{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:52:32Z","timestamp":1790355152671,"version":"4.1.0"},"reference-count":154,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004784","name":"Novartis Stiftung\u00c2f\u00fcr\u00c2Medizinisch-Biologische Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>\n                    Arterial occlusive disease is the narrowing of the arteries\n                    <jats:italic>via<\/jats:italic>\n                    atherosclerotic plaque buildup. The major risk factors for arterial occlusive disease are age, high levels of cholesterol and triglycerides, diabetes, high blood pressure, and smoking. Arterial occlusive disease is the leading cause of death in Western countries. Patients who suffer from arterial occlusive disease develop peripheral arterial disease (PAD) when the narrowing affects limbs, stroke when the narrowing affects carotid arteries, and heart disease when the narrowing affects coronary arteries. When lifestyle interventions (exercise, diet\u2026) fail, the only solution remains surgical endovascular and open revascularization. Unfortunately, these surgeries still suffer from high failure rates due to re-occlusive vascular wall adaptations, which is largely due to intimal hyperplasia (IH). IH develops in response to vessel injury, leading to inflammation, vascular smooth muscle cells dedifferentiation, migration, proliferation and secretion of extra-cellular matrix into the vessel\u2019s innermost layer or intima. Re-occlusive IH lesions result in costly and complex recurrent end-organ ischemia, and often lead to loss of limb, brain function, or life. Despite decades of IH research, limited therapies are currently available. Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is an endogenous gasotransmitter derived from cysteine metabolism. Although environmental exposure to exogenous high H\n                    <jats:sub>2<\/jats:sub>\n                    S is toxic, endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S has important vasorelaxant, cytoprotective and anti-inflammatory properties. Its vasculo-protective properties have attracted a remarkable amount of attention, especially its ability to inhibit IH. This review summarizes IH pathophysiology and treatment, and provides an overview of the potential clinical role of H\n                    <jats:sub>2<\/jats:sub>\n                    S to prevent IH and restenosis.\n                  <\/jats:p>","DOI":"10.3389\/fcvm.2022.876639","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:37:58Z","timestamp":1649637478000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Use of Hydrogen Sulfide to Protect Against Intimal Hyperplasia"],"prefix":"10.3389","volume":"9","author":[{"given":"Diane","family":"Macabrey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Longchamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"D\u00e9glise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Allagnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1177\/2047487312452968","article-title":"Peripheral arterial disease, prevalence and cumulative risk factor profile analysis.","volume":"21","author":"Eraso","year":"2014","journal-title":"Eur J Prev Cardiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis.","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1020","DOI":"10.1016\/S2214-109X(19)30255-4","article-title":"Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis.","volume":"7","author":"Song","year":"2019","journal-title":"Lancet Glob Health."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta18100","article-title":"Enhancements to angioplasty for peripheral arterial occlusive disease: systematic review, cost-effectiveness assessment and expected value of information analysis.","volume":"18","author":"Simpson","year":"2014","journal-title":"Health Technol Assess."},{"key":"B5","doi-asserted-by":"publisher","first-page":"E1150","DOI":"10.21037\/jtd.2016.10.93","article-title":"Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment.","volume":"8","author":"Buccheri","year":"2016","journal-title":"J Thorac Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.jvs.2016.10.098","article-title":"Drug-eluting stenting for femoropopliteal lesions, followed by cilostazol treatment, reduces stent restenosis in patients with symptomatic peripheral artery disease.","volume":"65","author":"Zen","year":"2017","journal-title":"J Vasc Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.jvs.2020.10.075","article-title":"Network meta-analysis of drug-coated balloon angioplasty versus primary nitinol stenting for femoropopliteal atherosclerotic disease.","volume":"73","author":"Abdoli","year":"2021","journal-title":"J Vasc Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1633","DOI":"10.4244\/EIJ-D-19-00292","article-title":"Efficacy and safety of a novel paclitaxel-nano-coated balloon for femoropopliteal angioplasty: one-year results of the effpac trial.","volume":"15","author":"Teichgraber","year":"2020","journal-title":"EuroIntervention."