{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:31:05Z","timestamp":1773477065906,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous Study Found That Implantation of a Cardioverter-Defibrillator Likely Caused a Worse Prognosis in Older Patients With non-Ischemic Systolic Heart Failure. This Suggests That More Precise Risk Stratification Is Needed in Elderly Patients. We Conducted a Retrospective Study to Evaluate the Association of \u03b1-Hydroxybutyrate Dehydrogenase (\u03b1-HBDH) With Mortality During Hospitalization in Elderly Patients With non-Ischemic Dilated Cardiomyopathy (NIDCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>1,019 Elderly Patients (age \u226560 Years) Diagnosed With NIDCM Were Retrospectively Enrolled From January 2010 to December 2019. Univariate and Multivariate Analyses Were Showed to Explore the Relationship Between \u03b1-HBDH and in- Hospital Death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in elevated \u03b1-HBDH group (&amp;gt;182 U\/L) had a longer hospital stays and higher in-hospital mortality. Univariate logistics regression analysis showed that elevated \u03b1-HBDH was significantly related to mortality (OR: 7.004, 95% CI: 3.583\u201313.693, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). Receiver operator characteristic (ROC) curve analysis reflected that \u03b1-HBDH levels had excellent predictive power for in-hospital death (AUC = 0.810, 95% CI: 0.745\u20130.876, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). After adjustment of age, serum creatine, albumin and LVEF, multivariate regression analysis validated the association of elevated \u03b1-HBDH with increased risk of in-hospital death (<jats:italic>p<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated \u03b1-HBDH level is significantly related to in-hospital mortality in older patients with NIDCM.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2022.995899","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T08:04:55Z","timestamp":1663661095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Elevated \u03b1-hydroxybutyrate dehydrogenase is associated with in-hospital mortality in non-ischemic dilated 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