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Endothelium, located in the inner surface of coronary artery, serves as the interface between the circulating inflammatory cells and vascular media or adventitia, which is the first target of inflammatory attacks during early stage of KD. A series of studies have determined vascular endothelial cells damages and dysfunction in KD patients. However, current therapeutic strategy is still challenging. So that it is critical to underline the mechanisms of endothelium injuries. In this review, the role of endothelial cells in the pathogenesis of KD and the therapeutic methods for endothelial cells were systematically described.<\/jats:p>","DOI":"10.3389\/fcvm.2022.981010","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T06:02:16Z","timestamp":1659938536000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Molecular mechanisms of endothelial dysfunction in Kawasaki-disease-associated 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