{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:05:56Z","timestamp":1785416756598,"version":"3.56.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>To the best of our knowledge, thus far there are no reported cases of melanotic neuroectodermal tumor of infancy (MNTI) with multiple complications. In this case report, we describe the clinical phenotype of MNTI in a 9-month-old female infant associated with tetralogy of Fallot (TOF), a congenital heart defect, and congenital hypothyroidism (CH). Our study showed that the growth of MNTI was delayed by a lower dosage of levothyroxine (L-T4) that was prescribed to treat CH because of the presence of TOF, a severe congenital heart disease. However, the standardized dosage of L-T4 improved thyroid function but stimulated the rapid growth of MNTI. Our report demonstrated that treatment with L-T4 affects the progression of MNTI. Our findings demonstrated the role of thyroid hormone in MNTI growth and progression. Furthermore, our study suggested that the treatment of co-morbidities in children with MNTI requires careful consideration of their effects on the growth and progression of MNTI.<\/jats:p>","DOI":"10.3389\/fcvm.2022.924538","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T09:03:03Z","timestamp":1668070983000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism"],"prefix":"10.3389","volume":"9","author":[{"given":"Hua-Chu","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Sheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"B1","first-page":"165","article-title":"Zur histogenese und morphologie der adamantinome und sonstiger kiefergeschwulste.","volume":"64","author":"Krombecher","year":"1918","journal-title":"Beitr Pathol Anat Allg Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.5858\/arpa.2018-0241-RA","article-title":"Melanotic neuroectodermal tumor of infancy.","volume":"142","author":"Soles","year":"2018","journal-title":"Arch Pathol Lab Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.anl.2015.10.010","article-title":"Clinicopathological features of melanotic neuroectodermal tumor of infancy: report of two cases.","volume":"43","author":"Higashi","year":"2016","journal-title":"Auris Nasus Larynx."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1016\/j.joms.2015.03.061","article-title":"Melanotic neuroectodermal tumor of infancy: a systematic review.","volume":"73","author":"Rachidi","year":"2015","journal-title":"J Oral Maxillofac Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00381-020-04509-6","article-title":"Melanotic neuroectodermal tumor of infancy to the skull: case-based review.","volume":"36","author":"Ebel","year":"2020","journal-title":"Childs Nerv Syst."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1002\/hed.25514","article-title":"Melanotic neuroectodermal tumor of infancy of the jaw bones: update on the factors influencing survival and recurrence.","volume":"40","author":"Pontes","year":"2018","journal-title":"Head Neck."},{"key":"B7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/1097-0142(196602)19:23.0.co;2-6","article-title":"Melanotic neuroectodermal tumor of infancy:a neoplasm of neural crese origin.","volume":"19","author":"Borello","year":"1966","journal-title":"Cancer."},{"key":"B8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ydbio.2021.01.018","article-title":"Neural crest metabolism: at the crossroads of development and disease.","volume":"475","author":"Bhattacharya","year":"2021","journal-title":"Dev Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"S110","DOI":"10.1016\/j.ydbio.2018.05.013","article-title":"Neurocristopathies: new insights 150 years after the neural crest discovery.","author":"Vega-Lopez","year":"2018","journal-title":"Dev Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/j.1365-4362.1977.tb04299.x","article-title":"Cutaneous manifestations of neural crest disorders (neurocristopathies).","volume":"16","author":"Reed","year":"1977","journal-title":"Int J Dermatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jcms.2017.12.001","article-title":"Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: a French multicenter study.","volume":"46","author":"Moreau","year":"2018","journal-title":"J Craniomaxillofac Surg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s12253-017-0228-0","article-title":"Primary ewing sarcoma\/primitive neuroectodermal tumor of the kidney: a clinicopathologic study of 23 cases.","volume":"24","author":"Murugan","year":"2018","journal-title":"Pathol Oncol Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3760\/cma.j.issn.0529-5807.2018.01.003","article-title":"Expert consensus on standardized pathological diagnosis of melanoma in China (2017 edition).","volume":"47","year":"2018","journal-title":"Chinese J Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1080\/14737140.2016.1197122","article-title":"Biology and management of clear cell sarcoma: state of the art and future perspectives.","volume":"16","author":"Cornillie","year":"2016","journal-title":"Expert Rev Anticancer Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1590\/0103-6440201801787","article-title":"Melanotic neuroectodermal tumor of infancy: a clinicopathological case report.","volume":"29","author":"Fernandes","year":"2018","journal-title":"Braz Dent J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"784","DOI":"10.4103\/jcrt.JCRT_612_20","article-title":"Melanotic neuroectodermal tumor of infancy (MNTI)-A rare entity.","volume":"18","author":"Goel","year":"2022","journal-title":"J Cancer Res Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.4103\/jomfp.JOMFP_237_16","article-title":"Melanotic neuroectodermal tumor of infancy: a rare entity.","volume":"23","author":"Sharma","year":"2019","journal-title":"J Oral Maxillofac Pathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s00701-009-0472-5","article-title":"Melanotic neuroectodermal tumor of infancy (MNT1) arising in the skull. Short review of two cases.","volume":"152","author":"Lambropoulos","year":"2010","journal-title":"Acta Neurochir."},{"key":"B19","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1002\/bdr2.1508","article-title":"Alcohol-mediated calcium signals dysregulate pro-survival Snai2\/PUMA\/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors.","volume":"111","author":"Flentke","year":"2019","journal-title":"Birth Defects Res."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.042234","article-title":"Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid.","volume":"12","author":"Sudiwala","year":"2019","journal-title":"Dis Model Mech."},{"key":"B21","doi-asserted-by":"publisher","first-page":"304","DOI":"10.4149\/neo_2019_190429N378","article-title":"PAX3 silencing suppresses gastric cancer proliferation and angiogenesis via MET\/PI3K signaling.","volume":"67","author":"Lv","year":"2020","journal-title":"Neoplasma."},{"key":"B22","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s12031-019-01283-2","article-title":"PAX3 promotes proliferation of human glioma cells by WNT\/\u03b2-catenin signaling pathways.","volume":"68","author":"Liang","year":"2019","journal-title":"J Mol Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","article-title":"Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis.","volume":"58","author":"van der Linde","year":"2011","journal-title":"J Am Coll Cardiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrg2279","article-title":"The multifaceted role of Notch in cardiac development and disease.","volume":"9","author":"High","year":"2008","journal-title":"Nat Rev Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1161\/CIRCRESAHA.118.313250","article-title":"Whole exome sequencing reveals the major genetic contributors to nonsyndromic tetralogy of fallot.","volume":"124","author":"Page","year":"2019","journal-title":"Circ Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/MED.0000000000000520","article-title":"Update on congenital hypothyroidism.","volume":"27","author":"Cherella","year":"2020","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"key":"B27","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1530\/EJE-17-1017","article-title":"The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.","volume":"178","author":"Sun","year":"2018","journal-title":"Eur J Endocrinol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/B978-0-444-64029-1.00016-3","article-title":"Neurodevelopmental outcome of children with congenital heart disease.","volume":"162","author":"Liamlahi","year":"2019","journal-title":"Handb Clin Neurol."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.924538\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T09:03:07Z","timestamp":1668070987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.924538\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":28,"alternative-id":["10.3389\/fcvm.2022.924538"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.924538","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"article-number":"924538"}}