{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:22:37Z","timestamp":1791908557731,"version":"4.3.4"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aimed to investigate the diagnostic accuracy of Murray law\u2013based quantitative flow ratio (\u03bcQFR) from a single angiographic view in patients with abnormal cardiac structure, left ventricular diastolic dysfunction, and valvular regurgitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>\u03bcQFR is a novel fluid dynamics method for deriving fractional flow reserve (FFR). In addition, current studies of \u03bcQFR mainly analyzed patients with normal cardiac structure and function. The accuracy of \u03bcQFR when patients had abnormal cardiac structure, left ventricular diastolic dysfunction, and valvular regurgitation has not been clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively analyzed 261 patients with 286 vessels that underwent both FFR and \u03bcQFR prior to intervention. The cardiac structure and function were measured using echocardiography. Pressure wire\u2013derived FFR \u22640.80 was defined as hemodynamically significant coronary stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u03bcQFR had a moderate correlation with FFR (<jats:italic>r<\/jats:italic>\u2009=\u20090.73, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), and the Bland\u2013Altman plot presented no difference between the \u03bcQFR and FFR (0.006\u2009\u00b1\u20090.075, <jats:italic>p<\/jats:italic>\u2009=\u20090.192). With FFR as the standard, the diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of \u03bcQFR were 94.06% (90.65\u201396.50), 82.56% (72.87\u201389.90), 99.00% (96.44\u201399.88), 97.26 (89.91\u201399.30), and 92.96% (89.29\u201395.44), respectively. The concordance of \u03bcQFR\/FFR was not associated with abnormal cardiac structure, valvular regurgitation (aortic valve, mitral valve, and tricuspid valve), and left ventricular diastolic function. Coronary hemodynamics showed no difference between normality and abnormality of cardiac structure and left ventricular diastolic function. Coronary hemodynamics demonstrated no difference among valvular regurgitation (none, mild, moderate, or severe).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\u03bcQFR showed an excellent agreement with FFR. The effect of abnormal cardiac structure, valvular regurgitation, and left ventricular diastolic function did not correlate with the diagnostic accuracy of \u03bcQFR. Coronary hemodynamics showed no difference in patients with abnormal cardiac structure, valvular regurgitation, and left ventricular diastolic function.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1134623","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T04:57:28Z","timestamp":1684904248000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["The effects of cardiac structure, valvular regurgitation, and left ventricular diastolic dysfunction on the diagnostic accuracy of Murray law\u2013based quantitative flow 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