{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:19:11Z","timestamp":1780460351212,"version":"3.54.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The previously built score models of contrast-induced acute kidney injury (CI-AKI) were principally founded on selective percutaneous coronary intervention (PCI) cases. Our study was to form a risk score model of CI-AKI and make a temporal validation in a population who underwent emergency PCIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients who underwent emergency PCIs from 2013 to 2018 and divided them into the derivation and validation cohorts. Logistic regression analysis was harnessed to create the risk model. In this research, we defined CI-AKI as an increase in serum creatinine (SCr) \u22650.5 mg\/dL (44.2 \u03bcmol\/L) above baseline within seven days following exposure to contrast medium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3564 patients who underwent emergency PCIs were enrolled and divided into the derivation (2376 cases) and validation cohorts (1188 cases), with CI-AKI incidence of 6.61 and 5.39%, respectively. By logistic analysis, the CI-AKI risk score model was constituted by 8 variables: female (1 point), history of transient ischemic attack (TIA)\/stroke (1 point), left ventricular ejection fraction (LVEF) classification (1 point per class), big endothelin-1 (ET-1) classification (1 point per class), estimated glomerular filtration rate (eGFR) classification (1 point per class), intra-aortic balloon pump (IABP) application (1 point), left anterior descending (LAD) stented (1 point), and administration of diuretic (2 points). The patients could be further divided into three groups: low-risk, moderate-risk, and high-risk groups, in accordance with the risk scores of 3\u20136, 7\u201310, and \u226511 points, and to the CI-AKI rates of 1.4, 11.9, and 42.6%. The CI-AKI risk score model performed well in discrimination (<jats:italic>C<\/jats:italic> statistic = 0.787, 95% CI: 0.731\u20130.844) and calibration ability, and showed a superior clinical utility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We developed a simple CI-AKI risk score model which performs well as a tool for CI-AKI prediction in patients who underwent emergency PCIs.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.989243","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T07:55:36Z","timestamp":1665647736000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A risk score model of contrast-induced acute kidney injury in patients with emergency percutaneous coronary interventions"],"prefix":"10.3389","volume":"9","author":[{"given":"Ying","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runlin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.2214\/ajr.183.6.01831673","article-title":"Contrast-induced nephropathy","volume":"183","author":"Gleeson","year":"2004","journal-title":"Am J Roentgenol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s12928-020-00660-8","article-title":"Contrast-induced acute kidney injury","volume":"35","author":"Chandiramani","year":"2020","journal-title":"Cardiovasc Interv Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1161\/01.CIR.0000016043.87291.33","article-title":"Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention","volume":"105","author":"Rihal","year":"2002","journal-title":"Circulation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.jacc.2007.12.035","article-title":"Contrast-induced acute kidney injury","volume":"51","author":"McCullough","year":"2008","journal-title":"J Am Coll Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.iccl.2020.03.001","article-title":"Pathophysiology of contrast-induced acute kidney injury","volume":"9","author":"Bansal","year":"2020","journal-title":"Interv Cardiol Clin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.amjcard.2012.11.018","article-title":"Contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention without acute left ventricular ejection fraction impairment","volume":"111","author":"Pyxaras","year":"2013","journal-title":"Am J Cardiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijcard.2014.03.146","article-title":"Association of contrast-induced acute kidney injury with long-term cardiovascular events in acute coronary syndrome patients with chronic kidney disease undergoing emergent percutaneous coronary intervention","volume":"174","author":"Watabe","year":"2014","journal-title":"Int J Cardiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"E19","DOI":"10.1002\/ccd.25822","article-title":"Incidence, prognostic impact, and optimal definition of contrast-induced acute kidney injury in consecutive patients with stable or unstable coronary artery disease undergoing percutaneous coronary intervention. 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