{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:00:11Z","timestamp":1791165611864,"version":"4.1.0"},"reference-count":285,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"Background<\/jats:title>Increasing evidence has spurred a considerable evolution of concepts related to atherosclerosis, prompting the need to provide a comprehensive view of the growing literature. By retrieving publications in the Web of Science Core Collection (WoSCC) of Clarivate Analytics, we conducted a bibliometric analysis of the scientific literature on atherosclerosis to describe the research landscape.<\/jats:p><\/jats:sec>Methods<\/jats:title>A search was conducted of the WoSCC for articles and reviews serving exclusively as a source of information on atherosclerosis published between 2012 and 2022. Microsoft Excel 2019 was used to chart the annual productivity of research relevant to atherosclerosis. Through CiteSpace and VOSviewer, the most prolific countries or regions, authors, journals, and resource-, intellectual-, and knowledge-sharing in atherosclerosis research, as well as co-citation analysis of references and keywords, were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 20,014 publications were retrieved. In terms of publications, the United States remains the most productive country (6,390, 31,93%). The most publications have been contributed by Johns Hopkins Univ (730, 3.65%). ALVARO ALONSO produced the most published works (171, 0.85%). With a betweenness centrality of 0.17, ERIN D MICHOS was the most influential author. The most prolific journal was identified as Atherosclerosis<\/jats:italic> (893, 4.46%). Circulation<\/jats:italic> received the most co-citations (14,939, 2.79%). Keywords with the ongoing strong citation bursts were \u201cnucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome,\u201d \u201cshort-chain fatty acids (SCFAs),\u201d \u201cexosome,\u201d and \u201chomeostasis,\u201d etc.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The research on atherosclerosis is driven mostly by North America and Europe. Intensive research has focused on the link between inflammation and atherosclerosis, as well as its complications. Specifically, the NLRP3 inflammasome, interleukin-1\u03b2, gut microbiota and SCFAs, exosome, long non-coding RNAs, autophagy, and cellular senescence were described to be hot issues in the field.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.956482","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:22:25Z","timestamp":1661242945000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Global research trends in atherosclerosis: A bibliometric and visualized study"],"prefix":"10.3389","volume":"9","author":[{"given":"Wende","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update: a report from the American heart association.","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.106.676890","article-title":"Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications.","volume":"116","author":"Tabas","year":"2007","journal-title":"Circulation."},{"key":"B3","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2013an inflammatory disease.","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.tcm.2008.11.004","article-title":"Monocyte-endothelial cell interactions in the development of atherosclerosis.","volume":"18","author":"Mestas","year":"2008","journal-title":"Trends Cardiovasc Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/s0092-8674(01)00238-0","article-title":"Atherosclerosis. the road ahead.","volume":"104","author":"Glass","year":"2001","journal-title":"Cell."},{"key":"B6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis.","volume":"145","author":"Moore","year":"2011","journal-title":"Cell."},{"key":"B7","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease.","volume":"20","author":"Doran","year":"2020","journal-title":"Nat Rev Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1172\/JCI97950","article-title":"The role of non-resolving inflammation in atherosclerosis.","volume":"128","author":"Kasikara","year":"2018","journal-title":"J Clin Invest."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of plaque formation and rupture.","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/2048872612438026","article-title":"The treatment of acute myocardial infarction: the Past, the Present, and the Future.","volume":"1","author":"Braunwald","year":"2012","journal-title":"Eur Heart J Acute Cardiovasc Care."},{"key":"B11","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nri1882","article-title":"The immune response in atherosclerosis: a double-edged sword.","volume":"6","author":"Hansson","year":"2006","journal-title":"Nat Rev Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1016\/S0140-6736(16)31357-5","article-title":"Interpretation of the evidence for the efficacy and safety of statin therapy.","volume":"388","author":"Collins","year":"2016","journal-title":"Lancet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/eurheartj\/ehu505","article-title":"Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective.","volume":"36","author":"Jernberg","year":"2015","journal-title":"Eur Heart J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1016\/j.jacc.2018.08.1043","article-title":"Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week.","volume":"72","author":"Libby","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182413154","article-title":"Global trends in atherosclerosis research in the epigenetics field: bibliometric and visualization studies.","volume":"18","author":"Jia","year":"2021","journal-title":"Int J Environ Res Public Health."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3015-z","article-title":"Particulate matter and atherosclerosis: a bibliometric analysis of original research articles published in 1973-2014.","volume":"16","author":"Wang","year":"2016","journal-title":"BMC Public Health."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109133","article-title":"Carotid atherosclerosis biomarkers in cardiovascular diseases prevention: a systematic review and bibliometric analysis.","volume":"129","author":"Fu","year":"2020","journal-title":"Eur J Radiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/1094428114562629","article-title":"Bibliometric methods in management and organization.","volume":"18","author":"Zupic","year":"2015","journal-title":"Organ Res Methods."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s41043-016-0076-7","article-title":"Bibliometric analysis of publications on Campylobacter: (2000-2015).","volume":"35","author":"Sweileh","year":"2016","journal-title":"J Health Popul Nutr."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-018-0456-x","article-title":"Global output of research on epidermal parasitic skin diseases from 1967 to 2017.","volume":"7","author":"Sweileh","year":"2018","journal-title":"Infect Dis Poverty."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.1097\/MCG.0000000000001351","article-title":"Ulcerative colitis: a critical approach to the global research output employing density-equalizing mapping and scientometric methods.","volume":"55","author":"Sch\u00f6ffel","year":"2021","journal-title":"J Clin Gastroenterol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jcis.2012.04.051","article-title":"The most frequently cited adsorption research articles in the science citation index (Expanded).","volume":"379","author":"Fu","year":"2012","journal-title":"J Colloid Interface Sci."},{"key":"B23","first-page":"5","article-title":"Keywords plus: ISI\u2019s breakthrough retrieval method. Part 1. Expanding your searching power on current contents on diskette.","volume":"32","author":"Garfield","year":"1990","journal-title":"Curr Contents."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-015-0124-x","article-title":"Bibliometric analysis on global Catha edulis (Khat) research production during the period of 1952-2014.","volume":"11","author":"Zyoud","year":"2015","journal-title":"Glob Health."},{"key":"B25","doi-asserted-by":"publisher","first-page":"118","DOI":"10.34172\/ijhpm.2020.29","article-title":"Gastric cancer: bibliometric analysis of epidemiological, geographical and socio-economic parameters of the global research landscape.","volume":"10","author":"Klingelh\u00f6fer","year":"2021","journal-title":"Int J Health Policy Manag."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19074165","article-title":"Global trends of nutrition in cancer research: a bibliometric and visualized analysis study over the past 10 years.","volume":"19","author":"Youn","year":"2022","journal-title":"Int J Environ Res Public Health."