{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:06:30Z","timestamp":1790813190619,"version":"4.1.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Studies have established a link between periodontal disease and cardiovascular disease (CVD), but it is unclear whether there is a sex difference in their association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PubMed, Embase, and Cochrane databases were searched until June, 21 2022. Cardiovascular outcomes included any CVD, myocardial infarction (MI), coronary heart disease (CHD), or stroke. Studies reported the prevalence of CVD in patients with periodontal disease and the relationship between periodontal disease and CVD. The study is registered with PROSPERO (CRD42022333663). The level of evidence and recommendations is assessed by the Grading of Recommendations for Assessment, Development and Evaluation (GRADE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-six studies were included. In patients with periodontal disease, the prevalence of CVD was 7.2% [9 studies; 95% confidence interval (CI): 2.7\u201313.6%], and prevalence for CHD, hypertension, stroke, and heart failure was 6.6, 25.3, 1, and 1.1%, respectively. There was a significant association between periodontal disease and CVD in men [odds ratio (OR) = 1.22; 95% CI: 1.12\u20131.34] and women (OR = 1.11; 95% CI: 1.05\u20131.17), with no significant sex difference (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cardiovascular disease is relatively common in patients with periodontal disease, and an increased risk of CVD is associated with periodontal disease independent of sex. Interventions targeting periodontal disease may be beneficial for CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:ext-link>\n                      , identifier CRD42022333663.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2023.1114927","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T10:02:27Z","timestamp":1677492147000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":92,"title":["Periodontal disease is associated with the risk of cardiovascular disease independent of sex: A meta-analysis"],"prefix":"10.3389","volume":"10","author":[{"given":"Yurong","family":"Leng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongda","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/08830185.2018.1539084","article-title":"Psoriasis and cardiovascular disease: the elusive link.","volume":"38","author":"Manolis","year":"2019","journal-title":"Int Rev Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1080\/00016357.2020.1774076","article-title":"Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic review.","volume":"78","author":"Colonia-Garc\u00eda","year":"2020","journal-title":"Acta Odontol Scand."},{"key":"B3","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1902\/jop.2005.76.3.406","article-title":"Is periodontitis associated with oral neoplasms?","volume":"76","author":"Tezal","year":"2005","journal-title":"J Periodontol."},{"key":"B4","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study.","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.hlc.2018.05.102","article-title":"Periodontal disease, systemic inflammation and the risk of cardiovascular disease.","volume":"27","author":"Carrizales-Sep\u00falveda","year":"2018","journal-title":"Heart Lung Circ."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.37.291.25448","article-title":"Oral cancer: a major and growing public health problem towards a national policy of prevention and early detection in Tunisia.","volume":"37","author":"Touil","year":"2020","journal-title":"Pan Afr Med J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1001\/archotol.133.5.450","article-title":"Chronic periodontitis and the risk of tongue cancer.","volume":"133","author":"Tezal","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.critrevonc.2015.08.018","article-title":"Is there a relationship between periodontal disease and oral cancer? 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