},{"key":"B9","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.jvs.2019.01.080","article-title":"Systematic review and updated meta-analysis of the use of drug-coated balloon angioplasty versus plain old balloon angioplasty for femoropopliteal arterial disease.","volume":"70","author":"Caradu","year":"2019","journal-title":"J Vasc Surg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.avsg.2017.12.003","article-title":"Comparison of drug-eluting stent with bare-metal stent implantation in femoropopliteal artery disease: a systematic review and meta-analysis.","volume":"50","author":"Ding","year":"2018","journal-title":"Ann Vasc Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0140-6736(03)12275-1","article-title":"Drug-eluting stents in vascular intervention.","volume":"361","author":"Fattori","year":"2003","journal-title":"Lancet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nrcardio.2011.132","article-title":"Restenosis after PCI. Part 1: pathophysiology and risk factors.","volume":"9","author":"Jukema","year":"2011","journal-title":"Nat Rev Cardiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejvs.2019.09.006","article-title":"Editor\u2019s Choice \u2013 European society for vascular surgery (ESVS) 2020 clinical practice guidelines on the management of acute limb ischaemia.","volume":"59","author":"Bjorck","year":"2020","journal-title":"Eur J Vasc Endovasc Surg."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011245","article-title":"Risk of death following application of paclitaxel-coated balloons and stents in the femoropopliteal artery of the leg: a systematic review and meta-analysis of randomized controlled trials.","volume":"7","author":"Katsanos","year":"2018","journal-title":"J Am Heart Assoc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1161\/CIRCULATIONAHA.119.044697","article-title":"Mortality and paclitaxel-coated devices: an individual patient data meta-analysis.","volume":"141","author":"Rocha-Singh","year":"2020","journal-title":"Circulation."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1161\/CIRCULATIONAHA.120.047376","article-title":"Us food and drug administration perspective on \u201cmortality and paclitaxel-coated devices: an individual patient data meta-analysis\u201d.","volume":"141","author":"Royce","year":"2020","journal-title":"Circulation."},{"key":"B17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/1526602820904783","article-title":"Mortality after paclitaxel-coated device use in patients with chronic limb-threatening ischemia: a systematic review and meta-analysis of randomized controlled trials.","volume":"27","author":"Dinh","year":"2020","journal-title":"J Endovasc Ther."},{"key":"B18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ejvs.2019.10.002","article-title":"Editor\u2019s choice \u2013 drug coated balloon angioplasty vs. standard percutaneous transluminal angioplasty in below the knee peripheral arterial disease: a systematic review and meta-analysis.","volume":"59","author":"Ipema","year":"2020","journal-title":"Eur J Vasc Endovasc Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jvir.2019.11.015","article-title":"Risk of death and amputation with use of paclitaxel-coated balloons in the infrapopliteal arteries for treatment of critical limb ischemia: a systematic review and meta-analysis of randomized controlled trials.","volume":"31","author":"Katsanos","year":"2020","journal-title":"J Vasc Interv Radiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1056\/NEJMoa2005206","article-title":"Mortality with paclitaxel-coated devices in peripheral artery disease.","volume":"383","author":"Nordanstig","year":"2020","journal-title":"N Engl J Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1001\/jamacardio.2019.0325","article-title":"Association of survival with femoropopliteal artery revascularization with drug-coated devices.","volume":"4","author":"Secemsky","year":"2019","journal-title":"JAMA Cardiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1161\/CIRCULATIONAHA.119.041099","article-title":"Paclitaxel-coated balloons and eluting stents: is there a mortality risk in patients with peripheral artery disease?","volume":"140","author":"Beckman","year":"2019","journal-title":"Circulation."},{"key":"B23","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S0140-6736(17)31927-X","article-title":"Coronary balloon angioplasty, stents, and scaffolds.","volume":"390","author":"Byrne","year":"2017","journal-title":"Lancet."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05631-9","article-title":"Head-to-head comparison of sirolimus- versus paclitaxel-coated balloon angioplasty in the femoropopliteal artery: study protocol for the randomized controlled sirona trial.","volume":"22","author":"Teichgraber","year":"2021","journal-title":"Trials."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0902-5","article-title":"Safety and efficacy of ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer drug-eluting stents: a meta-analysis of randomized trials.","volume":"18","author":"Zhu","year":"2018","journal-title":"BMC Cardiovasc Disord."},{"key":"B26","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.jcin.2016.12.002","article-title":"Meta-analysis of randomized clinical trials comparing biodegradable polymer drug-eluting stent to second-generation durable polymer drug-eluting stents.","volume":"10","author":"El-Hayek","year":"2017","journal-title":"JACC Cardiovasc Interv."