{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:57:31Z","timestamp":1790888251059,"version":"4.1.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>The goal of this study was to assess the impact of neutrophil count, in patients with acute type A aortic dissection (ATAAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively collected data from patients between September 2017 and June 2021. Youden's index was used to determine the optimal cut-off value for the neutrophil count and patients were divided into two subgroups. A restricted cubic spline (RCS) was used to model the relationship between variables and in-hospital mortality. The least absolute shrinkage and selection operator (LASSO) method and multivariate logistic regression analyses were used to investigate the independent prognostic factors for in-hospital mortality in patients with ATAAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 467 patients were enrolled in this study. In-hospital mortality was 7.28%. The group with elevated neutrophil counts had significantly higher mortality than the group with decreased neutrophil counts (10.8% vs. 3.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). This data shows that elevated neutrophil count was significantly associated with in-hospital mortality (OR 3.07, 95% CI 1.22\u20137.62, <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neutrophil count is an independent risk factor for in-hospital mortality in patients with ATAAD. It is an effective inflammatory index, which can be individualized for patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1095646","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T06:44:18Z","timestamp":1677825858000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic significance of neutrophil count on in-hospital mortality in patients with acute type A aortic dissection"],"prefix":"10.3389","volume":"10","author":[{"given":"Weiqi","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"w14489","DOI":"10.4414\/smw.2017.14489","article-title":"Acute aortic dissection: pathogenesis, risk factors and diagnosis","volume":"147","author":"Gawinecka","year":"2017","journal-title":"Swiss Med Wkly"},{"key":"B2","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1001\/jama.2016.10026","article-title":"Acute aortic dissection and intramural hematoma: a systematic review","volume":"316","author":"Mussa","year":"2016","journal-title":"JAMA"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.21037\/jtd.2018.03.48","article-title":"Inflammation is related to preoperative hypoxemia in patients with acute Stanford type A aortic dissection","volume":"10","author":"Duan","year":"2018","journal-title":"J Thorac Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","article-title":"Neutrophils as regulators of cardiovascular inflammation","volume":"17","author":"Silvestre-Roig","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1161\/STROKEAHA.118.021564","article-title":"Polymorphonuclear neutrophils play a decisive role for brain injury and neurological recovery poststroke","volume":"50","author":"Hermann","year":"2019","journal-title":"Stroke"},{"key":"B6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0741-5214(92)90101-D","article-title":"Correlation of inflammatory infiltrate with the enlargement of experimental aortic aneurysms","volume":"16","author":"Anidjar","year":"1992","journal-title":"J Vasc Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"R204","DOI":"10.1186\/cc2872","article-title":"Acute renal failure - 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