{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:19:16Z","timestamp":1779927556164,"version":"3.53.1"},"reference-count":112,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>The importance of right heart failure (RHF) treatment is magnified over the years due to the increased risk of mortality. Additionally, the multifactorial origin and pathophysiological mechanisms of RHF render this clinical condition and the choices for appropriate therapeutic target strategies remain to be complex. The recent change in the United Network for Organ Sharing (UNOS) allocation criteria of heart transplant may have impacted for the number of left ventricular assist devices (LVADs), but LVADs still have been widely used to treat advanced heart failure, and 4.1 to 7.4% of LVAD patients require a right ventricular assist device (RVAD). In addition, patients admitted with primary left ventricular failure often need right ventricular support. Thus, there is unmet need for temporary or long-term support RVAD implantation exists. In RHF treatment with mechanical circulatory support (MCS) devices, the timing of the intervention and prediction of duration of the support play a major role in successful treatment and outcomes. In this review, we attempt to describe the prevalence and pathophysiological mechanisms of RHF origin, and provide an overview of existing treatment options, strategy and device choices for MCS treatment for RHF.<\/jats:p>","DOI":"10.3389\/fcvm.2022.951234","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T10:01:46Z","timestamp":1663927306000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Mechanical circulatory support devices and treatment strategies for right heart failure"],"prefix":"10.3389","volume":"9","author":[{"given":"Taiyo","family":"Kuroda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Fukamachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshid H.","family":"Karimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart disease and stroke statistics-2022 update: a report from the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 esc guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the european society of cardiology (esc) with the special contribution of the heart failure association (hfa) of the esc","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(17)32520-5","article-title":"Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals","volume":"391","author":"Conrad","year":"2018","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.15420\/cfr.2016:25:2","article-title":"Global public health burden of heart failure","volume":"3","author":"Savarese","year":"2017","journal-title":"Card Fail Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1016\/S0140-6736(17)31071-1","article-title":"Heart failure","volume":"390","author":"Metra","year":"2017","journal-title":"Lancet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e578","DOI":"10.1161\/CIR.0000000000000560","article-title":"Evaluation and management of right-sided heart failure: a scientific statement from the american heart association","volume":"137","author":"Konstam","year":"2018","journal-title":"Circulation."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.3909\/ricm0602","article-title":"Contribution of right ventricular dysfunction to heart failure mortality: a meta-analysis","volume":"13","author":"Iglesias-Garriz","year":"2012","journal-title":"Rev Cardiovasc Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S0300-8932(10)70066-X","volume":"63","author":"Skhiri","year":"2010","journal-title":"Rev Esp Cardiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/S0735-1097(02)02048-X","article-title":"Pathophysiology and management of right heart ischemia","volume":"40","author":"Goldstein","year":"2002","journal-title":"J Am Coll Cardiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1161\/01.CIR.75.5.996","article-title":"Starling MR, Crawford MH, Simmons RS, Lasher JC, et al. 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