{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:15:52Z","timestamp":1781111752880,"version":"3.54.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to evaluate the prognostic value of gated SPECT MPI in non-obstructed coronary arteries (INOCA) patients, sought to stratify patients more accurately and thus derive more reliable prognostic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In total, 167 patients with INOCA were enrolled. The patients were divided into two groups according to their SSS. Patients were followed-up regularly in terms of major adverse cardiovascular event (MACE), including cardiac death, nonfatal myocardial infarction, stroke, re-hospitalization with angina pectoris, and recurrent angina pectoris. Kaplan-Meier curves and Cox's proportional hazards models were used to analyze survival and identify predictive factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adverse cardiac events occurred in 33 cases (19.8%). The rate of MACE was higher in the summed stress score (SSS) \u22654 group than in the SSS 0\u20133 group (30.1% vs. 9.5%, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and MACE-free survival was lower (annual MACE-free rates of 87.5% vs. 96.2%, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). Event-free survival was consistently higher in patients with normal arteries than in those with non-obstructive coronary artery disease (annual MACE-free rates of 96.1% and 88.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.035). When the SSS and the CAG results were combined, patients with normal coronary arteries (SSS 0\u20133) had the best prognosis and those with non-obstructive coronary artery stenosis (SSS\u2009\u2265\u20094) had the worst. However, the early prognosis of patients with non-obstructive coronary artery disease and SSS of 0\u20133 was comparable to that of patients with normal coronary arteries and SSS\u2009\u2265\u20094 (annual MACE-free rates of 100%, 94.6%, 93.1%, and 78.2%, respectively). Multivariate Cox's regression indicated that the SSS [hazard ratio (HR)\u2009=\u20091.126, 95% confidence interval (CI) 1.042\u20131.217, <jats:italic>P<\/jats:italic>\u2009=\u20090.003] and non-obstructive coronary artery disease (HR\u2009=\u20092.559, 95% CI 1.249\u20135.246, <jats:italic>P\u2009<\/jats:italic>=\u20090.01) were predictors of adverse cardiac events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SPECT MPI data were prognostic for INOCA patients, thus identifying groups at high risk. The long-term predictive efficacy of such data exceeded that of CAG data. A combination of the two measures more accurately stratified INOCA patients in terms of risk.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1115135","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T15:17:51Z","timestamp":1688483871000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic utility of 99mTc-MIBI single photon emission computerized tomography myocardial perfusion imaging in patients with ischemia and non-obstructive coronary artery 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