{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:39:46Z","timestamp":1782902386908,"version":"3.54.5"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"Background<\/jats:title>Danlou tablets exert auxiliary advantages in treating coronary heart disease (CHD), but a summary of evidence-based proof is lacking. This study aims to systematically evaluate Danlou tablets in treating CHD from two aspects, including efficacy and safety.<\/jats:p><\/jats:sec>Methods<\/jats:title>By a thorough retrieval of the four English databases, namely, PubMed, The Cochrane Library, Embase, and Web of Science, and the four Chinese databases, namely, CNKI, Wanfang, VIP database, and China Biomedical Literature Service System, we found all randomized controlled trials (RCTs) related to Danlou tablets in treating CHD. The retrieval time was from the construction of the database to April 2022. We engaged two researchers to screen the studies, extract the required data, and assess the risk of bias. We then used RevMan5.3 and STATA.14 software to conduct a meta-analysis. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the quality of outcome indicators.<\/jats:p><\/jats:sec>Results<\/jats:title>Seventeen RCTs involving 1,588 patients were included. The meta-analysis results are displayed as follows: clinical treatment effect [risk ratio (RR)\u2009=\u20091.22, 95% confidence interval (CI): 1.16, 1.28, P\u2009<\/jats:italic>&lt;\u20090.00001], angina pectoris duration [MD\u2009=\u2009\u22120.2.15, 95% CI: \u22122.91, \u22121.04, P\u2009<\/jats:italic>&lt;\u20090.00001], angina pectoris frequency [standard mean difference (SMD)\u2009=\u2009\u22122.48, 95% CI: \u22123.42, \u22121.54, P\u2009<\/jats:italic>&lt;\u20090.00001], angina pectoris degree [SMD\u2009=\u2009\u22120.96, 95% CI: \u22121.39, \u22120.53, P\u2009<\/jats:italic>&lt;\u20090.0001], TC [MD\u2009=\u2009\u22120.71, 95% CI: \u22120.92, \u22120.51, P\u2009<\/jats:italic>&lt;\u20090.00001], TG [MD\u2009=\u2009\u22120.38, 95% CI: \u22120.53, \u22120.22, P\u2009<\/jats:italic>&lt;\u20090.00001], low-density lipoprotein cholesterol [MD\u2009=\u2009\u22120.64, 95% CI: \u22120.76, \u22120.51, P\u2009<\/jats:italic>&lt;\u20090.00001], high-density lipoprotein cholesterol [MD\u2009=\u20090.16, 95% CI: 0.11, 0.21, P\u2009<\/jats:italic>&lt;\u20090.00001], and adverse events [RR\u2009=\u20090.46, 95% CI: 0.24, 0.88, P\u2009<\/jats:italic>=\u20090.02].<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The current evidence suggests that the combination of Danlou tablets and Western medicine can enhance the efficacy of CHD and does not increase adverse events. However, because of the limited number and quality of the included studies, the results of our study should be treated with caution. Further large-scale RCTs are necessary to verify the benefits of this approach.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1100006","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:36:42Z","timestamp":1686119802000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of Danlou tablets in traditional Chinese medicine for coronary heart disease: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"10","author":[{"given":"WeiLi","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/eurheartj\/ehx628","article-title":"European Society of Cardiology: cardiovascular disease statistics 2017","volume":"39","author":"Timmis","year":"2018","journal-title":"Eur Heart J"},{"key":"B2","first-page":"659","article-title":"Meta analysis and trial sequential analysis of colchicine in the treatment of coronary heart disease","volume":"36","author":"Yu","year":"2021","journal-title":"Chin Circ J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1472-6882-10-37","article-title":"Modelling of inquiry diagnosis for coronary heart disease in traditional Chinese medicine by using multi-label learning","volume":"10","author":"Liu","year":"2010","journal-title":"BMC Complement Altern Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"9413704","DOI":"10.1155\/2021\/9413704","article-title":"Tongxinluo capsule combined with atorvastatin for coronary heart disease: a systematic review and meta-analysis","volume":"2021","author":"Liu","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jep.2013.11.007","article-title":"A network-based analysis of the types of coronary artery disease from traditional Chinese medicine perspective: potential for therapeutics and drug discovery","volume":"151","author":"Zhou","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.jep.2011.08.071","article-title":"Analysis on outcome of 5284 patients with coronary artery disease: the role of integrative medicine","volume":"141","author":"Gao","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"714517","DOI":"10.1155\/2012\/714517","article-title":"Clinical and epidemiological investigation of TCM syndromes of patients with coronary heart disease in China","volume":"2012","author":"Ren","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"6949348","DOI":"10.1155\/2018\/6949348","article-title":"Shexiang Baoxin pills as an adjuvant treatment for chronic heart failure: a system review and meta-analysis","volume":"2018","author":"Dong","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.7661\/j.cjim.20200321.010","article-title":"Consensus of Chinese experts on treating angina pectoris of coronary heart disease with Shexiang Baoxin