","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cell.2019.01.050","article-title":"Energetic trade-offs and hypometabolic states promote disease tolerance","volume":"177","author":"Ganeshan","year":"2019","journal-title":"Cell."},{"key":"B258","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s42255-021-00392-w","article-title":"Mitohormesis reprogrammes macrophage metabolism to enforce tolerance","volume":"3","author":"Timblin","year":"2021","journal-title":"Nat Metab."},{"key":"B259","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.immuni.2020.09.011","article-title":"Tetracycline antibiotics induce host-dependent disease tolerance to infection","volume":"54","author":"Colaco","year":"2021","journal-title":"Immunity."},{"key":"B260","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1016\/j.celrep.2017.08.098","article-title":"Inflammatory resolution triggers a prolonged phase of immune suppression through COX-1\/mPGES-1-derived prostaglandin E2","volume":"20","author":"Newson","year":"2017","journal-title":"Cell Rep."},{"key":"B261","doi-asserted-by":"publisher","first-page":"25758","DOI":"10.1074\/jbc.M112.362343","article-title":"NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response","volume":"287","author":"Liu","year":"2012","journal-title":"J Biol Chem."},{"key":"B262","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/s41590-021-00975-5","article-title":"Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation","volume":"22","author":"Abdel-Hakeem","year":"2021","journal-title":"Nat Immunol."},{"key":"B263","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nature08778","article-title":"SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation","volume":"464","author":"Hirschey","year":"2010","journal-title":"Nature."},{"key":"B264","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/s41591-019-0633-x","article-title":"Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells","volume":"25","author":"Frodermann","year":"2019","journal-title":"Nat Med."},{"key":"B265","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1152\/japplphysiol.91530.2008","article-title":"Bone marrow fat accumulation after 60 days of bed rest persisted 1 year after activities were resumed along with hemopoietic stimulation: the women international space simulation for exploration study","volume":"107","author":"Trudel","year":"2009","journal-title":"J Appl Physiol."},{"key":"B266","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt","year":"2014","journal-title":"Nat Med."},{"key":"B267","doi-asserted-by":"publisher","first-page":"16574","DOI":"10.1073\/pnas.1310655110","article-title":"Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via beta-adrenergic induction of myelopoiesis","volume":"110","author":"Powell","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B268","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41586-019-0948-2","article-title":"Sleep modulates haematopoiesis and protects against atherosclerosis","volume":"566","author":"McAlpine","year":"2019","journal-title":"Nature."},{"key":"B269","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s11325-018-1701-z","article-title":"Sleep quality in survivors of critical illness","volume":"23","author":"Alexopoulou","year":"2018","journal-title":"Sleep Breath."},{"key":"B270","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1126\/science.aau3879","article-title":"Somatic mutant clones colonize the human esophagus with age","volume":"362","author":"Martincorena","year":"2018","journal-title":"Science."},{"key":"B271","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jcrc.2017.09.035","article-title":"Increased DNA damage and increased apoptosis and necrosis in patients with severe sepsis and septic shock","volume":"43","author":"Bahar","year":"2018","journal-title":"J Crit Care."},{"key":"B272","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.exphem.2017.11.002","article-title":"An inflammatory environment containing TNFalpha favors Tet2-mutant clonal hematopoiesis","volume":"59","author":"Abegunde","year":"2018","journal-title":"Exp Hematol."},{"key":"B273","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nature25434","article-title":"Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation","volume":"554","author":"Shen","year":"2018","journal-title":"Nature."},{"key":"B274","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.stem.2018.10.013","article-title":"Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis","volume":"23","author":"Cai","year":"2018","journal-title":"Cell Stem Cell."},{"key":"B275","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1161\/CIRCRESAHA.117.312115","article-title":"Somatic mutations and clonal hematopoiesis: unexpected potential new drivers of age-related cardiovascular disease","volume":"122","author":"Fuster","year":"2018","journal-title":"Circ Res."},{"key":"B276","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N Engl J Med."},{"key":"B277","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41586-018-0125-z","article-title":"Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host","volume":"557","author":"Meisel","year":"2018","journal-title":"Nature."},{"key":"B278","doi-asserted-by":"publisher","first-page":"108326","DOI":"10.1016\/j.celrep.2020.108326","article-title":"TET2-Loss-of-Function-driven clonal hematopoiesis exacerbates experimental insulin resistance in aging and obesity","volume":"33","author":"Fuster","year":"2020","journal-title":"Cell Rep."},{"key":"B279","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.cell.2021.01.049","article-title":"Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis","volume":"184","author":"Heyde","year":"2021","journal-title":"Cell."},{"key":"B280","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.stem.2021.03.002","article-title":"Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNgamma signaling","volume":"28","author":"Hormaechea-Agulla","year":"2021","journal-title":"Cell Stem Cell."