{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:12:06Z","timestamp":1787026326806,"version":"build-2736575974"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ventricular tachycardia ablation (VTA) with hemodynamic compromise presents a challenge. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support allows the safe completion of the procedure. There are limited data regarding the safety of weaning off VA-ECMO at the end of the procedure. We report our experience with early VA-ECMO de-cannulation after VTA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>All patients undergoing VA-ECMO-assisted VTA, between January 2013 and December 2020 at a large tertiary center were included. Clinical characteristics, history of arrhythmia, procedural details, and outcomes were collected. Patients weaned from VA-ECMO immediately at the end of the procedure were compared to those that were de-cannulated at a later time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 46 patients (93.5% male, age 62 \u00b1 10 years) were ablated with VA-ECMO support. Most had ischemic cardiomyopathy (65%) and (70%) presented with VT storm. The clinical VT was induced in the majority of patients (76%). A total of 99 VTs were induced of which 76 (77%) were targeted and successfully ablated. Non-inducibility was achieved in 74% of cases and most patients (83%) were de-cannulated at the end of the procedure on the procedure table. Survival at 1 year was higher among early de-cannulated patients (86 vs. 38% [log-rank\n                      <jats:italic>p<\/jats:italic>\n                      -value &amp;lt; 0.001]). At 1-year follow-up, 91.3% of surviving patients were free of appropriate ICD shocks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>De-cannulation from VA-ECMO may be done immediately at the conclusion of VTA in most cases. Failure to timely wean off VA-ECMO is a strong predictor of mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2022.998079","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:55:36Z","timestamp":1666054536000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Early de-cannulation from extracorporeal membrane oxygenation following ventricular tachycardia radiofrequency ablation"],"prefix":"10.3389","volume":"9","author":[{"given":"Avi","family":"Sabbag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnatan","family":"Nissan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Beinart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Sternik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igal","family":"Kassif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eilon","family":"Ram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Nof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC).","volume":"36","author":"Priori","year":"2015","journal-title":"Eur Heart J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1540-8159.2008.00999.x","article-title":"Ablation of ventricular tachycardia in patients with structural heart disease.","volume":"31","author":"Zeppenfeld","year":"2008","journal-title":"Pac Clin Electrophysiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.hrthm.2017.09.005","article-title":"Outcomes of rescue cardiopulmonary support for periprocedural acute hemodynamic decompensation in patients undergoing catheter ablation of electrical storm.","volume":"15","author":"Enriquez","year":"2018","journal-title":"Heart Rhythm."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/j.hrthm.2018.04.028","article-title":"Outcomes with prophylactic use of percutaneous left ventricular assist devices in high-risk patients undergoing catheter ablation of scar-related ventricular tachycardia: a propensity-score matched analysis.","volume":"15","author":"Muser","year":"2018","journal-title":"Heart Rhythm."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.hrthm.2014.04.018","article-title":"Procedural and clinical outcomes after catheter ablation of unstable ventricular tachycardia supported by a percutaneous left ventricular assist device.","volume":"11","author":"Aryana","year":"2014","journal-title":"Heart Rhythm."},{"key":"B6","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/europace\/eur347","article-title":"Efficacy and safety of ventricular tachycardia ablation with mechanical circulatory support compared with substrate-based ablation techniques.","volume":"14","author":"Bunch","year":"2012","journal-title":"Europace."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004492","article-title":"Extracorporeal membrane oxygenation for hemodynamic support of ventricular tachycardia ablation.","volume":"9","author":"Baratto","year":"2016","journal-title":"Circ Arrhythm Electrophysiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1161\/CIRCULATIONAHA.105.170769","article-title":"Standards for statistical models used for public reporting of health outcomes: an American Heart Association scientific statement from the quality of care and outcomes research interdisciplinary writing group: cosponsored by the council on epidemiology and prevention and the stroke council. endorsed by the American College of Cardiology Foundation.","volume":"113","author":"Krumholz","year":"2006","journal-title":"Circulation."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1016\/j.rec.2017.12.013","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease.","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01914-2018","article-title":"Pulmonary hypertension in chronic lung disease and hypoxia.","volume":"53","author":"Nathan","year":"2019","journal-title":"Eur Respir J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1161\/01.cir.101.11.1288","article-title":"Linear ablation lesions for control of unmappable ventricular tachycardia in patients with ischemic and nonischemic cardiomyopathy.","volume":"101","author":"Marchlinski","year":"2000","journal-title":"Circulation."},{"key":"B12","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1161\/CIRCEP.114.002155","article-title":"Acute hemodynamic decompensation during catheter ablation of scar-related ventricular tachycardia: incidence, predictors, and impact on mortality.","volume":"8","author":"Santangeli","year":"2015","journal-title":"Circ Arrhythm Electrophysiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.jtcvs.2010.07.017","article-title":"Infections occurring during extracorporeal membrane oxygenation use in adult patients.","volume":"140","author":"Sun","year":"2010","journal-title":"J Thorac Cardiovasc Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.jacep.2019.11.004","article-title":"Cardiac magnetic resonance-guided ventricular tachycardia substrate ablation.","volume":"6","author":"Soto-Iglesias","year":"2020","journal-title":"JACC Clin Electrophysiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.hrthm.2017.05.018","article-title":"Cardiac magnetic resonance-aided scar dechanneling: influence on acute and long-term outcomes.","volume":"14","author":"Andreu","year":"2017","journal-title":"Heart Rhythm."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.998079\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:55:38Z","timestamp":1666054538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2022.998079\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":15,"alternative-id":["10.3389\/fcvm.2022.998079"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2022.998079","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"article-number":"998079"}}