},{"key":"B27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrcardio.2016.166","article-title":"Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease.","volume":"14","author":"Pasterkamp","year":"2017","journal-title":"Nat Rev Cardiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1161\/CIRCRESAHA.116.310197","article-title":"Genome editing in cardiovascular biology.","volume":"120","author":"Seeger","year":"2017","journal-title":"Circ Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1161\/CIRCRESAHA.117.305365","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes.","volume":"117","author":"Karakikes","year":"2015","journal-title":"Circ Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1161\/CIRCRESAHA.115.306300","article-title":"MicroRNA regulation of atherosclerosis.","volume":"118","author":"Feinberg","year":"2016","journal-title":"Circ Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1161\/CIRCRESAHA.119.315938","article-title":"Noncoding RNAs in vascular diseases.","volume":"126","author":"Ja\u00e9","year":"2020","journal-title":"Circ Res."},{"key":"B32","author":"Chen","year":"2019","journal-title":"Visualizing Patterns and Trends in Scientific Literature."},{"key":"B33","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s11192-017-2542-4","article-title":"The hot spot transformation in the research evolution of maker.","volume":"113","author":"Chen","year":"2017","journal-title":"Scientometrics."},{"key":"B34","first-page":"1","article-title":"Science mapping: a systematic review of the literature.","volume":"2","author":"Chen","year":"2017","journal-title":"J Data Inf Sci."},{"key":"B35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2307\/3033543","article-title":"A set of measures of centrality based on betweenness.","volume":"40","author":"Freeman","year":"1977","journal-title":"Sociometry."},{"key":"B36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1023\/A:1024940629314","article-title":"Bursty and hierarchical structure in streams.","volume":"7","author":"Kleinberg","year":"2003","journal-title":"Data Min Knowl Discov."},{"key":"B37","first-page":"1","article-title":"The citespace manual.","volume":"1","author":"Chen","year":"2014","journal-title":"Coll Comput Inform."},{"key":"B38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/asi.4630240406","article-title":"Co-citation in the scientific literature: a new measure of the relationship between two documents.","volume":"24","author":"Small","year":"1973","journal-title":"J Am Soc Inf Sci."},{"key":"B39","doi-asserted-by":"crossref","DOI":"10.1016\/j.leaqua.2020.101381","article-title":"A bibliometric review of the leadership development field: how we got here, where we are, and where we are headed.","volume":"32","author":"Vogel","year":"2021","journal-title":"Leadersh Q."},{"key":"B40","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping.","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics."},{"key":"B41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/asi.5090140103","article-title":"Bibliographic coupling between scientific papers.","volume":"14","author":"Kessler","year":"1963","journal-title":"Am. Doc."},{"key":"B42","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.joi.2016.10.006","article-title":"Constructing bibliometric networks: a comparison between full and fractional counting.","volume":"10","author":"Perianes-Rodriguez","year":"2016","journal-title":"J Informetr."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with canakinumab for atherosclerotic disease.","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis.","volume":"473","author":"Libby","year":"2011","journal-title":"Nature."},{"key":"B45","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance.","volume":"13","author":"Moore","year":"2013","journal-title":"Nat Rev Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis.","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American heart association.","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis.","volume":"5","author":"Libby","year":"2019","journal-title":"Nat Rev Dis Primers."},{"key":"B49","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","article-title":"Vascular smooth muscle cells in atherosclerosis.","volume":"16","author":"Basatemur","year":"2019","journal-title":"Nat Rev Cardiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41569-019-0169-2","article-title":"Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities.","volume":"16","author":"B\u00e4ck","year":"2019","journal-title":"Nat Rev Cardiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"Immunity and Inflammation in Atherosclerosis.","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction.","volume":"381","author":"Tardif","year":"2019","journal-title":"N Engl J Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the American heart association.","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation."},{"key":"B54","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/aris.1440370106","article-title":"Visualizing knowledge domains.","volume":"37","author":"B\u00f6rner","year":"2003","journal-title":"Annu Rev Inf Sci Technol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.joi.2010.07.002","article-title":"A unified approach to mapping and clustering of bibliometric networks.","volume":"4","author":"Waltman","year":"2010","journal-title":"J Inform."},{"key":"B57","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3109\/07853899009147259","article-title":"Bibliometrics and evaluation of research performance.","volume":"22","author":"Luukkonen","year":"1990","journal-title":"Ann Med."},{"key":"B58","author":"Corbin","year":"2014","journal-title":"Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease.","volume":"376","author":"Sabatine","year":"2017","journal-title":"N Engl J Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1161\/CIR.0000000000000152","article-title":"Heart disease and stroke statistics\u20132015 update: a report from the American Heart Association.","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation."},{"key":"B61","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jacc.2015.05.069","article-title":"Plaque characterization by coronary computed tomography angiography and the likelihood of acute coronary events in mid-term follow-up.","volume":"66","author":"Motoyama","year":"2015","journal-title":"J Am Coll Cardiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1056\/NEJMoa1410489","article-title":"Ezetimibe added to statin therapy after acute coronary syndromes.","volume":"372","author":"Cannon","year":"2015","journal-title":"N Engl J Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","article-title":"Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial.","volume":"391","author":"Ridker","year":"2018","journal-title":"Lancet."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1172\/JCI75005","article-title":"Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression.","volume":"127","author":"Rahman","year":"2017","journal-title":"J Clin Invest."},{"key":"B65","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/ni.2639","article-title":"CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.","volume":"14","author":"Sheedy","year":"2013","journal-title":"Nat Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/eurheartj\/ehu272","article-title":"The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study.","volume":"36","author":"Morton","year":"2015","journal-title":"Eur Heart J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"4334","DOI":"10.1172\/JCI81676","article-title":"MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.","volume":"125","author":"Ouimet","year":"2015","journal-title":"J Clin Invest."},{"key":"B68","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ni.2205","article-title":"The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.","volume":"13","author":"van Gils","year":"2012","journal-title":"Nat Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1093\/eurheartj\/ehw024","article-title":"Residual inflammatory risk: addressing the obverse side of the atherosclerosis prevention coin.","volume":"37","author":"Ridker","year":"2016","journal-title":"Eur Heart J."},{"key":"B70","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrcardio.2015.164","article-title":"Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis.","volume":"13","author":"Yahagi","year":"2016","journal-title":"Nat Rev Cardiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.jacc.2014.11.041","article-title":"The myth of the \u201cvulnerable plaque\u201d: transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment.","volume":"65","author":"Arbab-Zadeh","year":"2015","journal-title":"J Am Coll Cardiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.atherosclerosissup.2021.01.001","article-title":"Similarities and differences between European and American guidelines on the management of blood lipids to reduce cardiovascular risk.","volume":"42","author":"Tokg\u00f6zo\u011flu","year":"2020","journal-title":"Atheroscler Suppl."