},{"key":"B281","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","article-title":"Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1beta\/NLRP3 inflammasome","volume":"71","author":"Sano","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"B282","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1161\/CIRCRESAHA.118.313225","article-title":"CRISPR-Mediated gene editing to assess the roles of Tet2 and Dnmt3a in clonal hematopoiesis and cardiovascular disease","volume":"123","author":"Sano","year":"2018","journal-title":"Circ Res."},{"key":"B283","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1161\/CIRCRESAHA.120.317104","article-title":"Clonal hematopoiesis-driver DNMT3A mutations alter immune cells in heart failure","volume":"128","author":"Abplanalp","year":"2021","journal-title":"Circ Res."},{"key":"B284","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature15252","article-title":"Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature."},{"key":"B285","doi-asserted-by":"publisher","first-page":"E1490","DOI":"10.1073\/pnas.1616420114","article-title":"Dnmt3a restrains mast cell inflammatory responses","volume":"114","author":"Leoni","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B286","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1001\/jamacardio.2022.0386","article-title":"TET2-driven clonal hematopoiesis and response to canakinumab: an exploratory analysis of the CANTOS Randomized Clinical Trial","volume":"7","author":"Svensson","year":"2022","journal-title":"JAMA Cardiol."},{"key":"B287","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1093\/eurheartj\/ehz591","article-title":"Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation","volume":"41","author":"Mas-Peiro","year":"2020","journal-title":"Eur Heart J."},{"key":"B288","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/s41591-021-01371-0","article-title":"Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection","volume":"27","author":"Zekavat","year":"2021","journal-title":"Nat Med."},{"key":"B289","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1124\/pr.115.011106","article-title":"Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology","volume":"68","author":"Jaisser","year":"2016","journal-title":"Pharmacol Rev."},{"key":"B290","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1161\/CIRCRESAHA.116.310480","article-title":"T-Cell mineralocorticoid receptor controls blood pressure by regulating interferon-gamma","volume":"120","author":"Sun","year":"2017","journal-title":"Circ Res."},{"key":"B291","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1161\/HYPERTENSIONAHA.117.09070","article-title":"Mineralocorticoid receptor deficiency in T cells attenuates pressure overload-induced cardiac hypertrophy and dysfunction through modulating T-cell activation","volume":"70","author":"Li","year":"2017","journal-title":"Hypertension."},{"key":"B292","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1172\/JCI41080","article-title":"Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice","volume":"120","author":"Usher","year":"2010","journal-title":"J Clin Invest."},{"key":"B293","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/jhh.2012.27","article-title":"Salt, aldosterone and hypertension","volume":"27","author":"Pimenta","year":"2013","journal-title":"J Hum Hypertens."},{"key":"B294","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.yjmcc.2017.12.011","article-title":"Neutrophil gelatinase-associated lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation","volume":"115","author":"Buonafine","year":"2018","journal-title":"J Mol Cell Cardiol."},{"key":"B295","doi-asserted-by":"publisher","first-page":"e120196","DOI":"10.1172\/jci.insight.120196","article-title":"Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury","volume":"3","author":"Sun","year":"2018","journal-title":"JCI Insight."},{"key":"B296","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/cc13958","article-title":"Plasma and urine neutrophil gelatinase-associated lipocalin in the diagnosis of new onset acute kidney injury in critically ill patients","volume":"18","author":"Matsa","year":"2014","journal-title":"Crit Care."},{"key":"B297","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1042\/CS20171592","article-title":"More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases","volume":"132","author":"Buonafine","year":"2018","journal-title":"Clin Sci."},{"key":"B298","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1161\/HYPERTENSIONAHA.117.09791","article-title":"Aldosterone target NGAL (neutrophil gelatinase-associated lipocalin) is involved in cardiac remodeling after myocardial infarction through NFkappaB pathway","volume":"70","author":"Martinez-Martinez","year":"2017","journal-title":"Hypertension."},{"key":"B299","doi-asserted-by":"publisher","first-page":"R33","DOI":"10.1530\/JME-15-0318","article-title":"Mineralocorticoid regulation of cell function: the role of rapid signalling and gene transcription pathways","volume":"58","author":"Ong","year":"2017","journal-title":"J Mol Endocrinol."},{"key":"B300","doi-asserted-by":"publisher","first-page":"e0122850","DOI":"10.1371\/journal.pone.0122850","article-title":"Toll-like receptor 4 promotes autonomic dysfunction, inflammation and microglia activation in the hypothalamic paraventricular nucleus: role of endoplasmic reticulum stress","volume":"10","author":"Masson","year":"2015","journal-title":"PLoS ONE."},{"key":"B301","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1161\/HYPERTENSIONAHA.109.142836","article-title":"Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction","volume":"55","author":"Yu","year":"2010","journal-title":"Hypertension."