{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:51:28Z","timestamp":1753890688672,"version":"3.41.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>A 37-year-old woman presented with worsening intermittent chest pain and dyspnea in the previous year. Although the dyspnea was exertion-dependent, her chest pain was heavily dependent on her postural position, worsening in the supine position but alleviated by lying prone or by sitting up and leaning forward. She was cyanotic, and a diastolic murmur in the left third intercostal space was auscultated. An electrocardiogram recorded when she laid flat and had angina pectoris attacks showed ST-segment elevation in the aVR and depression in the II, III, aVF, and V3\u2013V6 leads. However, when she sat up for a few minutes, her symptoms and ST-segment abnormalities disappeared. Echocardiography and cardiac computed tomography angiography revealed large unruptured aneurysms of the left and non-coronary sinuses, along with a dilated aortic root, severe aortic regurgitation, and right ventricular high pressure. Coronary angiography showed \u223c90% pulsating stenosis of the left main coronary artery and \u223c80% pulsating stenosis of the proximal left circumflex artery, presumably caused by pulsation of the dilated sinus of Valsalva aneurysm under blood pressure. Genetic testing revealed c.1781 C\u2009&amp;gt;\u2009G nonsense mutations in the <jats:italic>FLNA<\/jats:italic> gene. The patient underwent surgery, which confirmed dual unruptured left\/non-coronary sinus of Valsalva aneurysms. Our case illustrates an unusual postural form of angina pectoris and false \u201cpulmonary hypertension\u201d caused by large dual unruptured left\/non-coronary sinus of Valsalva aneurysms.<\/jats:p>","DOI":"10.3389\/fcvm.2023.1120633","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T04:37:28Z","timestamp":1679459848000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report: Unruptured sinus of Valsalva aneurysms causing postural angina pectoris and false \u201cpulmonary hypertension\u201d"],"prefix":"10.3389","volume":"10","author":[{"given":"Chi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/clc.22359","article-title":"Sinus of Valsalva aneurysms: review of the literature and an update on management","volume":"38","author":"Weinreich","year":"2015","journal-title":"Clin Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S0022-5223(19)37013-8","article-title":"Ruptured aneurysms of the sinus of Valsalva in oriental patients","volume":"99","author":"Chu","year":"1990","journal-title":"J Thorac Cardiovasc Surg"},{"article-title":"Heritable thoracic aortic disease overview","year":"1993","author":"Milewicz","key":"B3"},{"key":"B4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrcardio.2009.45","article-title":"Ruptured sinus of Valsalva aneurysm presenting as ST-elevation myocardial infarction","volume":"6","author":"Lindsay","year":"2009","journal-title":"Nat Rev Cardiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/ejcts\/ezs450","article-title":"Surgery for ruptured sinus of Valsalva aneurysm: 25-year experience with 55 patients","volume":"43","author":"Sarikaya","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"B6","first-page":"441","article-title":"Sinus of Valsalva aneurysm with rupture. 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