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124223","article-title":"Focus on the Role of NLRP3 Inflammasome in Diseases.","volume":"21","author":"Fusco","year":"2020","journal-title":"Int J Mol Sci."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003031","article-title":"NLRP3 inflammasome expression and activation in human atherosclerosis.","volume":"5","author":"Paramel Varghese","year":"2016","journal-title":"J Am Heart Assoc."},{"key":"B75","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.03.024","article-title":"Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis.","volume":"24","author":"Shi","year":"2015","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B76","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.atherosclerosis.2017.10.027","article-title":"NLRP3 inflammasome pathways in atherosclerosis.","volume":"267","author":"Baldrighi","year":"2017","journal-title":"Atherosclerosis."},{"key":"B77","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1161\/01.ATV.0000064374.15232.C3","article-title":"Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice.","volume":"23","author":"Kirii","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"E41","DOI":"10.1161\/hh1901.098735","article-title":"Interleukin-18\/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability.","volume":"89","author":"Mallat","year":"2001","journal-title":"Circ Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature."},{"key":"B80","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming.","volume":"172","author":"Christ","year":"2018","journal-title":"Cell."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1161\/ATVBAHA.117.309575","article-title":"NLRP3 inflammasome inhibition by MCC950 reduces atherosclerotic lesion development in apolipoprotein e-deficient mice-brief report.","volume":"37","author":"van der Heijden","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154231","article-title":"The impact of hyperglycaemia on PKM2-mediated NLRP3 inflammasome\/stress granule signalling in macrophages and its correlation with plaque vulnerability: an in vivo and in vitro study.","volume":"107","author":"Li","year":"2020","journal-title":"Metabolism."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.18","article-title":"Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome.","volume":"2","author":"Menu","year":"2011","journal-title":"Cell Death Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1093\/cvr\/cvab010","article-title":"NLRP3 inflammasome as a key driver of vascular disease.","volume":"118","author":"Takahashi","year":"2022","journal-title":"Cardiovasc Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.jacbts.2020.03.016","article-title":"Sex-specific effects of the Nlrp3 inflammasome on atherogenesis in LDL receptor-deficient mice.","volume":"5","author":"Chen","year":"2020","journal-title":"JACC Basic Transl Sci."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010340","article-title":"NLRP3 inflammasome activation controls vascular smooth muscle cells phenotypic switch in atherosclerosis.","volume":"23","author":"Burger","year":"2021","journal-title":"Int J Mol Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1002\/jcp.25930","article-title":"NLRP3 inflammasome: its regulation and involvement in atherosclerosis.","volume":"233","author":"Hoseini","year":"2018","journal-title":"J Cell Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics.","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat Rev Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/S0140-6736(11)61931-4","article-title":"Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.","volume":"379","author":"Sarwar","year":"2012","journal-title":"Lancet"},{"key":"B90","first-page":"394","article-title":"Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.","volume":"121","author":"Bevilacqua","year":"1985","journal-title":"Am J Pathol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1172\/JCI113346","article-title":"Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.","volume":"81","author":"Libby","year":"1988","journal-title":"J Clin Invest."},{"key":"B92","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family.","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1172\/JCI114498","article-title":"Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.","volume":"85","author":"Loppnow","year":"1990","journal-title":"J Clin Invest."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152474","article-title":"Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling.","volume":"11","author":"Beltrami-Moreira","year":"2016","journal-title":"PLoS One."},{"key":"B95","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1172\/JCI67526","article-title":"Collagenases and cracks in the plaque.","volume":"123","author":"Libby","year":"2013","journal-title":"J Clin Invest."},{"key":"B96","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.bbrc.2012.07.011","article-title":"Oxidized low-density lipoprotein induces secretion of interleukin-1\u03b2 by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation.","volume":"425","author":"Jiang","year":"2012","journal-title":"Biochem Biophys Res Commun."},{"key":"B97","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.cmet.2018.05.027","article-title":"Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1\u03b2 Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis.","volume":"28","author":"Tumurkhuu","year":"2018","journal-title":"Cell Metab."},{"key":"B98","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/imr.12606","article-title":"The family of the interleukin-1 receptors.","volume":"281","author":"Boraschi","year":"2018","journal-title":"Immunol Rev."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.589654","article-title":"Targeting IL-1\u03b2 in the treatment of atherosclerosis.","volume":"11","author":"Mai","year":"2020","journal-title":"Front Immunol."},{"key":"B100","first-page":"8383","article-title":"Circulating exosomes and exosomal lncRNA HIF1A-AS1 in atherosclerosis.","volume":"10","author":"Wang","year":"2017","journal-title":"Int J Clin Exp Pathol."},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185406","article-title":"Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis.","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One."},{"key":"B102","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ejphar.2018.11.005","article-title":"Knockdown of growth-arrest specific transcript 5 restores oxidized low-density lipoprotein-induced impaired autophagy flux via upregulating miR-26a in human endothelial cells.","volume":"843","author":"Liang","year":"2019","journal-title":"Eur J Pharmacol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/j.biopha.2018.09.175","article-title":"Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of miR-26a-5p via inhibiting TLR4\/NF-\u03baB pathway in human endothelial cells.","volume":"108","author":"Zhong","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B104","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3892\/mmr.2018.8982","article-title":"Exosomal MALAT1 derived from oxidized low-density lipoprotein-treated endothelial cells promotes M2 macrophage polarization.","volume":"18","author":"Huang","year":"2018","journal-title":"Mol Med Rep."},{"key":"B105","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1515\/hsz-2019-0219","article-title":"Exosomal MALAT1 derived from ox-LDL-treated endothelial cells induce neutrophil extracellular traps to aggravate atherosclerosis.","volume":"401","author":"Gao","year":"2020","journal-title":"Biol Chem."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.145","article-title":"Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction.","volume":"7","author":"Shan","year":"2016","journal-title":"Cell Death Dis."},{"key":"B107","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/biof.1665","article-title":"Exosomal LINC01005 derived from oxidized low-density lipoprotein-treated endothelial cells regulates vascular smooth muscle cell phenotypic switch.","volume":"46","author":"Zhang","year":"2020","journal-title":"Biofactors."},{"key":"B108","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/iub.298","article-title":"Role of Kr\u00fcppel-like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells.","volume":"62","author":"Zheng","year":"2010","journal-title":"IUBMB Life."},{"key":"B109","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nm.3866","article-title":"KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.","volume":"21","author":"Shankman","year":"2015","journal-title":"Nat Med."