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1002\/2211-5463.12917","article-title":"Paclitaxel induces apoptosis through the TAK1-JNK activation pathway.","volume":"10","author":"Yu-Wei","year":"2020","journal-title":"FEBS Open Bio."},{"key":"B28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jvssci.2021.04.001","article-title":"Targeting smooth muscle cell phenotypic switching in vascular disease.","volume":"2","author":"Chakraborty","year":"2021","journal-title":"JVS Vasc Sci."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01066","article-title":"Hydrogen Sulfide (H2S)-releasing compounds: therapeutic potential in cardiovascular diseases.","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Pharmacol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001986","article-title":"Hydrogen sulfide levels and Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) activity are attenuated in the setting of critical limb ischemia (CLI).","volume":"4","author":"Islam","year":"2015","journal-title":"J Am Heart Assoc."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1101\/2021.02.16.21251804","article-title":"Plasma hydrogen sulfide production capacity is positively associated with post-operative survival in patients undergoing surgical revascularization.","author":"Longchamp","year":"","journal-title":"medRxiv."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.2353\/ajpath.2007.060939","article-title":"Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries.","volume":"170","author":"Meng","year":"2007","journal-title":"Am J Pathol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3892\/mmr.2012.853","article-title":"Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty.","volume":"5","author":"Ma","year":"2012","journal-title":"Mol Med Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.yjmcc.2011.12.004","article-title":"Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in alpha5beta1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells.","volume":"52","author":"Yang","year":"2012","journal-title":"J Mol Cell Cardiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.actbio.2019.07.042","article-title":"Hydrogen sulfide-releasing peptide hydrogel limits the development of intimal hyperplasia in human vein segments.","volume":"97","author":"Longchamp","year":"2019","journal-title":"Acta Biomater."},{"key":"B36","doi-asserted-by":"publisher","first-page":"p. 125","DOI":"10.1016\/b978-0-12-420219-1.00004-5","article-title":"Diseases of small and medium-sized blood vessels.","author":"Stone","year":"2016","journal-title":"Cardiovascular Pathology."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3304","DOI":"10.1093\/eurheartj\/eht241","article-title":"Human autopsy study of drug-eluting stents restenosis: histomorphological predictors and neointimal characteristics.","volume":"34","author":"Nakano","year":"2013","journal-title":"Eur Heart J."},{"key":"B38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/cvr\/cvn099","article-title":"Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans.","volume":"79","author":"Nakashima","year":"2008","journal-title":"Cardiovasc Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.yjmcc.2015.11.013","article-title":"Role of smooth muscle Nox4-Based NADPH oxidase in neointimal hyperplasia.","volume":"89","author":"Tong","year":"2015","journal-title":"J Mol Cell Cardiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/s0741-5214(96)80034-6","article-title":"Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production.","volume":"23","author":"Sterpetti","year":"1996","journal-title":"J Vasc Surg."},{"key":"B41","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease.","volume":"84","author":"Owens","year":"2004","journal-title":"Physiol Rev."},{"key":"B42","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.bbagrm.2014.06.004","article-title":"Epigenetic regulation of smooth muscle cell plasticity.","volume":"1849","author":"Liu","year":"2015","journal-title":"Biochim Biophys Acta."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1161\/01.atv.0000042206.98651.15","article-title":"Differential gene expression in vascular smooth muscle cells in primary atherosclerosis and in stent stenosis in humans.","volume":"22","author":"Zhang","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/joim.12486","article-title":"Vascular proteomics in metabolic and cardiovascular diseases.","volume":"280","author":"Lynch","year":"2016","journal-title":"J Intern Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/cvr\/cvy022","article-title":"Smooth muscle cell fate and plasticity in atherosclerosis.","volume":"114","author":"Allahverdian","year":"2018","journal-title":"Cardiovasc Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1161\/hh2401.100844","article-title":"Contribution of adventitial fibroblasts to neointima formation and vascular remodeling: from innocent bystander to active participant.","volume":"89","author":"Sartore","year":"2001","journal-title":"Circ Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.ajpath.2019.10.021","article-title":"Recent developments in vascular adventitial pathobiology: the dynamic adventitia as a complex regulator of vascular disease.","volume":"190","author":"Tinajero","year":"2019","journal-title":"Am J Pathol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1113\/JP270033","article-title":"Origin and differentiation of vascular smooth muscle cells.","volume":"593","author":"Wang","year":"2015","journal-title":"J Physiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1172\/JCI19628","article-title":"Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice.","volume":"113","author":"Hu","year":"2004","journal-title":"J Clin Invest."