{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:48:16Z","timestamp":1789264096625,"version":"build-2803163510"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Type A aortic dissection (TAAD) has a rapid onset and high mortality. Currently, aortic diameter is the major criterion for evaluating the risk of TAAD. We attempted to find other aortic morphological indicators to further analyze their relationships with the risk of type A dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included the imaging and clinical data of 112 patients. The patients were divided into three groups, of which Group 1 had 49 patients with normal aortic diameter, Group 2 had 22 patients with ascending aortic aneurysm, and Group 3 had 41 patients with TAAD. We used AW Server software, version 3.2, to measure aorta-related morphological indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First, in Group 1, the univariate analysis results showed that ascending aortic diameter was correlated with patient age (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.35) and ascending aortic length (AAL) (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.43). AAL was correlated with age (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.12) and height (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.11). Further analysis of the aortic morphological indicators among the three groups found that the median aortic diameter was 36.20 mm in Group 1 (Q1\u2013Q3: 33.40\u201337.70 mm), 42.5 mm in Group 2 (Q1\u2013Q3: 41.52\u201344.17 mm) and 48.6 mm in Group 3 (Q1\u2013Q3: 42.4\u201355.3 mm). There was no significant difference between Groups 2 and 3 (<jats:italic>P<\/jats:italic> &amp;gt; 0.05). Group 3 had the longest AAL (median: 109.4 mm, Q1\u2013Q3: 118.3\u2013105.3 mm), followed by Group 2 (median: 91.0 mm, Q1\u2013Q3: 95.97\u201384.12 mm) and Group 1 (81.20 mm, Q1\u2013Q3: 76.90\u201386.20 mm), and there were statistically significant differences among the three groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The Aortic Bending Index (ABI) was 14.95 mm\/cm in Group 3 (Q1\u2013Q3: 14.42\u201315.78 mm\/cm), 13.80 mm\/cm in Group 2 (Q1\u2013Q3: 13.42\u201314.42 mm\/cm), and 13.29 mm\/cm in Group 1 (Q1\u2013Q3: 12.71\u201313.78 mm\/cm), and the difference was statistically significant in comparisons between any two groups (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Regression analysis showed that aortic diameter + AAL + ABI differentiated Group 2 and Group 3 with statistical significance (area under the curve (AUC) = 0.834), which was better than aortic diameter alone (AUC = 0.657; <jats:italic>P<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We introduced the new concept of ABI, which has certain clinical significance in distinguishing patients with aortic dissection and aneurysm. Perhaps the ascending aortic diameter combined with AAL and ABI could be helpful in predicting the occurrence of TAAD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.927105","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T05:38:53Z","timestamp":1655703533000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Relationship Between Length and Curvature of Ascending Aorta and Type a Dissection"],"prefix":"10.3389","volume":"9","author":[{"given":"Lianjie","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanteng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1161\/CIRCULATIONAHA.106.630400","article-title":"Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002","volume":"114","author":"Olsson","year":"2006","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1378\/chest.117.5.1271","article-title":"Epidemiology and clinicopathology of aortic dissection","volume":"117","author":"M\u00e9sz\u00e1ros","year":"2000","journal-title":"Chest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease","volume":"283","author":"Hagan","year":"2000","journal-title":"JAMA."},{"key":"B4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/00005792-195809000-00003","article-title":"Dissecting aneurysm of the aorta: a review of 505 cases","volume":"37","author":"Hirst","year":"1958","journal-title":"Medicine"},{"key":"B5","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.jtcvs.2021.04.053","article-title":"2021 The American Association for Thoracic Surgery expert consensus document: surgical treatment of acute type A aortic dissection","volume":"162","author":"Malaisrie","year":"2021","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.5603\/KP.2014.0225","article-title":"2014 ESC Guidelines on the diagnosis and treatment of aortic diseases","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1161\/CIRCULATIONAHA.107.702720","article-title":"Aortic diameter >or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD)","volume":"116","author":"Pape","year":"2007","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/ejcts\/ezaa351","article-title":"Type A aortic dissection in aneurysms having modelled pre-dissection maximum diameter below 45 mm: should we implement current guidelines to improve the survival benefit of prophylactic surgery?","volume":"59","author":"Tozzi","year":"2021","journal-title":"Eur J