},{"key":"B110","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1097\/FJC.0000000000000974","article-title":"Exosomes-mediated LncRNA ZEB1-AS1 facilitates cell injuries by miR-590-5p\/ETS1 axis through the TGF-\u03b2\/Smad pathway in oxidized low-density lipoprotein-induced human umbilical vein endothelial cells.","volume":"77","author":"Chen","year":"2021","journal-title":"J Cardiovasc Pharmacol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites.","volume":"165","author":"Koh","year":"2016","journal-title":"Cell."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011472.pub2","article-title":"Dietary fibre for the primary prevention of cardiovascular disease.","volume":"2016","author":"Hartley","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"B113","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/B978-0-12-805130-6.00005-7","article-title":"Chapter 5-the relationship between probiotics and dietary fiber consumption and cardiovascular health.","author":"Prasad","year":"2017","journal-title":"Dietary Fiber for the Prevention of Cardiovascular Disease."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1161\/CIRCULATIONAHA.118.036652","article-title":"Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.","volume":"139","author":"Bartolomaeus","year":"2019","journal-title":"Circulation."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1007\/s10753-020-01205-0","article-title":"Sodium butyrate downregulates implant-induced inflammation in mice.","volume":"43","author":"de Lazari","year":"2020","journal-title":"Inflammation."},{"key":"B116","doi-asserted-by":"publisher","first-page":"8388","DOI":"10.3168\/jds.2020-18189","article-title":"Sodium butyrate reduces bovine mammary epithelial cell inflammatory responses induced by exogenous lipopolysaccharide, by inactivating NF-\u03baB signaling.","volume":"103","author":"Sun","year":"2020","journal-title":"J Dairy Sci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.numecd.2014.01.002","article-title":"Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NF\u03baB activation.","volume":"24","author":"Aguilar","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37246-7","article-title":"Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males.","volume":"9","author":"Cleophas","year":"2019","journal-title":"Sci Rep."},{"key":"B119","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10863-020-09841-9","article-title":"Butyrate mitigates TNF-\u03b1-induced attachment of monocytes to endothelial cells.","volume":"52","author":"Wang","year":"2020","journal-title":"J Bioenerg Biomembr."},{"key":"B120","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jnutbio.2016.05.002","article-title":"Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells.","volume":"34","author":"Aguilar","year":"2016","journal-title":"J Nutr Biochem."},{"key":"B121","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jnutbio.2018.02.011","article-title":"Butyrate from pectin fermentation inhibits intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E-deficient mice.","volume":"56","author":"Chen","year":"2018","journal-title":"J Nutr Biochem."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1111\/bph.14933","article-title":"Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice.","volume":"177","author":"Du","year":"2020","journal-title":"Br J Pharmacol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.cca.2020.01.006","article-title":"Autophagy in chronic stress induced atherosclerosis.","volume":"503","author":"Li","year":"2020","journal-title":"Clin Chim Acta."},{"key":"B124","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1002\/jcb.27694","article-title":"LncRNA MALAT1 promotes oxidized low-density lipoprotein-induced autophagy in HUVECs by inhibiting the PI3K\/AKT pathway.","volume":"120","author":"Li","year":"2019","journal-title":"J Cell Biochem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuroscience.2018.11.024","article-title":"MALAT1 lncRNA induces autophagy and protects brain microvascular endothelial cells against oxygen-glucose deprivation by binding to mir-200c-3p and upregulating SIRT1 expression.","volume":"397","author":"Wang","year":"2019","journal-title":"Neuroscience."},{"key":"B126","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.18632\/oncotarget.23230","article-title":"LncRNA MALAT1 regulates smooth muscle cell phenotype switch via activation of autophagy.","volume":"9","author":"Song","year":"2017","journal-title":"Oncotarget."},{"key":"B127","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1093\/cvr\/cvy202","article-title":"Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-\/-mice.","volume":"115","author":"Gast","year":"2019","journal-title":"Cardiovasc Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"114568","DOI":"10.18632\/oncotarget.21603","article-title":"LncRNA BANCR facilitates vascular smooth muscle cell proliferation and migration through JNK pathway.","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.3892\/ol.2014.2487","article-title":"BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma.","volume":"8","author":"Wang","year":"2014","journal-title":"Oncol Lett."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2018-0461","article-title":"LncRNA DYNLRB2-2 inhibits THP-1 macrophage foam cell formation by enhancing autophagy.","author":"Li","year":"2019","journal-title":"Biol Chem."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism.","volume":"458","author":"Singh","year":"2009","journal-title":"Nature."},{"key":"B132","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1194\/jlr.M044669","article-title":"A lincRNA-DYNLRB2-2\/GPR119\/GLP-1R\/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.","volume":"55","author":"Hu","year":"2014","journal-title":"J Lipid Res."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025908","article-title":"Translating the science of aging into therapeutic interventions.","volume":"6","author":"Kirkland","year":"2016","journal-title":"Cold Spring Harb Perspect Med."},{"key":"B134","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing.","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature."},{"key":"B135","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo.","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc Natl Acad Sci USA."},{"key":"B136","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat Cell Biol."},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205002","article-title":"TGF-\u03b2 signaling in cellular senescence and aging-related pathology.","volume":"20","author":"Tominaga","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1038\/onc.2011.485","article-title":"SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells.","volume":"31","author":"Canino","year":"2012","journal-title":"Oncogene."},{"key":"B139","doi-asserted-by":"publisher","first-page":"932","DOI":"10.18632\/aging.100520","article-title":"IL1- and TGF\u03b2-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine \u2018bystander senescence\u2019.","volume":"4","author":"Hubackova","year":"2012","journal-title":"Aging."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12734","article-title":"Emerging roles of extracellular vesicles in cellular senescence and aging.","volume":"17","author":"Takasugi","year":"2018","journal-title":"Aging Cell."},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.693067","article-title":"Vascular endothelial senescence: pathobiological insights, emerging long noncoding RNA targets, challenges and therapeutic opportunities.","volume":"12","author":"Sun","year":"2021","journal-title":"Front Physiol."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112974","article-title":"The role of immune cells in oxi-inflamm-aging.","volume":"10","author":"Mart\u00ednez de Toda","year":"2021","journal-title":"Cells."},{"key":"B143","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.cmet.2016.11.013","article-title":"Assisted living in the atheroma: elderly macrophages promote plaques.","volume":"24","author":"Libby","year":"2016","journal-title":"Cell Metab."},{"key":"B144","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis.","volume":"354","author":"Childs","year":"2016","journal-title":"Science."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-2399-x","article-title":"Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling.","volume":"10","author":"Zhu","year":"2017","journal-title":"BMC Res Notes."},{"key":"B146","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/s0047-6374(01)00412-2","article-title":"Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells.","volume":"123","author":"Zhang","year":"2002","journal-title":"Mech Ageing Dev."},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1186\/2045-824X-4-12","article-title":"Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability.","volume":"4","author":"Krouwer","year":"2012","journal-title":"Vasc Cell."