},{"key":"B50","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.atherosclerosis.2006.05.033","article-title":"Characterisation of progenitor cells in human atherosclerotic vessels.","volume":"191","author":"Torsney","year":"2007","journal-title":"Atherosclerosis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1161\/CIRCULATIONAHA.109.899252","article-title":"Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential.","volume":"121","author":"Campagnolo","year":"2010","journal-title":"Circulation."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020540","article-title":"Vascular wall-resident Cd44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation.","volume":"6","author":"Klein","year":"2011","journal-title":"PLoS One."},{"key":"B53","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/89121","article-title":"Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy.","volume":"7","author":"Shimizu","year":"2001","journal-title":"Nat Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1161\/01.RES.0000096651.13001.B4","article-title":"Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries.","volume":"93","author":"Tanaka","year":"2003","journal-title":"Circ Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.tcm.2010.12.001","article-title":"Circulating smooth muscle progenitors and atherosclerosis.","volume":"20","author":"Albiero","year":"2010","journal-title":"Trends Cardiovasc Med."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117409","article-title":"Adventitial vessel growth and progenitor cells activation in an ex vivo culture system mimicking human saphenous vein wall strain after coronary artery bypass grafting.","volume":"10","author":"Prandi","year":"2015","journal-title":"PLoS One."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1016\/j.biomaterials.2013.12.041","article-title":"The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins.","volume":"35","author":"Longchamp","year":"2014","journal-title":"Biomaterials."},{"key":"B58","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.","volume":"322","author":"Yang","year":"2008","journal-title":"Science."},{"key":"B59","doi-asserted-by":"publisher","first-page":"H2316","DOI":"10.1152\/ajpheart.00331.2004","article-title":"Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats.","volume":"287","author":"Cheng","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels.","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/jb\/mvp111","article-title":"Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide.","volume":"146","author":"Shibuya","year":"2009","journal-title":"J Biochem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"26358","DOI":"10.1074\/jbc.M110.147439","article-title":"Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.","volume":"285","author":"Ishii","year":"2010","journal-title":"J Biol Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1161\/HYPERTENSIONAHA.117.10562","article-title":"Cystathionine gamma-lyase-produced hydrogen sulfide controls endothelial no bioavailability and blood pressure.","volume":"71","author":"Szijarto","year":"2018","journal-title":"Hypertension."},{"key":"B64","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1161\/CIRCULATIONAHA.118.034757","article-title":"Cystathionine \u03b3 lyase sulfhydrates the RNA binding protein human antigen R to preserve endothelial cell function and delay atherogenesis.","volume":"139","author":"Bibli","year":"2019","journal-title":"Circulation."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101379","article-title":"Shear stress regulates cystathionine gamma lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation.","volume":"28","author":"Bibli","year":"2020","journal-title":"Redox Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1161\/ATVBAHA.118.311402","article-title":"Cystathionine \u03b3-lyase modulates flow-dependent vascular remodeling.","volume":"38","author":"Yuan","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.bcp.2017.09.010","article-title":"A timeline of hydrogen sulfide (H2S) research: from environmental toxin to biological mediator.","volume":"149","author":"Szabo","year":"2018","journal-title":"Biochem Pharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation.","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem Rev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.jmb.2016.12.015","article-title":"Functional and molecular insights of hydrogen sulfide signaling and protein sulfhydration.","volume":"429","author":"Sen","year":"2017","journal-title":"J Mol Biol."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-Sulfhydration.","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci Signal."},{"key":"B71","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1161\/CIRCULATIONAHA.120.051877","article-title":"Mapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function.","volume":"143","author":"Bibli","year":"2021","journal-title":"Circulation."