{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:13:35Z","timestamp":1787318015304,"version":"build-2736575974"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to construct a model to predict the risk of in-hospital death in patients with acute renal injury (AKI) receiving continuous renal replacement therapy (CRRT) after acute type A aortic dissection (ATAAD) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the data of patients with AKI undergoing CRRT after ATAAD surgery. The patients were divided into survival and nonsurvival groups based on their vital status at hospital discharge. The data were analyzed using univariate and multivariate logistic regression analyses. Establish a risk prediction model using a nomogram and its discriminative ability was validated using C statistic and the receiver operating characteristic (ROC) curve. Its calibration ability was tested using a calibration curve, 10-fold cross-validation and Hosmer\u2013Lemeshow test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 175 patients, in-hospital death occurred in 61 (34.9%) patients. The following variables were incorporated in predicting in-hospital death: age &amp;gt; 65 years, lactic acid 12 h after CRRT, liver dysfunction, and permanent neurological dysfunction. The risk model revealed good discrimination (C statistic = 0.868, 95% CI: 0.806\u20130.930; a bootstrap-corrected C statistic of 0.859, the area under the ROC = 0.868). The calibration curve showed good consistency between predicted and actual probabilities (\n                      <jats:italic>via<\/jats:italic>\n                      1,000 bootstrap samples, mean absolute error = 2.2%; Hosmer\u2013Lemeshow test,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.846). The 10-fold cross validation of the nomogram showed that the average misdiagnosis rate was 16.64%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed model could be used to predict the probability of in-hospital death in patients undergoing CRRT for AKI after ATAAD surgery. It had the potential to assist doctors to identify the gravity of the situation and make the targeted therapeutic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2022.891038","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:53:41Z","timestamp":1651452821000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Development and Validation of a Prognostic Model to Predict the Risk of In-hospital Death in Patients With Acute Kidney Injury Undergoing Continuous Renal Replacement Therapy After Acute Type a Aortic Dissection"],"prefix":"10.3389","volume":"9","author":[{"given":"Rui","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maomao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuran","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/j.athoracsur.2016.05.006","article-title":"Long-term survival in patients with acute kidney injury after acute type A aortic dissection repair","volume":"102","author":"Sasabuchi","year":"2016","journal-title":"Ann Thorac Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1093\/eurheartj\/ehx319","article-title":"Acute aortic syndromes: diagnosis and management, an update","volume":"39","author":"Bossone","year":"2018","journal-title":"Eur Heart J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1161\/CIRCULATIONAHA.110.006320","article-title":"Correlates of delayed recognition and treatment of acute type A aortic dissection: the International Registry of Acute Aortic Dissection (IRAD)","volume":"124","author":"Harris","year":"2011","journal-title":"Circulation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.amjcard.2015.04.043","article-title":"Impact of acute kidney injury on early to long-term outcomes in patients who underwent surgery for type A acute aortic dissection","volume":"116","author":"Ko","year":"2015","journal-title":"Am J Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3978\/j.issn.2305-5839.2015.12.63","article-title":"Multiple imputation with multivariate imputation by chained equation (mice) package","volume":"4","author":"Zhang","year":"2016","journal-title":"Ann Transl Med."},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2011.38.7589","article-title":"Missing data in clinical studies: issues and methods","volume-title":"J Clin Oncol.","author":"Ibrahim","year":"2012"},{"key":"B7","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1037\/1082-989X.7.2.147","article-title":"Missing data: our view of the state of the art","volume":"7","author":"Schafer","year":"2002","journal-title":"Psychol Methods."},{"key":"B8","doi-asserted-by":"publisher","first-page":"4400","DOI":"10.1158\/1078-0432.CCR-07-4713","article-title":"Comparison of nomograms with other methods for predicting outcomes in prostate cancer: a critical analysis of the literature","volume":"14","author":"Shariat","year":"2008","journal-title":"Clin Cancer Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1093\/eurheartj\/ehu207","article-title":"Towards better clinical prediction models: seven steps for development and an ABCD for validation","volume":"35","author":"Steyerberg","year":"2014","journal-title":"Eur Heart J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"935","DOI":"10.3109\/0886022X.2011.615964","article-title":"In critically ill patients requiring CRRT, AKI is associated with increased respiratory failure and death versus ESRD","volume":"33","author":"Walcher","year":"2011","journal-title":"Ren Fail."},{"key":"B11","doi-asserted-by":"publisher","first-page":"E11","DOI":"10.1111\/j.1525-1594.2010.01115.x","article-title":"Norepinephrine and hospital mortality in critically ill patients undergoing continuous renal replacement therapy","volume":"35","author":"Chou","year":"2011","journal-title":"Artif Organs."},{"key":"B12","doi-asserted-by":"publisher","first-page":"250","DOI":"10.23876\/j.krcp.2017.36.3.250","article-title":"Heart rate is associated with mortality in patients undergoing continuous renal replacement therapy","volume":"36","author":"Lee","year":"2017","journal-title":"Kidney Res Clin Pract."