{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:40:10Z","timestamp":1774330810581,"version":"3.50.1"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012429","name":"Central Universities in China","doi-asserted-by":"publisher","award":["ZYGX2020ZB038"],"award-info":[{"award-number":["ZYGX2020ZB038"]}],"id":[{"id":"10.13039\/501100012429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate exercise tolerance in non-obstructive hypertrophic cardiomyopathy (HCM) by investigating the value of myocardial work (MW) combined with strain peak dispersion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 65 patients with non-obstructive HCM and normal left ventricular ejection fraction were enrolled and 60 healthy subjects were selected as controls. The automated function imaging (AFI)-two-dimensional ultrasonic speckle-tracking technology was used to obtain the values for peak global longitudinal strain (GLS), longitudinal strain peak time dispersion (PSD), 18-segment systolic longitudinal peak strain (LPS), 18-segment longitudinal strain peak time (TTPLS), global waste work (GWW), global constructive work (GCW), global work index (GWI), global work efficiency (GWE), and exercise metabolic equivalents (METS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) Values for LV-GLS (\u221217.77 \u00b1 0.20 vs. \u221221.66 \u00b1 0.42%) were lower and PSD (95.10 \u00b1 8.15 vs. 28.97 \u00b1 1.50 ms) was prolonged in patients with HCM (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). (2) An increasing trend was shown in the basal segment &amp;lt; intermediate segment &amp;lt; apical segment for both patients with HCM and controls, although each segment had lower values in the HCM group. (3) TTPLS was prolonged in the HCM group (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). (4) GWE, GWI, and GCW were all lower (<jats:italic>p<\/jats:italic> &amp;lt; 0.01) and GWW was higher in patients with HCM (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). (5) Values of GWE were less than 92.5%, GWI less than 1,200 mmHg, GCW less than 1,399 mmHg, these abnormal values are helpful for the diagnosis of impaired exercise tolerance and poor prognosis (6) The METS and LV-GLS of HCM in the asymmetric group were significantly lower than that in AHCM group, but the PSD was significantly greater than that in the AHCM group. Values of LPS-BL (\u221213.13% \u00b1 2.51% vs \u221210.17% \u00b1 2.20%) in the apical HCM group were better than in the asymmetric HCM group (<jats:italic>p<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GCW, GWI, and GWE can be safely measured by resting echocardiography to evaluate exercise tolerance in patients with HCM who cannot perform an exercise-based examination. Such measurements provide a basis for clinical decisions regarding exercise and drug prescription.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.927671","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T09:11:01Z","timestamp":1658826661000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of Exercise Tolerance in Non-obstructive Hypertrophic Cardiomyopathy With Myocardial Work and Peak Strain Dispersion by Speckle-Tracking 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