{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:21:49Z","timestamp":1768688509821,"version":"3.49.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to evaluate the prognosis of patients with anomalous left coronary artery originating from pulmonary artery with varying cardiac function after surgical correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single-center retrospective cohort study including 51 patients with anomalous left coronary artery originating from pulmonary artery, all of whom underwent surgery at our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 5 deaths occurred in the pre-operative low cardiac function group (<jats:italic>n<\/jats:italic> = 39). After corrected by body surface area, parameters such as left coronary artery, right coronary artery, left atrial diameter, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, and main pulmonary artery diameter, were lower in patients in the normal cardiac function group than in the low cardiac function group. The rate of collateral circulation formation was higher in the normal cardiac function group. The proportion of changes of T wave was higher in the low cardiac function group (<jats:italic>P<\/jats:italic> = 0.005), and the duration of vasoactive drugs (dopamine, milrinone, epinephrine, nitroglycerin.) was longer in the low cardiac function group. Left ventricular end-diastolic diameter, left ventricular end-systolic diameter, main pulmonary artery diameter, and left atrial diameter were smaller than those pre-operatively (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Left ventricular ejection fraction was higher than that pre-operatively (<jats:italic>P<\/jats:italic> = 0.003). The degree of mitral regurgitation in the low cardiac function group was reduced post-operatively (<jats:italic>P<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a significant difference between the pre-operative baseline data of the low cardiac function group and the normal cardiac function group. After surgical repair, cardiac function gradually returned to normal in the low cardiac function group. The low cardiac function group required vasoactive drugs for a longer period of time. The left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, and main pulmonary artery diameter decreased and gradually returned to normal after surgery. The degree of mitral regurgitation in the low cardiac function group was reduced after surgery.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.961491","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T04:35:13Z","timestamp":1660019713000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pre-operative evaluation and mid-term outcomes of anomalous origin of the left coronary artery from the pulmonary artery based on left ventricular ejection fraction"],"prefix":"10.3389","volume":"9","author":[{"given":"Shu-Liang","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Kang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Qing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Hui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ru","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"E63","DOI":"10.1161\/circ.105.10.e63","article-title":"Anomalous pulmonary origin of the left coronary artery","volume":"105","author":"Cheng","year":"2002","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.ahj.2006.07.023","article-title":"Anomalous right coronary artery arising from the pulmonary artery: a report of 7 cases and a review of the literature","volume":"152","author":"Williams","year":"2006","journal-title":"Am Heart J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0022-5223(94)70212-8","article-title":"Anomalous left coronary artery from the pulmonary artery. Significance of intercoronary collaterals","volume":"108","author":"Berdjis","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/jocs.15285","article-title":"Long-term surgical results of anomalous origin of the left coronary artery from the pulmonary artery repair in infants and older patients","volume":"36","author":"Furuta","year":"2021","journal-title":"J Card Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.athoracsur.2014.12.035","article-title":"Outcomes of anomalous left coronary artery from pulmonary artery repair: beyond normal function","volume":"99","author":"Cabrera","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00246-014-1038-8","article-title":"Repair of anomalous left coronary artery from the pulmonary artery in the modern era: pre-operative predictors of immediate post-operative outcomes and long term cardiac follow-up","volume":"36","author":"Weigand","year":"2015","journal-title":"Pediatr Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1016\/j.athoracsur.2015.11.020","article-title":"Surgical intervention for anomalous origin of left coronary artery from the pulmonary artery in children: a long-term follow-up","volume":"101","author":"Naimo","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/ejcts\/ezw268","article-title":"Long-term results after repair of anomalous origin of left coronary artery from the pulmonary artery: Takeuchi repair versus coronary transfer","volume":"51","author":"Neumann","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.athoracsur.2006.11.005","article-title":"Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery","volume":"83","author":"Lange","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e002826","DOI":"10.1161\/CIRCHEARTFAILURE.115.002826","article-title":"Heart failure and midrange ejection fraction: implications of recovered ejection fraction for exercise tolerance and outcomes","volume":"9","author":"Nadruz W","year":"2016","journal-title":"Circ Heart Fail"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1007\/s003300050885","article-title":"Anomalous origin of the left coronary artery arising from the pulmonary trunk: report of an adult case with long-term follow-up after surgery","volume":"9","author":"Mesurolle","year":"1999","journal-title":"Eur Radiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s002460010142","article-title":"Electrocardiographic and echocardiographic features that distinguish anomalous origin of the left coronary artery from pulmonary artery from idiopathic dilated cardiomyopathy","volume":"22","author":"Chang","year":"2001","journal-title":"Pediatr Cardiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e18046","DOI":"10.1097\/MD.0000000000018046","article-title":"Echocardiographic diagnosis of anomalous origin of the left coronary artery from the pulmonary artery","volume":"98","author":"Yuan","year":"2019","journal-title":"Medicine"},{"key":"B14","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/icvts\/ivt061","article-title":"Repair of anomalous origin of the left coronary artery from the pulmonary artery in infants","volume":"16","author":"Kazmierczak","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"B15","unstructured":"The surgical outcome of anomalous origin of the left coronary artery from the pulmonary artery5760\n            MuzaffarT\n            Ahmad GanieF\n            Gpoal SwamyS\n            WaniNU\n          31066728Int Cardiovasc Res J82014"},{"key":"B16","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0003-4975(03)00344-8","article-title":"Anomalous coronary artery origin from the pulmonary artery: correlation between surgical timing and left ventricular function recovery","volume":"76","author":"Michielon","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.athoracsur.2013.11.042","article-title":"Twenty-year outcome of anomalous origin of left coronary artery from pulmonary artery: management of mitral regurgitation","volume":"97","author":"Kudumula","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"B18","first-page":"38","article-title":"Midterm results after surgical repair of the anomalous origin of the coronary artery","volume-title":"Circulation","author":"Lambert","year":"1996"},{"key":"B19","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.rec.2011.04.014","article-title":"Outcomes of coronary reimplantation for correction of anomalous origin of left coronary artery from pulmonary artery","volume":"64","author":"Ram\u00edrez","year":"2011","journal-title":"Rev Esp Cardiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1177\/2150135115596584","article-title":"Anomalous origins of coronary arteries from the pulmonary artery: a comprehensive review of literature and surgical options","volume":"6","author":"Karimi","year":"2015","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s00431-008-0667-4","article-title":"Resolution of pathologic Q wave, left ventricular dysfunction and mitral regurgitation after dual coronary repair of the anomalous origin of the left coronary artery from the pulmonary artery","volume":"167","author":"Chiu","year":"2008","journal-title":"Eur J Pediatr"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.jacc.2010.06.064","article-title":"30-year outcome of anatomic correction of anomalous origin of the left coronary artery from the pulmonary artery","volume":"57","author":"El-Hamamsy","year":"2011","journal-title":"J Am Coll Cardiol"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.961491\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:19:39Z","timestamp":1718133579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.961491\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":22,"alternative-id":["10.3389\/fcvm.2022.961491"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.961491","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,9]]},"article-number":"961491"}}