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1089\/ars.2019.7777","article-title":"Direct proteomic mapping of cysteine persulfidation.","volume":"33","author":"Fu","year":"2020","journal-title":"Antioxid Redox Signal."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.cmet.2019.10.007","article-title":"Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-Sulfhydration.","volume":"30","author":"Zivanovic","year":"2019","journal-title":"Cell Metab."},{"key":"B74","doi-asserted-by":"publisher","first-page":"H13","DOI":"10.1152\/ajpheart.00598.2010","article-title":"Vascular complications of cystathionine beta-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research.","volume":"300","author":"Beard","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.750926","article-title":"Plasma hydrogen sulfide is positively associated with post-operative survival in patients undergoing surgical revascularization.","volume":"8","author":"Longchamp","year":"2021","journal-title":"Front Cardiovasc Med."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.09.459573","article-title":"Sodium thiosulfate acts as an H2S mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerization.","author":"Macabrey","year":"","journal-title":"bioRxiv."},{"key":"B77","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/cvr\/cvz086","article-title":"Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine upsilon-lyase.","volume":"116","author":"Trocha","year":"2019","journal-title":"Cardiovasc Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1096\/fj.05-4712fje","article-title":"Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells.","volume":"20","author":"Yang","year":"2006","journal-title":"FASEB J."},{"key":"B79","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/cvr\/cvp420","article-title":"Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells.","volume":"86","author":"Yang","year":"2010","journal-title":"Cardiovasc Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.yexcr.2016.08.004","article-title":"Inhibition of hydrogen sulfide on the proliferation of vascular smooth muscle cells involved in the modulation of calcium sensing receptor in high homocysteine.","volume":"347","author":"Wang","year":"2016","journal-title":"Exp Cell Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1159\/000373973","article-title":"Calcium sensing receptor regulating smooth muscle cells proliferation through initiating cystathionine-gamma-lyase\/hydrogen sulfide pathway in diabetic rat.","volume":"35","author":"Zhong","year":"2015","journal-title":"Cell Physiol Biochem."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.13.460108","article-title":"Hydrogen sulfide release via the ace inhibitor zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis.","author":"Macabrey","year":"","journal-title":"bioRxiv."},{"key":"B83","doi-asserted-by":"publisher","first-page":"H1446","DOI":"10.1152\/ajpheart.00506.2012","article-title":"Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca2+-Activated K+ channels and smooth muscle Ca2+ sparks.","volume":"304","author":"Jackson-Weaver","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.vph.2018.01.001","article-title":"Gliclazide, a KATP channel blocker, inhibits vascular smooth muscle cell proliferation through the CaMKK\u03b2-AMPK pathway.","volume":"102","author":"Lee","year":"2018","journal-title":"Vascul Pharmacol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/jcmm.12077","article-title":"Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells.","volume":"17","author":"Altaany","year":"2013","journal-title":"J Cell Mol Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation.","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B87","doi-asserted-by":"publisher","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis.","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B88","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.phrs.2016.08.026","article-title":"Regulation and role of endogenously produced hydrogen sulfide in angiogenesis.","volume":"113","author":"Katsouda","year":"2016","journal-title":"Pharmacol Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cardiores.2007.05.026","article-title":"The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation.","volume":"76","author":"Cai","year":"2007","journal-title":"Cardiovasc Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1089\/ars.2012.4565","article-title":"VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells.","volume":"19","author":"Tao","year":"2013","journal-title":"Antioxid Redox Signal."},{"key":"B91","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cell.2018.03.001","article-title":"Amino acid restriction triggers angiogenesis via GCN2\/ATF4 regulation of VEGF and H2S production.","volume":"173","author":"Longchamp","year":"2018","journal-title":"Cell."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005478","article-title":"The coordination of S-Sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide.","volume":"7","author":"Altaany","year":"2014","journal-title":"Sci Signal."