},{"key":"B302","doi-asserted-by":"publisher","first-page":"43107","DOI":"10.1038\/srep43107","article-title":"Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R\/PKCgamma\/Rac1 pathway in salt-induced hypertension","volume":"7","author":"Su","year":"2017","journal-title":"Sci Rep."},{"key":"B303","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s12012-013-9219-x","article-title":"Interaction between AT1 receptor and NF-kappaB in hypothalamic paraventricular nucleus contributes to oxidative stress and sympathoexcitation by modulating neurotransmitters in heart failure","volume":"13","author":"Yu","year":"2013","journal-title":"Cardiovasc Toxicol."},{"key":"B304","doi-asserted-by":"publisher","first-page":"H423","DOI":"10.1152\/ajpheart.00685.2001","article-title":"The renin-angiotensin-aldosterone system excites hypothalamic paraventricular nucleus neurons in heart failure","volume":"283","author":"Zhang","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B305","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nature12143","article-title":"Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH","volume":"497","author":"Zhang","year":"2013","journal-title":"Nature."},{"key":"B306","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0140-6736(99)05320-9","article-title":"Hypertensive cardiovascular damage in patients with primary autonomic failure","volume":"355","author":"Vagaonescu","year":"2000","journal-title":"Lancet."},{"key":"B307","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1161\/HYPERTENSIONAHA.115.06617","article-title":"Mineralocorticoid receptor activation contributes to the supine hypertension of autonomic failure","volume":"67","author":"Arnold","year":"2016","journal-title":"Hypertension."},{"key":"B308","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1161\/01.HYP.0000224296.96235.dd","article-title":"11beta-hydroxysteroid dehydrogenase type 2 activity in hypothalamic paraventricular nucleus modulates sympathetic excitation","volume":"48","author":"Zhang","year":"2006","journal-title":"Hypertension"},{"key":"B309","doi-asserted-by":"publisher","first-page":"H1067","DOI":"10.1152\/ajpheart.01131.2007","article-title":"Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats","volume":"294","author":"Zhang","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B310","doi-asserted-by":"publisher","first-page":"H733","DOI":"10.1152\/ajpheart.00873.2011","article-title":"PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone\/NaCl-induced hypertension in mice","volume":"302","author":"Xue","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B311","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ccc.2007.10.003","article-title":"The alteration of autonomic function in multiple organ dysfunction syndrome","volume":"24","author":"Schmidt","year":"2008","journal-title":"Crit Care Clin."},{"key":"B312","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1016\/S0140-6736(03)14899-4","article-title":"Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock","volume":"362","author":"Sharshar","year":"2003","journal-title":"Lancet."},{"key":"B313","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1210\/jc.2003-030505","article-title":"Circulating aldosterone levels are unexpectedly low in children with acute meningococcal disease","volume":"89","author":"Lichtarowicz-Krynska","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"key":"B314","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4266\/kjccm.2017.00094","article-title":"Implications of plasma renin activity and plasma aldosterone concentration in critically ill patients with septic shock","volume":"32","author":"Chung","year":"2017","journal-title":"Korean J Crit Care Med."},{"key":"B315","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.3390\/ijms18051032","article-title":"Aldosterone and mineralocorticoid receptors-physiology and pathophysiology","volume":"18","author":"Funder","year":"2017","journal-title":"Int J Mol Sci."},{"key":"B316","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10741-005-2344-2","article-title":"Mineralocorticoid receptors: distribution and activation","volume":"10","author":"Funder","year":"2005","journal-title":"Heart Fail Rev."},{"key":"B317","doi-asserted-by":"publisher","first-page":"9202","DOI":"10.1073\/pnas.1633591100","article-title":"Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor","volume":"100","author":"Fjeld","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B318","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1161\/HYPERTENSIONAHA.109.136242","article-title":"Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction","volume":"54","author":"Mihailidou","year":"2009","journal-title":"Hypertension."},{"key":"B319","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2147\/IBPC.S13783","article-title":"Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine","volume":"6","author":"Funder","year":"2013","journal-title":"Integr Blood Press Control."},{"key":"B320","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1097\/CCM.0000000000002724","article-title":"Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a multispecialty task force of the society of critical care medicine (SCCM) and the European society of intensive care medicine (ESICM)","volume":"45","author":"Annane","year":"2017","journal-title":"Crit Care Med."},{"key":"B321","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1186\/s13054-014-0538-5","article-title":"Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx","volume":"18","author":"Chappell","year":"2014","journal-title":"Crit Care."},{"key":"B322","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1164\/rccm.201801-0064OC","article-title":"Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia","volume":"198","author":"Byrne","year":"2018","journal-title":"Am J Respir Crit Care Med."},{"key":"B323","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1128\/IAI.02158-14","article-title":"Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors beta1 and beta2","volume":"82","author":"Echeverria","year":"2014","journal-title":"Infect Immun."