{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:27:29Z","timestamp":1771568849631,"version":"3.50.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Studies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to optimize the yield of such strategy are needed. We therefore aimed to investigate whether 12-lead ECG changes post-TAVR may help identify patients with abnormal EPS findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Consecutive patients with new-onset LBBB post-TAVR who underwent EPS were included. PR and QRS intervals were measured on 12-lead ECG pre-TAVR and during EPS. Abnormal EPS was defined as an HV interval &amp;gt; 55 ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 61 patients, 28 (46%) had an HV interval &amp;gt; 55 ms after TAVR. Post-TAVR PR interval and \u0394PR (PR-post\u2013pre-TAVR) were significantly longer in patients with prolonged HV (PR: 188 \u00b1 38 vs. 228 \u00b1 34 ms, <jats:italic>p<\/jats:italic> &amp;lt; 0.001, \u0394PR: 10 \u00b1 30 vs. 34 \u00b1 23 ms, <jats:italic>p<\/jats:italic> = 0.001), while no difference was found in QRS duration. PR and \u0394PR intervals both effectively discriminated patients with HV &amp;gt; 55 ms (AUC = 0.804 and 0.769, respectively; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). A PR &amp;gt; 200 ms identified patients with abnormal EPS results with a sensitivity of 89% and a negative predictive value (NPV) of 88%. \u0394PR \u2265 20 ms alone provided a somewhat lower sensitivity (64%) but combining both criteria (i.e., PR &amp;gt; 200 ms <jats:italic>or<\/jats:italic> \u0394PR \u2265 20 ms) identified almost every patients with abnormal HV (sensitivity = 96%, NPV = 95%). Selecting EPS candidate based on both criteria would avoid 1\/3 of exams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR \u2264 200 ms <jats:italic>and<\/jats:italic> \u0394PR &amp;lt; 20 ms the likelihood of abnormal EPS is very low independently of QRS changes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.910693","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T07:22:03Z","timestamp":1662448923000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval 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