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/nep.13661","article-title":"Development of a new mortality scoring system for acute kidney injury with continuous renal replacement therapy","volume":"24","author":"Kim","year":"2019","journal-title":"Nephrology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jcrc.2019.11.001","article-title":"Short, and long-term mortality among cardiac intensive care unit patients started on continuous renal replacement therapy","volume":"55","author":"Keleshian","year":"2020","journal-title":"J Crit Care."},{"key":"B15","first-page":"10","article-title":"Prognostic value of a new scoring system for hospital mortality in acute renal failure","volume":"53","author":"Lins","year":"2000","journal-title":"Clin Nephrol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12871-017-0312-8","article-title":"A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score","volume":"17","author":"da Hora Passos","year":"2017","journal-title":"BMC Anesthesiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e772","DOI":"10.1097\/CCM.0000000000002407","article-title":"ICU patients requiring renal replacement therapy initiation: fewer survivors and more dialysis dependents from 80 years old","volume":"45","author":"Commereuc","year":"2017","journal-title":"Crit Care Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.jss.2013.04.056","article-title":"Changes in blood lactate levels after major elective abdominal surgery and the association with outcomes: a prospective observational study","volume":"184","author":"Li","year":"2013","journal-title":"J Surg Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1001\/jama.2010.158","article-title":"Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial","volume":"303","author":"Jones","year":"2010","journal-title":"JAMA."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1378\/chest.12-0878","article-title":"Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock","volume":"143","author":"Puskarich","year":"2013","journal-title":"Chest."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2110-5820-3-3","article-title":"Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in intensive care unit: an observational study","volume":"3","author":"Marty","year":"2013","journal-title":"Ann Intensive Care."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/j.amjmed.2015.07.033","article-title":"The incidence and outcomes of ischemic hepatitis: a systematic review with meta-analysis","volume":"128","author":"Tapper","year":"2015","journal-title":"Am J Med."},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.1016\/S1089-3261(02)00056-9","article-title":"The liver in heart failure","volume-title":"Clin Liver Dis.","author":"Giallourakis","year":"2002"},{"key":"B24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/cld.573","article-title":"Congestive hepatopathy","volume":"8","author":"Hilscher","year":"2016","journal-title":"Clin Liver Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1007\/s00134-011-2248-7","article-title":"Impact of hypoxic hepatitis on mortality in the intensive care unit","volume":"37","author":"Fuhrmann","year":"2011","journal-title":"Intensive Care Med."},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1016\/S0002-9343(00)00461-7","article-title":"Ischemic hepatitis: clinical presentation and pathogenesis","volume-title":"Am J Med.","author":"Seeto","year":"2000"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.2169\/internalmedicine.46.0059","article-title":"Hypoxic hepatopathy: pathophysiology and prognosis","volume":"46","author":"Birrer","year":"2007","journal-title":"Intern Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"CMAJ."},{"key":"B29","doi-asserted-by":"publisher","first-page":"S","DOI":"10.1016\/S0016-5085(13)61656-X","article-title":"Su1289 role of ejection fraction (EF) as a predictor of ischemic hepatitis in patients with shock","volume":"144","author":"Makker","year":"2013","journal-title":"Gastroenterology."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e008834","DOI":"10.1161\/JAHA.118.008834","article-title":"Cardiac and vascular surgery-associated acute kidney injury: the 20th international consensus conference of the ADQI (acute disease quality initiative) group","volume":"7","author":"Nadim","year":"2018","journal-title":"J Am Heart Assoc."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the international registry of acute aortic dissection: a 20-year experience of collaborative clinical research","volume":"137","author":"Evangelista","year":"2018","journal-title":"Circulation."},{"key":"B32","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1055\/s-0035-1563536","article-title":"Survival, neurologic injury, and kidney function after surgery for acute type A aortic dissection","volume":"64","author":"Schoenrath","year":"2016","journal-title":"Thorac Cardiovasc Surg."},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1038\/nrcardio.2014.203","article-title":"Management of acute aortic syndrome","volume-title":"Nat Rev Cardiol.","author":"Clough","year":"2015"},{"key":"B34","doi-asserted-by":"publisher","first-page":"65","DOI":"10.21037\/jovs.2018.03.13","article-title":"Malperfusion syndromes in type A aortic dissection: what we have learned from IRAD","volume":"4","author":"Berretta","year":"2018","journal-title":"J Vis Surg."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.891038\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:54:01Z","timestamp":1651452841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.891038\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":34,"alternative-id":["10.3389\/fcvm.2022.891038"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.891038","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]},"article-number":"891038"}}