{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:59:39Z","timestamp":1779314379774,"version":"3.51.4"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81973324"],"award-info":[{"award-number":["81973324"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Sedentary behavior is a risk factor for several diseases, and previous studies have mostly reported the effects of acute sedentary behavior on vascular endothelial function. Data on the relationship between sedentary lifestyle habits and vascular function in large sample populations are lacking. Therefore, the aim of this study was to assess the correlation between self-reported sedentary behavior and peripheral vascular function in a check-up population from real-world data.<\/jats:p><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 13,220 participants from two health management centers of general tertiary hospitals located in northern and southern China between 2017 and 2021. All participants had undergone both questionnaires and brachial artery flow-mediated dilation (FMD) measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 3,205 participants with FMD\u2009\u2264\u20095.0% were identified to have endothelial dysfunction. In a multivariable regression model including lifestyle habits such as sedentary behavior and cardiovascular risk factors, taking leisure sedentary time &amp;lt;2\u2005h\/day as a reference, the risk of vascular endothelial dysfunction gradually increased with time: 2\u20134\u2005h\/day (OR<jats:italic>\u2009<\/jats:italic>=\u20091.182, 95% CI: 1.058\u20131.321, <jats:italic>P\u2009<\/jats:italic>=\u20090.003), 4\u20136\u2005h\/day (OR<jats:italic>\u2009<\/jats:italic>=\u20091.248, 95% CI: 1.100\u20131.414, <jats:italic>P\u2009<\/jats:italic>=\u20090.001) and &amp;gt;6\u2005h\/day (OR<jats:italic>\u2009<\/jats:italic>=\u20091.618, 95% CI: 1.403\u20131.866, <jats:italic>P\u2009<\/jats:italic>&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Longer leisure sedentary time is associated with a higher prevalence of vascular endothelial dysfunction. These findings suggest that leisure sedentary behavior is a risk factor for the occurrence of vascular endothelial dysfunction in the Chinese check-up population.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1148353","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T07:34:55Z","timestamp":1691566495000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China"],"prefix":"10.3389","volume":"10","author":[{"given":"Ping-ting","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai-qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-mei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-xiang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.amjcard.2018.10.014","article-title":"Impact of prolonged sitting on peripheral and central vascular health","volume":"123","author":"Credeur","year":"2019","journal-title":"Am J Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s11886-022-01657-w","article-title":"Is sedentary behavior a novel risk factor for cardiovascular disease?","volume":"24","author":"Duran","year":"2022","journal-title":"Curr Cardiol Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/gerona\/gly101","article-title":"Sedentary behavior and prevalent diabetes in 6,166 older women: the objective physical activity and cardiovascular health study","volume":"74","author":"Bellettiere","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.3390\/ijerph17103545","article-title":"Association of sedentary behavior and depression among college students majoring in design","volume":"17","author":"Xu","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e729","DOI":"10.1161\/STROKEAHA.121.034194","article-title":"Objectively measured physical activity and sedentary time among adults with and without stroke: a national cohort study","volume":"52","author":"Duran","year":"2021","journal-title":"Stroke"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1161\/STROKEAHA.121.034985","article-title":"Association between excess leisure sedentary time and risk of stroke in young individuals","volume":"52","author":"Joundi","year":"2021","journal-title":"Stroke"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1001\/jamaoncol.2020.2045","article-title":"Association of sedentary behavior with cancer mortality in middle-aged and older US adults","volume":"6","author":"Gilchrist","year":"2020","journal-title":"JAMA Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.7326\/M17-0212","article-title":"Patterns of sedentary behavior and mortality in U.S. middle-aged and older adults: a national cohort study","volume":"167","author":"Diaz","year":"2017","journal-title":"Ann Intern Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ypmed.2016.11.021","article-title":"Sedentary time assessed by actigraphy and mortality: the Rotterdam study","volume":"95","author":"Koolhaas","year":"2017","journal-title":"Prev Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0140-6736(12)60646-1","article-title":"Global physical activity levels: surveillance progress, pitfalls, and prospects","volume":"380","author":"Hallal","year":"2012","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.amepre.2011.05.003","article-title":"The descriptive epidemiology of sitting. 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