},{"key":"B93","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/j.1476-5381.2010.01191.x","article-title":"Hydrogen sulphide and angiogenesis: mechanisms and applications.","volume":"164","author":"Szabo","year":"2011","journal-title":"Br J Pharmacol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.2174\/138920111798281117","article-title":"Hydrogen sulfide regulates intracellular Ca2+ concentration in endothelial cells from excised rat aorta.","volume":"12","author":"Moccia","year":"2011","journal-title":"Curr Pharm Biotechnol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1002\/jnr.23427","article-title":"Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia.","volume":"92","author":"Jang","year":"2014","journal-title":"J Neurosci Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"C3","DOI":"10.1152\/ajpcell.00282.2016","article-title":"Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications.","volume":"312","author":"Szabo","year":"2017","journal-title":"Am J Physiol Cell Physiol."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00686","article-title":"The role of hydrogen sulfide on cardiovascular homeostasis: an overview with update on immunomodulation.","volume":"8","author":"Pan","year":"2017","journal-title":"Front Pharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1111\/bph.12246","article-title":"The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-\/-) mice.","volume":"169","author":"Liu","year":"2013","journal-title":"Br J Pharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1111\/bph.14719","article-title":"Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine \u03b3 lyase S-sulfhydration in ApoE-knockout atherosclerotic mice.","volume":"176","author":"Fan","year":"2019","journal-title":"Br J Pharmacol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function.","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/srep04774","article-title":"Hydrogen sulfide attenuates the recruitment of CD11b+Gr-1+ myeloid cells and regulates Bax\/Bcl-2 signaling in myocardial ischemia injury.","volume":"4","author":"Zhang","year":"2014","journal-title":"Sci Rep."},{"key":"B102","doi-asserted-by":"publisher","first-page":"430","DOI":"10.7150\/ijbs.3632","article-title":"Hydrogen sulfide mitigates cardiac remodeling during myocardial infarction via improvement of angiogenesis.","volume":"8","author":"Qipshidze","year":"2012","journal-title":"Int J Biol Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3727\/096368917X695029","article-title":"Hydrogen sulfide reduces recruitment of CD11b+Gr-1+ cells in mice with myocardial infarction.","volume":"26","author":"Wu","year":"2017","journal-title":"Cell Transplant."},{"key":"B104","doi-asserted-by":"publisher","first-page":"H2410","DOI":"10.1152\/ajpheart.00044.2012","article-title":"The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability.","volume":"302","author":"Predmore","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cbi.2017.07.002","article-title":"Sodium thiosulfate post-conditioning protects rat hearts against ischemia reperfusion injury via reduction of apoptosis and oxidative stress.","volume":"274","author":"Ravindran","year":"2017","journal-title":"Chem Biol Interact."},{"key":"B106","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/ATVBAHA.108.179333","article-title":"Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.","volume":"29","author":"Wang","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"9741","DOI":"10.1074\/jbc.M113.517995","article-title":"Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor \u03baB (NF-\u03baB) pathway.","volume":"289","author":"Du","year":"2014","journal-title":"J Biol Chem."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/j.cellsig.2013.07.010","article-title":"Dysregulation of cystathionine gamma-lyase (CSE)\/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage.","volume":"25","author":"Wang","year":"2013","journal-title":"Cell Signal."},{"key":"B109","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions.","volume":"45","author":"Sen","year":"2012","journal-title":"Mol Cell."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/srep00499","article-title":"Hydrogen sulfide and resolution of acute inflammation: a comparative study utilizing a novel fluorescent probe.","volume":"2","author":"Dufton","year":"2012","journal-title":"Sci Rep."},{"key":"B111","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.biopha.2016.07.003","article-title":"Hydrogen sulfide inhibits development of atherosclerosis through up-regulating protein S-nitrosylation.","volume":"83","author":"Lin","year":"2016","journal-title":"Biomed Pharmacother."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1873962","article-title":"Antioxidant and cell-signaling functions of hydrogen sulfide in the central nervous system.","volume":"2018","author":"Shefa","year":"2018","journal-title":"Oxid Med Cell Longev."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194176","article-title":"Hydrogen sulfide mediates athero-protection against oxidative stress via S-sulfhydration.","volume":"13","author":"Cheung","year":"2018","journal-title":"PLoS One."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7100129","article-title":"Role of hydrogen sulfide in NRF2- and sirtuin-dependent maintenance of cellular redox balance.","volume":"7","author":"Corsello","year":"2018","journal-title":"Antioxidants (Basel)."