{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:35:09Z","timestamp":1789623309419,"version":"build-2803163510"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Takotsubo syndrome is a well-characterized cause of acute yet reversible heart failure associated with periods of intense emotional stress, often mimicking on presentation an acute coronary syndrome. Animal models of Takotsubo syndrome have been developed, either through the application of a stressor, or administration of exogenous catecholamine. We found that in a model of isoproterenol-induced Takotsubo syndrome in anesthetized rats hyperthermia (40\u201341\u00b0C) would occur after the administration of isoproterenol. Maintenance of this hyperthermia would result in an apical hypocontractility typical of the syndrome, whereas prevention of hyperthermia with active cooling to maintain a euthermic core body temperature prevented (but did not subsequently reverse) apical hypocontractility. <jats:italic>In vitro<\/jats:italic> experimentation with isolated cardiomyocytes showed no effect of hyperthermia on either baseline contractility or contractility change after beta-adrenoceptor stimulation. We suggest that the rise in body temperature that is characteristic of catecholamine storm may be a component in the development of Takotsubo syndrome.<\/jats:p>","DOI":"10.3389\/fcvm.2022.869585","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T06:37:30Z","timestamp":1658817450000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Hyperthermia as a trigger for Takotsubo syndrome in a rat model"],"prefix":"10.3389","volume":"9","author":[{"given":"Matthew H.","family":"Tranter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Redfors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam S.","family":"Couch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Lyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmir","family":"Omerovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian E.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.hfc.2012.12.010","article-title":"Takotsubo cardiomyopathy: the pathophysiology","volume":"9","author":"Tranter","year":"2013","journal-title":"Heart Fail Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ejhf.424","article-title":"Current state of knowledge on Takotsubo syndrome: a position statement from the taskforce on Takotsubo syndrome of the Heart Failure Association of the European Society of Cardiology","volume":"18","author":"Lyon","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.chest.2021.04.072","article-title":"Incidence and clinical impact of right ventricular involvement (biventricular ballooning) in Takotsubo syndrome: results from the GEIST registry","volume":"160","author":"El-Battrawy","year":"2021","journal-title":"Chest"},{"key":"B4","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1161\/CIRCULATIONAHA.112.111591","article-title":"High levels of circulating epinephrine trigger apical cardiodepression in a \u03b22-adrenergic receptor\/Gi-dependent manner: a new model of Takotsubo cardiomyopathy","volume":"126","author":"Paur","year":"2012","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1016\/j.ijcard.2012.12.092","article-title":"Novel rat model reveals important roles of \u03b2-adrenoreceptors in stress-induced cardiomyopathy","volume":"168","author":"Shao","year":"2013","journal-title":"Int J Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1253\/circj.66.712","article-title":"Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of \u201cTako-Tsubo\u201d cardiomyopathy","volume":"66","author":"Ueyama","year":"2002","journal-title":"Circ J Off J Jpn Circ Soc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"101746","DOI":"10.1016\/j.scr.2020.101746","article-title":"Generation of iPSC-lines from two independent Takotsubo syndrome patients with recurrent Takotsubo events","volume":"44","author":"H\u00fcbscher","year":"2020","journal-title":"Stem Cell Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ijcard.2017.11.007","article-title":"Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes","volume":"254","author":"El-Battrawy","year":"2018","journal-title":"Int J Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/BC.2004.001","article-title":"The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. 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