pill","volume":"38","author":"Fan","year":"2018","journal-title":"Chin J Integr Tradit West Med"},{"key":"B11","first-page":"2861","article-title":"Research progress on pharmacological action and clinical application of Danlou tablet","volume":"41","author":"Liu","year":"2019","journal-title":"Hebei Med J"},{"key":"B12","doi-asserted-by":"publisher","first-page":"111911","DOI":"10.1016\/j.jep.2019.111911","article-title":"Anti-inflammatory and antioxidative effects of Dan-Lou tablets in the treatment of coronary heart disease revealed by metabolomics integrated with molecular mechanism studies","volume":"240","author":"Li","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"104306","DOI":"10.1016\/j.phrs.2019.104306","article-title":"Ethanol extracts of Danlou tablet attenuate atherosclerosis via inhibiting inflammation and promoting lipid effluent","volume":"146","author":"Hao","year":"2019","journal-title":"Pharmacol Res"},{"key":"B14","first-page":"391","article-title":"Clinical application guide of Chinese patent medicine in treating coronary heart disease (2020)","volume":"41","year":"2021","journal-title":"Chin J Integr Tradit West Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1161\/01.cir.59.3.607","article-title":"Report of the Joint International Society and Federation of Cardiology\/World Health Organization task force on standardization of clinical nomenclature","volume":"59","year":"1979","journal-title":"Circulation"},{"key":"B16","doi-asserted-by":"publisher","first-page":"5630","DOI":"10.1136\/bmj.g5630","article-title":"A GRADE working group approach for rating the quality of treatment effect estimates from network meta-analysis","volume":"349","author":"Puhan","year":"2014","journal-title":"Br Med J"},{"key":"B17","first-page":"1748","article-title":"Effect of Danlou tablet on electrocardiogram and serum sPLA2, LP-PLA2 and ox-LDL levels in patients with coronary heart disease with mutual obstruction of phlegm and stasis syndrome","volume":"36","author":"Su","year":"2021","journal-title":"Guangming J Chin Med"},{"key":"B18","first-page":"20","article-title":"A randomized parallel control study of Danlou Tablet combined with Western medicine in the treatment of Angina pectoris of coronary heart disease with mutual obstruction of phlegm and stasis syndrome","volume":"27","author":"Tan","year":"2013","journal-title":"J Pract Tradit Chin Intern Med"},{"key":"B19","first-page":"35","article-title":"Clinical observation of Danlou tablet in treating stable angina pectoris of coronary heart disease (Phlegm turbidiasis and blood stasis syndrome). Master","author":"Tang","year":"2013","journal-title":"J Heilongjiang Univ Tradit Chin Med"},{"key":"B20","first-page":"24","article-title":"Clinical study of Danlou tablet in treating unstable angina pectoris with phlegm and blood stasis blocking collaterals syndrome. Master","author":"Wang","year":"2015","journal-title":"J Changchun Univ Chin Med"},{"key":"B21","first-page":"1051","article-title":"Clinical evaluation of Danlou tablet in treating angina pectoris of coronary heart disease with mutual obstruction of phlegm and blood stasis syndrome","volume":"32","author":"Wang","year":"2012","journal-title":"Chin J Integr Tradit West Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"596","DOI":"10.15900\/j.cnki.zylf1995.2021.04.041","article-title":"Effect of Danlou tablet combined with isosorbide mononitrate on angina attack and hemodynamic indicators in elderly patients with coronary heart disease","volume":"27","author":"Wang","year":"2021","journal-title":"Chin J Drug Abuse Prev Treat"},{"key":"B23","first-page":"2524","article-title":"Clinical effect of Danlou tablet on angina pectoris of coronary heart disease and its effect on vascular endothelial function","volume":"40","author":"Wang","year":"2018","journal-title":"Guangxi Med J"},{"key":"B24","first-page":"1530","article-title":"Clinical study on angina pectoris of coronary heart disease treated by integrated traditional Chinese and Western medicine","volume":"21","author":"Wei","year":"2015","journal-title":"J Basic Chin Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.3760\/cma.j.cn115682-20200311-01626","article-title":"Clinical application of Danlou tablet combined with Omaha case management model in patients with chronic stable coronary heart disease","volume":"26","author":"Xing","year":"2020","journal-title":"Chin J Mod Nurs"},{"key":"B26","doi-asserted-by":"publisher","first-page":"94","DOI":"10.19347\/j.cnki.2096-1413.201824044","article-title":"Curative effect of Danlou tablet on angina pectoris of coronary heart disease with mutual obstruction of phlegm and blood stasis syndrome","volume":"3","author":"Zhang","year":"2018","journal-title":"Curr Med Res Pract"},{"key":"B27","first-page":"3558","article-title":"Analysis of electrocardiogram and TCM syndrome of Danlou tablet in treatment of stable angina pectoris of coronary heart disease with phlegm and stasis interaction syndrome","volume":"32","author":"Ma","year":"2017","journal-title":"Guangming J Chin Med"},{"key":"B28","first-page":"1022","article-title":"Clinical observation of Danlou tablet in treating unstable angina pectoris of coronary heart disease with phlegm and blood stasis syndrome","volume":"12","author":"Ren","year":"2014","journal-title":"Chin J Integr Med Cardio-Cerebrovasc Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"82","DOI":"10.16282\/j.cnki.cn11-9336\/r.2017.30.064","article-title":"Effect