Cardiothorac Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.jtcvs.2017.10.140","article-title":"Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm","volume":"155","author":"Zafar","year":"2018","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.jacc.2013.12.028","article-title":"How does the ascending aorta geometry change when it dissects?","volume":"63","author":"Rylski","year":"2014","journal-title":"J Am Coll Cardiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.jacc.2019.07.078","article-title":"Ascending aortic length and risk of aortic adverse events: the neglected dimension","volume":"74","author":"Wu","year":"2019","journal-title":"J Am Coll Cardiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e020140","DOI":"10.1161\/JAHA.120.020140","article-title":"Ascending aortic length and its association with type A aortic dissection","volume":"10","author":"Eliathamby","year":"2021","journal-title":"J Am Heart Assoc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ijcard.2018.10.052","article-title":"Aortic arch tortuosity, a novel biomarker for thoracic aortic disease, is increased in adults with bicuspid aortic valve","volume":"284","author":"Alhafez","year":"2019","journal-title":"Int J Cardiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"372","DOI":"10.21037\/jtd-20-2728","article-title":"New indicators for systematic assessment of aortic morphology: a narrative review","volume":"13","author":"Luan","year":"2021","journal-title":"J Thorac Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.athoracsur.2010.10.042","article-title":"Pathogenesis of acute aortic dissection: a finite element stress analysis","volume":"91","author":"Nathan","year":"2011","journal-title":"Ann Thorac Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/ejcts\/ezw025","article-title":"Ascending aortic elongation and the risk of dissection","volume":"50","author":"Kr\u00fcger","year":"2016","journal-title":"Eur J Cardiothorac Surg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1159\/000381281","article-title":"Aortic size distribution in the general population: explaining the size paradox in aortic dissection","volume":"131","author":"Paruchuri","year":"2015","journal-title":"Cardiology."},{"key":"B18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1532-429X-16-9","article-title":"Observational study of regional aortic size referenced to body size: production of a cardiovascular magnetic resonance nomogram","volume":"16","author":"Davis","year":"2014","journal-title":"J Cardiovasc Magn Reson."},{"key":"B19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.athoracsur.2005.06.026","article-title":"Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms","volume":"81","author":"Davies","year":"2006","journal-title":"Ann Thorac Surg."},{"key":"B20","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1067\/mva.2003.213","article-title":"Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter","volume":"37","author":"Fillinger","year":"2003","journal-title":"J Vasc Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jvs.2007.09.002","article-title":"Peak wall stress measurement in elective and acute abdominal aortic aneurysms","volume":"47","author":"Heng","year":"2008","journal-title":"J Vasc Surg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/ejcts\/ezx503","article-title":"Aortic elongation in aortic aneurysm and dissection: the T\u00fcbingen Aortic Pathoanatomy (TAIPAN) project","volume":"54","author":"Kr\u00fcger","year":"2018","journal-title":"Eur J Cardiothorac Surg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1093\/ehjci\/jez012","article-title":"Normal values of aortic dimensions assessed by multidetector computed tomography in the Copenhagen General Population Study","volume":"20","author":"Pham","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging."},{"key":"B24","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.jcmg.2008.06.010","article-title":"Age-associated elongation of the ascending aorta in adults","volume":"1","author":"Sugawara","year":"2008","journal-title":"JACC Cardiovasc Imaging."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1136\/heartjnl-2018-313270","article-title":"Age-dependent aortic elongation: a new predictor for type A aortic dissection?","volume":"104","author":"Akin","year":"2018","journal-title":"Heart."},{"key":"B26","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s11517-012-0876-x","article-title":"Mechanical behaviour and rupture of normal and pathological human ascending aortic wall","volume":"50","author":"Garc\u00eda-Herrera","year":"2012","journal-title":"Med Biol Eng Comput."},{"key":"B27","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/ajh.2008.10","article-title":"Do hypertensive individuals have enlarged aortic root diameters? Insights from studying the various subtypes of hypertension","volume":"21","author":"Farasat","year":"2008","journal-title":"Am J Hypertens."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.927105\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T05:38:55Z","timestamp":1655703535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.927105\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":27,"alternative-id":["10.3389\/fcvm.2022.927105"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.927105","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,20]]},"article-number":"927105"}}