{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:06:40Z","timestamp":1788538000463,"version":"build-2803163510"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The hybrid arch repair (HAR) is an appealing surgical option in the management of aortic arch diseases. The aim is to evaluate the short and mid-term outcomes of type II HAR involving replacement of the ascending aorta, arch debranching, and zone 0 stent graft deployment in diverse arch pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>200 patients with various diffuse aortic pathologies involving the arch were enrolled between 2016 and 2019. Complex arch diseases included acute type A dissection (<jats:italic>n<\/jats:italic> = 129, 64.5%), acute type B dissection (<jats:italic>n<\/jats:italic> = 16, 8.0%), aortic arch aneurysm (<jats:italic>n<\/jats:italic> = 42, 21.0%) and penetrating arch ulcer (<jats:italic>n<\/jats:italic> = 13, 6.5%). Mortality, morbidity, survival and re-intervention were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall 30-day mortality rate was 8.0% (16\/200). Stroke was present in 3.5% (7\/200) of the general cohort and spinal cord injury was occurred in 3.0% (6\/200). Multivariable logistic analysis showed that cardiac malperfusion and CPB time were the risk factors associated with 30-day mortality. The mean follow-up duration was 25.9 months (range 1\u201357.2 months), and the 3-year survival rate was 83.1%. On Cox regression analysis, age, diabetes, cardiac malperfusion and CPB time predicted short and mid-term overall mortality. A total of 3 patients required reintervention during the follow-up due to the thrombosis of epiaortic artificial vessels (<jats:italic>n<\/jats:italic> = 1), anastomotic leak at the site of the proximal ascending aorta (<jats:italic>n<\/jats:italic> = 1) and the type I endoleak (<jats:italic>n<\/jats:italic> = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Type II HAR was performed with satisfactory early and mid-term outcomes in complex aortic arch pathologies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.882783","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T10:37:25Z","timestamp":1654166245000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Early and Midterm Outcomes of Type II Hybrid Arch Repair for Complex Aortic Arch Pathology"],"prefix":"10.3389","volume":"9","author":[{"given":"Yanxiang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojun","family":"Dun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuntao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.athoracsur.2017.06.072","article-title":"Safety of moderate hypothermia with antegrade perfusion in total aortic arch replacement","volume":"105","author":"Keeling","year":"2018","journal-title":"Ann Thorac Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.jtcvs.2010.02.055","article-title":"Have hybrid procedures replaced open aortic arch reconstruction in high-risk patients? 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