{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:19:47Z","timestamp":1776917987255,"version":"3.51.2"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>A 49-year-old man presented to the hospital with symptoms of acute cerebral infarction and pulmonary embolism who underwent transcatheter closure of atrial septal defect a year before. Transthoracic echocardiography showed a 13 \u00d7 9 mm hypoechoic mass attached to the left-atrial side of the device, which was suspected to be a neoplasm or thrombus. The patient was indicated for surgery after multidisciplinary discussion due to ineffective medical therapy and typical stroke and pulmonary embolism symptoms. Three-dimensional transesophageal echocardiography (3D-TEE) revealed left-atrial vegetation (21 \u00d7 16 mm) and right-atrial vegetation (8 \u00d7 6 mm) attached to the device, which was confirmed as thrombus by surgical separation and laboratory examination. This case highlights the importance of 3D-TEE and a multidisciplinary team in the diagnosis and therapy of device-related thrombus.<\/jats:p>","DOI":"10.3389\/fcvm.2022.987538","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T05:49:20Z","timestamp":1662529760000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: Bi-atrial thrombus after occlusion of atrial septal defect with acute cerebral infarction and pulmonary embolism"],"prefix":"10.3389","volume":"9","author":[{"given":"Wei","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ejim.2019.12.010","article-title":"Light anti-thrombotic regimen for prevention of device thrombosis and\/or thrombotic complications after interatrial shunts device-based closure","volume":"74","author":"Rigatelli","year":"2020","journal-title":"Eur J Intern Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.cjca.2016.02.068","article-title":"Long-term complications after transcatheter atrial septal defect closure: a review of the medical literature","volume":"32","author":"Jalal","year":"2016","journal-title":"Can J Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jacc.2003.10.030","article-title":"Incidence and clinical course of thrombus formation on atrial septal defect and patient foramen ovale closure devices in 1,000 consecutive patients","volume":"43","author":"Krumsdorf","year":"2004","journal-title":"J Am Coll Cardiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/echo.15269","article-title":"Bi-atrial thrombus straddling a patent foramen ovale with bilateral embolization: a therapeutic challenge","volume":"39","author":"Dattani","year":"2022","journal-title":"Echocardiography."},{"key":"B5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.case.2019.09.008","article-title":"Very late amplatzer device thrombosis and stroke","volume":"4","author":"Giraldo-Gonzalez","year":"2020","journal-title":"Case."},{"key":"B6","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/echo.15326","article-title":"Abrupt formation of intracardiac thrombus during patent foramen ovale closure by three-dimensional transesophageal echocardiography","volume":"39","author":"Zhang","year":"2022","journal-title":"Echocardiography."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1093\/eurheartj\/ehq249","article-title":"Esc guidelines for the management of grown-up congenital heart disease (new version 2010)","volume":"31","author":"Baumgartner","year":"2010","journal-title":"Eur Heart J."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.987538\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T05:49:23Z","timestamp":1662529763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.987538\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":7,"alternative-id":["10.3389\/fcvm.2022.987538"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.987538","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"article-number":"987538"}}