},{"key":"B148","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1161\/ATVBAHA.114.303415","article-title":"Disturbed flow promotes endothelial senescence via a p53-dependent pathway.","volume":"34","author":"Warboys","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091408","article-title":"Extracellular vesicles as new players in cellular senescence.","volume":"17","author":"Urbanelli","year":"2016","journal-title":"Int J Mol Sci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.arr.2016.05.011","article-title":"Senescent endothelial cells: potential modulators of immunosenescence and ageing.","volume":"29","author":"Pantsulaia","year":"2016","journal-title":"Ageing Res Rev."},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072003","article-title":"Senescent microvesicles: a novel advance in molecular mechanisms of atherosclerotic calcification.","volume":"19","author":"Alique","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051495","article-title":"Protein carbamylation: a marker reflecting increased age-related cell oxidation.","volume":"19","author":"Carracedo","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"778","DOI":"10.18632\/aging.101191","article-title":"Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification.","volume":"9","author":"Alique","year":"2017","journal-title":"Aging."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1073\/pnas.1322153111","article-title":"Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes.","volume":"111","author":"Hayashi","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B155","doi-asserted-by":"publisher","first-page":"3832","DOI":"10.18632\/aging.102020","article-title":"Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice.","volume":"11","author":"Caland","year":"2019","journal-title":"Aging."},{"key":"B156","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/15548627.2017.1395114","article-title":"Endothelial autophagic flux hampers atherosclerotic lesion development.","volume":"14","author":"Kheloufi","year":"2018","journal-title":"Autophagy."},{"key":"B157","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1253\/circj.cj-10-0916","article-title":"Role of cellular senescence in lifestyle-related disease.","volume":"74","author":"Minamino","year":"2010","journal-title":"Circ J."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1016\/j.bbadis.2018.08.015","article-title":"Vascular smooth muscle cell senescence and age-related diseases: state of the art.","volume":"1865","author":"Chi","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"B159","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.ahj.2003.10.047","article-title":"Vascular smooth muscle cells and calcification in atherosclerosis.","volume":"147","author":"Trion","year":"2004","journal-title":"Am Heart J."},{"key":"B160","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/cvr\/cvy007","article-title":"Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.","volume":"114","author":"Grootaert","year":"2018","journal-title":"Cardiovasc Res."},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.758402","article-title":"Roles for the 8-oxoguanine DNA repair system in protecting telomeres from oxidative stress.","volume":"9","author":"De Rosa","year":"2021","journal-title":"Front Cell Dev Biol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/S0140-6736(01)05633-1","article-title":"Telomere shortening in atherosclerosis.","volume":"358","author":"Samani","year":"2001","journal-title":"Lancet."},{"key":"B163","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.jacc.2018.06.014","article-title":"Telomere length as cardiovascular aging biomarker: JACC Review topic of the week.","volume":"72","author":"De Meyer","year":"2018","journal-title":"J Am Coll Cardiol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1161\/01.RES.0000233315.38086.bc","article-title":"Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.","volume":"99","author":"Matthews","year":"2006","journal-title":"Circ Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev-physiol-021115-105127","article-title":"Damage and repair in vascular disease.","volume":"78","author":"Uryga","year":"2016","journal-title":"Annu Rev Physiol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1161\/CIRCULATIONAHA.115.016457","article-title":"Vascular smooth muscle cell senescence promotes atherosclerosis and features of plaque vulnerability.","volume":"132","author":"Wang","year":"2015","journal-title":"Circulation."},{"key":"B167","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1111\/acel.12458","article-title":"Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.","volume":"15","author":"Roos","year":"2016","journal-title":"Aging Cell."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1161\/CIRCULATIONAHA.117.033249","article-title":"Defective base excision repair of oxidative DNA damage in vascular smooth muscle cells promotes atherosclerosis.","volume":"138","author":"Shah","year":"2018","journal-title":"Circulation."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1073\/pnas.0507444103","article-title":"The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.","volume":"103","author":"Vartanian","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1161\/ATVBAHA.115.305896","article-title":"Senescent vascular smooth muscle cells drive inflammation through an interleukin-1\u03b1-dependent senescence-associated secretory phenotype.","volume":"35","author":"Gardner","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1161\/CIRCRESAHA.120.318353","article-title":"SIRT6 protects smooth muscle cells from senescence and reduces atherosclerosis.","volume":"128","author":"Grootaert","year":"2021","journal-title":"Circ Res."},{"key":"B172","doi-asserted-by":"publisher","first-page":"3968","DOI":"10.1080\/21655979.2021.1948289","article-title":"Anagliptin prevented interleukin 1\u03b2 (IL-1\u03b2)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1).","volume":"12","author":"Zhao","year":"2021","journal-title":"Bioengineered."},{"key":"B173","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1093\/eurheartj\/ehz919","article-title":"Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis.","volume":"41","author":"Stojanovi\u0107","year":"2020","journal-title":"Eur Heart J."},{"key":"B174","doi-asserted-by":"publisher","first-page":"H1673","DOI":"10.1152\/ajpheart.00455.2009","article-title":"Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition.","volume":"297","author":"Nakano-Kurimoto","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.exger.2010.07.005","article-title":"Pathophysiology of vascular calcification: pivotal role of cellular senescence in vascular smooth muscle cells.","volume":"45","author":"Burton","year":"2010","journal-title":"Exp Gerontol."},{"key":"B176","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","article-title":"Vascular calcification: pathobiological mechanisms and clinical implications.","volume":"99","author":"Johnson","year":"2006","journal-title":"Circ Res."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.47","article-title":"Role of protein kinase C \u03b4 in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells.","volume":"4","author":"Larroque-Cardoso","year":"2013","journal-title":"Cell Death Dis."},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3018190","article-title":"Moderate autophagy inhibits vascular smooth muscle cell senescence to stabilize progressed atherosclerotic Plaque via the mTORC1\/ULK1\/ATG13 signal pathway.","volume":"2017","author":"Luo","year":"2017","journal-title":"Oxid Med Cell Longev."},{"key":"B179","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-016-2796-9","article-title":"The PI3K\/Akt\/mTOR pathway regulates the replicative senescence of human VSMCs.","volume":"422","author":"Tan","year":"2016","journal-title":"Mol Cell Biochem."},{"key":"B180","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.exger.2017.08.001","article-title":"Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53\/p21\/p16.","volume":"109","author":"Sung","year":"2018","journal-title":"Exp Gerontol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.vph.2016.02.007","article-title":"Genistein-induced LKB1-AMPK activation inhibits senescence of VSMC through autophagy induction.","volume":"81","author":"Lee","year":"2016","journal-title":"Vascul Pharmacol."},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111314","article-title":"Nifedipine-induced AMPK activation alleviates senescence by increasing autophagy and suppressing of Ca2+ levels in vascular smooth muscle cells.","volume":"190","author":"Kim","year":"2020","journal-title":"Mech Ageing Dev."},{"key":"B183","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell."},{"key":"B184","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1161\/CIRCULATIONAHA.109.854299","article-title":"Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.","volume":"120","author":"Spyridopoulos","year":"2009","journal-title":"Circulation."