{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:04:34Z","timestamp":1784322274071,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019558","name":"Qingdao Key Health Discipline Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Double-chambered right ventricle (DCRV) is a rare congenital heart defect in adults, manifesting with progressive right ventricular outflow tract obstruction. We describe the first case of DCRV coexisting with hypertrophic cardiomyopathy, which is complicated by atrial flutter. A middle-aged woman with recurrent symptomatic atrial flutter who had previously been diagnosed with biventricular hypertrophic cardiomyopathy was admitted to our department. Echocardiography and cardiac magnetic resonance revealed asymmetrical interventricular septal hypertrophy, and abnormal muscle bundles within the right ventricle, generating an obstructive gradient. Genetic testing detected a hypertrophic cardiomyopathy-associated mutation: <jats:italic>MYH7<\/jats:italic>, c.4135G &amp;gt; A, p. Ala1379Thr. A diagnosis of DCRV complicated by hypertrophic cardiomyopathy and atrial flutter was made. Surgical intervention was performed, which included radiofrequency ablation, removal of abnormal muscle bundles, and ventricular septal defect repair. Intraoperative transesophageal echocardiography demonstrated the well-corrected right ventricular outflow tract. Free of early postoperative complications, the patient was discharged in sinus rhythm on the 11th day after the surgery. Unfortunately, the patient died from a sudden death 38 days following the surgery. In conclusion, the coexistence of DCRV with hypertrophic cardiomyopathy in patients is an uncommon condition. The present case highlights the importance of diagnostic imaging in the management of this disorder.<\/jats:p>","DOI":"10.3389\/fcvm.2022.937758","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T07:23:44Z","timestamp":1658474624000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report: Double-chambered right ventricle diagnosed in a middle-aged female with hypertrophic cardiomyopathy and atrial flutter: A rare case"],"prefix":"10.3389","volume":"9","author":[{"given":"Junye","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellina","family":"Maduray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongshuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingquan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.carpath.2013.03.004","article-title":"Double-chambered right ventricle: a review.","volume":"22","author":"Loukas","year":"2013","journal-title":"Cardiovasc Pathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/ehf2.12650","article-title":"Double-chambered right ventricle complicated by hypertrophic obstructive cardiomyopathy diagnosed as Noonan syndrome.","volume":"7","author":"Yamamoto","year":"2020","journal-title":"ESC Heart Fail."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.722340","article-title":"Hypertrophic cardiomyopathy: from phenotype and pathogenesis to treatment.","volume":"8","author":"Cheng","year":"2021","journal-title":"Front Cardiovasc Med."},{"key":"B4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/hrt.2003.017137","article-title":"The role of echocardiography in diagnosing double chambered right ventricle in adults.","volume":"90","author":"Hoffman","year":"2004","journal-title":"Heart."},{"key":"B5","doi-asserted-by":"publisher","first-page":"891","DOI":"10.33963\/KP.a2021.0023","article-title":"Double chambered right ventricle in a patient with hypertrophic cardiomyopathy. A unique coexistence.","volume":"79","author":"Tyczy\u0144ski","year":"2021","journal-title":"Kardiol Pol."},{"key":"B6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.athoracsur.2011.08.043","article-title":"Outcomes of surgical repair of double-chambered right ventricle.","volume":"93","author":"Said","year":"2012","journal-title":"Ann Thorac Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/europace\/eul084","article-title":"Sustained monomorphic ventricular tachycardia associated with unrepaired double-chambered right ventricle.","volume":"8","author":"Alvarez","year":"2006","journal-title":"Europace."},{"key":"B8","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.ijcard.2014.04.177","article-title":"Long-term natural history and postoperative outcome of double-chambered right ventricle\u2013experience from two tertiary adult congenital heart centres and review of the literature.","volume":"174","author":"Kahr","year":"2014","journal-title":"Int J Cardiol."},{"key":"B9","first-page":"301","article-title":"Surgical management of double-chambered right ventricle in adults.","volume":"38","author":"Darwazah","year":"2011","journal-title":"Tex Heart Inst J."},{"key":"B10","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0002-9149(01)01862-8","article-title":"Difficulty in diagnosing double-chambered right ventricle in adults.","volume":"88","author":"Lascano","year":"2001","journal-title":"Am J Cardiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-5-2","article-title":"Double-chambered right ventricle in an adult patient diagnosed by transthoracic echocardiography.","volume":"5","author":"Romano","year":"2007","journal-title":"Cardiovasc Ultrasound."},{"key":"B12","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/CIRCULATIONAHA.105.592345","article-title":"Adult congenital heart disease: right ventricular outflow tract lesions.","volume":"115","author":"Bashore","year":"2007","journal-title":"Circulation."},{"key":"B13","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1093\/eurheartj\/ehq249","article-title":"ESC guidelines for the management of grown-up congenital heart disease (new version 2010).","volume":"31","author":"Baumgartner","year":"2010","journal-title":"Eur Heart J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1161\/01.cir.30.5.679","article-title":"Development of right ventricular obstruction by aberrant muscular bands.","volume":"30","author":"Hartmann","year":"1964","journal-title":"Circulation."},{"key":"B15","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/s0022-5223(03)00044-8","article-title":"Rapid progression of midventricular obstruction in adults with double-chambered right ventricle.","volume":"126","author":"Oliver","year":"2003","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0003-4975(10)62343-0","article-title":"Double-chambered right ventricle.","volume":"44","author":"Simpson","year":"1987","journal-title":"Ann Thorac Surg."},{"key":"B17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0003-4975(00)01320-5","article-title":"Double-chambered right ventricle presenting in adulthood.","volume":"70","author":"McElhinney","year":"2000","journal-title":"Ann Thorac Surg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1136\/hrt.2005.068577","article-title":"Historical trends in reported survival rates in patients with hypertrophic cardiomyopathy.","volume":"92","author":"Elliott","year":"2006","journal-title":"Heart."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European society of cardiology (ESC).","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J."},{"key":"B20","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jacc.2007.11.071","article-title":"Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy in relation to delayed enhancement on cardiovascular magnetic resonance.","volume":"51","author":"Adabag","year":"2008","journal-title":"J Am Coll Cardiol."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.937758\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T07:23:58Z","timestamp":1658474638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.937758\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":20,"alternative-id":["10.3389\/fcvm.2022.937758"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.937758","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"937758"}}