},{"key":"B115","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen sulfide induces keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via NRF2 activation.","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes."},{"key":"B116","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through NRF2 signaling.","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ Res."},{"key":"B117","doi-asserted-by":"publisher","first-page":"H1215","DOI":"10.1152\/ajpheart.00796.2012","article-title":"Hydrogen sulfide preconditions the db\/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner.","volume":"304","author":"Peake","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1161\/ATVBAHA.112.300484","article-title":"Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.","volume":"33","author":"Nicholson","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.freeradbiomed.2017.06.016","article-title":"Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling.","volume":"110","author":"Tian","year":"2017","journal-title":"Free Radic Biol Med."},{"key":"B120","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging.","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell."},{"key":"B121","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species.","volume":"552","author":"Turrens","year":"2003","journal-title":"J Physiol."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101772","article-title":"Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics.","volume":"38","author":"Paul","year":"2021","journal-title":"Redox Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1089\/ars.2015.6475","article-title":"Salusin-\u03b2 promotes vascular smooth muscle cell migration and intimal hyperplasia after vascular injury via ROS\/NF\u03baB\/MMP-9 Pathway.","volume":"24","author":"Sun","year":"2016","journal-title":"Antioxid Redox Signal."},{"key":"B124","doi-asserted-by":"publisher","first-page":"204","DOI":"10.5551\/jat.19448","article-title":"Oxidized high-density lipoprotein induces the proliferation and migration of vascular smooth muscle cells by promoting the production of ROS.","volume":"21","author":"Wang","year":"2014","journal-title":"J Atheroscler Thromb."},{"key":"B125","doi-asserted-by":"publisher","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic.","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B126","doi-asserted-by":"publisher","first-page":"H2693","DOI":"10.1152\/ajpheart.00853.2007","article-title":"S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway.","volume":"293","author":"Chuah","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1177\/0963689717724792","article-title":"S-allylcysteine improves blood flow recovery and prevents ischemic injury by augmenting neovasculogenesis.","volume":"26","author":"Syu","year":"2017","journal-title":"Cell Transplant."},{"key":"B128","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/978-3-319-18144-8_16","article-title":"The pharmacological effects of s-propargyl-cysteine, a novel endogenous H2S-producing compound.","volume":"230","author":"Wen","year":"2015","journal-title":"Handb Exp Pharmacol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/FJC.0b013e3181ac8e12","article-title":"S-Propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia\/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway.","volume":"54","author":"Wang","year":"2009","journal-title":"J Cardiovasc Pharmacol."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069205","article-title":"Cardioprotective effects of a novel hydrogen sulfide agent-controlled release formulation of S-Propargyl-Cysteine on heart failure rats and molecular mechanisms.","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS One."},{"key":"B131","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1089\/ars.2013.5449","article-title":"S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3.","volume":"20","author":"Kan","year":"2014","journal-title":"Antioxid Redox Signal."},{"key":"B132","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/cvr\/cvu026","article-title":"Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ace inhibition.","volume":"102","author":"Bucci","year":"2014","journal-title":"Cardiovasc Res."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-15-20","article-title":"Antihypertensive drug treatment changes in the general population: the colaus study.","volume":"15","author":"Christe","year":"2014","journal-title":"BMC Pharmacol Toxicol."},{"key":"B134","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(94)92811-8","article-title":"GISSI-3.","volume":"344","author":"Julian","year":"1994","journal-title":"Lancet."},{"key":"B135","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/s0895-7061(99)00042-4","article-title":"Effects of the administration of an angiotensin-converting enzyme inhibitor during the acute phase of myocardial infarction in patients with arterial hypertension. SMILE study investigators. Survival of myocardial infarction long-term evaluation.","volume":"12","author":"Borghi","year":"1999","journal-title":"Am J Hypertens."