},{"key":"B185","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1161\/hc0502.103348","article-title":"T-cell-mediated lysis of endothelial cells in acute coronary syndromes.","volume":"105","author":"Nakajima","year":"2002","journal-title":"Circulation."},{"key":"B186","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1161\/CIRCRESAHA.117.311751","article-title":"Short leukocyte telomere length precedes clinical expression of atherosclerosis: the blood-and-muscle model.","volume":"122","author":"Benetos","year":"2018","journal-title":"Circ Res."},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4227","article-title":"Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.","volume":"349","author":"Haycock","year":"2014","journal-title":"BMJ."},{"key":"B188","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/acel.12430","article-title":"CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study.","volume":"15","author":"Spyridopoulos","year":"2016","journal-title":"Aging Cell."},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12675","article-title":"Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK.","volume":"17","author":"Callender","year":"2018","journal-title":"Aging Cell."},{"key":"B190","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.0105-2896.2005.00262.x","article-title":"Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging.","volume":"205","author":"Fann","year":"2005","journal-title":"Immunol Rev."},{"key":"B191","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/acel.12552","article-title":"Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern.","volume":"16","author":"Suarez-\u00c1lvarez","year":"2017","journal-title":"Aging Cell."},{"key":"B192","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00011-005-1377-2","article-title":"Gamma interferon: a central mediator in atherosclerosis.","volume":"54","author":"Leon","year":"2005","journal-title":"Inflamm Res."},{"key":"B193","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1161\/ATVBAHA.111.229237","article-title":"Leukocyte telomere length is associated with high-risk plaques on virtual histology intravascular ultrasound and increased proinflammatory activity.","volume":"31","author":"Calvert","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1182\/blood-2010-10-313106","article-title":"p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.","volume":"118","author":"Cudejko","year":"2011","journal-title":"Blood."},{"key":"B195","doi-asserted-by":"publisher","first-page":"9240","DOI":"10.18632\/aging.103200","article-title":"BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake.","volume":"12","author":"Wang","year":"2020","journal-title":"Aging."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.","volume":"66","author":"Mridha","year":"2017","journal-title":"J Hepatol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature."},{"key":"B198","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ni.2228","article-title":"A role for the NLRP3 inflammasome in metabolic diseases\u2013did Warburg miss inflammation?.","volume":"13","author":"Wen","year":"2012","journal-title":"Nat Immunol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/path.4357","article-title":"NLRPs, microbiota, and gut homeostasis: unravelling the connection.","volume":"233","author":"Zambetti","year":"2014","journal-title":"J Pathol."},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201800027","article-title":"The microbiota-inflammasome hypothesis of major depression.","volume":"40","author":"Inserra","year":"2018","journal-title":"Bioessays."},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8070205","article-title":"NLPR3 inflammasomes and their significance for atherosclerosis.","volume":"8","author":"Poznyak","year":"2020","journal-title":"Biomedicines."},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-020-00892-2","article-title":"The role of the gut microbiota in coronary heart disease.","volume":"22","author":"Liu","year":"2020","journal-title":"Curr Atheroscler Rep."},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006347","article-title":"Trimethylamine-N-oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway.","volume":"6","author":"Chen","year":"2017","journal-title":"J Am Heart Assoc."},{"key":"B204","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bbrc.2016.11.017","article-title":"Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome.","volume":"481","author":"Sun","year":"2016","journal-title":"Biochem Biophys Res Commun."},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002767","article-title":"Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-\u03baB.","volume":"5","author":"Seldin","year":"2016","journal-title":"J Am Heart Assoc."},{"key":"B206","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1161\/ATVBAHA.119.313414","article-title":"Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-\u03baB (Nuclear Factor \u03baB) signals.","volume":"40","author":"Zhang","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000492853","article-title":"Short-chain fatty acids manifest stimulative and protective effects on intestinal barrier function through the inhibition of NLRP3 inflammasome and autophagy.","volume":"49","author":"Feng","year":"2018","journal-title":"Cell Physiol Biochem."},{"key":"B208","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.redox.2018.02.007","article-title":"Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: antioxidant action of butyrate.","volume":"16","author":"Yuan","year":"2018","journal-title":"Redox Biol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0276-5","article-title":"Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination.","volume":"51","author":"Xu","year":"2019","journal-title":"Exp Mol Med."},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01535","article-title":"The human-associated archaeon methanosphaera stadtmanae is recognized through its RNA and induces TLR8-dependent NLRP3 inflammasome activation.","volume":"8","author":"Vierbuchen","year":"2017","journal-title":"Front Immunol."},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106289","article-title":"The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis.","volume":"181","author":"Zhang","year":"2022","journal-title":"Pharmacol Res."},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117747","article-title":"Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis.","volume":"253","author":"Xu","year":"2020","journal-title":"Life Sci."},{"key":"B213","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.intimp.2019.05.006","article-title":"NLRP3 inflammasome as a treatment target in atherosclerosis: a focus on statin therapy.","volume":"73","author":"Parsamanesh","year":"2019","journal-title":"Int Immunopharmacol."},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01947","article-title":"Alterations in gut microbiota by statin therapy and possible intermediate effects on hyperglycemia and hyperlipidemia.","volume":"10","author":"Kim","year":"2019","journal-title":"Front Microbiol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"e2210","DOI":"10.1128\/mBio.02210-15","article-title":"Resveratrol attenuates trimethylamine-N-Oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota.","volume":"7","author":"Chen","year":"2016","journal-title":"mBio."},{"key":"B216","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.biopha.2018.08.148","article-title":"Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-\/- mice.","volume":"107","author":"Shi","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B217","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.intimp.2016.12.031","article-title":"Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats.","volume":"44","author":"Dinesh","year":"2017","journal-title":"Int Immunopharmacol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.lfs.2016.02.004","article-title":"Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats.","volume":"148","author":"Doss","year":"2016","journal-title":"Life Sci."},{"key":"B219","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/s41591-018-0128-1","article-title":"Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.","volume":"24","author":"Roberts","year":"2018","journal-title":"Nat Med."},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900797","article-title":"The Potential of Probiotics in the Prevention and Treatment of Atherosclerosis.","volume":"64","author":"O\u2019Morain","year":"2020","journal-title":"Mol Nutr Food Res."},{"key":"B221","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/19490976.2017.1293224","article-title":"Fecal microbiota transplantation in metabolic syndrome: history, present and future.","volume":"8","author":"de Groot","year":"2017","journal-title":"Gut Microbes."