},{"key":"B324","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1097\/CCM.0000000000003778","article-title":"Circulating endothelial cells from septic shock patients convert to fibroblasts are associated with the resuscitation fluid dose and are biomarkers for survival prediction","volume":"47","author":"Tapia","year":"2019","journal-title":"Crit Care Med."},{"key":"B325","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease: jacc state-of-the-art review","volume":"73","author":"Kovacic","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B326","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1136\/emj.20.4.306","article-title":"Salt of the earth or a drop in the ocean? A pathophysiological approach to fluid resuscitation","volume":"20","author":"Gosling","year":"2003","journal-title":"Emerg Med J."},{"key":"B327","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00134-018-5147-3","article-title":"Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population","volume":"44","author":"Van Regenmortel","year":"2018","journal-title":"Intensive Care Med."},{"key":"B328","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.celrep.2017.10.002","article-title":"Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension","volume":"21","author":"Barbaro","year":"2017","journal-title":"Cell Rep."},{"key":"B329","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.acra.2017.03.012","article-title":"3 Tesla (23)Na magnetic resonance imaging during acute kidney injury","volume":"24","author":"Hammon","year":"2017","journal-title":"Acad Radiol"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00126-6.","article-title":"Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study","author":"Huang","year":"2022","journal-title":"Lancet Respir Med."},{"key":"B331","doi-asserted-by":"publisher","first-page":"e2128568","DOI":"10.1001\/jamanetworkopen.2021.28568","article-title":"Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review","volume":"4","author":"Groff","year":"2021","journal-title":"JAMA Netw Open."},{"key":"B332","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/S2213-2600(21)00383-0","article-title":"Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study","volume":"9","author":"Evans","year":"2021","journal-title":"Lancet Respir Med."},{"key":"B333","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s41581-021-00487-3","article-title":"Long COVID and kidney disease","volume":"17","author":"Yende","year":"2021","journal-title":"Nat Rev Nephrol."},{"key":"B334","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/anae.15293","article-title":"Renal impairment and its impact on clinical outcomes in patients who are critically ill with COVID-19: a multicentre observational study","volume":"76","author":"Gasparini","year":"2021","journal-title":"Anaesthesia."},{"key":"B335","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell."},{"key":"B336","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/resp.13233","article-title":"Pneumonia as a cardiovascular disease","volume":"23","author":"Restrepo","year":"2018","journal-title":"Respirology."},{"key":"B337","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41420-021-00428-w","article-title":"SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes","volume":"7","author":"Ferreira","year":"2021","journal-title":"Cell Death Discov."},{"key":"B338","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41420-019-0181-7","article-title":"SARS-Coronavirus open reading frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes","volume":"5","author":"Shi","year":"2019","journal-title":"Cell Death Discov."},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006944.","article-title":"Impaired exercise capacity in post-COVID syndrome: the role of VWF-ADAMTS13 axis","author":"Prasannan","year":"2022","journal-title":"Blood Adv."},{"key":"B340","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1172\/JCI133737","article-title":"Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease","volume":"130","author":"Roy","year":"2020","journal-title":"J Clin Invest."},{"key":"B341","doi-asserted-by":"publisher","first-page":"710608","DOI":"10.3389\/fimmu.2021.710608","article-title":"Traumatic brain injury induces cGAS activation and type I interferon signaling in aged mice","volume":"12","author":"Barrett","year":"2021","journal-title":"Front Immunol."},{"key":"B342","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3389\/fimmu.2016.00609","article-title":"Type-I interferon responses: from friend to foe in the battle against chronic viral infection","volume":"7","author":"Murira","year":"2016","journal-title":"Front Immunol."},{"key":"B343","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/s41590-021-01113-x","article-title":"Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection","volume":"23","author":"Phetsouphanh","year":"2022","journal-title":"Nat Immunol."},{"key":"B344","doi-asserted-by":"publisher","first-page":"eabe4782","DOI":"10.1126\/sciimmunol.abe4782","article-title":"Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells","volume":"6","author":"Kusnadi","year":"2021","journal-title":"Sci Immunol."},{"key":"B345","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.4049\/jimmunol.2100068","article-title":"Metabolic defects of peripheral T cells in COVID-19 patients","volume":"206","author":"Liu","year":"2021","journal-title":"J Immunol."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.854421\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T06:05:34Z","timestamp":1657865134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.854421\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":345,"alternative-id":["10.3389\/fcvm.2022.854421"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.854421","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"article-number":"854421"}}