of Danlou tablet combined with trimetazidine on unstable angina pectoris","volume":"5","author":"Tian","year":"2017","journal-title":"Cardiovasc Dis Electron J Integr Tradit Chin West Med"},{"key":"B30","first-page":"116","article-title":"Danlou tablet for treating 50 cases of coronary heart disease with phlegm and blood stasis syndrome","volume":"17","author":"Wang","year":"2019","journal-title":"J China Prescription Drug"},{"key":"B31","first-page":"33","article-title":"Clinical effect of Danlou tablet on angina pectoris of senile coronary heart disease with mutual obstruction of phlegm and blood stasis syndrome","volume":"12","author":"Yang","year":"2014","journal-title":"Contemp Med Symp"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.12102\/j.issn.1672-1349.2018.10.003","article-title":"Effect of Danlou tablet on blood lipid and hemorheology in patients with coronary heart disease complicated with hyperlipidemia","volume":"16","author":"Zhang","year":"2018","journal-title":"Chin J Integr Med Cardio-Cerebrovasc Dis"},{"key":"B33","first-page":"98","article-title":"Clinical observation of Danlou tablet in treating 70 cases of angina pectoris of coronary heart disease with mutual obstruction of phlegm and blood stasis syndrome","volume":"22","author":"Zhou","year":"2013","journal-title":"Chin J Ethnomed Ethnopharm"},{"key":"B34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2147\/PPA.S46990","article-title":"Comparative evaluation of the impact of four-week therapy with amlodipine and atenolol on quality of life and blood lipid composition in patients with coronary heart disease associated with metabolic syndrome","volume":"85","author":"Kalyuzhin","year":"2013","journal-title":"Ter Arkh"},{"key":"B35","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur Heart J"},{"key":"B36","doi-asserted-by":"publisher","first-page":"97","DOI":"10.12032\/ATR20200602","article-title":"The efficacy and safety of clopidogrel and aspirin in coronary heart disease with angina pectoris: a systematic review and meta-analysis","volume":"2","author":"Tian","year":"2020","journal-title":"Asian Toxicol Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1093\/fampra\/19.6.596","article-title":"Acceptance of guideline recommendations and perceived implementation of coronary heart disease prevention among primary care physicians in five European countries: the Reassessing European Attitudes about Cardiovascular Treatment (REACT) survey","volume":"19","author":"Hobbs","year":"2002","journal-title":"Fam Pract"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1161\/CIRCULATIONAHA.113.004243","article-title":"C-reactive protein, but not low-density lipoprotein cholesterol levels, associate with coronary atheroma regression and cardiovascular events after maximally intensive statin therapy","volume":"128","author":"Puri","year":"2013","journal-title":"Circulation"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.12102\/j.issn.1672-1349.2020.24.013","article-title":"Research progress of coronary heart disease angina pectoris in modern Chinese medicine","volume":"18","author":"Wang","year":"2020","journal-title":"Chin J Integr Med Cardio-Cerebrovasc Dis"},{"key":"B40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/HM9.0000000000000014","article-title":"Outcome measures in clinical trials of traditional Chinese medicine for stable angina pectoris","volume":"1","author":"Xing","year":"2021","journal-title":"Acupunct Herb Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"23416","DOI":"10.1097\/MD.0000000000023416","article-title":"Effects of Danlou tablet for the treatment of stable angina pectoris: a study protocol of a randomized, double-blind, and placebo-controlled clinical trial","volume":"99","author":"Yang","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s11655-016-2448-7","article-title":"Protective effects of Danlou tablet against murine myocardial ischemia and reperfusion injury in vivo","volume":"24","author":"Qi","year":"2018","journal-title":"Chin J Integr Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jpba.2013.02.011","article-title":"Qualitative and quantitative analysis of the major constituents in Chinese medicinal preparation Dan-Lou tablet by ultra high performance liquid chromatography\/diode-array detector\/quadrupole time-of-flight tandem mass spectrometry","volume":"80","author":"Dong","year":"2013","journal-title":"J Pharm Biomed Anal"},{"key":"B44","doi-asserted-by":"publisher","first-page":"369","DOI":"10.13193\/j.issn.1673-7717.2019.02.027","article-title":"Clinical observation of Danlou tablet combined with aspirin in treating angina pectoris of senile coronary heart disease","volume":"37","author":"Yang","year":"2019","journal-title":"Chin Arch Tradit Chin Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"81","DOI":"10.7326\/AITC201712050","article-title":"Dyslipidemia","volume":"167","author":"Kopin","year":"2017","journal-title":"Ann Intern Med"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1100006\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:37:10Z","timestamp":1686119830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1100006\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":45,"alternative-id":["10.3389\/fcvm.2023.1100006"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2023.1100006","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"article-number":"1100006"}}