},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2022.109013","article-title":"The critical role of short-chain fatty acids in health and disease: a subtle focus on cardiovascular disease-NLRP3 inflammasome-angiogenesis axis.","volume":"238","author":"Yao","year":"2022","journal-title":"Clin Immunol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities.","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jhep.2019.09.014","article-title":"Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1.","volume":"72","author":"Jiang","year":"2020","journal-title":"J Hepatol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1161\/ATVBAHA.118.311576","article-title":"Multifaceted mechanisms of vascular calcification in aging.","volume":"39","author":"Pescatore","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B226","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1161\/ATVBAHA.116.308886","article-title":"Prothrombin loading of vascular smooth muscle cell-derived exosomes regulates coagulation and calcification.","volume":"37","author":"Kapustin","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107881","article-title":"Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo.","volume":"32","author":"Bouchareychas","year":"2020","journal-title":"Cell Rep."},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-022-00815-5","article-title":"The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities.","volume":"12","author":"Sun","year":"2022","journal-title":"Cell Biosci."},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12154","article-title":"Roles of extracellular vesicles in the aging microenvironment and age-related diseases.","volume":"10","author":"Yin","year":"2021","journal-title":"J Extracell Vesicles."},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.780897","article-title":"hPMSCs-derived exosomal miRNA-21 protects against aging-related oxidative damage of CD4+ T cells by targeting the PTEN\/PI3K-Nrf2 axis.","volume":"12","author":"Xiong","year":"2021","journal-title":"Front Immunol."},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00765-3","article-title":"Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a\/Src.","volume":"6","author":"Xiao","year":"2021","journal-title":"Signal Transduct Target Ther."},{"key":"B232","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1038\/s41418-018-0255-8","article-title":"Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians.","volume":"26","author":"Storci","year":"2019","journal-title":"Cell Death Differ."},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.44","article-title":"Senotherapeutics for healthy ageing.","volume":"17","author":"Niedernhofer","year":"2018","journal-title":"Nat Rev Drug Discov."},{"key":"B234","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1289\/ehp.7523","article-title":"Ambient air pollution and atherosclerosis in Los Angeles.","volume":"113","author":"K\u00fcnzli","year":"2005","journal-title":"Environ Health Perspect."},{"key":"B235","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1093\/aje\/kwm359","article-title":"Long-term exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the multi-ethnic study of atherosclerosis.","volume":"167","author":"Diez Roux","year":"2008","journal-title":"Am J Epidemiol."},{"key":"B236","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/eurheartj\/eht426","article-title":"Are air pollution and traffic noise independently associated with atherosclerosis: the heinz nixdorf recall study.","volume":"35","author":"K\u00e4lsch","year":"2014","journal-title":"Eur Heart J."},{"key":"B237","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1093\/ehjci\/jeaa073","article-title":"Long-term exposure to ambient air pollution is associated with coronary artery calcification among asymptomatic adults.","volume":"22","author":"Huynh","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging."},{"key":"B238","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1289\/ehp.1104049","article-title":"Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: a Canadian national-level cohort study.","volume":"120","author":"Crouse","year":"2012","journal-title":"Environ Health Perspect."},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-016-0111-6","article-title":"Risk estimates of mortality attributed to low concentrations of ambient fine particulate matter in the Canadian community health survey cohort.","volume":"15","author":"Pinault","year":"2016","journal-title":"Environ Health."},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-019-0518-y","article-title":"Low concentrations of fine particle air pollution and mortality in the Canadian Community Health Survey cohort.","volume":"18","author":"Christidis","year":"2019","journal-title":"Environ Health."},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108890","article-title":"Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation.","volume":"180","author":"Riggs","year":"2020","journal-title":"Environ Res."},{"key":"B242","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1093\/ije\/dyl132","article-title":"Inflammatory markers and particulate air pollution: characterizing the pathway to disease","volume":"35","author":"Zeka","year":"2006","journal-title":"Int J Epidemiol."},{"key":"B243","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1136\/oemed-2012-100864","article-title":"The biological effects of individual-level PM(2.5) exposure on systemic immunity and inflammatory response in traffic policemen","volume":"70","author":"Zhao","year":"2013","journal-title":"Occup Environ Med."},{"key":"B244","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.yrtph.2015.09.034","article-title":"Evaluation of atherosclerosis as a potential mode of action for cardiovascular effects of particulate matter.","volume":"73","author":"Prueitt","year":"2015","journal-title":"Regul Toxicol Pharmacol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"709","DOI":"10.3109\/08958371003631608","article-title":"Urban particulate matter in Beijing, China, enhances allergen-induced murine lung eosinophilia.","volume":"22","author":"He","year":"2010","journal-title":"Inhal Toxicol."},{"key":"B246","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3109\/08958371003621633","article-title":"Subchronic effects of nasally instilled diesel exhaust particulates on the nasal and airway epithelia in mice.","volume":"22","author":"Yoshizaki","year":"2010","journal-title":"Inhal Toxicol."},{"key":"B247","doi-asserted-by":"publisher","first-page":"250","DOI":"10.5114\/aoms.2018.81039","article-title":"Potential injurious effects of the fine particulate PM2.5 on the progression of atherosclerosis in apoE-deficient mice by activating platelets and leukocytes.","volume":"15","author":"Zhu","year":"2019","journal-title":"Arch Med Sci."},{"key":"B248","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1016\/j.bbagen.2016.03.033","article-title":"Direct effects of airborne PM2.5 exposure on macrophage polarizations.","volume":"1860","author":"Zhao","year":"2016","journal-title":"Biochim Biophys Acta."},{"key":"B249","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/cvr\/cvz228","article-title":"Air pollution and cardiovascular disease: car sick.","volume":"116","author":"Miller","year":"2020","journal-title":"Cardiovasc Res."},{"key":"B250","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1161\/CIRCRESAHA.115.304666","article-title":"CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure.","volume":"115","author":"Rao","year":"2014","journal-title":"Circ Res."},{"key":"B251","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ecoenv.2019.03.068","article-title":"PM2.5 promotes plaque vulnerability at different stages of atherosclerosis and the formation of foam cells via TLR4\/MyD88\/NF\u03baB pathway.","volume":"176","author":"Geng","year":"2019","journal-title":"Ecotoxicol Environ Saf."},{"key":"B252","first-page":"3967","article-title":"COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.","volume":"9","author":"Yin","year":"2017","journal-title":"Am J Transl Res."},{"key":"B253","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1177\/0748233719871778","article-title":"Ambient fine particulate matter induces inflammatory responses of vascular endothelial cells through activating TLR-mediated pathway.","volume":"35","author":"Le","year":"2019","journal-title":"Toxicol Ind Health."},{"key":"B254","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/jat.3143","article-title":"PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through the ERK\/AKT\/NF-\u03baB-dependent pathway.","volume":"36","author":"Rui","year":"2016","journal-title":"J Appl Toxicol."