{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:22:53Z","timestamp":1788801773115,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left atrial (LA) remodeling is associated with adverse cardiovascular events, including heart failure (HF) and stroke in patients with atrial fibrillation (AF). However, there are limited data on the value of right atrial (RA) remodeling in this population. We investigated the prognostic role of RA enlargement in patients with non-valvular AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We analyzed 254 consecutive patients (age = 69 \u00b1 12years, male:female = 165:89, mean left ventricular ejection fraction = 58.0 \u00b1 7.2%) with non-valvular AF who underwent two-dimensional echocardiography from a single center. RA and LA volumes were measured from apical views and indexed to the body surface areas (right atrial volume index [RAVI] and left atrial volume index [LAVI]) and RAVI &amp;gt; 30mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      and LAVI &amp;gt; 34mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      were considered as enlarged. The relationship between RA enlargement and composite clinical outcome of hospitalization for HF (HHF), stroke, systemic embolism, or death from any cause was assessed. Right atrial (RA) enlargement was associated with older age and more frequent prevalence of persistent or permanent AF. During a median follow-up of 47.1 months, 77 patients (30%) had experienced primary composite outcome. In a multivariable model, RA enlargement, but not LA enlargement, was independently associated with adverse clinical outcomes even after adjusting for clinical and echocardiographic factors {adjusted hazard ratio [HR], 1.90 [95% confidence interval (CI), 1.14\u20133.18],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014 for primary composite outcome; adjusted HR, 2.70 [95% CI, 1.27\u20135.67],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001 for HHF or all cause death}.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RA enlargement was independently associated with an increased risk of HF, stroke, systemic embolization or death in patients with non-valvular AF, suggesting that RA volume can be helpful in assessing future cardiovascular risk in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2022.989012","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T03:09:06Z","timestamp":1663902546000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of right atrial enlargement on clinical outcome in patients with atrial fibrillation"],"prefix":"10.3389","volume":"9","author":[{"given":"Kyu-Yong","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Huan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Soo","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Woo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Don","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Ill","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hyeok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hee","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1093\/eurheartj\/ehi825","article-title":"Prevalence, incidence and lifetime risk of atrial fibrillation: The rotterdam study.","volume":"27","author":"Heeringa","year":"2006","journal-title":"Eur Heart J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1161\/01.cir.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: The framingham heart study.","volume":"98","author":"Benjamin","year":"1998","journal-title":"Circulation."},{"key":"B3","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1161\/01.STR.28.7.1507","article-title":"Risk factors.","volume":"28","author":"Sacco","year":"1997","journal-title":"Stroke."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1161\/01.Cir.96.9.3157","article-title":"Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat.","volume":"96","author":"Ausma","year":"1997","journal-title":"Circulation."},{"key":"B5","doi-asserted-by":"publisher","first-page":"S162","DOI":"10.1046\/j.1540.8167.90306.x","article-title":"Echocardiographic and electrocardiographic predictors for atrial fibrillation recurrence following cardioversion.","volume":"14","author":"Bollmann","year":"2003","journal-title":"J Cardiovasc Electrophysiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1016\/j.jacc.2005.03.020","article-title":"Are transthoracic echocardiographic parameters associated with atrial fibrillation recurrence or stroke? 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