{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:40:58Z","timestamp":1782286858699,"version":"3.54.5"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>During on-pump coronary artery bypass grafting (ONCAB), graft flushing for distal anastomoses testing also perfuses the downstream myocardium. This single-center retrospective study evaluated the impact of specific preservation solutions on myocardial protection during ONCAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Between July 2019 and March 2020 either DuraGraft (DG) or 0.9% Saline\/Biseko (SB) was applied to 272 ONCAB. Overall, 166 patients were propensity-matched into two groups. Cardiac enzymes [high-sensitive Troponin I (hs-TnI) and creatine kinase (CK)] were evaluated 7 days post-surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post-surgery, hs-TnI values were significantly lower from 3 to 6 h (h) up to 4 days in the DG group: 3\u20136 h: 4,034 ng\/L [IQR 1,853\u20138,654] vs. 5,532 ng\/L [IQR 3,633\u20148,862], <jats:italic>p<\/jats:italic> = 0.05; 12\u201324 h: 2,420 ng\/L [IQR 1,408\u20135,782] vs. 4,166 [IQR 2,052\u20138,624], <jats:italic>p<\/jats:italic> &amp;lt; 0.01; 2 days: 1,095 ng\/L [IQR 479\u20132,311] vs. 1,564 ng\/L [IQR 659\u20135,057], <jats:italic>p<\/jats:italic> = 0.02 and at 4 days: 488 ng\/L [IQR 232\u20131,061] vs. 745 ng\/L [IQR 319\u20131,820], <jats:italic>p<\/jats:italic> = 0.03. The maximum value: 4,151 ng\/L [IQR 2,056\u20138,621] vs. 6,349 ng\/L [IQR 4,061\u201312,664], <jats:italic>p<\/jats:italic> &amp;lt; 0.01 and the median area under the curve (AUC): 6,146 ng\/L\/24 h [IQR 3,121\u201313,248] vs. 10,735 ng\/L\/24 h [IQR 4,859\u201321,484], <jats:italic>p<\/jats:italic> = 0.02 were lower in the DG group. CK values were not significantly different between groups: maximum value 690 [IQR 417\u2013947] vs. 631 [464\u2013979], <jats:italic>p<\/jats:italic> = 0.61 and AUC 1,986 [1,226\u20132,899] vs. 2,081 [1,311\u20133,063], <jats:italic>p<\/jats:italic> = 0.37.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeated graft flushing with DG resulted in lower Troponin values post-surgery suggesting enhanced myocardial protection compared to SB. Additional studies are warranted to further assess the myocardial protection properties of DG.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.922357","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T04:48:03Z","timestamp":1658983683000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Graft preservation confers myocardial protection during coronary artery bypass grafting"],"prefix":"10.3389","volume":"9","author":[{"given":"Philipp","family":"Szalkiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian Y.","family":"Emmert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul 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