},{"key":"B255","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1289\/ehp.5913","article-title":"Proinflammatory and cytotoxic effects of Mexico City air pollution particulate matter in vitro are dependent on particle size and composition.","volume":"111","author":"Osornio-Vargas","year":"2003","journal-title":"Environ Health Perspect."},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105830","article-title":"Mitochondrial alterations triggered by repeated exposure to fine (PM2.5-0.18) and quasi-ultrafine (PM0.18) fractions of ambient particulate matter.","volume":"142","author":"Sotty","year":"2020","journal-title":"Environ Int."},{"key":"B257","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.envpol.2019.03.045","article-title":"PM2.5 aggravates the lipid accumulation, mitochondrial damage and apoptosis in macrophage foam cells.","volume":"249","author":"Liu","year":"2019","journal-title":"Environ Pollut."},{"key":"B258","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1089\/ars.2014.5868","article-title":"Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation.","volume":"22","author":"Zhang","year":"2015","journal-title":"Antioxid Redox Signal."},{"key":"B259","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation.","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature."},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00579","article-title":"Dynamic aspects of macrophage polarization during atherosclerosis progression and regression.","volume":"5","author":"Peled","year":"2014","journal-title":"Front Immunol."},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149910","article-title":"Increased M1 macrophages infiltration is associated with thrombogenesis in rheumatic mitral stenosis patients with atrial fibrillation.","volume":"11","author":"He","year":"2016","journal-title":"PLoS One."},{"key":"B262","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.freeradbiomed.2017.10.386","article-title":"ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro.","volume":"113","author":"Ding","year":"2017","journal-title":"Free Radic Biol Med."},{"key":"B263","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1002\/jat.4110","article-title":"Progress in research on effect of PM2.5 on occurrence and development of atherosclerosis.","volume":"41","author":"Tian","year":"2021","journal-title":"J Appl Toxicol."},{"key":"B264","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1194\/jlr.M044552","article-title":"ABCG1-mediated generation of extracellular cholesterol microdomains.","volume":"55","author":"Freeman","year":"2014","journal-title":"J Lipid Res."},{"key":"B265","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/jbt.21452","article-title":"Particulate matter promotes in vitro receptor-recognizable low-density lipoprotein oxidation and dysfunction of lipid receptors.","volume":"27","author":"Manzano-Le\u00f3n","year":"2013","journal-title":"J Biochem Mol Toxicol."},{"key":"B266","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1161\/CIRCULATIONAHA.112.108753","article-title":"Altered activation of endothelial anti- and proapoptotic pathways by high-density lipoprotein from patients with coronary artery disease: role of high-density lipoprotein-proteome remodeling.","volume":"127","author":"Riwanto","year":"2013","journal-title":"Circulation."},{"key":"B267","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1161\/ATVBAHA.116.308193","article-title":"Association of air pollution exposures with high-density lipoprotein cholesterol and particle number: the multi-ethnic study of atherosclerosis.","volume":"37","author":"Bell","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-016-0139-3","article-title":"Effects of urban fine particulate matter and ozone on HDL functionality.","volume":"13","author":"Ramanathan","year":"2016","journal-title":"Part Fibre Toxicol."},{"key":"B269","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.toxlet.2018.03.022","article-title":"Air pollution is associated with the development of atherosclerosis via the cooperation of CD36 and NLRP3 inflammasome in ApoE-\/- mice.","volume":"290","author":"Du","year":"2018","journal-title":"Toxicol Lett."},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-020-00367-x","article-title":"Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?.","volume":"17","author":"Holme","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"B271","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1161\/01.cir.0000013838.94747.64","article-title":"Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults.","volume":"105","author":"Brook","year":"2002","journal-title":"Circulation."},{"key":"B272","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular (endothelial) dysfunction.","volume":"174","author":"Daiber","year":"2017","journal-title":"Br J Pharmacol."},{"key":"B273","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1165\/rcmb.2008-0402OC","article-title":"Particulate matter disrupts human lung endothelial barrier integrity via ROS?and p38 MAPK-dependent pathways.","volume":"42","author":"Wang","year":"2010","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B274","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1177\/0960327110374207","article-title":"Oxidative stress induced by urban fine particles in cultured EA.hy926 cells.","volume":"30","author":"Han","year":"2011","journal-title":"Hum Exp Toxicol."},{"key":"B275","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.tiv.2009.08.004","article-title":"Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter.","volume":"24","author":"Montiel-D\u00e1valos","year":"2010","journal-title":"Toxicol In Vitro."},{"key":"B276","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1177\/0960327111401050","article-title":"Effects of atorvastatin on fine particle-induced inflammatory response, oxidative stress and endothelial function in human umbilical vein endothelial cells.","volume":"30","author":"Zhao","year":"2011","journal-title":"Hum Exp Toxicol."},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.136397","article-title":"PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells.","volume":"710","author":"Wang","year":"2020","journal-title":"Sci Total Environ."},{"key":"B278","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1093\/toxsci\/kfw237","article-title":"Diesel exhaust particles contribute to endothelia apoptosis via autophagy pathway.","volume":"156","author":"Wang","year":"2017","journal-title":"Toxicol Sci."},{"key":"B279","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jes.2017.05.019","article-title":"The effects of autophagy on vascular endothelial cells induced by airborne PM2.5.","volume":"66","author":"Zhou","year":"2018","journal-title":"J Environ Sci."},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.07.105","article-title":"PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance.","volume":"254","author":"Wang","year":"2019","journal-title":"Environ Pollut."},{"key":"B281","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.envpol.2019.05.066","article-title":"Fine air pollution particles induce endothelial senescence via redox-sensitive activation of local angiotensin system.","volume":"252","author":"Sharma","year":"2019","journal-title":"Environ Pollut."},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201909081","article-title":"VE-cadherin endocytosis controls vascular integrity and patterning during development.","volume":"219","author":"Grimsley-Myers","year":"2020","journal-title":"J Cell Biol."},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121659","article-title":"PM2.5 induces vascular permeability increase through activating MAPK\/ERK signaling pathway and ROS generation.","volume":"386","author":"Long","year":"2020","journal-title":"J Hazard Mater."},{"key":"B284","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.3892\/mmr.2017.6877","article-title":"PM2.5 exposure decreases viability, migration and angiogenesis in human umbilical vein endothelial cells and human microvascular endothelial cells.","volume":"16","author":"Chen","year":"2017","journal-title":"Mol Med Rep."},{"key":"B285","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.etap.2019.04.008","article-title":"Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF\/VEGFR2\/MEK1\/2\/ERK1\/2\/mTOR pathway in human umbilical vein endothelial cells.","volume":"69","author":"Zhu","year":"2019","journal-title":"Environ Toxicol Pharmacol."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.956482\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:22:49Z","timestamp":1661242969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.956482\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":285,"alternative-id":["10.3389\/fcvm.2022.956482"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.956482","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]},"article-number":"956482"}}