},{"key":"B136","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1007\/s12325-018-0697-x","article-title":"Efficacy and safety of zofenopril versus ramipril in the treatment of myocardial infarction and heart failure: a review of the published and unpublished data of the randomized double-blind smile-4 study.","volume":"35","author":"Borghi","year":"2018","journal-title":"Adv Ther."},{"key":"B137","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1056\/NEJM199501123320203","article-title":"The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction. The survival of myocardial infarction long-term evaluation (SMILE) study investigators.","volume":"332","author":"Ambrosioni","year":"1995","journal-title":"N Engl J Med."},{"key":"B138","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ejvs.2021.09.032","article-title":"Hydrogen sulphide release via the angiotensin converting enzyme inhibitor zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis.","volume":"63","author":"Macabrey","year":"2021","journal-title":"Eur J Vasc Endovasc Surg."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01134","article-title":"H2S donors reverse age-related gastric malfunction impaired due to fructose-induced injury via CBS, CSE, and TST expression.","volume":"11","author":"Pavlovskiy","year":"2020","journal-title":"Front Pharmacol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/bph.14641","article-title":"A proof-of-concept, phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug.","volume":"177","author":"Wallace","year":"2020","journal-title":"Br J Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.freeradbiomed.2006.12.011","article-title":"Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative.","volume":"42","author":"Li","year":"2007","journal-title":"Free Radic Biol Med."},{"key":"B142","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1053\/j.gastro.2006.11.042","article-title":"Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat.","volume":"132","author":"Wallace","year":"2007","journal-title":"Gastroenterology."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2008.07.029","article-title":"Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation.","volume":"594","author":"Baskar","year":"2008","journal-title":"Eur J Pharmacol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"H801","DOI":"10.1152\/ajpheart.00377.2008","article-title":"Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling.","volume":"295","author":"Jha","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"H2S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase.","volume":"127","author":"Kondo","year":"2013","journal-title":"Circulation."},{"key":"B146","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/1755-5922.12128","article-title":"A Novel hydrogen sulfide prodrug, Sg1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patients.","volume":"33","author":"Polhemus","year":"2015","journal-title":"Cardiovasc Ther."},{"key":"B147","doi-asserted-by":"publisher","first-page":"R592","DOI":"10.1152\/ajpregu.00421.2012","article-title":"Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing.","volume":"305","author":"Olson","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1111\/bph.12825","article-title":"Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats.","volume":"172","author":"Snijder","year":"2015","journal-title":"Br J Pharmacol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/nep.13081","article-title":"Systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients.","volume":"23","author":"Peng","year":"2018","journal-title":"Nephrology (Carlton)."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/j.jvs.2012.12.069","article-title":"Local drug delivery to prevent restenosis.","volume":"57","author":"Seedial","year":"2013","journal-title":"J Vasc Surg."},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016391","article-title":"Periprocedural hydrogen sulfide therapy improves vascular remodeling and attenuates vein graft disease.","volume":"9","author":"Kip","year":"2020","journal-title":"J Am Heart Assoc."},{"key":"B152","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.pharmthera.2010.11.003","article-title":"Local drug delivery for percutaneous coronary intervention.","volume":"129","author":"Sharma","year":"2011","journal-title":"Pharmacol Ther."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1089\/ars.2019.7884","article-title":"Enhanced analgesic effects and gastrointestinal safety of a novel, hydrogen sulfide-releasing anti-inflammatory drug (ATB-352): a role for endogenous cannabinoids.","volume":"33","author":"Costa","year":"2020","journal-title":"Antioxid Redox Signal."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.2215\/CJN.10241110","article-title":"Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers.","volume":"6","author":"Farese","year":"2011","journal-title":"Clin J Am Soc Nephrol."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.876639\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:38:04Z","timestamp":1649637484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.876639\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":154,"alternative-id":["10.3389\/fcvm.2022.876639"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.876639","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,11]]},"article-number":"876639"}}