{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:41:51Z","timestamp":1793295711931,"version":"4.5.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dyslipidemia contributes to the progression of arterial stiffness (AS). The purpose of this study was to investigate the association of the different lipid parameters with arterial stiffness index (ASI) in a middle-aged population free of cardiovascular (CV) disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 71,326 volunteers from the UK Biobank population, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), lipoprotein (a) [Lp(a)], apolipoproteins A and B (Apo A and Apo B), and ASI were measured. Values for non-HDL, TC\/HDL, TG\/HDL, and LDL\/HDL were calculated. AS was defined as an ASI &amp;gt; 10 m\/s. Associations between lipid parameters and ASI were performed using multiple linear logistic regressions. The results reported from univariate models were the squared partial correlation coefficient, <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>, and from multivariate models, the adjusted coefficient of determination, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>, to describe the contribution of ASI variability for each lipid parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that TG\/HDL was mainly associated with ASI [\u03b2 = 0.53 (0.01), <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 3.66%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001 and adjusted \u03b2 = 0.21 (0.01), <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 13.58%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001] and AS [odds ratio (OR) = 1.86 (1.80\u20131.92), <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 1.65%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001 and adjusted OR = 1.15 (1.13\u20131.17), <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 8.54%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001] rather than the others. TG\/HDL remained the only lipid parameter that showed added value in linear multivariate models. TG\/HDL remained less associated with AS than age (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 5.55%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), mean blood pressure (BP; <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 5.31%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), and gender (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 4.44%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), but more highly associated than body mass index (BMI; <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 1.95%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), heart rate (HR; <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.81%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), fasting glucose (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.18%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), tobacco (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.05%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), and glomerular filtration rate (GFR; <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.01%, <jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In primary CV prevention, lipids, especially through the TG\/HDL ratio, could be more instructive in preventing the increase in AS than other modifiable factors.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.899841","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T08:26:01Z","timestamp":1654071961000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Association Between Lipids and Arterial Stiffness for Primary Cardiovascular Prevention in a General Middle-Aged European Population"],"prefix":"10.3389","volume":"9","author":[{"given":"Alexandre","family":"Vall\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1056\/NEJM199806043382302","article-title":"Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. 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